Disorganization of thymic medulla precedes evolution towards diabetes in female NOD mice.

abstract：:Infectious agents have been implicated in the etiopathogenesis of various vasculitides via numerous and overlapping mechanisms including direct microbial invasion of endothelial cells, immune complex mediated vessel wall damage and stimulation of autoreactive B and/or T cells through molecular mimicry and superantigen...

journal_title：Autoimmunity

authors： Lidar M,Lipschitz N,Langevitz P,Shoenfeld Y

更新日期：2009-08-01 00:00:00

abstract：:A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...

journal_title：Autoimmunity

authors： Frey AB,Rao TD

更新日期：1999-01-01 00:00:00

abstract：:The possible immunosuppressive action of antithyroid drugs in vivo has been assessed using Buffalo (Buf) strain rats with thyroiditis produced by neonatal thymectomy; this model shares many features with spontaneous thyroiditis in man. Both propylthiouracil and methimazole significantly reduced the severity of thyroid...

journal_title：Autoimmunity

authors： Cohen SB,Weetman AP

更新日期：1988-01-01 00:00:00

abstract：:Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene e...

journal_title：Autoimmunity

authors： Haas JP,Metzler M,Frank C,Haefner R,Wassmuth R

更新日期：2009-05-01 00:00:00

abstract：:Augmented and prolonged expression of CD40 ligand (CD40L) was recently reported in lymphoid cells from human lupus patients, suggesting that CD40/CD40L pathway was involved in the pathogenesis of systemic autoimmune diseases. This study was thus designed to study the expression of CD40 and CD40L among cell populations...

journal_title：Autoimmunity

authors： Liu MF,Chao SC,Wang CR,Lei HY

更新日期：2001-01-01 00:00:00

abstract：:Autoantigen-reactive T lymphocytes have been implicated in the pathogenesis organ-specific autoimmune disease. Thyroglobulin (Tg) is one of the primary autoantigens associated with autoimmune lymphocytic thyroiditis (LT). These experiments investigated the pathogenicity of a lymphocyte line derived from spontaneously-...

journal_title：Autoimmunity

authors： Allen EM,Thupari JN

更新日期：1996-01-01 00:00:00

abstract：:The MRL/lpr model of SLE resembles human lupus in its various immunopathologic characteristics including the presence of high-level IgG and anti-DNA antibody production and multisystem organ involvement (nephritis, arthritis, and vasculitis). Our previous studies have shown that IL-1 overactivity in B cells plays a po...

journal_title：Autoimmunity

authors： Mao C,Singh AK

更新日期：1996-01-01 00:00:00

abstract：:Evidence is growing that autoimmune reactivity results from a combination of endogenous (e.g. MHC type) and environmental factors. Our experimental study focuses on the induction of autoimmune reactivity by microbial factors. Splenic formation and serum levels of anti-erythrocyte antibodies and circulating immune comp...

journal_title：Autoimmunity

authors： Hol C,Bloembergen P,van Dijk H

更新日期：1993-01-01 00:00:00

abstract：:We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...

journal_title：Autoimmunity

authors： Wong A,Tait R,Kenny T,Gorin F,Robbins D

更新日期：1995-01-01 00:00:00

abstract：:Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...

journal_title：Autoimmunity

authors： Jones BM,Liu T,Wong RW

更新日期：1999-10-01 00:00:00

abstract：:Guillain-Barre syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. However, GBS patients frequently display a psychosyndrome, indicating an accompanying involvement of the central nervous system (CNS), although the cause is not understood. Hepatic encephalopathy is possibly the best characterize...

journal_title：Autoimmunity

authors： Görtzen A,Schlüter S,Veh RW

更新日期：2004-09-01 00:00:00

abstract：:This review focuses on recent advances and new hypothesis in the understanding of the T and dendritic cells contribution to the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). The new data show that non-specific amplification of muscle inflammation by T...

journal_title：Autoimmunity

authors： Chevrel G,Page G,Miossec P

更新日期：2006-05-01 00:00:00

abstract：:On different tissue sections, binding of gliadin to reticular matrix components was observed which was Ca2+-dependent, inhibited by Cu2+ and Zn2+ ions, by putrescine, and by preincubation with antibodies against tissue transglutaminase (tTG) suggesting that binding of gliadin is mediated by tTG. tTG was able to bind t...

journal_title：Autoimmunity

authors： Uhlig H,Osman AA,Tanev ID,Viehweg J,Mothes T

更新日期：1998-01-01 00:00:00

abstract：:NZB (H-2d) mice are well known for the production of IgM autoantibodies to ssDNA. However, an F1 cross between NZB and either NZW or SWR mice is required to produce IgG nephritogenic antibodies to dsDNA and glomerulonephritis. The contribution of parental class II loci in the hybrid mice is clearly important to the de...

journal_title：Autoimmunity

authors： Cawley D,Chiang BL,Ansari A,Gershwin ME

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To assess muscle strength in patients with idiopathic inflammatory myopathies (IIM) using neuromuscular scales and isokinetic testing. METHODS:Muscle function was evaluated in 27 IIM patients being followed at the Rheumatology Unit of the University of Pisa using: (i) a modified version of the grading system...

journal_title：Autoimmunity

authors： Neri R,Mosca M,Stampacchia G,Vesprini E,Tavoni A,d'Ascanio A,Bombardieri S

更新日期：2006-05-01 00:00:00

abstract：:Although thyroid-associated ophthalmopathy (TAO) is now generally accepted as an autoimmune inflammatory disorder of the extraocular muscles and the orbital connective tissue, its aetiopathogenesis remains poorly understood. Recent data indicate that impaired interactions between T cells and extracellular matrix (ECM)...

journal_title：Autoimmunity

authors： Bednarczuk T,Kiljanski J,Mrowiec T,Slon M,Ing E,Stolarski C,Kennerdell JS,Gorski A,Nauman J,Wall JR

更新日期：1998-01-01 00:00:00

abstract：:Glucocorticoids (GCs) strongly impact on different T cell subsets inducing generally immunosuppressive effects, whereas much less is known about the effect of GC on natural killer (NK) cells. The aims of this study were to investigate the effects of GC on T cell functions, including T cell-mediated anti-tumor immune r...

journal_title：Autoimmunity

authors： Yakimchuk K,Chen L,Hasni MS,Okret S,Jondal M

更新日期：2015-03-01 00:00:00

abstract：:Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strept...

journal_title：Autoimmunity

authors： Guilherme L,Kalil J,Cunningham M

更新日期：2006-02-01 00:00:00

abstract：:We have used the reverse transcriptase polymerase chain reaction (RT-PCR) technique to assess the expression of cytokine genes in various T cell subsets of autoimmune-prone mice. Our study confirmed the previously described features in lpr mice that IFN-gamma, TNF-alpha, and TNF-beta were transcribed by various T cell...

journal_title：Autoimmunity

authors： Mori K,Kobayashi S,Inobe M,Jia WY,Tamakoshi M,Miyazaki T,Uede T

更新日期：1994-01-01 00:00:00

abstract：:Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...

journal_title：Autoimmunity

authors： Frusić-Zlotkin M,Raichenberg D,Wang X,David M,Michel B,Milner Y

更新日期：2006-11-01 00:00:00

abstract：:Although a variety of eye muscle antigens are recognized by autoantibodies in the serum from patients with thyroid associated ophthalmopathy (TAO) 64 kDa membrane proteins, which are also expressed in the thyroid, are most closely linked to the development of ophthalmopathy in patients with autoimmune thyroid disease....

journal_title：Autoimmunity

authors： Boucher A,Bernard N,Zhang ZG,Rodien P,Salvi M,Wall JR

更新日期：1993-01-01 00:00:00

abstract：:It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...

journal_title：Autoimmunity

authors： Suzuki N,Otuka I,Harada T,Mizushima Y,Sakane T

更新日期：1994-01-01 00:00:00

abstract：:The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients,...

journal_title：Autoimmunity

authors： Dar SA,Haque S,Mandal RK,Singh T,Wahid M,Jawed A,Panda AK,Akhter N,Lohani M,Areeshi MY,Rai G,Datt S,Bhattacharya SN,Ramachandran VG,Das S

更新日期：2017-05-01 00:00:00

abstract：:Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...

journal_title：Autoimmunity

authors： Bhol KC,Ahmed AR

更新日期：2002-03-01 00:00:00

abstract：:The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...

journal_title：Autoimmunity

authors： Banica L,Besliu A,Pistol G,Stavaru C,Ionescu R,Forsea AM,Tanaseanu C,Dumitrache S,Otelea D,Tamsulea I,Tanaseanu S,Chitonu C,Paraschiv S,Balteanu M,Stefanescu M,Matache C

更新日期：2009-01-01 00:00:00

abstract：:Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...

journal_title：Autoimmunity

authors： Lucke S,Klöting I,Pusch A,Heinrich HW,Hahn HJ

更新日期：2003-05-01 00:00:00

abstract：:Numerous studies have shown that autoantigens may be clustered in the blebs of apoptotic cells. However, it is not yet clear in what circumstances apoptotic cells could be immunogenic rather than tolerogenic when interacting with macrophages, dendritic cells, and B cells. In order to further study this question we com...

journal_title：Autoimmunity

authors： Shoshan Y,Mevorach D

更新日期：2004-03-01 00:00:00

abstract：:To assess the specificity of autoantibodies (aAbs) directed against the ribosomal P-proteins (RPPaAbs) in patients with systemic lupus erythematosus (SLE) and to investigate aAbs directed to other ribosomal proteins, 100 SLE, 100 rheumatoid arthritis (RA), 25 thyroiditis and 20 blood-donors were analyzed in a comparat...

journal_title：Autoimmunity

authors： Desbos A,Gonzalo P,Monier JC,Tebib J,Reboud JP,Perrier H,Bienvenu J,Fabien N

更新日期：2002-11-01 00:00:00

abstract：:Mitochondrial antigens were purified from rat liver and characterized by immunoblotting. Sera from 19 well defined patients with primary biliary cirrhosis (PBC) reacted with two mitochondrial polypeptides of 68 Kd and 45 Kd. Antibodies to these antigens were not detected in any of the sera of patients with cirrhosis o...

journal_title：Autoimmunity

authors： Zurgil N,Konikoff F,Bakimer R,Slor H,Shoenfeld Y

更新日期：1989-01-01 00:00:00

abstract：:Autoantibodies directed against nuclear antigens often arise in autoimmune disease associated with the failure to clear apoptotic cells in a swift and timely manner. Nucleic acids present in apoptotic cells and in membranous microparticles derived thereof exert adjuvant activity in the immune response to apoptosis. Th...

journal_title：Autoimmunity

authors： Bekeredjian-Ding I

更新日期：2013-08-01 00:00:00