Abstract:
:Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene expression in OA-JIA patients. In cells from affected joints compared to peripheral blood, gene expression of HLA-DRA as well as total HLA-DQA1 was significantly upregulated. Differential analyses of HLA-DQA1 allelic expression showed DQA1*02 and *04 to be comparatively increased. Intra-articular upregulation of HLA-DQA1 was predominantly observed for the OA-JIA associated allele HLA-DQA1*04. Nevertheless, the Y-box mutation of the disease-associated allele DQA1*0401 was not a common denominator for expression behaviour.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Haas JP,Metzler M,Frank C,Haefner R,Wassmuth Rdoi
10.1080/08916930902832652subject
Has Abstractpub_date
2009-05-01 00:00:00pages
389-91issue
4eissn
0891-6934issn
1607-842Xpii
10.1080/08916930902832652journal_volume
42pub_type
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