Production of non-pathogenic human monoclonal antibodies to desmoglein 3 from pemphigus vulgaris patient.

abstract：:On different tissue sections, binding of gliadin to reticular matrix components was observed which was Ca2+-dependent, inhibited by Cu2+ and Zn2+ ions, by putrescine, and by preincubation with antibodies against tissue transglutaminase (tTG) suggesting that binding of gliadin is mediated by tTG. tTG was able to bind t...

journal_title：Autoimmunity

authors： Uhlig H,Osman AA,Tanev ID,Viehweg J,Mothes T

更新日期：1998-01-01 00:00:00

abstract：:Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...

journal_title：Autoimmunity

authors： Lucke S,Klöting I,Pusch A,Heinrich HW,Hahn HJ

更新日期：2003-05-01 00:00:00

abstract：:The objective of this study was to research the functionality of anti-endothelial cell antibodies (AECA) in pulmonary arterial hypertension (PAH) by assessing the effects of IgG from AECA-positive PAH patients on the induction of adhesion molecules on human umbilical vein endothelial cells (HUVECs) and on the producti...

journal_title：Autoimmunity

authors： Arends SJ,Damoiseaux JG,Duijvestijn AM,Debrus-Palmans L,Boomars KA,Brunner-La Rocca HP,Cohen Tervaert JW,van Paassen P

更新日期：2013-11-01 00:00:00

abstract：:In a previous study, we showed that the Ly6G(-)CD11b(+) blood monocytes residing in naïve mice are intrinsically immunosuppressive and that loss of this suppressive function may contribute to the development of autoimmunity in experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis....

journal_title：Autoimmunity

authors： Slaney CY,Toker A,Fraser JD,Harper JL,Bäckström BT

更新日期：2013-06-01 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating autoimmune disease that affects more than 1 million people worldwide and severely compromises motor and sensory function through demyelination and axonal loss. This review covers current therapies, lessons learned from failed clinical trials, genetic susceptibility, key cell ty...

journal_title：Autoimmunity

authors： Slavin A,Kelly-Modis L,Labadia M,Ryan K,Brown ML

更新日期：2010-11-01 00:00:00

abstract：:CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...

journal_title：Autoimmunity

authors： Martens HA,Kallenberg CG,Bijl M

更新日期：2009-05-01 00:00:00

abstract：:Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. It is characterized by frequent re...

journal_title：Autoimmunity

authors： Kujur W,Gurram RK,Maurya SK,Nadeem S,Chodisetti SB,Khan N,Agrewala JN

更新日期：2017-08-01 00:00:00

abstract：:In the present study, the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in kidney lymphoid cells of lupus-prone mice (MRL-lpr/lpr) is shown by Northern blot and nuclear run on transcription assay. By quantification analysis of hsp 70 gene transcription, more than ten times of the enhan...

journal_title：Autoimmunity

authors： Deguchi Y

更新日期：1991-01-01 00:00:00

abstract：:A robust and precise enzyme linked immunosorbent assay (ELISA) with proven sensitivity and specificity has been employed to detect human antibodies (allogenic/autogenic) to human acetylcholinesterase (AChE). The sensitivity of the method has been established using mouse monoclonal antibodies (0.8 ng/ml) and uniquely, ...

journal_title：Autoimmunity

authors： Geen J,Howells RC,Ludgate M,Hullin DA,Hogg SI

更新日期：2004-12-01 00:00:00

abstract：:It has been shown in animal toxicity models that administration of Cyclosporine, CsA, to a pregnant mouse greatly increases the risk that the offspring will develop autoimmunity. Immunization starting at birth has been shown to prevent autoimmunity in other animal models of autoimmunity and early immunization is assoc...

journal_title：Autoimmunity

authors： Classen JB

更新日期：1998-01-01 00:00:00

abstract：:Congenital heart block is a serious condition with significant mortality due in most cases to the transplacental transfer of autoantibodies from an otherwise asymptomatic mother. Although SSA/Ro and SSB/La autoantibodies have been implicated, attention has focused recently on autoantibodies to envelope proteins of end...

journal_title：Autoimmunity

authors： de Parseval N,Forrest G,Venables PJ,Heidmann T

更新日期：1999-01-01 00:00:00

abstract：:A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...

journal_title：Autoimmunity

authors： Matache C,Stefanescu M,Onu A,Szegli G,Barel M,Tanaseanu S,Matei I,Bouillie S,Frade R

更新日期：1996-01-01 00:00:00

abstract：:In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...

journal_title：Autoimmunity

authors： Boissier MC,Texier B,Carlioz A,Fournier C

更新日期：1989-01-01 00:00:00

abstract：:We have used the reverse transcriptase polymerase chain reaction (RT-PCR) technique to assess the expression of cytokine genes in various T cell subsets of autoimmune-prone mice. Our study confirmed the previously described features in lpr mice that IFN-gamma, TNF-alpha, and TNF-beta were transcribed by various T cell...

journal_title：Autoimmunity

authors： Mori K,Kobayashi S,Inobe M,Jia WY,Tamakoshi M,Miyazaki T,Uede T

更新日期：1994-01-01 00:00:00

abstract：:Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...

journal_title：Autoimmunity

authors： Villarroya H,Dalix AM,Paraut M,Oriol R

更新日期：1990-01-01 00:00:00

abstract：:Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable ath...

journal_title：Autoimmunity

authors： Kyaw T,Tipping P,Bobik A,Toh BH

更新日期：2017-02-01 00:00:00

abstract：:In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...

journal_title：Autoimmunity

authors： Celada F

更新日期：2011-06-01 00:00:00

abstract：:In this study we investigated one of the possible mechanisms of p56lck down-regulation in peripheral blood lymphocytes (PBLs) from Systemic Lupus Erythematosus (SLE) patients and we correlated p56lck dysregulation with accelerated apoptosis in SLE PBLs. PBLs from SLE patients and healthy donors were isolated. p56lck p...

journal_title：Autoimmunity

authors： Matache C,Onu A,Stefanescu M,Tanaseanu S,Dragomir C,Dolganiuc A,Szegli G

更新日期：2001-01-01 00:00:00

abstract：:Evidence is growing that autoimmune reactivity results from a combination of endogenous (e.g. MHC type) and environmental factors. Our experimental study focuses on the induction of autoimmune reactivity by microbial factors. Splenic formation and serum levels of anti-erythrocyte antibodies and circulating immune comp...

journal_title：Autoimmunity

authors： Hol C,Bloembergen P,van Dijk H

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVES:Autoimmune sensorineural hearing loss (ASNHL) is a relatively rare disorder which can lead to total deafness. At present, no specific laboratory test with adequate sensitivity and specificity is available to confirm the clinical suspicion of ASNHL. The aim of this study was to identify if evaluation of anti-...

journal_title：Autoimmunity

authors： Bonaguri C,Orsoni JG,Zavota L,Monica C,Russo A,Pellistri I,Rubino P,Giovannelli L,Manzotti F,Piazza F

更新日期：2007-02-01 00:00:00

abstract：:The T cell repertoire expressed by Tsk2 mice, a novel experimental model of systemic sclerosis, was examined to determine whether cells infiltrating the areas of involved skin exhibit a T cell receptor (TCR) bias. Reverse transcription-polymerase chain reactions (RT-PCR) were conducted using RNA extracted from lymph n...

journal_title：Autoimmunity

authors： Wooley PH,Sud S,Langendorfer A,Calkins C,Christner PJ,Peters J,Jimenez SA

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:There have been few reports on the association of rheumatoid arthritis (RA) with anti-neutrophil cytoplasmic antigen (ANCA)-associated systemic vasculitides. METHODS:Here we present four cases of RA overlapping with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CS...

journal_title：Autoimmunity

authors： Szilasi M,Mátyus J,File I,Szücs G,Rákóczi E,Pfliegler G,Szabó Z,Végh E,Szekanecz Z

更新日期：2012-06-01 00:00:00

abstract：:CD4+ T cells play a crucial role in the development of lupus in MRL-lpr/lpr mice: incomplete deletion/silencing of self-reactive CD4+ T cells leads to T cell activation, which causes both polyclonal B cell activation and T cell infiltration of multiple organs. Furthermore, anti-CD4 antibody therapy ameliorates disease...

journal_title：Autoimmunity

authors： Duan JM,Fagard R,Madaio MP

更新日期：1996-01-01 00:00:00

abstract：:Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...

journal_title：Autoimmunity

authors： Jones BM,Liu T,Wong RW

更新日期：1999-10-01 00:00:00

abstract：:During apo blebs, containing nuclear components, are formed at the cells' surfaces. When these blebs separate from the dying cell an apo cell body remains. The contents of apo blebs are modified and can be released, especially in patients with systemic lupus erythematosus (SLE) since impaired clearance of apo material...

journal_title：Autoimmunity

authors： Fransen JH,Hilbrands LB,Jacobs CW,Adema GJ,Berden JH,Van der Vlag J

更新日期：2009-05-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice (H-2g7) and C57BL/6 mice (H-2b) by a ...

journal_title：Autoimmunity

authors： Slavin A,Ewing C,Liu J,Ichikawa M,Slavin J,Bernard CC

更新日期：1998-01-01 00:00:00

abstract：:A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...

journal_title：Autoimmunity

authors： Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

更新日期：2006-09-01 00:00:00

abstract：:We report in this paper on obvious fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). B6 CD8+ splenocytes were transferred into (bm 12 x bm 1)F1 mice to induce GVHR. Recipient mice had been thymectomized and administrated with anti-CD8 monoclonal antibody (mAb) to deplete CD8...

journal_title：Autoimmunity

authors： Inada S,Suzuki K,Kimura T,Hayashi A,Narita T,Yui R,Asakura H,Fujiwara M

更新日期：1995-01-01 00:00:00

abstract：:Mitochondrial antigens were purified from rat liver and characterized by immunoblotting. Sera from 19 well defined patients with primary biliary cirrhosis (PBC) reacted with two mitochondrial polypeptides of 68 Kd and 45 Kd. Antibodies to these antigens were not detected in any of the sera of patients with cirrhosis o...

journal_title：Autoimmunity

authors： Zurgil N,Konikoff F,Bakimer R,Slor H,Shoenfeld Y

更新日期：1989-01-01 00:00:00

abstract：:We reported a patient who gave birth to 3 children with transient neonatal hypothyroidism. She had 3 different antibodies (Ab) to the thyrotropin receptor (TSHR) in her serum, viz., TSH binding-inhibiting (TBIAb), thyroid-stimulating (TSAb) and an additional stimulating Ab (SAb). The SAb differed from TSAb in that its...

journal_title：Autoimmunity

authors： Zakarija M,De Forteza R,McKenzie JM,Ghandur-Mnaymneh L

更新日期：1994-01-01 00:00:00