Abstract:
:In the present study, the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in kidney lymphoid cells of lupus-prone mice (MRL-lpr/lpr) is shown by Northern blot and nuclear run on transcription assay. By quantification analysis of hsp 70 gene transcription, more than ten times of the enhanced transcription of hsp 70 gene in kidney lymphoid cells of lupus-prone mice was first found, in comparison to normal control mice (MRL(-)+/+). The elevation of transcriptional level of hsp 70 gene was also found to increase during growing process and seemed to have positive correlation with deterioration of lupus-related renal disorders in lupus-prone mice. Our observation suggests that heat shock proteins may be involved in possible significance in the pathophysiology of nephrotic lesions of lupus-prone mice due to lupus-related change of kidney lymphoid cells.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Deguchi Ydoi
10.3109/08916939108997141subject
Has Abstractpub_date
1991-01-01 00:00:00pages
1-5issue
1eissn
0891-6934issn
1607-842Xjournal_volume
10pub_type
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