Allogeneic hematopoietic stem cell transplantation for severe autoimmune diseases.


:Allogeneic hematopoietic stem cell transplantation (HSCT) offers the unique opportunity to replace a diseased hematopoietic or immune system by healthy donor cells. Proof of principle comes from experimental animal data, from the experience with severe aplastic anemia, from observations of patients with concomitant autoimmune disease and from scattered case reports. Complete remissions have been described as well as failures. Allogeneic HSCT remains associated with significant morbidity and mortality. The potential risks might outweight the benefits. Currently, allogeneic HSCT cannot be recommended in general. Carefully conducted prospective studies are warranted to define target populations and best technology to be used. Conditions for such studies have been identified by an international expert panel.






Gratwohl A




Has Abstract


2008-12-01 00:00:00














  • Thymic remodeling associated with hyperplasia in myasthenia gravis.

    abstract::Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...


    pub_type: 杂志文章,评审


    authors: Le Panse R,Bismuth J,Cizeron-Clairac G,Weiss JM,Cufi P,Dartevelle P,De Rosbo NK,Berrih-Aknin S

    更新日期:2010-08-01 00:00:00

  • Lack of 64,000-M(r) islet autoantigen overexpression and antibody development following coxsackievirus B4 infection in diabetes-resistant mice.

    abstract::Congenic B10.BR/SgSnJ H-2kTlaa mice were infected with a diabetogenic strain of coxsackievirus CB4 to correlate abnormalities of sugar metabolism with virus replication in islets, 64,000-M(r) (64K) islet autoantigen expression, 64K antibody development, and pancreas histopathology in early and late infection. Plaque a...


    pub_type: 杂志文章


    authors: Gerling I,Chatterjee NK

    更新日期:1993-01-01 00:00:00

  • Functional implications of IgG anti-endothelial cell antibodies in pulmonary arterial hypertension.

    abstract::The objective of this study was to research the functionality of anti-endothelial cell antibodies (AECA) in pulmonary arterial hypertension (PAH) by assessing the effects of IgG from AECA-positive PAH patients on the induction of adhesion molecules on human umbilical vein endothelial cells (HUVECs) and on the producti...


    pub_type: 杂志文章


    authors: Arends SJ,Damoiseaux JG,Duijvestijn AM,Debrus-Palmans L,Boomars KA,Brunner-La Rocca HP,Cohen Tervaert JW,van Paassen P

    更新日期:2013-11-01 00:00:00

  • Different islet protein expression profiles during spontaneous diabetes development vs. allograft rejection in BB-DP rats.

    abstract::Type 1 diabetes (T1D) is characterized by selective autoimmune destruction of the insulin producing beta-cells in the islets of Langerhans. When the beta-cells are destroyed exogenous administration of insulin is necessary for maintenance of glucose homeostasis. Allogeneic islet transplantation has been used as a mean...


    pub_type: 杂志文章


    authors: Christensen UB,Larsen PM,Fey S,Karlsen AE,Pociot F,Nerup J,Sparre T

    更新日期:2006-06-01 00:00:00

  • Enhanced expression of heat shock protein gene in kidney lymphoid cells of lupus-prone mice during growing process.

    abstract::In the present study, the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in kidney lymphoid cells of lupus-prone mice (MRL-lpr/lpr) is shown by Northern blot and nuclear run on transcription assay. By quantification analysis of hsp 70 gene transcription, more than ten times of the enhan...


    pub_type: 杂志文章


    authors: Deguchi Y

    更新日期:1991-01-01 00:00:00

  • Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM.

    abstract::Insulin-dependent diabetes mellitus (IDDM) is preceded by the presence of antibodies against islet proteins including a protein tyrosine phosphatase (PTP) designated IA-2. Recently, we cloned a novel PTP named IAR which shares 43% sequence identity with IA-2 and is recognised by antibodies from a majority of patients ...


    pub_type: 杂志文章


    authors: Schmidli RS,Colman PG,Cui L,Yu WP,Kewming K,Jankulovski C,Harrison LC,Pallen CJ,DeAizpurua HJ

    更新日期:1998-01-01 00:00:00

  • Follow-up of avidity and titer of anti-myeloperoxidase antibodies in sera from patients with primary ANCA-associated vasculitis.

    abstract::Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV). Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA....


    pub_type: 杂志文章


    authors: Lin W,Chen M,Zhao MH

    更新日期:2009-03-01 00:00:00

  • The clinical characteristics of autoimmune haemolytic anaemia/Evans syndrome patients with clonal immunoglobulin/T cell receptor gene rearrangement.

    abstract:OBJECTIVE:To investigate the clinical features of AIHA/ES patients with clonal Ig/TCR gene rearrangement. METHODS:Ig/TCR gene rearrangements were measured by BIOMED-2 PCR. 44 primary AIHA/ES patients were enrolled in the study. Clinical characteristics were analyzed and compared between patients with and without clona...


    pub_type: 杂志文章


    authors: Zhu H,Zhao M,Cao Z,Yang J,Li Y,Xing L

    更新日期:2020-11-01 00:00:00

  • The pathogenicity of spontaneously-occurring thyroglobulin-reactive T lymphocytes from BB/WOR rats.

    abstract::Autoantigen-reactive T lymphocytes have been implicated in the pathogenesis organ-specific autoimmune disease. Thyroglobulin (Tg) is one of the primary autoantigens associated with autoimmune lymphocytic thyroiditis (LT). These experiments investigated the pathogenicity of a lymphocyte line derived from spontaneously-...


    pub_type: 杂志文章


    authors: Allen EM,Thupari JN

    更新日期:1996-01-01 00:00:00

  • Immunopurification and characterization of thyroid autoantibodies with dual specificity for thyroglobulin and thyroperoxidase.

    abstract::The presence of autoantibodies (aAbs) to thyroglobulin (TG) and thyroperoxidase (TPO) in most of the patients with autoimmune thyroid disease is now well documented. Studies of these aAbs suggested that some, termed TGPO aAbs, could interact with both TG and TPO. This hypothesis was investigated using IgG fraction fro...


    pub_type: 杂志文章


    authors: Ruf J,Ferrand M,Durand-Gorde JM,Carayon P

    更新日期:1992-01-01 00:00:00

  • Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand.

    abstract::Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...


    pub_type: 杂志文章


    authors: Saito K,Mori S,Date F,Ono M

    更新日期:2013-06-01 00:00:00

  • Serum CXCL10 levels and neuromuscular manifestations in patients with autoimmune thyroid diseases.

    abstract:OBJECTIVE:Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. DESIGN:A total of ...


    pub_type: 杂志文章


    authors: Cakir M,Levendoglu F,Kiyici A,Coskun Y

    更新日期:2011-09-01 00:00:00

  • Preferential adsorption of cationic anti-DNA antibodies with immobilized polyanionic compounds, dextran sulfate.

    abstract::It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...


    pub_type: 杂志文章


    authors: Suzuki N,Otuka I,Harada T,Mizushima Y,Sakane T

    更新日期:1994-01-01 00:00:00

  • Reduced tetanus antibody titers in overweight children.

    abstract::Under-nutrition impairs immune responses, but far less is known about the impact of over-nutrition, such as obesity, on the response to vaccines. We measured the effect of childhood overweight status on inflammatory mediators, circulating immunoglobulins and tetanus antibodies in fifteen overweight children (BMI > 85 ...


    pub_type: 杂志文章


    authors: Eliakim A,Schwindt C,Zaldivar F,Casali P,Cooper DM

    更新日期:2006-03-01 00:00:00

  • Anti-ribonucleoprotein antibodies mediate enhanced lung injury following mesenteric ischemia/reperfusion in Rag-1(-/-) mice.

    abstract::Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...


    pub_type: 杂志文章


    authors: Keith MP,Moratz C,Egan R,Zacharia A,Greidinger EL,Hoffman RW,Tsokos GC

    更新日期:2007-05-01 00:00:00

  • Nitric oxide mediates IL-1beta stimulation of heat shock protein but not IL-1beta inhibition of glutamic acid decarboxylase.

    abstract::Interleukin-1beta (IL-1beta) has been implicated to play an important role in the autoimmune beta cell lesion of insulin-dependent diabetes mellitus (IDDM) because of its inhibition of insulin secretion, direct islet cytotoxicity and alteration of islet cell antigen expression. We have previously demonstrated that IL-...


    pub_type: 杂志文章


    authors: Hao W,Myhre AP,Palmer JP

    更新日期:1999-01-01 00:00:00

  • Exposure of chromatin and not high affinity for dsDNA determines the nephritogenic impact of anti-dsDNA antibodies in (NZBxNZW)F1 mice.

    abstract::Recent studies have demonstrated that the nephritogenicity of antibodies to dsDNA and nucleosomes confers to binding of glomerular membrane-associated nucleosomes, and not to cross-reacting glomerular antigens. There is no known parameter that determines antibody pathogenicity aside from specificity for dsDNA/nucleoso...


    pub_type: 杂志文章


    authors: Mjelle JE,Kalaaji M,Rekvig OP

    更新日期:2009-02-01 00:00:00

  • Neonatal lupus: review of proposed pathogenesis and clinical data from the US-based Research Registry for Neonatal Lupus.

    abstract::Congenital heart block (CHB), a life-threatening manifestation of neonatal lupus, offers aunique opportunity to study the effect or arm of immunity and define the pathogenicity of an autoantibody in mediating tissue injury. This review focuses on our recent in vitro model which supports a cascade from antibody insult ...


    pub_type: 杂志文章,评审


    authors: Buyon JP,Clancy RM

    更新日期:2003-02-01 00:00:00

  • Expression of rheumatoid factor idiotypes 17.109, 6B6.6 and 4C9 in the sera of Pima Indians.

    abstract::This study was undertaken to determine whether the expression of 17.109, 6B6.6 and 4C9 rheumatoid factor (RF) idiotypes is predictive of the development of rheumatoid arthritis (RA) and whether the RF response is idiotypically restricted in an inbred population of Pima Indians who have a genetic predisposition for the...


    pub_type: 杂志文章


    authors: Davidson A,Keiser HD,del Puente A,Bennett PH,Schrohenloher R,Koopman WJ

    更新日期:1994-01-01 00:00:00

  • T cell interactions with extracellular matrix proteins in patients with thyroid-associated ophthalmopathy.

    abstract::Although thyroid-associated ophthalmopathy (TAO) is now generally accepted as an autoimmune inflammatory disorder of the extraocular muscles and the orbital connective tissue, its aetiopathogenesis remains poorly understood. Recent data indicate that impaired interactions between T cells and extracellular matrix (ECM)...


    pub_type: 杂志文章


    authors: Bednarczuk T,Kiljanski J,Mrowiec T,Slon M,Ing E,Stolarski C,Kennerdell JS,Gorski A,Nauman J,Wall JR

    更新日期:1998-01-01 00:00:00

  • Protective effects of quercetin treatment in a pristane-induced mouse model of lupus nephritis.

    abstract:INTRODUCTION:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice ...


    pub_type: 杂志文章


    authors: Dos Santos M,Poletti PT,Favero G,Stacchiotti A,Bonomini F,Montanari CC,Bona SR,Marroni NP,Rezzani R,Veronese FV

    更新日期:2018-03-01 00:00:00

  • Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C.

    abstract::Numerous human Cytochrome P450 enzymes (CYPs) associated with 'phase I' drug metabolism have been identified. Among them, CYP2D6 is thought to be the major target autoantigen to anti-liver kidney microsome (LKM)-1 autoantibody, a characteristic feature of autoimmune hepatitis (AIH) type II. In this study, we were able...


    pub_type: 杂志文章


    authors: Miyakawa H,Kitazawa E,Kikuchi K,Fujikawa H,Kawaguchi N,Abe K,Matsushita M,Matsushima H,Igarashi T,Hankins RW,Kako M

    更新日期:2000-01-01 00:00:00

  • Dietary protein restriction reduces the frequency and delays the onset of insulin dependent diabetes in BB rats.

    abstract::Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy...


    pub_type: 杂志文章


    authors: Atkinson MA,Winter WE,Skordis N,Beppu H,Riley WM,Maclaren NK

    更新日期:1988-01-01 00:00:00

  • Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitis.

    abstract::Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. It is characterized by frequent re...


    pub_type: 杂志文章


    authors: Kujur W,Gurram RK,Maurya SK,Nadeem S,Chodisetti SB,Khan N,Agrewala JN

    更新日期:2017-08-01 00:00:00

  • Concentric fibrosis and cellular infiltration around bile ducts induced by graft-versus-host reaction in mice: a role of CD8+ cells.

    abstract::We report in this paper on obvious fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). B6 CD8+ splenocytes were transferred into (bm 12 x bm 1)F1 mice to induce GVHR. Recipient mice had been thymectomized and administrated with anti-CD8 monoclonal antibody (mAb) to deplete CD8...


    pub_type: 杂志文章


    authors: Inada S,Suzuki K,Kimura T,Hayashi A,Narita T,Yui R,Asakura H,Fujiwara M

    更新日期:1995-01-01 00:00:00

  • Anti-astrocyte autoantibodies in Guillain-Barre Syndrome--possible involvement in the pathophysiology of a psychosyndrome?

    abstract::Guillain-Barre syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. However, GBS patients frequently display a psychosyndrome, indicating an accompanying involvement of the central nervous system (CNS), although the cause is not understood. Hepatic encephalopathy is possibly the best characterize...


    pub_type: 杂志文章


    authors: Görtzen A,Schlüter S,Veh RW

    更新日期:2004-09-01 00:00:00

  • Induction of hyperacute brain inflammation and demyelination by activated encephalitogenic T cells and a monoclonal antibody specific for a myelin/oligodendrocyte glycoprotein.

    abstract::CNS demyelinating inflammatory disease can be a multifactorial process mediated by cellular and antibody-mediated immune processes. Myelin basic protein (MBP)-specific T cells and pathogenic 8-18C5 antibody, specific for a myelin/oligodendrocyte glycoprotein (MOG), a minor component of CNS white matter, can coexist in...


    pub_type: 杂志文章


    authors: Schluesener HJ,Lider O,Sobel RA

    更新日期:1989-01-01 00:00:00

  • Morphological analysis of autoimmune disease in MRL-lpr,Yaa male mice with rapidly progressive systemic lupus erythematosus.

    abstract::We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...


    pub_type: 杂志文章


    authors: Suzuka H,Yoshifusa H,Nakamura Y,Miyawaki S,Shibata Y

    更新日期:1993-01-01 00:00:00

  • A study of conformational restraints on reactivity of human PR3-specific autoantibodies (ANCA) facilitated through protein folding manipulations of a new recombinant proteinase 3 protein.

    abstract::Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes utilizing a novel recombinant PR3 (rPR3) produced to accommodate manipulations of the N-terminal domain. The rPR3 molecule contains an N-terminus six ...


    pub_type: 杂志文章


    authors: Farrag L,Pendergraft WF 3rd,Yang JJ,Jennette JC,Falk RJ,Preston GA

    更新日期:2007-11-01 00:00:00

  • Effect of administration of apoptotic blebs on disease development in lupus mice.

    abstract:INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...


    pub_type: 杂志文章


    authors: Fransen JH,Berden JH,Koeter CM,Adema GJ,Van Der Vlag J,Hilbrands LB

    更新日期:2012-06-01 00:00:00