Allogeneic hematopoietic stem cell transplantation for severe autoimmune diseases.

abstract：:T helper type 17 (Th17) cells, a newly identified effector T-cell subset, have recently been shown to play a role in numerous autoimmune diseases, including iodine-induced autoimmune thyroiditis in non-obese diabetic (NOD)-H2(h4) mice, which had previously been thought Th1-dominant. We here studied the role of Th17 in...

journal_title：Autoimmunity

authors： Horie I,Abiru N,Saitoh O,Ichikawa T,Iwakura Y,Eguchi K,Nagayama Y

更新日期：2011-03-01 00:00:00

abstract：:Subcutaneous insulin treatment of young diabetes prone BB rats has been shown previously to suppress the development of autoimmune diabetes. In this study the hypothesis was tested that exogenous insulin may deviate the autoimmune process by acting on the Th1/Th2 cytokine balance in the pancreas. BB rats were implante...

journal_title：Autoimmunity

authors： Kolb H,Wörz-Pagenstert U,Kleemann R,Rothe H,Rowsell P,Rastegar S,Scott FW

更新日期：1997-01-01 00:00:00

abstract：:An analysis of the cell-surface expression of activation markers on B- and T-cells was done to compare patients with myasthenia gravis (MG) and healthy non-myasthenic controls. Marker expression was determined by immunostaining of peripheral blood mononuclear cells (PBMC) isolated from MG patients and from controls. T...

journal_title：Autoimmunity

authors： Ragheb S,Bealmear B,Lisak R

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:Autoimmune sensorineural hearing loss (ASNHL) is a relatively rare disorder which can lead to total deafness. At present, no specific laboratory test with adequate sensitivity and specificity is available to confirm the clinical suspicion of ASNHL. The aim of this study was to identify if evaluation of anti-...

journal_title：Autoimmunity

authors： Bonaguri C,Orsoni JG,Zavota L,Monica C,Russo A,Pellistri I,Rubino P,Giovannelli L,Manzotti F,Piazza F

更新日期：2007-02-01 00:00:00

abstract：:Augmented and prolonged expression of CD40 ligand (CD40L) was recently reported in lymphoid cells from human lupus patients, suggesting that CD40/CD40L pathway was involved in the pathogenesis of systemic autoimmune diseases. This study was thus designed to study the expression of CD40 and CD40L among cell populations...

journal_title：Autoimmunity

authors： Liu MF,Chao SC,Wang CR,Lei HY

更新日期：2001-01-01 00:00:00

abstract：:We have used the MRL/lpr murine model of spontaneous lupus to investigate three questions in infection immunity: (1) does mycobacterial infection have any effect on the mortality of the autoimmunity-prone lpr mice?; (2) does the infection modify the progression of kidney disease of lpr lupus?; and (3) does the lpr gen...

journal_title：Autoimmunity

authors： Castro AP,Esaguy N,Aguas AP

更新日期：1993-01-01 00:00:00

abstract：:Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...

journal_title：Autoimmunity

authors： Sjöber K,Eriksson S,Tenngart B,Roth EB,Leffler H,Stenberg P

更新日期：2002-08-01 00:00:00

abstract：:We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...

journal_title：Autoimmunity

authors： Wong A,Tait R,Kenny T,Gorin F,Robbins D

更新日期：1995-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are evolutionary conserved molecules that recognize various microbial components and host-derived agonists from damaged cells and play a central role in innate and adaptive immunity. It has been reported that MyD88, the adaptor molecule downstream of all TLRs, except TLR3, is essential for i...

journal_title：Autoimmunity

authors： Pagni PP,Traub S,Demaria O,Chasson L,Alexopoulou L

更新日期：2010-06-01 00:00:00

abstract：:Hybridoma cell lines producing natural autoantibodies (NAA), generated from A.SW mice with progressive experimental autoimmune encephalomyelitis (P-EAE), have been shown to cause demyelination and renal pathology when injected into naive mice. To investigate the relative contribution of these antibodies to disease pat...

journal_title：Autoimmunity

authors： Peterson LK,Tsunoda I,Fujinami RS

更新日期：2008-08-01 00:00:00

abstract：:Under-nutrition impairs immune responses, but far less is known about the impact of over-nutrition, such as obesity, on the response to vaccines. We measured the effect of childhood overweight status on inflammatory mediators, circulating immunoglobulins and tetanus antibodies in fifteen overweight children (BMI > 85 ...

journal_title：Autoimmunity

authors： Eliakim A,Schwindt C,Zaldivar F,Casali P,Cooper DM

更新日期：2006-03-01 00:00:00

abstract：:The T cell repertoire expressed by Tsk2 mice, a novel experimental model of systemic sclerosis, was examined to determine whether cells infiltrating the areas of involved skin exhibit a T cell receptor (TCR) bias. Reverse transcription-polymerase chain reactions (RT-PCR) were conducted using RNA extracted from lymph n...

journal_title：Autoimmunity

authors： Wooley PH,Sud S,Langendorfer A,Calkins C,Christner PJ,Peters J,Jimenez SA

更新日期：1998-01-01 00:00:00

abstract：:In this study we investigated one of the possible mechanisms of p56lck down-regulation in peripheral blood lymphocytes (PBLs) from Systemic Lupus Erythematosus (SLE) patients and we correlated p56lck dysregulation with accelerated apoptosis in SLE PBLs. PBLs from SLE patients and healthy donors were isolated. p56lck p...

journal_title：Autoimmunity

authors： Matache C,Onu A,Stefanescu M,Tanaseanu S,Dragomir C,Dolganiuc A,Szegli G

更新日期：2001-01-01 00:00:00

abstract：:Over the past decade, multi-level complex behavior and reactive nature of biological systems, has been a focus point for the biomedical community. We have developed a computational approach, termed Reactive Animation (RA) for simulating such complex biological systems. RA is an approach for describing the dynamic char...

journal_title：Autoimmunity

authors： Vainas O,Harel D,Cohen IR,Efroni S

更新日期：2011-06-01 00:00:00

abstract：:Integrin-adressin binding is a critical step in lymphocte attachment to target tissues. The mucosal recognition systems (alpha E beta 7, alpha 4 beta 7, MADcam-1) have been implicated in the autoimmune process in rheumatoid arthritis. We developed a model for in vivo study of radio-labelled lymphocyte circulation and ...

journal_title：Autoimmunity

authors： Jorgensen C,Couret I,Canovas F,Bologna C,Brochier J,Reme T,Sany J

更新日期：1996-01-01 00:00:00

abstract：:A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...

journal_title：Autoimmunity

authors： Matache C,Stefanescu M,Onu A,Szegli G,Barel M,Tanaseanu S,Matei I,Bouillie S,Frade R

更新日期：1996-01-01 00:00:00

abstract：:It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...

journal_title：Autoimmunity

authors： Suzuki N,Otuka I,Harada T,Mizushima Y,Sakane T

更新日期：1994-01-01 00:00:00

abstract：:The cytokine profile and occurrence of apoptosis during experimental melanin-protein induced uveitis (EMIU) were investigated and compared with that of experimental autoimmune uveoretinitis (EAU). EMIU or EAU was induced in Lewis rats. Eyes were collected at different time points after immunization. Cytokine mRNA expr...

journal_title：Autoimmunity

authors： Li Q,Sun B,Matteson DM,O'Brien TP,Chan CC

更新日期：1999-01-01 00:00:00

abstract：:It has been shown in animal toxicity models that administration of Cyclosporine, CsA, to a pregnant mouse greatly increases the risk that the offspring will develop autoimmunity. Immunization starting at birth has been shown to prevent autoimmunity in other animal models of autoimmunity and early immunization is assoc...

journal_title：Autoimmunity

authors： Classen JB

更新日期：1998-01-01 00:00:00

abstract：:The MRL/lpr model of SLE resembles human lupus in its various immunopathologic characteristics including the presence of high-level IgG and anti-DNA antibody production and multisystem organ involvement (nephritis, arthritis, and vasculitis). Our previous studies have shown that IL-1 overactivity in B cells plays a po...

journal_title：Autoimmunity

authors： Mao C,Singh AK

更新日期：1996-01-01 00:00:00

abstract：:Infectious agents have been implicated in the etiopathogenesis of various vasculitides via numerous and overlapping mechanisms including direct microbial invasion of endothelial cells, immune complex mediated vessel wall damage and stimulation of autoreactive B and/or T cells through molecular mimicry and superantigen...

journal_title：Autoimmunity

authors： Lidar M,Lipschitz N,Langevitz P,Shoenfeld Y

更新日期：2009-08-01 00:00:00

abstract：:T and B lymphocytes are central regulators and effectors of immune responses and are believed to have a key role in many autoimmune diseases. Targeting the activation or effector function of lymphocytes is a potentially effective approach to treat autoimmunity. Typically, T-cell activation occurs after engagement of t...

journal_title：Autoimmunity

authors： Felix NJ,Suri A,Salter-Cid L,Nadler SG,Gujrathi S,Corbo M,Aranda R

更新日期：2010-11-01 00:00:00

abstract：:The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrate...

journal_title：Autoimmunity

authors： Foteinos G,Xu Q

更新日期：2009-11-01 00:00:00

abstract：:Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis. Using indirect immunofluorescence on ethanol-fixed neutrophils, two major fluoroscopic patterns can be recognised: a diffuse cytoplasmic staining (C-ANCA), and a perinuclear/nuclear staining (P-ANC...

journal_title：Autoimmunity

authors： Radice A,Sinico RA

更新日期：2005-02-01 00:00:00

abstract：:Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy...

journal_title：Autoimmunity

authors： Atkinson MA,Winter WE,Skordis N,Beppu H,Riley WM,Maclaren NK

更新日期：1988-01-01 00:00:00

abstract：:The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...

journal_title：Autoimmunity

authors： Rask L,Jonsson AK,Svensson AC,Gustafsson K,Andersson L

更新日期：1991-01-01 00:00:00

abstract：:The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins including ionized Ca(2+)-binding adaptor 1, microglia response factor-1, and daintain are identical with AIF-1. The expre...

journal_title：Autoimmunity

authors： Liu G,Ma H,Jiang L,Zhao Y

更新日期：2007-03-01 00:00:00

abstract：:Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...

journal_title：Autoimmunity

authors： Jones BM,Liu T,Wong RW

更新日期：1999-10-01 00:00:00

abstract：:CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...

journal_title：Autoimmunity

authors： Martens HA,Kallenberg CG,Bijl M

更新日期：2009-05-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is characterised by immune-mediated damage to the intra-hepatic biliary epithelial cells (BEC). Immuno-modulatory/suppressive therapy represents, therefore, alogical approach to treatment in this disease. Conventional immuno-suppressive and immuno-modulatory agents suffer from the bread...

journal_title：Autoimmunity

authors： Jones DE,Palmer JM,Robe A,Kirby JA

更新日期：2002-12-01 00:00:00