New developments in the pathogenesis of systemic sclerosis.

abstract：:Experimental autoimmune uveoretinitis (EAU) induced by immunization of albino Lewis rats with a retinal soluble antigen (S-antigen) has been studied extensively by many workers. An intraorchidic injection of S-antigen 4 days prior to immunization of the animal with the antigen emulsified in adjuvant was found to preve...

journal_title：Autoimmunity

authors： Peng B,Yoshitoshi T,Shichi H

更新日期：1992-01-01 00:00:00

abstract：:The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...

journal_title：Autoimmunity

authors： Banica L,Besliu A,Pistol G,Stavaru C,Ionescu R,Forsea AM,Tanaseanu C,Dumitrache S,Otelea D,Tamsulea I,Tanaseanu S,Chitonu C,Paraschiv S,Balteanu M,Stefanescu M,Matache C

更新日期：2009-01-01 00:00:00

abstract：:Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...

journal_title：Autoimmunity

authors： Lucke S,Klöting I,Pusch A,Heinrich HW,Hahn HJ

更新日期：2003-05-01 00:00:00

abstract：:Guillain-Barre syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. However, GBS patients frequently display a psychosyndrome, indicating an accompanying involvement of the central nervous system (CNS), although the cause is not understood. Hepatic encephalopathy is possibly the best characterize...

journal_title：Autoimmunity

authors： Görtzen A,Schlüter S,Veh RW

更新日期：2004-09-01 00:00:00

abstract：:CNS demyelinating inflammatory disease can be a multifactorial process mediated by cellular and antibody-mediated immune processes. Myelin basic protein (MBP)-specific T cells and pathogenic 8-18C5 antibody, specific for a myelin/oligodendrocyte glycoprotein (MOG), a minor component of CNS white matter, can coexist in...

journal_title：Autoimmunity

authors： Schluesener HJ,Lider O,Sobel RA

更新日期：1989-01-01 00:00:00

abstract：:The expression of major histocompatibility complex class II molecules (Ia antigen) has been analyzed by immunoperoxidase staining in thyroids of normal C3H mice, of iodine-deficient mice with a hyperplastic goiter and of mice during goiter involution induced by administration of either a high iodide dose (HID, 10 micr...

journal_title：Autoimmunity

authors： Toussaint-Demylle D,Many MC,Theisen H,Kraal G,Denef JF

更新日期：1990-01-01 00:00:00

abstract：:Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...

journal_title：Autoimmunity

authors： Lorini R,Orecchia G,Martinetti M,Dugoujon JM,Cuccia M

更新日期：1992-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...

journal_title：Autoimmunity

authors： Kaplan MJ

更新日期：2009-11-01 00:00:00

abstract：:Anti-M2 of anti-mitochondrial antibody (AMA) is a serological marker of primary biliary cirrhosis (PBC). Anti-pyruvate dehydrogenase complex-E2 (anti-PDC-E2) is recognized as the most frequently occurring anti-M2, and a routine laboratory test for this antibody has already been established. However, it is also known t...

journal_title：Autoimmunity

authors： Miyakawa H,Abe K,Kitazawa E,Kikuchi K,Fujikawa H,Matsushita M,Kawaguchi N,Kako M

更新日期：1999-01-01 00:00:00

abstract：:The concordance rate of Graves' disease in pairs of identical twins of 30 to 60% points to the influence of environmental factors, and infections have often been incriminated in the pathogenesis. More than 15 years ago we demonstrated an increased frequency of antibodies to Yersinia enterocolitica (Y. ent.) serotype 3...

journal_title：Autoimmunity

authors： Bech K

更新日期：1990-01-01 00:00:00

abstract：:Programmed cell death 1 (PD-1) was isolated in 1992 by subtractive-hybridization technique, as a molecule whose expression is enhanced by apoptotic stimuli. Since then we have been analyzing the function of PD-1 in the regulation of immune responses. Generation of PD-1 deficient mice, pathophysiological analyses of au...

journal_title：Autoimmunity

authors： Okazaki T,Wang J

更新日期：2005-08-01 00:00:00

abstract：:Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...

journal_title：Autoimmunity

authors： Sjöber K,Eriksson S,Tenngart B,Roth EB,Leffler H,Stenberg P

更新日期：2002-08-01 00:00:00

abstract：:Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...

journal_title：Autoimmunity

authors： Igarashi T,Itoh Y,Fukunaga Y,Yamamoto M

更新日期：1995-01-01 00:00:00

abstract：:Murine monoclonal antibodies (mAb) produced against native human thyroid peroxidase (TPO) are powerful tools for analyzing the autoantibody (Aab) epitopes on TPO. Binding sites of thirteen mAbs cover all or most antigenic regions on TPO. We determined the competition between Aabs from 75 AITD patients and 13 mAbs in b...

journal_title：Autoimmunity

authors： Czarnocka B,Pastuszko D,Carayon P,Ruf J,Gardas A

更新日期：1996-01-01 00:00:00

abstract：:Diabetes mellitus is a disorder characterized by hyperglycemia in both the fasting and post-prandial states. The two most common forms of diabetes mellitus, type 1 and type 2 (previously called juvenile-onset and adult-onset, respectively), comprise the vast majority of cases. Type 1 diabetes (T1DM) has been shown to ...

journal_title：Autoimmunity

authors： Taplin CE,Barker JM

更新日期：2008-02-01 00:00:00

abstract：:To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and meas...

journal_title：Autoimmunity

authors： Kim JY,Yoon HK,Song ST,Park SR,Shim SC

更新日期：2017-12-01 00:00:00

abstract：:Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...

journal_title：Autoimmunity

authors： Eliaou JF,Andary M,Favier F,Carayon P,Poncelet P,Sany J,Brochier J,Clot J

更新日期：1988-01-01 00:00:00

abstract：:Glucocorticoids (GCs) strongly impact on different T cell subsets inducing generally immunosuppressive effects, whereas much less is known about the effect of GC on natural killer (NK) cells. The aims of this study were to investigate the effects of GC on T cell functions, including T cell-mediated anti-tumor immune r...

journal_title：Autoimmunity

authors： Yakimchuk K,Chen L,Hasni MS,Okret S,Jondal M

更新日期：2015-03-01 00:00:00

abstract：:The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...

journal_title：Autoimmunity

authors： Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

更新日期：2015-01-01 00:00:00

abstract：:Autoantigen-reactive T lymphocytes have been implicated in the pathogenesis organ-specific autoimmune disease. Thyroglobulin (Tg) is one of the primary autoantigens associated with autoimmune lymphocytic thyroiditis (LT). These experiments investigated the pathogenicity of a lymphocyte line derived from spontaneously-...

journal_title：Autoimmunity

authors： Allen EM,Thupari JN

更新日期：1996-01-01 00:00:00

abstract：:Epitopes for > 95% stimulating thyrotropin receptor autoantibodies (TSHRAbs) causally implicated in Graves' disease (Basedow's disease or primary hyperthyroidism) have been identified on on the N-terminal portion of the TSHR extracellular domain, residues 8-165. If the stimulating TSHRAb activity is solely dependent o...

journal_title：Autoimmunity

authors： Kohn LD,Harii N

更新日期：2003-09-01 00:00:00

abstract：:The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...

journal_title：Autoimmunity

authors： Canti V,Castiglioni MT,Rosa S,Franchini S,Sabbadini MG,Manfredi AA,Rovere-Querini P

更新日期：2012-03-01 00:00:00

abstract：:Decades of research have provided strong evidence for a reciprocal relationship between the immune system and hormones of the hypothalamus-pituitary-thyroid (HPT) axis. Thyroid stimulating hormone (TSH), in particular, has been shown to have a variety of immune-regulating cytokine-like activities that can influence th...

journal_title：Autoimmunity

authors： Klein JR

更新日期：2003-09-01 00:00:00

abstract：:Interleukin (IL)-15 and CD30 may be associated with the ongoing intestinal immunologic activation in celiac disease (CD). We studied duodenal biopsies and blood samples of patients with active CD (Cel) and controls in order to determine the regulatory role proposed for CD30(+) T cells in this Th1-driven disease and th...

journal_title：Autoimmunity

authors： Periolo N,Guillén L,Bernardo D,Niveloni SI,Hwang HJ,Garrote JA,Bai JC,Arranz E,Cherñavsky AC

更新日期：2010-06-01 00:00:00

abstract：:CD4+ T cells play a crucial role in the development of lupus in MRL-lpr/lpr mice: incomplete deletion/silencing of self-reactive CD4+ T cells leads to T cell activation, which causes both polyclonal B cell activation and T cell infiltration of multiple organs. Furthermore, anti-CD4 antibody therapy ameliorates disease...

journal_title：Autoimmunity

authors： Duan JM,Fagard R,Madaio MP

更新日期：1996-01-01 00:00:00

abstract：:Various amounts of the bacterium, Brucella abortus (BA) were injected intravenously into autoimmune NZB/W F1 mice and non-autoimmune BDF1 mice and then the localization of BA in the thymus was traced using an immunohistochemical method at 30 min and 3 h after injection. The results showed that a greater amount of BA b...

journal_title：Autoimmunity

authors： Ohmori J,Miyakawa K,Matsuno K,Kotani M

更新日期：1991-01-01 00:00:00

abstract：:An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...

journal_title：Autoimmunity

authors： Jaspan JB,Luo H,Ahmed B,Tenenbaum S,Voss T,Sander DM,Bollinger K,Baquet T,Garry RF

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16.4%. The diagnosis of CD is based on histopathological examination and se...

journal_title：Autoimmunity

authors： Lewandowska K,Ciepiela O,Szypowska A,Wyhowski J,Głodkowska-Mrówka E,Popko K,Ostafin M,Pyrżak B,Demkow U

更新日期：2018-03-01 00:00:00

abstract：:Six different hybridomas secreting anti-SCM mAb and one control mAb were placed into adult mice along with [14C] amino acids for biosynthetically labeling. After sacrifice, the 14C mAb ascites along with serum, heart, kidney, lung and skeletal muscle were recovered. Tissue associated specific radio-activity (SpAc) and...

journal_title：Autoimmunity

authors： Lange CF

更新日期：1994-01-01 00:00:00

abstract：:This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-re...

journal_title：Autoimmunity

authors： Suleyman S,Kasp E,Ellis B,Banga JP,Dumonde DC

更新日期：1991-01-01 00:00:00