Induction of hyperacute brain inflammation and demyelination by activated encephalitogenic T cells and a monoclonal antibody specific for a myelin/oligodendrocyte glycoprotein.

abstract：:Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...

journal_title：Autoimmunity

authors： Frusić-Zlotkin M,Raichenberg D,Wang X,David M,Michel B,Milner Y

更新日期：2006-11-01 00:00:00

abstract：:Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...

journal_title：Autoimmunity

authors： Keith MP,Moratz C,Egan R,Zacharia A,Greidinger EL,Hoffman RW,Tsokos GC

更新日期：2007-05-01 00:00:00

abstract：:Numerous groups have now validated high-throughput approaches to autoantibody profiling in a variety of systems. Recently, we have used autoantigen microarray technology to identify distinct autoantibody profiles in H-2 congenic MRL/lpr mice (Sekine et al., manuscript in preparation), and we are expanding this platfor...

journal_title：Autoimmunity

authors： Graham KL,Robinson WH,Steinman L,Utz PJ

更新日期：2004-06-01 00:00:00

abstract：:Infectious agents have been implicated in the etiopathogenesis of various vasculitides via numerous and overlapping mechanisms including direct microbial invasion of endothelial cells, immune complex mediated vessel wall damage and stimulation of autoreactive B and/or T cells through molecular mimicry and superantigen...

journal_title：Autoimmunity

authors： Lidar M,Lipschitz N,Langevitz P,Shoenfeld Y

更新日期：2009-08-01 00:00:00

abstract：:Carbonic anhydrase II (CAII) is expressed on alveolar epithelium and participates to CO2 elimination, fluid secretion and post-capillary pH regulation. CAII is overexpressed in animal models of lung fibrosis in sites of epithelial injury. Autoantibodies directed against CAII (anti-CAII) have been described in sera fro...

journal_title：Autoimmunity

authors： Alessandri C,Bombardieri M,Scrivo R,Viganego F,Conti F,de Luca N,Riccieri V,Valesini G

更新日期：2003-03-01 00:00:00

abstract：:The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...

journal_title：Autoimmunity

authors： Canti V,Castiglioni MT,Rosa S,Franchini S,Sabbadini MG,Manfredi AA,Rovere-Querini P

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in Euro...

journal_title：Autoimmunity

authors： Muro Y,Sugiura K,Akiyama M

更新日期：2013-06-01 00:00:00

abstract：:Peripheral blood B lymphocytes of multiple sclerosis (MS) patients and control persons were transformed with Epstein-Barr virus. Antibody production of transformed cells against isolated human myelin was investigated by enzyme-linked immunosorbent assay (ELISA). Cells producing reactive antibodies were cloned and prop...

journal_title：Autoimmunity

authors： Uhlig H,Dernick R

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:There have been few reports on the association of rheumatoid arthritis (RA) with anti-neutrophil cytoplasmic antigen (ANCA)-associated systemic vasculitides. METHODS:Here we present four cases of RA overlapping with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CS...

journal_title：Autoimmunity

authors： Szilasi M,Mátyus J,File I,Szücs G,Rákóczi E,Pfliegler G,Szabó Z,Végh E,Szekanecz Z

更新日期：2012-06-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is preceded by the presence of antibodies against islet proteins including a protein tyrosine phosphatase (PTP) designated IA-2. Recently, we cloned a novel PTP named IAR which shares 43% sequence identity with IA-2 and is recognised by antibodies from a majority of patients ...

journal_title：Autoimmunity

authors： Schmidli RS,Colman PG,Cui L,Yu WP,Kewming K,Jankulovski C,Harrison LC,Pallen CJ,DeAizpurua HJ

更新日期：1998-01-01 00:00:00

abstract：:Islet-infiltrating lymphocytes of individual male and female non-obese diabetic (NOD) mice were examined with the purpose of determining the differences that lead to a predominance of diabetes in female versus males NOD mice. When normalized for the amount of islet lymphocytes recovered, the infiltrating lymphocytes o...

journal_title：Autoimmunity

authors： Young EF,Hess PR,Arnold LW,Tisch R,Frelinger JA

更新日期：2009-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and contr...

journal_title：Autoimmunity

authors： Paradowska-Gorycka A,Sowinska A,Stypinska B,Grobelna MK,Walczyk M,Olesinska M,Piotrowski P,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：:Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV). Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA....

journal_title：Autoimmunity

authors： Lin W,Chen M,Zhao MH

更新日期：2009-03-01 00:00:00

abstract：:Macrophages from autoimmune diabetes prone BB rats were found to produce radical oxygen intermediates (ROI) at an enhanced rate when compared to diabetes resistant BB or normal Wistar rats. The release of ROI was determined by chemiluminescence using in parallel luminol and lucigenin as detector molecules. In diabetes...

journal_title：Autoimmunity

authors： Brenner HH,Burkart V,Rothe H,Kolb H

更新日期：1993-01-01 00:00:00

abstract：:Myocarditis, often initiated by viral infection, may progress to autoimmune inflammatory heart disease, dilated cardiomyopathy and heart failure. Although cardiac myosin is a dominant autoantigen in animal models of myocarditis and is released from the heart during viral myocarditis, the characterization, role and sig...

journal_title：Autoimmunity

authors： Mascaro-Blanco A,Alvarez K,Yu X,Lindenfeld J,Olansky L,Lyons T,Duvall D,Heuser JS,Gosmanova A,Rubenstein CJ,Cooper LT,Kem DC,Cunningham MW

更新日期：2008-09-01 00:00:00

abstract：:During apo blebs, containing nuclear components, are formed at the cells' surfaces. When these blebs separate from the dying cell an apo cell body remains. The contents of apo blebs are modified and can be released, especially in patients with systemic lupus erythematosus (SLE) since impaired clearance of apo material...

journal_title：Autoimmunity

authors： Fransen JH,Hilbrands LB,Jacobs CW,Adema GJ,Berden JH,Van der Vlag J

更新日期：2009-05-01 00:00:00

abstract：:In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...

journal_title：Autoimmunity

authors： Boissier MC,Texier B,Carlioz A,Fournier C

更新日期：1989-01-01 00:00:00

abstract：:The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...

journal_title：Autoimmunity

authors： Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

更新日期：2015-01-01 00:00:00

abstract：:We have shown that mice infected with mouse hepatitis virus A59 develop autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH). Because it has been proposed that the immune system is stimulated by alarm signals called damage-associated molecular patterns or alarmins, we investigated the partic...

journal_title：Autoimmunity

authors： Duhalde-Vega M,Retegui LA

更新日期：2011-12-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells represent an important regulatory T-cell subset that perceives signals of danger and/or cellular distress and modulate the adaptive immune response accordingly. In the presence of pathogens, iNKT cells acquire an adjuvant function that is fundamental to boost anti-microbial and ...

journal_title：Autoimmunity

authors： Caielli S,Sorini C,Falcone M

更新日期：2011-02-01 00:00:00

abstract：:A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...

journal_title：Autoimmunity

authors： Matache C,Stefanescu M,Onu A,Szegli G,Barel M,Tanaseanu S,Matei I,Bouillie S,Frade R

更新日期：1996-01-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM), celiac disease (CD) and autoimmune thyroid disease (ATD) are autoimmune conditions relatively common in paediatric age and frequently occur in association in the same subject. This event is not by chance and requires an explanation. Here, we studied the distribution of HLA-DQ αβ hetero...

journal_title：Autoimmunity

authors： Larizza D,Calcaterra V,Klersy C,Badulli C,Caramagna C,Ricci A,Brambilla P,Salvaneschi L,Martinetti M

更新日期：2012-09-01 00:00:00

abstract：:Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...

journal_title：Autoimmunity

authors： Girkontaite I,Urbonaviciute V,Maseda D,Neubert K,Herrmann M,Voll RE

更新日期：2007-06-01 00:00:00

abstract：:Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy...

journal_title：Autoimmunity

authors： Atkinson MA,Winter WE,Skordis N,Beppu H,Riley WM,Maclaren NK

更新日期：1988-01-01 00:00:00

abstract：:A robust and precise enzyme linked immunosorbent assay (ELISA) with proven sensitivity and specificity has been employed to detect human antibodies (allogenic/autogenic) to human acetylcholinesterase (AChE). The sensitivity of the method has been established using mouse monoclonal antibodies (0.8 ng/ml) and uniquely, ...

journal_title：Autoimmunity

authors： Geen J,Howells RC,Ludgate M,Hullin DA,Hogg SI

更新日期：2004-12-01 00:00:00

abstract：:It is generally accepted that thyroid-associated ophthalmopathy (TAO) is an autoimmune disease of the eye muscle (EM) and the surrounding orbital connective tissue in which circulating antibodies play an important role. Antibodies against EM membrane proteins of 63-67kDa mol. wt. seem to be the best markers of ophthal...

journal_title：Autoimmunity

authors： Gunji K,Kubota S,Stolarski C,Wengrowicz S,Kennerdell JS,Wall JR

更新日期：1999-01-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic beta cell destruction involving auto-reactive T-cells, pro-inflammatory cytokines, reactive oxygen species (ROS) and loss of insulin. Monozygotic twin studies show a 20-60% concordance with T1D indicating there may be an environmental component...

journal_title：Autoimmunity

authors： Bekris LM,Shephard C,Peterson M,Hoehna J,Van Yserloo B,Rutledge E,Farin F,Kavanagh TJ,Lernmark A

更新日期：2005-12-01 00:00:00

abstract：:The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...

journal_title：Autoimmunity

authors： Fujino Y,Li Q,Chung H,Hikita N,Nussenblatt RB,Gery I,Chan CC

更新日期：1992-01-01 00:00:00

abstract：:IL-6 is a paracrine and autocrine cytokine, which acts in the regulation of immunological and inflammatory processes. Its production can be observed in different cell types, as well as thyrocytes. The purpose of the study was to examine the serum IL-6 levels between the patients with Graves' disease (N = 47) and witho...

journal_title：Autoimmunity

authors： Molnár I,Balázs C

更新日期：1997-01-01 00:00:00

abstract：:The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...

journal_title：Autoimmunity

authors： Rask L,Jonsson AK,Svensson AC,Gustafsson K,Andersson L

更新日期：1991-01-01 00:00:00