Low prevalence of anti-small ubiquitin-like modifier activating enzyme antibodies in dermatomyositis patients.

abstract：:Macrophages from autoimmune diabetes prone BB rats were found to produce radical oxygen intermediates (ROI) at an enhanced rate when compared to diabetes resistant BB or normal Wistar rats. The release of ROI was determined by chemiluminescence using in parallel luminol and lucigenin as detector molecules. In diabetes...

journal_title：Autoimmunity

authors： Brenner HH,Burkart V,Rothe H,Kolb H

更新日期：1993-01-01 00:00:00

abstract：:Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. It has been proposed that IL-1 induces a race between protective and deleterious proteins i...

journal_title：Autoimmunity

authors： Christensen UB,Larsen PM,Fey SJ,Andersen HU,Nawrocki A,Sparre T,Mandrup-Poulsen T,Nerup J

更新日期：2000-01-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta) has been implicated to play an important role in the autoimmune beta cell lesion of insulin-dependent diabetes mellitus (IDDM) because of its inhibition of insulin secretion, direct islet cytotoxicity and alteration of islet cell antigen expression. We have previously demonstrated that IL-...

journal_title：Autoimmunity

authors： Hao W,Myhre AP,Palmer JP

更新日期：1999-01-01 00:00:00

abstract：:We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...

journal_title：Autoimmunity

authors： Suzuka H,Yoshifusa H,Nakamura Y,Miyawaki S,Shibata Y

更新日期：1993-01-01 00:00:00

abstract：:To explore the natural course of beta cell function in recent onset diabetes, a subgroup (n=157) of all incident cases (n=879) 15-34 years old, 1992-1993 in Sweden, and with positivity for at least one autoantibody of islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase an...

journal_title：Autoimmunity

authors： Törn C,Landin-Olsson M,Lernmark A,Scherstén B,Ostman J,Arnqvist HJ,Björk E,Blohmé G,Bolinder J,Eriksson J,Littorin B,Nyström L,Sundkvist G

更新日期：2001-01-01 00:00:00

abstract：:Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...

journal_title：Autoimmunity

authors： Frusić-Zlotkin M,Raichenberg D,Wang X,David M,Michel B,Milner Y

更新日期：2006-11-01 00:00:00

abstract：:This study was undertaken to determine whether the expression of 17.109, 6B6.6 and 4C9 rheumatoid factor (RF) idiotypes is predictive of the development of rheumatoid arthritis (RA) and whether the RF response is idiotypically restricted in an inbred population of Pima Indians who have a genetic predisposition for the...

journal_title：Autoimmunity

authors： Davidson A,Keiser HD,del Puente A,Bennett PH,Schrohenloher R,Koopman WJ

更新日期：1994-01-01 00:00:00

abstract：:Autoantibodies directed against nuclear antigens often arise in autoimmune disease associated with the failure to clear apoptotic cells in a swift and timely manner. Nucleic acids present in apoptotic cells and in membranous microparticles derived thereof exert adjuvant activity in the immune response to apoptosis. Th...

journal_title：Autoimmunity

authors： Bekeredjian-Ding I

更新日期：2013-08-01 00:00:00

abstract：:To assess the specificity of autoantibodies (aAbs) directed against the ribosomal P-proteins (RPPaAbs) in patients with systemic lupus erythematosus (SLE) and to investigate aAbs directed to other ribosomal proteins, 100 SLE, 100 rheumatoid arthritis (RA), 25 thyroiditis and 20 blood-donors were analyzed in a comparat...

journal_title：Autoimmunity

authors： Desbos A,Gonzalo P,Monier JC,Tebib J,Reboud JP,Perrier H,Bienvenu J,Fabien N

更新日期：2002-11-01 00:00:00

abstract：:Decades of research have provided strong evidence for a reciprocal relationship between the immune system and hormones of the hypothalamus-pituitary-thyroid (HPT) axis. Thyroid stimulating hormone (TSH), in particular, has been shown to have a variety of immune-regulating cytokine-like activities that can influence th...

journal_title：Autoimmunity

authors： Klein JR

更新日期：2003-09-01 00:00:00

abstract：:Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore,...

journal_title：Autoimmunity

authors： Sarter K,Kulagin M,Schett G,Harris NL,Zaiss MM

更新日期：2017-05-01 00:00:00

abstract：:Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological...

journal_title：Autoimmunity

authors： Petrovsky N,Brusic V

更新日期：2006-12-01 00:00:00

abstract：:In the present study, the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in kidney lymphoid cells of lupus-prone mice (MRL-lpr/lpr) is shown by Northern blot and nuclear run on transcription assay. By quantification analysis of hsp 70 gene transcription, more than ten times of the enhan...

journal_title：Autoimmunity

authors： Deguchi Y

更新日期：1991-01-01 00:00:00

abstract：:Epidermolysis bullosa acquisita (EBA) is a rare and acquired autoimmune subepidermal bullous disease of skin and mucosa. EBA includes various distinct clinical manifestations resembling genetic dystrophic epidermolysis bullosa (DEB), Bullous pemphigus, Brunsting-Perry pemphigoid, or cicatricial pemphigoid. These patie...

journal_title：Autoimmunity

authors： Chen M,Kim GH,Prakash L,Woodley DT

更新日期：2012-02-01 00:00:00

abstract：:Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes utilizing a novel recombinant PR3 (rPR3) produced to accommodate manipulations of the N-terminal domain. The rPR3 molecule contains an N-terminus six ...

journal_title：Autoimmunity

authors： Farrag L,Pendergraft WF 3rd,Yang JJ,Jennette JC,Falk RJ,Preston GA

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:T follicular helper (Tfh) cells are known to regulate humoral immune response. In this study we examined the correlation of different subsets of peripheral blood Tfh cells in patients with diabetic nephropathy (DN). METHODS:A total of 23 DN patients and 15 healthy controls (HC) were investigated for various...

journal_title：Autoimmunity

authors： Zhang N,Tai J,Qu Z,Zhang Z,Zhao S,He J,Zhang S,Jiang Y

更新日期：2016-09-01 00:00:00

abstract：:In a previous study, we showed that the Ly6G(-)CD11b(+) blood monocytes residing in naïve mice are intrinsically immunosuppressive and that loss of this suppressive function may contribute to the development of autoimmunity in experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis....

journal_title：Autoimmunity

authors： Slaney CY,Toker A,Fraser JD,Harper JL,Bäckström BT

更新日期：2013-06-01 00:00:00

abstract：:Autoantibodies against the beta-cell M(r) 64,000 protein (p64), recently identified as an isoform of glutamic acid decarboxylase (GAD), are prevalent in patients with insulin-dependent diabetes mellitus (IDDM). Dog islets were found to represent an abundant source of native p64 allowing the study of antigen-antibody i...

journal_title：Autoimmunity

authors： Bärmeier H,Ahlmén J,Landin-Olsson M,Rajotte RV,Sundkvist G,Warnock G,Lernmark A

更新日期：1992-01-01 00:00:00

abstract：MOTIVATION:The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to he...

journal_title：Autoimmunity

authors： Castiglione F,Santoni D,Rapin N

更新日期：2011-06-01 00:00:00

abstract：:We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...

journal_title：Autoimmunity

authors： Wong A,Tait R,Kenny T,Gorin F,Robbins D

更新日期：1995-01-01 00:00:00

abstract：:The T cell repertoire expressed by Tsk2 mice, a novel experimental model of systemic sclerosis, was examined to determine whether cells infiltrating the areas of involved skin exhibit a T cell receptor (TCR) bias. Reverse transcription-polymerase chain reactions (RT-PCR) were conducted using RNA extracted from lymph n...

journal_title：Autoimmunity

authors： Wooley PH,Sud S,Langendorfer A,Calkins C,Christner PJ,Peters J,Jimenez SA

更新日期：1998-01-01 00:00:00

abstract：:Interleukin (IL)-1 inhibits the function of insulin-producing rat pancreatic beta-cells in vitro and in vivo, and it has been postulated that the IL-1 effect is mediated through the cytokine inducible nitric oxide (NO) synthase. IL-1 inhibits the function of cultured human thyroid cells too, and in this study human th...

journal_title：Autoimmunity

authors： Rasmussen AK,Di Marco R,Diamant M,Feldt-Rasmussen U,Bendtzen K

更新日期：1994-01-01 00:00:00

abstract：:The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...

journal_title：Autoimmunity

authors： Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

更新日期：2015-01-01 00:00:00

abstract：:Worldwide population studies have generally agreed that rheumatoid arthritis (RA) is associated with a group of HLA-DRB1 alleles which share a common amino acid sequence at residues 70-74. This represents the first study to investigate the association of HLA-DRB1 genes with susceptibility to RA amongst Malay, Chinese ...

journal_title：Autoimmunity

authors： Kong KF,Yeap SS,Chow SK,Phipps ME

更新日期：2002-07-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice (H-2g7) and C57BL/6 mice (H-2b) by a ...

journal_title：Autoimmunity

authors： Slavin A,Ewing C,Liu J,Ichikawa M,Slavin J,Bernard CC

更新日期：1998-01-01 00:00:00

abstract：:The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrate...

journal_title：Autoimmunity

authors： Foteinos G,Xu Q

更新日期：2009-11-01 00:00:00

abstract：:The cytokine profile and occurrence of apoptosis during experimental melanin-protein induced uveitis (EMIU) were investigated and compared with that of experimental autoimmune uveoretinitis (EAU). EMIU or EAU was induced in Lewis rats. Eyes were collected at different time points after immunization. Cytokine mRNA expr...

journal_title：Autoimmunity

authors： Li Q,Sun B,Matteson DM,O'Brien TP,Chan CC

更新日期：1999-01-01 00:00:00

abstract：:Hybridoma cell lines producing natural autoantibodies (NAA), generated from A.SW mice with progressive experimental autoimmune encephalomyelitis (P-EAE), have been shown to cause demyelination and renal pathology when injected into naive mice. To investigate the relative contribution of these antibodies to disease pat...

journal_title：Autoimmunity

authors： Peterson LK,Tsunoda I,Fujinami RS

更新日期：2008-08-01 00:00:00

abstract：:Integrin-adressin binding is a critical step in lymphocte attachment to target tissues. The mucosal recognition systems (alpha E beta 7, alpha 4 beta 7, MADcam-1) have been implicated in the autoimmune process in rheumatoid arthritis. We developed a model for in vivo study of radio-labelled lymphocyte circulation and ...

journal_title：Autoimmunity

authors： Jorgensen C,Couret I,Canovas F,Bologna C,Brochier J,Reme T,Sany J

更新日期：1996-01-01 00:00:00

abstract：:In order to know whether effector cells are capable of recognizing the epidermal targets in pemphigus vulgaris (PV) and bullous pemphigoid (BP), non-adherent cells (NAC) of peripheral blood from 27 primary PV, 19 BP patients and 12 healthy volunteers were used in cytotoxic tests. Autologous, allogenic and murine epide...

journal_title：Autoimmunity

authors： Grando SA,Glukhenky BT,Drannik GN,Kostromin AP,Boiko YYa,Senyuk OF

更新日期：1989-01-01 00:00:00