In vivo migration of tonsil lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: involvement of LFA-1.

abstract：:Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...

journal_title：Autoimmunity

authors： Mzimela NC,Ngubane PS,Khathi A

更新日期：2019-02-01 00:00:00

abstract：:Interleukin (IL)-1 inhibits the function of insulin-producing rat pancreatic beta-cells in vitro and in vivo, and it has been postulated that the IL-1 effect is mediated through the cytokine inducible nitric oxide (NO) synthase. IL-1 inhibits the function of cultured human thyroid cells too, and in this study human th...

journal_title：Autoimmunity

authors： Rasmussen AK,Di Marco R,Diamant M,Feldt-Rasmussen U,Bendtzen K

更新日期：1994-01-01 00:00:00

abstract：:Numerous groups have now validated high-throughput approaches to autoantibody profiling in a variety of systems. Recently, we have used autoantigen microarray technology to identify distinct autoantibody profiles in H-2 congenic MRL/lpr mice (Sekine et al., manuscript in preparation), and we are expanding this platfor...

journal_title：Autoimmunity

authors： Graham KL,Robinson WH,Steinman L,Utz PJ

更新日期：2004-06-01 00:00:00

abstract：:Various amounts of the bacterium, Brucella abortus (BA) were injected intravenously into autoimmune NZB/W F1 mice and non-autoimmune BDF1 mice and then the localization of BA in the thymus was traced using an immunohistochemical method at 30 min and 3 h after injection. The results showed that a greater amount of BA b...

journal_title：Autoimmunity

authors： Ohmori J,Miyakawa K,Matsuno K,Kotani M

更新日期：1991-01-01 00:00:00

abstract：:We report in this paper on obvious fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). B6 CD8+ splenocytes were transferred into (bm 12 x bm 1)F1 mice to induce GVHR. Recipient mice had been thymectomized and administrated with anti-CD8 monoclonal antibody (mAb) to deplete CD8...

journal_title：Autoimmunity

authors： Inada S,Suzuki K,Kimura T,Hayashi A,Narita T,Yui R,Asakura H,Fujiwara M

更新日期：1995-01-01 00:00:00

abstract：:Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...

journal_title：Autoimmunity

authors： Saito K,Mori S,Date F,Ono M

更新日期：2013-06-01 00:00:00

abstract：:An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...

journal_title：Autoimmunity

authors： Jaspan JB,Luo H,Ahmed B,Tenenbaum S,Voss T,Sander DM,Bollinger K,Baquet T,Garry RF

更新日期：1995-01-01 00:00:00

abstract：:Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...

journal_title：Autoimmunity

authors： Bhol KC,Ahmed AR

更新日期：2002-03-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). Increased prevalence of atherosclerosis may explain part of this enhanced risk, but SLE related CVD can also result from other mechanisms. Vascular events may be the result of several pathophysiologic ...

journal_title：Autoimmunity

authors： Gustafsson JT,Svenungsson E

更新日期：2014-03-01 00:00:00

abstract：:Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression w...

journal_title：Autoimmunity

authors： Pilcher C,Williams W,Isenberg DA

更新日期：1991-01-01 00:00:00

abstract：:TGPO-aAb is a bispecific antibody which binds to thyroglobulin as well as thyroid peroxidase. It is supposed to be raised in some patients with autoimmune thyroid disease. We investigated 205 patients suffering from Graves' disease (n = 81), Hashimoto's thyroiditis (n = 36), toxic nodular goitre (n = 50), differentiat...

journal_title：Autoimmunity

authors： Zöphel K,Grüning T,Wunderlich G,Franke WG

更新日期：1999-01-01 00:00:00

abstract：:We have shown that mice infected with mouse hepatitis virus A59 develop autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH). Because it has been proposed that the immune system is stimulated by alarm signals called damage-associated molecular patterns or alarmins, we investigated the partic...

journal_title：Autoimmunity

authors： Duhalde-Vega M,Retegui LA

更新日期：2011-12-01 00:00:00

abstract：:The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomi...

journal_title：Autoimmunity

authors： Kiss E,Csipö I,Cohen JH,Reveil B,Kávai M,Szegedi G

更新日期：1996-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine an...

journal_title：Autoimmunity

authors： Sotto A,Bérard M,Bessis D,Porneuf M,Jourdan J,Boffa MC

更新日期：1995-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating autoimmune disease that affects more than 1 million people worldwide and severely compromises motor and sensory function through demyelination and axonal loss. This review covers current therapies, lessons learned from failed clinical trials, genetic susceptibility, key cell ty...

journal_title：Autoimmunity

authors： Slavin A,Kelly-Modis L,Labadia M,Ryan K,Brown ML

更新日期：2010-11-01 00:00:00

abstract：:T lymphocytes present in thyroid infiltrates of 6 patients with Hashimoto's thyroiditis (HT) and of 4 patients with Graves' disease (GD) were analyzed at clonal level and their profiles of mitogen-induced lymphokine secretion were characterized. Production of interleukin-2 (IL-2), interleukin-4 (IL-4), interferon-gamm...

journal_title：Autoimmunity

authors： Del Prete GF,Tiri A,De Carli M,Mariotti S,Pinchera A,Chretien I,Romagnani S,Ricci M

更新日期：1989-01-01 00:00:00

abstract：:The possible immunosuppressive action of antithyroid drugs in vivo has been assessed using Buffalo (Buf) strain rats with thyroiditis produced by neonatal thymectomy; this model shares many features with spontaneous thyroiditis in man. Both propylthiouracil and methimazole significantly reduced the severity of thyroid...

journal_title：Autoimmunity

authors： Cohen SB,Weetman AP

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. DESIGN:A total of ...

journal_title：Autoimmunity

authors： Cakir M,Levendoglu F,Kiyici A,Coskun Y

更新日期：2011-09-01 00:00:00

abstract：:In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...

journal_title：Autoimmunity

authors： Boissier MC,Texier B,Carlioz A,Fournier C

更新日期：1989-01-01 00:00:00

abstract：:Linomide is a potent immunomodulator that has been shown to inhibit autoimmunity in several animal models of autoimmune disease, including experimental autoimmune encephalomyelitis (EAE). Linomide's mechanism of action is unknown, however, it has been suggested to modulate the function of antigen presenting cells (APC...

journal_title：Autoimmunity

authors： Dahlén E,Andersson M,Dawe K,Tellander AC,Brunmark C,Björk A,Hedlund G

更新日期：2000-10-01 00:00:00

abstract：:This review focuses on recent advances and new hypothesis in the understanding of the T and dendritic cells contribution to the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). The new data show that non-specific amplification of muscle inflammation by T...

journal_title：Autoimmunity

authors： Chevrel G,Page G,Miossec P

更新日期：2006-05-01 00:00:00

abstract：:Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause t...

journal_title：Autoimmunity

authors： Mauney CH,Hollis T

更新日期：2018-05-01 00:00:00

abstract：:Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy...

journal_title：Autoimmunity

authors： Atkinson MA,Winter WE,Skordis N,Beppu H,Riley WM,Maclaren NK

更新日期：1988-01-01 00:00:00

abstract：:DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...

journal_title：Autoimmunity

authors： Pisetsky DS,Fairhurst AM

更新日期：2007-06-01 00:00:00

abstract：:Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...

journal_title：Autoimmunity

authors： Keith MP,Moratz C,Egan R,Zacharia A,Greidinger EL,Hoffman RW,Tsokos GC

更新日期：2007-05-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is characterised by immune-mediated damage to the intra-hepatic biliary epithelial cells (BEC). Immuno-modulatory/suppressive therapy represents, therefore, alogical approach to treatment in this disease. Conventional immuno-suppressive and immuno-modulatory agents suffer from the bread...

journal_title：Autoimmunity

authors： Jones DE,Palmer JM,Robe A,Kirby JA

更新日期：2002-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the dysfunction of T cells, B cells, and dendritic cells and by the production of antinuclear autoantibodies. This editorial provides a synopsis of newly discovered genetic factors and signaling pathways in lupus pathogenesis that ar...

journal_title：Autoimmunity

authors： Perl A

更新日期：2010-02-01 00:00:00

abstract：:Congenital heart block (CHB), a life-threatening manifestation of neonatal lupus, offers aunique opportunity to study the effect or arm of immunity and define the pathogenicity of an autoantibody in mediating tissue injury. This review focuses on our recent in vitro model which supports a cascade from antibody insult ...

journal_title：Autoimmunity

authors： Buyon JP,Clancy RM

更新日期：2003-02-01 00:00:00

abstract：:The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...

journal_title：Autoimmunity

authors： Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

更新日期：2015-01-01 00:00:00

abstract：:A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...

journal_title：Autoimmunity

authors： Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

更新日期：2006-09-01 00:00:00