Uric acid and HMGB1 are involved in the induction of autoantibodies elicited in mice infected with mouse hepatitis virus A59.

abstract：:Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and by ventricular dilatation. Abnormalities of the cellular and humoral immune system are present in patients with myocarditis and DCM. Various circulating cardiac autoantibodies have been d...

journal_title：Autoimmunity

authors： Felix SB,Staudt A,Friedrich GB

更新日期：2001-01-01 00:00:00

abstract：:It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...

journal_title：Autoimmunity

authors： Suzuki N,Otuka I,Harada T,Mizushima Y,Sakane T

更新日期：1994-01-01 00:00:00

abstract：:Under-nutrition impairs immune responses, but far less is known about the impact of over-nutrition, such as obesity, on the response to vaccines. We measured the effect of childhood overweight status on inflammatory mediators, circulating immunoglobulins and tetanus antibodies in fifteen overweight children (BMI > 85 ...

journal_title：Autoimmunity

authors： Eliakim A,Schwindt C,Zaldivar F,Casali P,Cooper DM

更新日期：2006-03-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) offers the unique opportunity to replace a diseased hematopoietic or immune system by healthy donor cells. Proof of principle comes from experimental animal data, from the experience with severe aplastic anemia, from observations of patients with concomitant au...

journal_title：Autoimmunity

authors： Gratwohl A

更新日期：2008-12-01 00:00:00

abstract：:Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological...

journal_title：Autoimmunity

authors： Petrovsky N,Brusic V

更新日期：2006-12-01 00:00:00

abstract：:The presence of autoantibodies (aAbs) to thyroglobulin (TG) and thyroperoxidase (TPO) in most of the patients with autoimmune thyroid disease is now well documented. Studies of these aAbs suggested that some, termed TGPO aAbs, could interact with both TG and TPO. This hypothesis was investigated using IgG fraction fro...

journal_title：Autoimmunity

authors： Ruf J,Ferrand M,Durand-Gorde JM,Carayon P

更新日期：1992-01-01 00:00:00

abstract：:We have used the MRL/lpr murine model of spontaneous lupus to investigate three questions in infection immunity: (1) does mycobacterial infection have any effect on the mortality of the autoimmunity-prone lpr mice?; (2) does the infection modify the progression of kidney disease of lpr lupus?; and (3) does the lpr gen...

journal_title：Autoimmunity

authors： Castro AP,Esaguy N,Aguas AP

更新日期：1993-01-01 00:00:00

abstract：:T lymphocytes present in thyroid infiltrates of 6 patients with Hashimoto's thyroiditis (HT) and of 4 patients with Graves' disease (GD) were analyzed at clonal level and their profiles of mitogen-induced lymphokine secretion were characterized. Production of interleukin-2 (IL-2), interleukin-4 (IL-4), interferon-gamm...

journal_title：Autoimmunity

authors： Del Prete GF,Tiri A,De Carli M,Mariotti S,Pinchera A,Chretien I,Romagnani S,Ricci M

更新日期：1989-01-01 00:00:00

abstract：:Embryonic tissue expresses a very low level of MHC molecules, and these few appear only late in ontogeny. Possibly related are deficiencies in the expression of TAP molecules and also the fetus' need to avoid maternal immunologic rejection. However, the fetus may overcome the lack of Ag-presenting molecules when threa...

journal_title：Autoimmunity

authors： Lee MS,Sarvetnick N

更新日期：1997-01-01 00:00:00

abstract：:Islet-infiltrating lymphocytes of individual male and female non-obese diabetic (NOD) mice were examined with the purpose of determining the differences that lead to a predominance of diabetes in female versus males NOD mice. When normalized for the amount of islet lymphocytes recovered, the infiltrating lymphocytes o...

journal_title：Autoimmunity

authors： Young EF,Hess PR,Arnold LW,Tisch R,Frelinger JA

更新日期：2009-01-01 00:00:00

abstract：:Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis. Using indirect immunofluorescence on ethanol-fixed neutrophils, two major fluoroscopic patterns can be recognised: a diffuse cytoplasmic staining (C-ANCA), and a perinuclear/nuclear staining (P-ANC...

journal_title：Autoimmunity

authors： Radice A,Sinico RA

更新日期：2005-02-01 00:00:00

abstract：:Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental anima...

journal_title：Autoimmunity

authors： Dancea S,Dellagi K,Renaud F,Mahouy G,Hauw JJ,Brouet JC

更新日期：1989-01-01 00:00:00

abstract：:A robust and precise enzyme linked immunosorbent assay (ELISA) with proven sensitivity and specificity has been employed to detect human antibodies (allogenic/autogenic) to human acetylcholinesterase (AChE). The sensitivity of the method has been established using mouse monoclonal antibodies (0.8 ng/ml) and uniquely, ...

journal_title：Autoimmunity

authors： Geen J,Howells RC,Ludgate M,Hullin DA,Hogg SI

更新日期：2004-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. It is characterized by frequent re...

journal_title：Autoimmunity

authors： Kujur W,Gurram RK,Maurya SK,Nadeem S,Chodisetti SB,Khan N,Agrewala JN

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice ...

journal_title：Autoimmunity

authors： Dos Santos M,Poletti PT,Favero G,Stacchiotti A,Bonomini F,Montanari CC,Bona SR,Marroni NP,Rezzani R,Veronese FV

更新日期：2018-03-01 00:00:00

abstract：:Recent studies have demonstrated that the nephritogenicity of antibodies to dsDNA and nucleosomes confers to binding of glomerular membrane-associated nucleosomes, and not to cross-reacting glomerular antigens. There is no known parameter that determines antibody pathogenicity aside from specificity for dsDNA/nucleoso...

journal_title：Autoimmunity

authors： Mjelle JE,Kalaaji M,Rekvig OP

更新日期：2009-02-01 00:00:00

abstract：:The possible immunosuppressive action of antithyroid drugs in vivo has been assessed using Buffalo (Buf) strain rats with thyroiditis produced by neonatal thymectomy; this model shares many features with spontaneous thyroiditis in man. Both propylthiouracil and methimazole significantly reduced the severity of thyroid...

journal_title：Autoimmunity

authors： Cohen SB,Weetman AP

更新日期：1988-01-01 00:00:00

abstract：:Type 1 diabetes (T1D) is characterized by selective autoimmune destruction of the insulin producing beta-cells in the islets of Langerhans. When the beta-cells are destroyed exogenous administration of insulin is necessary for maintenance of glucose homeostasis. Allogeneic islet transplantation has been used as a mean...

journal_title：Autoimmunity

authors： Christensen UB,Larsen PM,Fey S,Karlsen AE,Pociot F,Nerup J,Sparre T

更新日期：2006-06-01 00:00:00

abstract：:On different tissue sections, binding of gliadin to reticular matrix components was observed which was Ca2+-dependent, inhibited by Cu2+ and Zn2+ ions, by putrescine, and by preincubation with antibodies against tissue transglutaminase (tTG) suggesting that binding of gliadin is mediated by tTG. tTG was able to bind t...

journal_title：Autoimmunity

authors： Uhlig H,Osman AA,Tanev ID,Viehweg J,Mothes T

更新日期：1998-01-01 00:00:00

abstract：:Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...

journal_title：Autoimmunity

authors： Zhang D,Li H,Ma L,Zhang X,Xue F,Zhou Z,Chi Y,Liu X,Huang Y,Yang Y,Yang R

更新日期：2014-12-01 00:00:00

abstract：:The goal of contemporary research in pemphigus vulgaris and pemphigus foliaceus is to achieve and maintain clinical remission without corticosteroids. Recent advances of knowledge on pemphigus autoimmunity scrutinize old dogmas, resolve controversies, and open novel perspectives for treatment. Elucidation of intimate ...

journal_title：Autoimmunity

authors： Grando SA

更新日期：2012-02-01 00:00:00

abstract：:Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and n...

journal_title：Autoimmunity

authors： Khan MA,Alam K,Hassan SM,Rizvi MMA

更新日期：2017-06-01 00:00:00

abstract：:Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...

journal_title：Autoimmunity

authors： Keith MP,Moratz C,Egan R,Zacharia A,Greidinger EL,Hoffman RW,Tsokos GC

更新日期：2007-05-01 00:00:00

abstract：:Diabetes mellitus is a disorder characterized by hyperglycemia in both the fasting and post-prandial states. The two most common forms of diabetes mellitus, type 1 and type 2 (previously called juvenile-onset and adult-onset, respectively), comprise the vast majority of cases. Type 1 diabetes (T1DM) has been shown to ...

journal_title：Autoimmunity

authors： Taplin CE,Barker JM

更新日期：2008-02-01 00:00:00

abstract：:The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=2...

journal_title：Autoimmunity

authors： Wang ZH,Liao YH,Fu M

更新日期：2001-01-01 00:00:00

abstract：:HLA-DP+ T cells in peripheral blood from 23 patients with systemic lupus erythematosus (SLE) were examined using two-colour flow cytometry analysis. A marked increase of HLA-DP+ T cells was observed in patients with SLE (20.5-98.7%; 59.8 +/- 20.8%) in comparison to normal subjects (1.3-20.6%; 11.1 +/- 7.2%), and the r...

journal_title：Autoimmunity

authors： Tokano Y,Hishikawa T,Hirose T,Sekigawa I,Hashimoto H,Okumura K,Hirose S

更新日期：1990-01-01 00:00:00

abstract：:Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...

journal_title：Autoimmunity

authors： Le Panse R,Bismuth J,Cizeron-Clairac G,Weiss JM,Cufi P,Dartevelle P,De Rosbo NK,Berrih-Aknin S

更新日期：2010-08-01 00:00:00

abstract：:Numerous groups have now validated high-throughput approaches to autoantibody profiling in a variety of systems. Recently, we have used autoantigen microarray technology to identify distinct autoantibody profiles in H-2 congenic MRL/lpr mice (Sekine et al., manuscript in preparation), and we are expanding this platfor...

journal_title：Autoimmunity

authors： Graham KL,Robinson WH,Steinman L,Utz PJ

更新日期：2004-06-01 00:00:00

abstract：:Thyroid lymphocyte RNA from a Hashimoto patient with high serum levels of autoantibodies to thyroid peroxidase (TPO) was used to construct a phage display antibody library in the phagemid vector pComb3. The library (100,000cfu) encoded IgG1 heavy chains together with kappa light chains. Selection of the phages display...

journal_title：Autoimmunity

authors： Hexham JM,Partridge LJ,Furmaniak J,Petersen VB,Colls JC,Pegg C,Rees Smith B,Burton DR

更新日期：1994-01-01 00:00:00

abstract：:Chronic autoimmune thyroiditis (cAIT) leads to hypothyroidism due to T cell-mediated cytotoxicity in most cases. By contrast, Graves' disease (GD) with thyrotropin receptor stimulatory autoantibodies cause hyperthyroidism. Cytokines play a crucial role in modulating immune response in both disorders. The aim of study ...

journal_title：Autoimmunity

authors： Mikos H,Mikos M,Rabska-Pietrzak B,Niedziela M

更新日期：2014-11-01 00:00:00