Effect of mycobacterial infection in the lupus-prone MRL/lpr mice: enhancement of life span of autoimmune mice, amelioration of kidney disease and transient decrease in host resistance.


:We have used the MRL/lpr murine model of spontaneous lupus to investigate three questions in infection immunity: (1) does mycobacterial infection have any effect on the mortality of the autoimmunity-prone lpr mice?; (2) does the infection modify the progression of kidney disease of lpr lupus?; and (3) does the lpr gene change the resistance of mice to mycobacteria? Experimental infections were induced by intraperitoneal inoculation of 10(7) viable bacilli of Mycobacterium avium in 3 months old MRL/lpr mice and also in congeneic MRL/+ mice (lacking the lpr gene). MRL mice were sacrificed 1, 2.5 and 4 months after the M. avium injection. We found that infection caused lowering of urine protein concentration in lpr mice as compared with age-matched lpr controls. Mycobacteriosis also induced a marked decrease in the mortality of lpr animals, e.g. 85% of infected lpr mice reached the age of 7 months whereas only 10% of control lpr mice reached the same age. MRL/lpr mice showed, after 1 and 2.5 months of infection, higher mycobacterial loads than the congeneic non-lpr MRL mice; after 4 months of infection, however, differences in M. avium loads between the two groups of MRL mice became not statistically significant. We conclude that: (1) mycobacterial infection increases the life span of lpr mice; (2) the infection slows down the progression of kidney disease in the lupus-prone lpr animals; (3) the autoimmunity gene lpr is associated with a transient decrease in host resistance to mycobacteria.






Castro AP,Esaguy N,Aguas AP




Has Abstract


1993-01-01 00:00:00












  • Dietary protein restriction reduces the frequency and delays the onset of insulin dependent diabetes in BB rats.

    abstract::Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy...


    pub_type: 杂志文章


    authors: Atkinson MA,Winter WE,Skordis N,Beppu H,Riley WM,Maclaren NK

    更新日期:1988-01-01 00:00:00

  • Efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients.

    abstract:OBJECTIVE:To study efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. METHODS:The case records of 40 patients with lupus nephritis followed up in a single center between 1992 and 2011 (median duration = 8.37 years) were retrieved to determine efficacy and toxicity of the treat...


    pub_type: 杂志文章


    authors: Bozzolo EP,Ramirez GA,Bonavida G,Lanzani C,Scotti R,Dell'antonio G,Baldissera E,Canti V,Manfredi AA,Rovere-Querini P,Sabbadini MG

    更新日期:2013-12-01 00:00:00

  • Toll-like receptors and their role in the development of autoimmune diseases.

    abstract::Human Toll-like receptors (TLRs) are crucial for the recognition of invading pathogens and for the activation of both innate and adaptive immunity. Upon stimulation, TLRs recruit various protein kinases via several adaptor molecules, such as MyD88, leading to the activation of NFkB. The identification of TLR signaling...


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    authors: Toubi E,Shoenfeld Y

    更新日期:2004-05-01 00:00:00

  • Both early and late apoptotic blebs are taken up by DC and induce IL-6 production.

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    authors: Fransen JH,Hilbrands LB,Jacobs CW,Adema GJ,Berden JH,Van der Vlag J

    更新日期:2009-05-01 00:00:00

  • The origin of extracellular DNA during the clearance of dead and dying cells.

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    pub_type: 杂志文章,评审


    authors: Pisetsky DS,Fairhurst AM

    更新日期:2007-06-01 00:00:00

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    abstract::This review focuses on recent advances and new hypothesis in the understanding of the T and dendritic cells contribution to the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). The new data show that non-specific amplification of muscle inflammation by T...


    pub_type: 杂志文章,评审


    authors: Chevrel G,Page G,Miossec P

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    authors: Alderuccio F,Biondo M,Toh BH

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    authors: Peng SL

    更新日期:2007-09-01 00:00:00

  • Neonatal lupus: review of proposed pathogenesis and clinical data from the US-based Research Registry for Neonatal Lupus.

    abstract::Congenital heart block (CHB), a life-threatening manifestation of neonatal lupus, offers aunique opportunity to study the effect or arm of immunity and define the pathogenicity of an autoantibody in mediating tissue injury. This review focuses on our recent in vitro model which supports a cascade from antibody insult ...


    pub_type: 杂志文章,评审


    authors: Buyon JP,Clancy RM

    更新日期:2003-02-01 00:00:00

  • Targeting lymphocyte co-stimulation: from bench to bedside.

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    pub_type: 杂志文章,评审


    authors: Felix NJ,Suri A,Salter-Cid L,Nadler SG,Gujrathi S,Corbo M,Aranda R

    更新日期:2010-11-01 00:00:00

  • Reduced in vitro production of interferon-gamma, interleukin-4 and interleukin-12 and increased production of interleukin-6, interleukin-10 and tumour necrosis factor-alpha in systemic lupus erythematosus. Weak correlations of cytokine production with dis

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    pub_type: 杂志文章


    authors: Jones BM,Liu T,Wong RW

    更新日期:1999-10-01 00:00:00

  • IL-1 beta gene expression in B cells derived from the murine MRL/lpr model of lupus.

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    pub_type: 杂志文章


    authors: Mao C,Singh AK

    更新日期:1996-01-01 00:00:00

  • Quantitative analysis of islet glutamic acid decarboxylase p64 autoantibodies in insulin-dependent diabetes mellitus.

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    pub_type: 杂志文章


    authors: Bärmeier H,Ahlmén J,Landin-Olsson M,Rajotte RV,Sundkvist G,Warnock G,Lernmark A

    更新日期:1992-01-01 00:00:00

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    authors: Lin W,Chen M,Zhao MH

    更新日期:2009-03-01 00:00:00

  • Catastrophic relapse of Evans syndrome five years after allogeneic BMT notwithstanding full donor chimerism. Terminal hemolytic-uremic syndrome.

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    authors: Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

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    authors: Wu P,Wang Z,Lu S,Zhao X

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  • The clinical role of serum concentrations of selected cytokines: IL-1β, TNF-α and IL-6 in diagnosis of autoimmune thyroid disease (AITD) in children.

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    pub_type: 杂志文章


    authors: Haas JP,Metzler M,Frank C,Haefner R,Wassmuth R

    更新日期:2009-05-01 00:00:00