Abstract:
:Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental animals. However, indirect immunofluorescence studies showed IgM deposition in close contact to myelin sheaths. Minor but distinct alterations of nerves were found in the adult: the enlargement of Schmidt-Lanterman incisures seen in electron microscopy could explain the decrease of the proportion of fibers of small diameter found by morphometry of semi-thin section, and the reduction of the mean internodal length in fibers of a given diameter seen in teased nerve fibers studies.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Dancea S,Dellagi K,Renaud F,Mahouy G,Hauw JJ,Brouet JCdoi
10.3109/08916938909043611subject
Has Abstractpub_date
1989-01-01 00:00:00pages
29-37issue
1eissn
0891-6934issn
1607-842Xjournal_volume
3pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract::Non obese diabetic (NOD) mice spontaneously develop thyroiditis in addition to diabetes. Mononuclear cells begin to infiltrate the thyroid of these animals in the first month of life. The expression of major histocompatibility complex (MHC) class II (Ia) antigens by cells in the thyroid from NOD mice of various ages w...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409014653
更新日期:1994-01-01 00:00:00
abstract::In the present study, the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in kidney lymphoid cells of lupus-prone mice (MRL-lpr/lpr) is shown by Northern blot and nuclear run on transcription assay. By quantification analysis of hsp 70 gene transcription, more than ten times of the enhan...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939108997141
更新日期:1991-01-01 00:00:00
abstract::The immunomodulatory effects of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been elucidated at a cellular level and implicated in the pathogenesis of several complex diseases. Defects within the regulatory T cell compartment are one of the characteristics of primary biliary cirrhosis (PBC...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701619730
更新日期:2008-02-01 00:00:00
abstract::Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2019.1575820
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to characterise the functionally relevant minor lymphocyte subpopulations in whole blood of multiple sclerosis (MS) patients and their potential utility as biomarkers for treatment follow up. MATERIAL AND METHODS:Peripheral blood from 40 healthy donors (HD) and 66 MS patients [...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2016.1138271
更新日期:2016-06-01 00:00:00
abstract::The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrate...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002529
更新日期:2009-11-01 00:00:00
abstract::The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2015.1031889
更新日期:2015-01-01 00:00:00
abstract::Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes utilizing a novel recombinant PR3 (rPR3) produced to accommodate manipulations of the N-terminal domain. The rPR3 molecule contains an N-terminus six ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701680104
更新日期:2007-11-01 00:00:00
abstract::Numerous studies have shown that autoantigens may be clustered in the blebs of apoptotic cells. However, it is not yet clear in what circumstances apoptotic cells could be immunogenic rather than tolerogenic when interacting with macrophages, dendritic cells, and B cells. In order to further study this question we com...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930410001666622
更新日期:2004-03-01 00:00:00
abstract::Numerous groups have now validated high-throughput approaches to autoantibody profiling in a variety of systems. Recently, we have used autoantigen microarray technology to identify distinct autoantibody profiles in H-2 congenic MRL/lpr mice (Sekine et al., manuscript in preparation), and we are expanding this platfor...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930410001710686
更新日期:2004-06-01 00:00:00
abstract::This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-re...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109006744
更新日期:1991-01-01 00:00:00
abstract::CNS demyelinating inflammatory disease can be a multifactorial process mediated by cellular and antibody-mediated immune processes. Myelin basic protein (MBP)-specific T cells and pathogenic 8-18C5 antibody, specific for a myelin/oligodendrocyte glycoprotein (MOG), a minor component of CNS white matter, can coexist in...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909014690
更新日期:1989-01-01 00:00:00
abstract::To assess the specificity of autoantibodies (aAbs) directed against the ribosomal P-proteins (RPPaAbs) in patients with systemic lupus erythematosus (SLE) and to investigate aAbs directed to other ribosomal proteins, 100 SLE, 100 rheumatoid arthritis (RA), 25 thyroiditis and 20 blood-donors were analyzed in a comparat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/0891693021000045714
更新日期:2002-11-01 00:00:00
abstract::Autoantibodies directed against nuclear antigens often arise in autoimmune disease associated with the failure to clear apoptotic cells in a swift and timely manner. Nucleic acids present in apoptotic cells and in membranous microparticles derived thereof exert adjuvant activity in the immune response to apoptosis. Th...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2012.750298
更新日期:2013-08-01 00:00:00
abstract::Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2018.1522305
更新日期:2018-11-01 00:00:00
abstract::The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209112339
更新日期:1992-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002479
更新日期:2009-11-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a human herpesvirus hiding in a latent form in memory B cells in the majority of the world population. Although, primary EBV infection is asymptomatic or causes a self-limiting disease, infectious mononucleosis, the virus is associated with a wide variety of neoplasms developing in immunosu...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930802024772
更新日期:2008-05-01 00:00:00
abstract::A patient with chronic ITP relapsed after conventional therapy but following an infusion with low dose anti D (Rho) immunoglobulin, she entered a remission which has now lasted 10 months. This is difficult to explain on the basis of long term macrophage Fc receptor blockade and suggests an alternative mechanism of act...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909034366
更新日期:1989-01-01 00:00:00
abstract::The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2013.768617
更新日期:2013-05-01 00:00:00
abstract::Infectious agents have been implicated in the etiopathogenesis of various vasculitides via numerous and overlapping mechanisms including direct microbial invasion of endothelial cells, immune complex mediated vessel wall damage and stimulation of autoreactive B and/or T cells through molecular mimicry and superantigen...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930802613210
更新日期:2009-08-01 00:00:00
abstract::We have used the reverse transcriptase polymerase chain reaction (RT-PCR) technique to assess the expression of cytokine genes in various T cell subsets of autoimmune-prone mice. Our study confirmed the previously described features in lpr mice that IFN-gamma, TNF-alpha, and TNF-beta were transcribed by various T cell...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409014658
更新日期:1994-01-01 00:00:00
abstract::To explore the natural course of beta cell function in recent onset diabetes, a subgroup (n=157) of all incident cases (n=879) 15-34 years old, 1992-1993 in Sweden, and with positivity for at least one autoantibody of islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930108995996
更新日期:2001-01-01 00:00:00
abstract::We analysed the presence of anti-cyclic citrullinated peptide (anti-CCP) and anti-keratin (AKA) antibodies of the IgG class in sera of patients with defined juvenile idiopathic arthritis (JIA) of various subgroups with more than one year duration of the disease. Enzyme-linked immunosorbent assay (Immunoscan RA, Eurodi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/0891693021000014970
更新日期:2002-09-01 00:00:00
abstract::Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930290016655
更新日期:2002-03-01 00:00:00
abstract::In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909034357
更新日期:1989-01-01 00:00:00
abstract::We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309079229
更新日期:1993-01-01 00:00:00
abstract::Experimental myasthenia gravis (EMG) was elicited in female AO rats, 8-12 weeks of age, by injection of 100 micrograms/rat Torpedo marmorata acetylcholine receptor (AChR)-protein incorporated in CFA. Bordetella pertussis, 24 x 10(9) microorganisms, rat, was injected simultaneously as additional adjuvant. Rats were sac...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309019928
更新日期:1993-01-01 00:00:00
abstract::The possible immunosuppressive action of antithyroid drugs in vivo has been assessed using Buffalo (Buf) strain rats with thyroiditis produced by neonatal thymectomy; this model shares many features with spontaneous thyroiditis in man. Both propylthiouracil and methimazole significantly reduced the severity of thyroid...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938808997176
更新日期:1988-01-01 00:00:00
abstract::We have shown that mice infected with mouse hepatitis virus A59 develop autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH). Because it has been proposed that the immune system is stimulated by alarm signals called damage-associated molecular patterns or alarmins, we investigated the partic...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.579927
更新日期:2011-12-01 00:00:00