Increased vascular permeability of Brucella abortus bacilli in the thymus of NZB/W F1 mice.

abstract：OBJECTIVE:To assess muscle strength in patients with idiopathic inflammatory myopathies (IIM) using neuromuscular scales and isokinetic testing. METHODS:Muscle function was evaluated in 27 IIM patients being followed at the Rheumatology Unit of the University of Pisa using: (i) a modified version of the grading system...

journal_title：Autoimmunity

authors： Neri R,Mosca M,Stampacchia G,Vesprini E,Tavoni A,d'Ascanio A,Bombardieri S

更新日期：2006-05-01 00:00:00

abstract：:At least two signals for proliferation and cytokine secretion by T-cells are required. The first signal is delivered through the interaction of the T-cell receptor with major histocompatibility complex (MHC) molecules expressed on the surface of antigen-presenting cells (APC). The second or costimulatory signal is del...

journal_title：Autoimmunity

authors： Salmaso C,Olive D,Pesce G,Bagnasco M

更新日期：2002-05-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is characterised by immune-mediated damage to the intra-hepatic biliary epithelial cells (BEC). Immuno-modulatory/suppressive therapy represents, therefore, alogical approach to treatment in this disease. Conventional immuno-suppressive and immuno-modulatory agents suffer from the bread...

journal_title：Autoimmunity

authors： Jones DE,Palmer JM,Robe A,Kirby JA

更新日期：2002-12-01 00:00:00

abstract：:Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...

journal_title：Autoimmunity

authors： Zhang D,Li H,Ma L,Zhang X,Xue F,Zhou Z,Chi Y,Liu X,Huang Y,Yang Y,Yang R

更新日期：2014-12-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic beta cell destruction involving auto-reactive T-cells, pro-inflammatory cytokines, reactive oxygen species (ROS) and loss of insulin. Monozygotic twin studies show a 20-60% concordance with T1D indicating there may be an environmental component...

journal_title：Autoimmunity

authors： Bekris LM,Shephard C,Peterson M,Hoehna J,Van Yserloo B,Rutledge E,Farin F,Kavanagh TJ,Lernmark A

更新日期：2005-12-01 00:00:00

abstract：:The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=2...

journal_title：Autoimmunity

authors： Wang ZH,Liao YH,Fu M

更新日期：2001-01-01 00:00:00

abstract：:Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. It has been proposed that IL-1 induces a race between protective and deleterious proteins i...

journal_title：Autoimmunity

authors： Christensen UB,Larsen PM,Fey SJ,Andersen HU,Nawrocki A,Sparre T,Mandrup-Poulsen T,Nerup J

更新日期：2000-01-01 00:00:00

abstract：:Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...

journal_title：Autoimmunity

authors： Bhol KC,Ahmed AR

更新日期：2002-03-01 00:00:00

abstract：:This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-re...

journal_title：Autoimmunity

authors： Suleyman S,Kasp E,Ellis B,Banga JP,Dumonde DC

更新日期：1991-01-01 00:00:00

abstract：:The G to A transition at position +1057 single nucleotide polymorphism site in CD86 gene results in the alanine to threonine substitution, which further affects the antigen-presenting cells' signal transduction. Thus, the purpose of this study was to determine the association between CD86 +1057G/A polymorphism and the...

journal_title：Autoimmunity

authors： Wu P,Wang Z,Lu S,Zhao X

更新日期：2014-11-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and by ventricular dilatation. Abnormalities of the cellular and humoral immune system are present in patients with myocarditis and DCM. Various circulating cardiac autoantibodies have been d...

journal_title：Autoimmunity

authors： Felix SB,Staudt A,Friedrich GB

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To study efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. METHODS:The case records of 40 patients with lupus nephritis followed up in a single center between 1992 and 2011 (median duration = 8.37 years) were retrieved to determine efficacy and toxicity of the treat...

journal_title：Autoimmunity

authors： Bozzolo EP,Ramirez GA,Bonavida G,Lanzani C,Scotti R,Dell'antonio G,Baldissera E,Canti V,Manfredi AA,Rovere-Querini P,Sabbadini MG

更新日期：2013-12-01 00:00:00

abstract：:The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...

journal_title：Autoimmunity

authors： Alkhateeb A,Jarun Y,Tashtoush R

更新日期：2013-05-01 00:00:00

abstract：:A patient with chronic ITP relapsed after conventional therapy but following an infusion with low dose anti D (Rho) immunoglobulin, she entered a remission which has now lasted 10 months. This is difficult to explain on the basis of long term macrophage Fc receptor blockade and suggests an alternative mechanism of act...

journal_title：Autoimmunity

authors： Smith NA,Chakraverty RK,Obeid D,Boughton BJ

更新日期：1989-01-01 00:00:00

abstract：:It is generally accepted that thyroid-associated ophthalmopathy (TAO) is an autoimmune disease of the eye muscle (EM) and the surrounding orbital connective tissue in which circulating antibodies play an important role. Antibodies against EM membrane proteins of 63-67kDa mol. wt. seem to be the best markers of ophthal...

journal_title：Autoimmunity

authors： Gunji K,Kubota S,Stolarski C,Wengrowicz S,Kennerdell JS,Wall JR

更新日期：1999-01-01 00:00:00

abstract：:Elevated constitutive expression of major histocompatibility (MHC) class II antigens occurs in the enterocytes of patients with IBD. It has been suggested that this aberrant expression of class II molecules may play a role in the pathogenesis of IBD. We examined two possible reasons for such a finding. 1) Heightened s...

journal_title：Autoimmunity

authors： Salomon P,Pizzimenti A,Panja A,Reisman A,Mayer L

更新日期：1991-01-01 00:00:00

abstract：:Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...

journal_title：Autoimmunity

authors： Lorini R,Orecchia G,Martinetti M,Dugoujon JM,Cuccia M

更新日期：1992-01-01 00:00:00

abstract：:The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients,...

journal_title：Autoimmunity

authors： Dar SA,Haque S,Mandal RK,Singh T,Wahid M,Jawed A,Panda AK,Akhter N,Lohani M,Areeshi MY,Rai G,Datt S,Bhattacharya SN,Ramachandran VG,Das S

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...

journal_title：Autoimmunity

authors： Fransen JH,Berden JH,Koeter CM,Adema GJ,Van Der Vlag J,Hilbrands LB

更新日期：2012-06-01 00:00:00

abstract：:Linomide is a potent immunomodulator that has been shown to inhibit autoimmunity in several animal models of autoimmune disease, including experimental autoimmune encephalomyelitis (EAE). Linomide's mechanism of action is unknown, however, it has been suggested to modulate the function of antigen presenting cells (APC...

journal_title：Autoimmunity

authors： Dahlén E,Andersson M,Dawe K,Tellander AC,Brunmark C,Björk A,Hedlund G

更新日期：2000-10-01 00:00:00

abstract：:The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins including ionized Ca(2+)-binding adaptor 1, microglia response factor-1, and daintain are identical with AIF-1. The expre...

journal_title：Autoimmunity

authors： Liu G,Ma H,Jiang L,Zhao Y

更新日期：2007-03-01 00:00:00

abstract：:The objective of this study was to research the functionality of anti-endothelial cell antibodies (AECA) in pulmonary arterial hypertension (PAH) by assessing the effects of IgG from AECA-positive PAH patients on the induction of adhesion molecules on human umbilical vein endothelial cells (HUVECs) and on the producti...

journal_title：Autoimmunity

authors： Arends SJ,Damoiseaux JG,Duijvestijn AM,Debrus-Palmans L,Boomars KA,Brunner-La Rocca HP,Cohen Tervaert JW,van Paassen P

更新日期：2013-11-01 00:00:00

abstract：:Glycosaminoglycan (GAG) accumulation in the retrobulbar space of patients with thyroid-associated ophthalmopathy (TAO) has been documented in a number of immunohistochemical studies. In order to gain further insight into possible immunopathogenic mechanisms, the influence of humoral immunity on retrobulbar fibroblasts...

journal_title：Autoimmunity

authors： Kahaly G,Stover C,Otto E,Beyer J,Schuler M

更新日期：1992-01-01 00:00:00

abstract：:Autoantibodies directed against nuclear antigens often arise in autoimmune disease associated with the failure to clear apoptotic cells in a swift and timely manner. Nucleic acids present in apoptotic cells and in membranous microparticles derived thereof exert adjuvant activity in the immune response to apoptosis. Th...

journal_title：Autoimmunity

authors： Bekeredjian-Ding I

更新日期：2013-08-01 00:00:00

abstract：:The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for...

journal_title：Autoimmunity

authors： Song WC

更新日期：2006-08-01 00:00:00

abstract：:The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...

journal_title：Autoimmunity

authors： Banica L,Besliu A,Pistol G,Stavaru C,Ionescu R,Forsea AM,Tanaseanu C,Dumitrache S,Otelea D,Tamsulea I,Tanaseanu S,Chitonu C,Paraschiv S,Balteanu M,Stefanescu M,Matache C

更新日期：2009-01-01 00:00:00

abstract：:The nature of the immunosuppressive effect of antithyroid drugs has been a subject of controversy. It has been claimed that these agents exert a direct effect on the immune system, although we and others have suggested that the drugs affect the thyroid cells primarily with consequent reduced thyrocyte-immunocyte signa...

journal_title：Autoimmunity

authors： Aguayo J,Michaud P,Iitaka M,Degroot LJ,Row VV,Volpé R

更新日期：1989-01-01 00:00:00

abstract：:This review focuses on recent advances and new hypothesis in the understanding of the T and dendritic cells contribution to the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). The new data show that non-specific amplification of muscle inflammation by T...

journal_title：Autoimmunity

authors： Chevrel G,Page G,Miossec P

更新日期：2006-05-01 00:00:00

abstract：:Autoantibodies against the beta-cell M(r) 64,000 protein (p64), recently identified as an isoform of glutamic acid decarboxylase (GAD), are prevalent in patients with insulin-dependent diabetes mellitus (IDDM). Dog islets were found to represent an abundant source of native p64 allowing the study of antigen-antibody i...

journal_title：Autoimmunity

authors： Bärmeier H,Ahlmén J,Landin-Olsson M,Rajotte RV,Sundkvist G,Warnock G,Lernmark A

更新日期：1992-01-01 00:00:00

abstract：:Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...

journal_title：Autoimmunity

authors： Frusić-Zlotkin M,Raichenberg D,Wang X,David M,Michel B,Milner Y

更新日期：2006-11-01 00:00:00