Functional and isokinetic assessment of muscle strength in patients with idiopathic inflammatory myopathies.


OBJECTIVE:To assess muscle strength in patients with idiopathic inflammatory myopathies (IIM) using neuromuscular scales and isokinetic testing. METHODS:Muscle function was evaluated in 27 IIM patients being followed at the Rheumatology Unit of the University of Pisa using: (i) a modified version of the grading system used to assess Duchenne dystrophy, (ii) the four-stage grading system of Henriksson and Sandstedt, (iii) an isokinetic muscle strength test (Kin Com, Chatanooga) and (iv) the Health Assessment Questionnaire (HAQ). RESULTS:The neuromuscular scales showed normal or only mildly impaired muscle strength in 60% (Duchenne scale) and 80% (Henriksson and Sandstedt scale) of the patients, respectively, whereas isokinetic testing detected moderate to severe reductions in muscle strength in almost 70% of the patients. No correlations were observed between muscle strength and disease activity, therapy, age at evaluation and disease duration. There was a correlation between the results of the HAQ and neuromuscular testing, but not the isokinetic test. CONCLUSIONS:Although less easy and more expensive to administer, isokinetic testing appears to be a more sensitive instrument than the standard neuromuscular tests for assessing muscle function in IIM patients. In particular, it can detect small reductions in muscle strength.






Neri R,Mosca M,Stampacchia G,Vesprini E,Tavoni A,d'Ascanio A,Bombardieri S




Has Abstract


2006-05-01 00:00:00














  • Autoantibodies directed against ribosomal proteins in systemic lupus erythematosus and rheumatoid arthritis: a comparative study.

    abstract::To assess the specificity of autoantibodies (aAbs) directed against the ribosomal P-proteins (RPPaAbs) in patients with systemic lupus erythematosus (SLE) and to investigate aAbs directed to other ribosomal proteins, 100 SLE, 100 rheumatoid arthritis (RA), 25 thyroiditis and 20 blood-donors were analyzed in a comparat...


    pub_type: 杂志文章


    authors: Desbos A,Gonzalo P,Monier JC,Tebib J,Reboud JP,Perrier H,Bienvenu J,Fabien N

    更新日期:2002-11-01 00:00:00

  • Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis.

    abstract::The immunomodulatory effects of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been elucidated at a cellular level and implicated in the pathogenesis of several complex diseases. Defects within the regulatory T cell compartment are one of the characteristics of primary biliary cirrhosis (PBC...


    pub_type: 杂志文章


    authors: Oertelt-Prigione S,Mao TK,Selmi C,Tsuneyama K,Ansari AA,Coppel RL,Invernizzi P,Podda M,Gershwin ME

    更新日期:2008-02-01 00:00:00

  • Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease.

    abstract::Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...


    pub_type: 杂志文章


    authors: Sjöber K,Eriksson S,Tenngart B,Roth EB,Leffler H,Stenberg P

    更新日期:2002-08-01 00:00:00

  • A modified superantigen rescues Ly6G- CD11b+ blood monocyte suppressor function and suppresses antigen-specific inflammation in EAE.

    abstract::In a previous study, we showed that the Ly6G(-)CD11b(+) blood monocytes residing in naïve mice are intrinsically immunosuppressive and that loss of this suppressive function may contribute to the development of autoimmunity in experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis....


    pub_type: 杂志文章


    authors: Slaney CY,Toker A,Fraser JD,Harper JL,Bäckström BT

    更新日期:2013-06-01 00:00:00

  • The defective bone marrow-derived mesenchymal stem cells in patients with chronic immune thrombocytopenia.

    abstract::Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...


    pub_type: 杂志文章


    authors: Zhang D,Li H,Ma L,Zhang X,Xue F,Zhou Z,Chi Y,Liu X,Huang Y,Yang Y,Yang R

    更新日期:2014-12-01 00:00:00

  • Reduced in vitro production of interferon-gamma, interleukin-4 and interleukin-12 and increased production of interleukin-6, interleukin-10 and tumour necrosis factor-alpha in systemic lupus erythematosus. Weak correlations of cytokine production with dis

    abstract::Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...


    pub_type: 杂志文章


    authors: Jones BM,Liu T,Wong RW

    更新日期:1999-10-01 00:00:00

  • IL-1 beta gene expression in B cells derived from the murine MRL/lpr model of lupus.

    abstract::The MRL/lpr model of SLE resembles human lupus in its various immunopathologic characteristics including the presence of high-level IgG and anti-DNA antibody production and multisystem organ involvement (nephritis, arthritis, and vasculitis). Our previous studies have shown that IL-1 overactivity in B cells plays a po...


    pub_type: 杂志文章


    authors: Mao C,Singh AK

    更新日期:1996-01-01 00:00:00

  • Oral tolerisation to pyruvate dehydrogenase complex as a potential therapy for primary biliary cirrhosis.

    abstract::Primary biliary cirrhosis (PBC) is characterised by immune-mediated damage to the intra-hepatic biliary epithelial cells (BEC). Immuno-modulatory/suppressive therapy represents, therefore, alogical approach to treatment in this disease. Conventional immuno-suppressive and immuno-modulatory agents suffer from the bread...


    pub_type: 杂志文章


    authors: Jones DE,Palmer JM,Robe A,Kirby JA

    更新日期:2002-12-01 00:00:00

  • Anti-68 kDa antibodies in autoimmune sensorineural hearing loss: are these autoantibodies really a diagnostic tool?

    abstract:OBJECTIVES:Autoimmune sensorineural hearing loss (ASNHL) is a relatively rare disorder which can lead to total deafness. At present, no specific laboratory test with adequate sensitivity and specificity is available to confirm the clinical suspicion of ASNHL. The aim of this study was to identify if evaluation of anti-...


    pub_type: 杂志文章


    authors: Bonaguri C,Orsoni JG,Zavota L,Monica C,Russo A,Pellistri I,Rubino P,Giovannelli L,Manzotti F,Piazza F

    更新日期:2007-02-01 00:00:00

  • Functional implications of IgG anti-endothelial cell antibodies in pulmonary arterial hypertension.

    abstract::The objective of this study was to research the functionality of anti-endothelial cell antibodies (AECA) in pulmonary arterial hypertension (PAH) by assessing the effects of IgG from AECA-positive PAH patients on the induction of adhesion molecules on human umbilical vein endothelial cells (HUVECs) and on the producti...


    pub_type: 杂志文章


    authors: Arends SJ,Damoiseaux JG,Duijvestijn AM,Debrus-Palmans L,Boomars KA,Brunner-La Rocca HP,Cohen Tervaert JW,van Paassen P

    更新日期:2013-11-01 00:00:00

  • B cells participate in tolerance and autoimmunity through cytokine production.

    abstract::In the 1950s, the discovery of autoantibodies produced by B cells seemed to provide a compelling mechanism underlying autoimmune diseases. The discovery of T regulatory cells and other T helper cell subsets shifted the field back towards a T cell central view. The success of rituxan, a chimeric mAb targeting CD20 on B...


    pub_type: 杂志文章,评审


    authors: Luu VP,Vazquez MI,Zlotnik A

    更新日期:2014-02-01 00:00:00

  • Apoptosis and NET formation in the pathogenesis of SLE.

    abstract::Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...


    pub_type: 杂志文章,评审


    authors: Bouts YM,Wolthuis DF,Dirkx MF,Pieterse E,Simons EM,van Boekel AM,Dieker JW,van der Vlag J

    更新日期:2012-12-01 00:00:00

  • Mapping epitope specificities of monoclonal antibodies to thyroid peroxidase using recombinant antigen preparations.

    abstract::Five separate monoclonal antibodies (MoAbs) to human thyroid peroxidase (hTPO) were raised by immunising Balb/c mice with hTPO purified from detergent solubilised thyroid microsomes by high performance liquid chromatography (HPLC). The epitope specificities of these MoAbs were determined by assessing their ability to ...


    pub_type: 杂志文章


    authors: Ewins DL,Barnett PS,Tomlinson RW,McGregor AM,Banga JP

    更新日期:1992-01-01 00:00:00

  • Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease.

    abstract::Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strept...


    pub_type: 杂志文章,评审


    authors: Guilherme L,Kalil J,Cunningham M

    更新日期:2006-02-01 00:00:00

  • Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model.

    abstract::Blockade of the complement cascade at the C5a/C5a receptor (C5aR)-axis is believed to be an attractive treatment avenue in rheumatoid arthritis (RA). However, the effects of such interventions during the early phases of arthritis remain to be clarified. In this study we use the murine delayed-type hypersensitivity art...


    pub_type: 杂志文章


    authors: Atkinson SM,Nansen A,Usher PA,Sondergaard BC,Mackay CR,Friedrichsen B,Chang CC,Tang R,Skov S,Haase C,Hornum L

    更新日期:2015-01-01 00:00:00

  • Immunopathology of experimental autoimmune uveoretinitis in primates.

    abstract::The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...


    pub_type: 杂志文章


    authors: Fujino Y,Li Q,Chung H,Hikita N,Nussenblatt RB,Gery I,Chan CC

    更新日期:1992-01-01 00:00:00

  • Autoimmunity in vitiligo: relationship with HLA, Gm and Km polymorphisms.

    abstract::Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...


    pub_type: 杂志文章


    authors: Lorini R,Orecchia G,Martinetti M,Dugoujon JM,Cuccia M

    更新日期:1992-01-01 00:00:00

  • Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein.

    abstract::Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice (H-2g7) and C57BL/6 mice (H-2b) by a ...


    pub_type: 杂志文章


    authors: Slavin A,Ewing C,Liu J,Ichikawa M,Slavin J,Bernard CC

    更新日期:1998-01-01 00:00:00

  • Increase of class II HLA molecules on the membrane of B lymphocytes from patients with rheumatoid arthritis.

    abstract::Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...


    pub_type: 杂志文章


    authors: Eliaou JF,Andary M,Favier F,Carayon P,Poncelet P,Sany J,Brochier J,Clot J

    更新日期:1988-01-01 00:00:00

  • Efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients.

    abstract:OBJECTIVE:To study efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. METHODS:The case records of 40 patients with lupus nephritis followed up in a single center between 1992 and 2011 (median duration = 8.37 years) were retrieved to determine efficacy and toxicity of the treat...


    pub_type: 杂志文章


    authors: Bozzolo EP,Ramirez GA,Bonavida G,Lanzani C,Scotti R,Dell'antonio G,Baldissera E,Canti V,Manfredi AA,Rovere-Querini P,Sabbadini MG

    更新日期:2013-12-01 00:00:00

  • Both early and late apoptotic blebs are taken up by DC and induce IL-6 production.

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    authors: Fransen JH,Hilbrands LB,Jacobs CW,Adema GJ,Berden JH,Van der Vlag J

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  • Nuclear imaging of autoimmunity: focus on IBD and RA.

    abstract::There is a need for methods to improve the diagnosis, patient staging and evaluation of therapeutic response in patients with autoimmune conditions to improve patient care. Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are two inflammatory diseases characterized by involvement of innate and adaptive i...


    pub_type: 杂志文章,评审


    authors: McBride HJ

    更新日期:2010-11-01 00:00:00

  • Aminoguanidine, an inhibitor of nitric oxide formation, fails to protect against insulitis and hyperglycemia induced by multiple low dose streptozotocin injections in mice.

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    pub_type: 杂志文章


    authors: Holstad M,Sandler S

    更新日期:1993-01-01 00:00:00

  • Anti-astrocyte autoantibodies in Guillain-Barre Syndrome--possible involvement in the pathophysiology of a psychosyndrome?

    abstract::Guillain-Barre syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. However, GBS patients frequently display a psychosyndrome, indicating an accompanying involvement of the central nervous system (CNS), although the cause is not understood. Hepatic encephalopathy is possibly the best characterize...


    pub_type: 杂志文章


    authors: Görtzen A,Schlüter S,Veh RW

    更新日期:2004-09-01 00:00:00

  • New developments in the pathogenesis of systemic sclerosis.

    abstract::Systemic sclerosis (SSc) is characterized by extensive fibrosis, vasculopathy and activation of the immune system. Fibrosis can be caused by profibrotic cytokines, such as transforming growth factor-beta (TGFbeta), interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective tissue growth factor. Vascul...


    pub_type: 杂志文章,评审


    authors: Sakkas LI

    更新日期:2005-03-01 00:00:00

  • Effect of mycobacterial infection in the lupus-prone MRL/lpr mice: enhancement of life span of autoimmune mice, amelioration of kidney disease and transient decrease in host resistance.

    abstract::We have used the MRL/lpr murine model of spontaneous lupus to investigate three questions in infection immunity: (1) does mycobacterial infection have any effect on the mortality of the autoimmunity-prone lpr mice?; (2) does the infection modify the progression of kidney disease of lpr lupus?; and (3) does the lpr gen...


    pub_type: 杂志文章


    authors: Castro AP,Esaguy N,Aguas AP

    更新日期:1993-01-01 00:00:00

  • Ionic binding characteristics of monoclonal autoantibodies to DNA from NZB.H-2bm12 mice.

    abstract::NZB (H-2d) mice are well known for the production of IgM autoantibodies to ssDNA. However, an F1 cross between NZB and either NZW or SWR mice is required to produce IgG nephritogenic antibodies to dsDNA and glomerulonephritis. The contribution of parental class II loci in the hybrid mice is clearly important to the de...


    pub_type: 杂志文章


    authors: Cawley D,Chiang BL,Ansari A,Gershwin ME

    更新日期:1991-01-01 00:00:00

  • Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C.

    abstract::Numerous human Cytochrome P450 enzymes (CYPs) associated with 'phase I' drug metabolism have been identified. Among them, CYP2D6 is thought to be the major target autoantigen to anti-liver kidney microsome (LKM)-1 autoantibody, a characteristic feature of autoimmune hepatitis (AIH) type II. In this study, we were able...


    pub_type: 杂志文章


    authors: Miyakawa H,Kitazawa E,Kikuchi K,Fujikawa H,Kawaguchi N,Abe K,Matsushita M,Matsushima H,Igarashi T,Hankins RW,Kako M

    更新日期:2000-01-01 00:00:00

  • Flow cytometric analysis of the LE cell phenomenon.

    abstract::A flow cytometry-based phagocytosis assay was developed and utilized to measure the LE cell phenomenon at the single cell level in vitro. Since the lupus erythematosus (LE) cell phenomenon is a special form of necro-phagocytosis in the presence of anti-dsDNA antibodies, dead substrate cells or chicken erythrocytes nuc...


    pub_type: 杂志文章


    authors: Böhm I

    更新日期:2004-02-01 00:00:00

  • Bioinformatics for study of autoimmunity.

    abstract::Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological...


    pub_type: 杂志文章,评审


    authors: Petrovsky N,Brusic V

    更新日期:2006-12-01 00:00:00