Sera from lupus patients inhibit growth of P. falciparum in culture.


:A large number of malaria immune persons from Eastern India were found to possess antibodies to the ribosomal phosphoprotein P0 (PfP0) of the human malarial parasite Plasmodium falciparum. The characterization of PfP0 has been reported recently, and it has been shown that antibodies against PfP0 inhibit P. falciparum in vitro. About 10-15% of the patients suffering from the autoimmune disorder Systemic Lupus Erythematosus (SLE) possess autoantibodies to the human ribosomal P proteins. In order to test the cross-reactivity of the human and Plasmodium falciparum P0 proteins and to compare the SLE patients' and malaria immune persons' response, sera from 41 Indian SLE patients were tested against the P. falciparum PfP0 by Western blot analysis. Four of these samples (9.75%) were found to be cross-reactive to the carboxy-terminal domain of PfP0, but not to the amino-terminal domain of PfP0. The PfP0 reactive SLE sera inhibited the growth of Plasmodiumfalciparum in vitro. IgG purified from one such cross-reactive serum sample inhibited the growth of P. falciparum. Depletion of anti-P0 antibodies from this IgG preparation resulted in the removal of growth inhibition. Sera samples were collected from one of the PfP0 positive SLE patient from Mumbai, India, at different stages of the disease progression, and screened for the presence of anti-PfP0 antibodies. This patient's serum inhibited the parasite growth in vitro only during the phase in which anti-PfP0 antibodies were detected.






Singh S,Chatterjee S,Sohoni R,Badakere S,Sharma S




Has Abstract


2001-01-01 00:00:00












  • Assessment of common idiotype PR4-Id in serial bleeds from lupus patients.

    abstract::Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression w...


    pub_type: 杂志文章


    authors: Pilcher C,Williams W,Isenberg DA

    更新日期:1991-01-01 00:00:00

  • Organ-specific autoimmunity in granulocyte macrophage-colony stimulating factor (GM-CSF) deficient mice.

    abstract::Granulocyte macrophage-colony stimulating factor (GM-CSF) is a pleiotrophic proinflammatory cytokine that augments adaptive immunity by linking it to innate immunity. Experimental autoimmune gastritis is an animal model of human autoimmune gastritis and pernicious anaemia. We have previously shown that GM-CSF is expre...


    pub_type: 杂志文章


    authors: Alderuccio F,Biondo M,Toh BH

    更新日期:2002-02-01 00:00:00

  • Efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients.

    abstract:OBJECTIVE:To study efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. METHODS:The case records of 40 patients with lupus nephritis followed up in a single center between 1992 and 2011 (median duration = 8.37 years) were retrieved to determine efficacy and toxicity of the treat...


    pub_type: 杂志文章


    authors: Bozzolo EP,Ramirez GA,Bonavida G,Lanzani C,Scotti R,Dell'antonio G,Baldissera E,Canti V,Manfredi AA,Rovere-Querini P,Sabbadini MG

    更新日期:2013-12-01 00:00:00

  • Endocrine pancreas histology of congenic BB-rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X.

    abstract::Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...


    pub_type: 杂志文章


    authors: Lucke S,Klöting I,Pusch A,Heinrich HW,Hahn HJ

    更新日期:2003-05-01 00:00:00

  • Autoimmunity in vitiligo: relationship with HLA, Gm and Km polymorphisms.

    abstract::Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...


    pub_type: 杂志文章


    authors: Lorini R,Orecchia G,Martinetti M,Dugoujon JM,Cuccia M

    更新日期:1992-01-01 00:00:00

  • The effect of linomide, an immunoregulator in experimental autoimmune diseases, on humoral antibody responses in mice.

    abstract::Linomide (quinoline-3-carboxamide), a well tolerated, orally administered compound was recently shown to be effective in the prevention and treatment of several autoimmune diseases in experimental animal models. We have investigated its effect on specific humoral immune responses directed to T-cell-dependent soluble o...


    pub_type: 杂志文章


    authors: Morecki S,Nabet C,Falk P,Fridkis-Hareli M,Pecht I,Mond JJ,Slavin S

    更新日期:1997-01-01 00:00:00

  • Aβ anti-idiotypic antibodies are present in intravenous immunoglobulin and are produced in mice following its administration.

    abstract::The effects of intravenous immunoglobulin (IVIG) products were recently examined in patients with Alzheimer's disease (AD). Although encouraging results were obtained in pilot studies, later trials produced negative results. The rationale for these studies was that IVIG contains antibodies to amyloid-beta (Aβ). Howeve...


    pub_type: 杂志文章


    authors: Loeffler DA,Klaver AC,Coffey MP

    更新日期:2015-06-01 00:00:00

  • The dangerous liaison between iNKT cells and dendritic cells: does it prevent or promote autoimmune diseases?

    abstract::Invariant natural killer T (iNKT) cells represent an important regulatory T-cell subset that perceives signals of danger and/or cellular distress and modulate the adaptive immune response accordingly. In the presence of pathogens, iNKT cells acquire an adjuvant function that is fundamental to boost anti-microbial and ...


    pub_type: 杂志文章,评审


    authors: Caielli S,Sorini C,Falcone M

    更新日期:2011-02-01 00:00:00

  • Improvement of cardiac function after immunoadsorption in patients with dilated cardiomyopathy.

    abstract::Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and by ventricular dilatation. Abnormalities of the cellular and humoral immune system are present in patients with myocarditis and DCM. Various circulating cardiac autoantibodies have been d...


    pub_type: 杂志文章,评审


    authors: Felix SB,Staudt A,Friedrich GB

    更新日期:2001-01-01 00:00:00

  • Increase of class II HLA molecules on the membrane of B lymphocytes from patients with rheumatoid arthritis.

    abstract::Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...


    pub_type: 杂志文章


    authors: Eliaou JF,Andary M,Favier F,Carayon P,Poncelet P,Sany J,Brochier J,Clot J

    更新日期:1988-01-01 00:00:00

  • Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid.

    abstract::Decades of research have provided strong evidence for a reciprocal relationship between the immune system and hormones of the hypothalamus-pituitary-thyroid (HPT) axis. Thyroid stimulating hormone (TSH), in particular, has been shown to have a variety of immune-regulating cytokine-like activities that can influence th...


    pub_type: 杂志文章,评审


    authors: Klein JR

    更新日期:2003-09-01 00:00:00

  • Evidence for a retroviral trigger in Graves' disease.

    abstract::An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...


    pub_type: 杂志文章


    authors: Jaspan JB,Luo H,Ahmed B,Tenenbaum S,Voss T,Sander DM,Bollinger K,Baquet T,Garry RF

    更新日期:1995-01-01 00:00:00

  • Anti-ribonucleoprotein antibodies mediate enhanced lung injury following mesenteric ischemia/reperfusion in Rag-1(-/-) mice.

    abstract::Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...


    pub_type: 杂志文章


    authors: Keith MP,Moratz C,Egan R,Zacharia A,Greidinger EL,Hoffman RW,Tsokos GC

    更新日期:2007-05-01 00:00:00

  • Reduced in vitro production of interferon-gamma, interleukin-4 and interleukin-12 and increased production of interleukin-6, interleukin-10 and tumour necrosis factor-alpha in systemic lupus erythematosus. Weak correlations of cytokine production with dis

    abstract::Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...


    pub_type: 杂志文章


    authors: Jones BM,Liu T,Wong RW

    更新日期:1999-10-01 00:00:00

  • Targeting lymphocyte co-stimulation: from bench to bedside.

    abstract::T and B lymphocytes are central regulators and effectors of immune responses and are believed to have a key role in many autoimmune diseases. Targeting the activation or effector function of lymphocytes is a potentially effective approach to treat autoimmunity. Typically, T-cell activation occurs after engagement of t...


    pub_type: 杂志文章,评审


    authors: Felix NJ,Suri A,Salter-Cid L,Nadler SG,Gujrathi S,Corbo M,Aranda R

    更新日期:2010-11-01 00:00:00

  • CTLs' repertoire shaping in the thymus: a Monte Carlo simulation.

    abstract:MOTIVATION:The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to he...


    pub_type: 杂志文章


    authors: Castiglione F,Santoni D,Rapin N

    更新日期:2011-06-01 00:00:00

  • Monoclonal autoantibodies derived from multiple sclerosis patients and control persons and their reactivities with antigens of the central nervous system.

    abstract::Peripheral blood B lymphocytes of multiple sclerosis (MS) patients and control persons were transformed with Epstein-Barr virus. Antibody production of transformed cells against isolated human myelin was investigated by enzyme-linked immunosorbent assay (ELISA). Cells producing reactive antibodies were cloned and prop...


    pub_type: 杂志文章


    authors: Uhlig H,Dernick R

    更新日期:1989-01-01 00:00:00

  • Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway.

    abstract::Zinc transporter 8 (ZnT8), a product of the SLC30A8 gene, is a target-antigen in autoimmune diabetes. Associations between ZnT8 antibody (ZnT8A), phenotype and the genetic variant rs13266634 in the SLC30A8 gene have primarily been studied in patients with young-onset diabetes. We explored such associations in adult-on...


    pub_type: 杂志文章


    authors: Sørgjerd EP,Skorpen F,Kvaløy K,Midthjell K,Grill V

    更新日期:2013-02-01 00:00:00

  • The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): a meta-analysis.

    abstract:AIM:To assess the relationship of the Interleukin-10 (IL-10) -1082G/A (rs1800896), -819C/T (rs1800871) and -592C/A (rs1800872) polymorphism with inflammatory bowel disease (IBD) by means of meta-analysis. METHODS:Published data addressing the association between polymorphism of the IL-10 with Crohn's disease (CD) and ...


    pub_type: 杂志文章,meta分析


    authors: Zou L,Wang L,Gong X,Zhao H,Jiang A,Zheng S

    更新日期:2014-02-01 00:00:00

  • Bioinformatics for study of autoimmunity.

    abstract::Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological...


    pub_type: 杂志文章,评审


    authors: Petrovsky N,Brusic V

    更新日期:2006-12-01 00:00:00

  • Detection of antimitochondrial antibodies: characterization by enzyme immunoassay and immunoblotting.

    abstract::Mitochondrial antigens were purified from rat liver and characterized by immunoblotting. Sera from 19 well defined patients with primary biliary cirrhosis (PBC) reacted with two mitochondrial polypeptides of 68 Kd and 45 Kd. Antibodies to these antigens were not detected in any of the sera of patients with cirrhosis o...


    pub_type: 杂志文章


    authors: Zurgil N,Konikoff F,Bakimer R,Slor H,Shoenfeld Y

    更新日期:1989-01-01 00:00:00

  • Lack of effect of methimazole on thyrocyte cell-surface antigen expression.

    abstract::The nature of the immunosuppressive effect of antithyroid drugs has been a subject of controversy. It has been claimed that these agents exert a direct effect on the immune system, although we and others have suggested that the drugs affect the thyroid cells primarily with consequent reduced thyrocyte-immunocyte signa...


    pub_type: 杂志文章


    authors: Aguayo J,Michaud P,Iitaka M,Degroot LJ,Row VV,Volpé R

    更新日期:1989-01-01 00:00:00

  • HLA-DQA1 gene expression profiling in oligoarticular JIA.

    abstract::Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene e...


    pub_type: 杂志文章


    authors: Haas JP,Metzler M,Frank C,Haefner R,Wassmuth R

    更新日期:2009-05-01 00:00:00

  • Reactive animation: from piecemeal experimentation to reactive biological systems.

    abstract::Over the past decade, multi-level complex behavior and reactive nature of biological systems, has been a focus point for the biomedical community. We have developed a computational approach, termed Reactive Animation (RA) for simulating such complex biological systems. RA is an approach for describing the dynamic char...


    pub_type: 杂志文章,评审


    authors: Vainas O,Harel D,Cohen IR,Efroni S

    更新日期:2011-06-01 00:00:00

  • CTLA4Ig prevents initiation but not evolution of anti-phospholipid syndrome in NZW/BXSB mice.

    abstract::NZW "x" BXSB F1 mice develop SLE that is associated with an anti-phospholipid syndrome characterized by anti-cardiolipin antibodies, thrombocytopenia and small coronary artery thrombosis. This syndrome is immune mediated and, dependent, on CD4+T cells. To determine whether disease in these mice can be treated with blo...


    pub_type: 杂志文章


    authors: Akkerman A,Huang W,Wang X,Ramanujam M,Schiffer L,Madaio M,Factor SM,Davidson A

    更新日期:2004-09-01 00:00:00

  • Common immunogenetic profile in children with multiple autoimmune diseases: the signature of HLA-DQ pleiotropic genes.

    abstract::Type 1 diabetes mellitus (T1DM), celiac disease (CD) and autoimmune thyroid disease (ATD) are autoimmune conditions relatively common in paediatric age and frequently occur in association in the same subject. This event is not by chance and requires an explanation. Here, we studied the distribution of HLA-DQ αβ hetero...


    pub_type: 杂志文章


    authors: Larizza D,Calcaterra V,Klersy C,Badulli C,Caramagna C,Ricci A,Brambilla P,Salvaneschi L,Martinetti M

    更新日期:2012-09-01 00:00:00

  • Complement regulatory proteins and autoimmunity.

    abstract::The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for...


    pub_type: 杂志文章,评审


    authors: Song WC

    更新日期:2006-08-01 00:00:00

  • Serum CXCL10 levels and neuromuscular manifestations in patients with autoimmune thyroid diseases.

    abstract:OBJECTIVE:Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. DESIGN:A total of ...


    pub_type: 杂志文章


    authors: Cakir M,Levendoglu F,Kiyici A,Coskun Y

    更新日期:2011-09-01 00:00:00

  • Effect of passive transfer of human anti-myelin-associated glycoprotein IgM in marmoset.

    abstract::Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental anima...


    pub_type: 杂志文章


    authors: Dancea S,Dellagi K,Renaud F,Mahouy G,Hauw JJ,Brouet JC

    更新日期:1989-01-01 00:00:00

  • Serological proteome analysis reveals new specific biases in the IgM and IgG autoantibody repertoires in autoimmune polyendocrine syndrome type 1.

    abstract:OBJECTIVE:Autoimmune polyendocrine syndrome type 1 (APS 1) is caused by mutations in the AIRE gene that induce intrathymic T-cell tolerance breakdown, which results in tissue-specific autoimmune diseases. DESIGN:To evaluate the effect of a well-defined T-cell repertoire impairment on humoral self-reactive fingerprints...


    pub_type: 杂志文章


    authors: Dubucquoi S,Proust-Lemoine E,Kemp EH,Ryndak A,Lefèvre-Dutoit V,Bellart M,Saugier-Véber P,Duban-Deweer S,Wémeau JL,Prin L,Lefranc D

    更新日期:2015-01-01 00:00:00