Abstract:
BACKGROUND:T follicular helper (Tfh) cells are known to regulate humoral immune response. In this study we examined the correlation of different subsets of peripheral blood Tfh cells in patients with diabetic nephropathy (DN). METHODS:A total of 23 DN patients and 15 healthy controls (HC) were investigated for various subsets of Tfh cells by flow cytometry. The molecules ICOS+, PD-1+, CD28+, CD154+, IL-21+, IFN-γ+, IL-4+, IL-17+ Tfh cells were examined. The subsets of B cells were investigated by flow cytometry. The levels of 24 h urinary protein and estimated glomerular filtration rate (eGFR) were calculated. A potential correlation between the number of different subsets of Tfh cells, B cells and DN, was assessed. RESULTS:The circulating CD4+CXCR5+PD-1+, PD-1+CD154+, PD-1+CD28+, PD-1+IL-21+, PD-1+IL-4+, PD-1+-IL-17+-Tfh cell counts, CD38+CD19+, CD38+CD19+CD40+ B cells and plasma levels of IL-21 were significantly increased in DN patients (p < 0.05), as compared to that in the HC group. Furthermore, the circulating CD4+CXCR5+PD-1+ Tfh cell counts negatively correlated with eGFR; Tfh cell counts positively correlated with 24 h urinary protein concentration in DN patients. Post-treatment, there was a significant reduction in the CD4+CXCR5+PD-1+ Tfh cell counts and its subsets, with a corresponding decrease in plasma levels of IL-6 and IL-17A (p < 0.05) in DN patients, as compared to the HCs. CONCLUSION:An increased number of CD4+CXCR5+PD-1+ Tfh cells were observed in DN patients, which may be new targets for intervention in DN.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Zhang N,Tai J,Qu Z,Zhang Z,Zhao S,He J,Zhang S,Jiang Ydoi
10.1080/08916934.2016.1196677subject
Has Abstractpub_date
2016-09-01 00:00:00pages
405-413issue
6eissn
0891-6934issn
1607-842Xjournal_volume
49pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract::Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2012.719953
更新日期:2012-12-01 00:00:00
abstract::The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802282651
更新日期:2009-01-01 00:00:00
abstract::The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930600739647
更新日期:2006-08-01 00:00:00
abstract::Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV). Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA....
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802668594
更新日期:2009-03-01 00:00:00
abstract::Anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of autoantibody (AAb) to phospholipid (PL)-binding proteins, such as beta2-glycoprotein I (beta2GPI), and clinical manifestations including thrombosis and/or recurrent pregnancy loss. beta2GPI-reactive T cells are clearly implicat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902828254
更新日期:2009-05-01 00:00:00
abstract::CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930902827926
更新日期:2009-05-01 00:00:00
abstract::TGPO-aAb is a bispecific antibody which binds to thyroglobulin as well as thyroid peroxidase. It is supposed to be raised in some patients with autoimmune thyroid disease. We investigated 205 patients suffering from Graves' disease (n = 81), Hashimoto's thyroiditis (n = 36), toxic nodular goitre (n = 50), differentiat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908994744
更新日期:1999-01-01 00:00:00
abstract::We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993350
更新日期:1995-01-01 00:00:00
abstract::Linomide is a potent immunomodulator that has been shown to inhibit autoimmunity in several animal models of autoimmune disease, including experimental autoimmune encephalomyelitis (EAE). Linomide's mechanism of action is unknown, however, it has been suggested to modulate the function of antigen presenting cells (APC...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930008994093
更新日期:2000-10-01 00:00:00
abstract::During apo blebs, containing nuclear components, are formed at the cells' surfaces. When these blebs separate from the dying cell an apo cell body remains. The contents of apo blebs are modified and can be released, especially in patients with systemic lupus erythematosus (SLE) since impaired clearance of apo material...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902828049
更新日期:2009-05-01 00:00:00
abstract::Glucocorticoids (GCs) strongly impact on different T cell subsets inducing generally immunosuppressive effects, whereas much less is known about the effect of GC on natural killer (NK) cells. The aims of this study were to investigate the effects of GC on T cell functions, including T cell-mediated anti-tumor immune r...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2014.959164
更新日期:2015-03-01 00:00:00
abstract::Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701356846
更新日期:2007-06-01 00:00:00
abstract::A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600847598
更新日期:2006-09-01 00:00:00
abstract::In the present study, the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in kidney lymphoid cells of lupus-prone mice (MRL-lpr/lpr) is shown by Northern blot and nuclear run on transcription assay. By quantification analysis of hsp 70 gene transcription, more than ten times of the enhan...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939108997141
更新日期:1991-01-01 00:00:00
abstract::We report in this paper on obvious fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). B6 CD8+ splenocytes were transferred into (bm 12 x bm 1)F1 mice to induce GVHR. Recipient mice had been thymectomized and administrated with anti-CD8 monoclonal antibody (mAb) to deplete CD8...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995313
更新日期:1995-01-01 00:00:00
abstract::Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/0891693031000094683
更新日期:2003-05-01 00:00:00
abstract::Although a variety of eye muscle antigens are recognized by autoantibodies in the serum from patients with thyroid associated ophthalmopathy (TAO) 64 kDa membrane proteins, which are also expressed in the thyroid, are most closely linked to the development of ophthalmopathy in patients with autoimmune thyroid disease....
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939308993314
更新日期:1993-01-01 00:00:00
abstract::Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strept...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930500484674
更新日期:2006-02-01 00:00:00
abstract::Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/73-0891693021000005402
更新日期:2002-08-01 00:00:00
abstract::Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. It has been proposed that IL-1 induces a race between protective and deleterious proteins i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930008995982
更新日期:2000-01-01 00:00:00
abstract::This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-re...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109006744
更新日期:1991-01-01 00:00:00
abstract::The expression of major histocompatibility complex class II molecules (Ia antigen) has been analyzed by immunoperoxidase staining in thyroids of normal C3H mice, of iodine-deficient mice with a hyperplastic goiter and of mice during goiter involution induced by administration of either a high iodide dose (HID, 10 micr...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939009041050
更新日期:1990-01-01 00:00:00
abstract::The biological basis for autoimmunity and immunoincompetence in the BB rat has yet to be localized. In spite of normal thymic histology, thymocyte subsets and blastogenesis, thymus gland products (thymosins) have yet to be studied. In the present report, thymus gland function was studied by measuring thymosin alpha 1 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938809001924
更新日期:1988-01-01 00:00:00
abstract::Guillain-Barre syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. However, GBS patients frequently display a psychosyndrome, indicating an accompanying involvement of the central nervous system (CNS), although the cause is not understood. Hepatic encephalopathy is possibly the best characterize...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930412331279840
更新日期:2004-09-01 00:00:00
abstract::The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939108997111
更新日期:1991-01-01 00:00:00
abstract::Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice (H-2g7) and C57BL/6 mice (H-2b) by a ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939809003872
更新日期:1998-01-01 00:00:00
abstract::The functional and phenotypic characteristics of lymphocytes separated from myasthenic thymoma (Th-L) were compared with those of lymphocytes separated from non-thymomatous thymus associated with thymoma (NTh-L) of the same patients and NTh-L of myasthenia gravis (MG) patients without thymoma. We examined whether Th-L...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939808996286
更新日期:1998-01-01 00:00:00
abstract::The concordance rate of Graves' disease in pairs of identical twins of 30 to 60% points to the influence of environmental factors, and infections have often been incriminated in the pathogenesis. More than 15 years ago we demonstrated an increased frequency of antibodies to Yersinia enterocolitica (Y. ent.) serotype 3...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939009087588
更新日期:1990-01-01 00:00:00
abstract::The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=2...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930109014693
更新日期:2001-01-01 00:00:00
abstract::Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.757307
更新日期:2013-06-01 00:00:00