Abstract:
:Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/MpJ-lpr/lpr (MRL-Fas(lpr)) mice and the expression of 6 costimulatory molecules that play important roles in the immune response: CD80, CD86, OX40 ligand (OX40L), 4-1BB ligand (4-1BBL), glucocorticoid-induced TNF receptor-related protein ligand (GITRL), and B cell-activating factor of the tumor necrosis factor family (BAFF). Expression of the costimulatory molecules in the submandibular salivary glands of age-matched autoimmune MRL-Fas(lpr) mice and non-autoimmune MRL/MpJ-+/+(MRL/+) and C3H/HeJ-lpr/lpr (C3H-Fas(lpr)) mice was examined immunohistochemically and scored on a scale of 0 to 3. The severity of sialadenitis was evaluated histologically and scored on a scale of 0 to 3. We found that all of the costimulatory molecules were expressed in duct epithelial cells of salivary glands from MRL-Fas(lpr) mice, whereas immunoreactivity was absent or weak in the MRL/+ mice. The staining intensity for all 6 costimulatory molecules was significantly higher in the MRL-Fas(lpr) than in the MRL/+ mice. Partial correlation analysis was performed to assess the degree of association between costimulatory molecule staining scores and disease scores, which clearly revealed a significant correlation for only GITRL and 4-1BBL. These molecules showed negligible immunoreactivity in the submandibular glands of C3H-Fas(lpr) mice, suggesting that their expression was independent of the Fas(lpr) mutation. In conclusion, the expression of GITRL and 4-1BBL in salivary gland duct epithelial cells is associated with background genes in the MRL strain, but not with the Fas(lpr) mutation itself, and contributes significantly to the pathogenesis of autoimmune sialadenitis in MRL-Fas(lpr) mice. These results suggest that GITRL and 4-1BBL may be effective targets for the development of therapies for Sjögren's syndrome.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Saito K,Mori S,Date F,Ono Mdoi
10.3109/08916934.2012.757307subject
Has Abstractpub_date
2013-06-01 00:00:00pages
231-7issue
4eissn
0891-6934issn
1607-842Xjournal_volume
46pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract::Thyroid lymphocyte RNA from a Hashimoto patient exhibiting high titre serum IgG autoantibodies against thyroglobulin (Tg) has been used to construct a Fab library in phage lambda. Screening of this library with radioiodinated Tg has permitted the cloning of an anti-Tg antibody (MH52) with an affinity of 4.5 x 10(9) mo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209150320
更新日期:1992-01-01 00:00:00
abstract::Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600971836
更新日期:2006-11-01 00:00:00
abstract::Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV). Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA....
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802668594
更新日期:2009-03-01 00:00:00
abstract::Recent studies have demonstrated that the nephritogenicity of antibodies to dsDNA and nucleosomes confers to binding of glomerular membrane-associated nucleosomes, and not to cross-reacting glomerular antigens. There is no known parameter that determines antibody pathogenicity aside from specificity for dsDNA/nucleoso...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802375729
更新日期:2009-02-01 00:00:00
abstract::The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2013.768617
更新日期:2013-05-01 00:00:00
abstract::Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to develop when the mice are ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008993383
更新日期:1990-01-01 00:00:00
abstract::The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939108997111
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2020.1815194
更新日期:2020-11-01 00:00:00
abstract::Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701262986
更新日期:2007-05-01 00:00:00
abstract::Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916930903518107
更新日期:2010-08-01 00:00:00
abstract::CD4+ T cells play a crucial role in the development of lupus in MRL-lpr/lpr mice: incomplete deletion/silencing of self-reactive CD4+ T cells leads to T cell activation, which causes both polyclonal B cell activation and T cell infiltration of multiple organs. Furthermore, anti-CD4 antibody therapy ameliorates disease...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995346
更新日期:1996-01-01 00:00:00
abstract::Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes utilizing a novel recombinant PR3 (rPR3) produced to accommodate manipulations of the N-terminal domain. The rPR3 molecule contains an N-terminus six ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701680104
更新日期:2007-11-01 00:00:00
abstract::The T cell repertoire expressed by Tsk2 mice, a novel experimental model of systemic sclerosis, was examined to determine whether cells infiltrating the areas of involved skin exhibit a T cell receptor (TCR) bias. Reverse transcription-polymerase chain reactions (RT-PCR) were conducted using RNA extracted from lymph n...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939809008039
更新日期:1998-01-01 00:00:00
abstract::Anti-M2 of anti-mitochondrial antibody (AMA) is a serological marker of primary biliary cirrhosis (PBC). Anti-pyruvate dehydrogenase complex-E2 (anti-PDC-E2) is recognized as the most frequently occurring anti-M2, and a routine laboratory test for this antibody has already been established. However, it is also known t...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908994755
更新日期:1999-01-01 00:00:00
abstract::The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930600739647
更新日期:2006-08-01 00:00:00
abstract::During apo blebs, containing nuclear components, are formed at the cells' surfaces. When these blebs separate from the dying cell an apo cell body remains. The contents of apo blebs are modified and can be released, especially in patients with systemic lupus erythematosus (SLE) since impaired clearance of apo material...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902828049
更新日期:2009-05-01 00:00:00
abstract::GM2 ganglioside is a potential peripheral nerve antigen for neuropathy-associated autoantibodies. However little data are available on their pathogenic effects, if any. In this study we have screened both neuropathy-associated and control sera for anti-GM2 antibodies and subsequently used high titre sera for immunohis...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930008994083
更新日期:2000-09-01 00:00:00
abstract::Autoantibodies against the beta-cell M(r) 64,000 protein (p64), recently identified as an isoform of glutamic acid decarboxylase (GAD), are prevalent in patients with insulin-dependent diabetes mellitus (IDDM). Dog islets were found to represent an abundant source of native p64 allowing the study of antigen-antibody i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209004823
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:There have been few reports on the association of rheumatoid arthritis (RA) with anti-neutrophil cytoplasmic antigen (ANCA)-associated systemic vasculitides. METHODS:Here we present four cases of RA overlapping with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CS...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.677078
更新日期:2012-06-01 00:00:00
abstract::The presence of autoantibodies (aAbs) to thyroglobulin (TG) and thyroperoxidase (TPO) in most of the patients with autoimmune thyroid disease is now well documented. Studies of these aAbs suggested that some, termed TGPO aAbs, could interact with both TG and TPO. This hypothesis was investigated using IgG fraction fro...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209035153
更新日期:1992-01-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM), celiac disease (CD) and autoimmune thyroid disease (ATD) are autoimmune conditions relatively common in paediatric age and frequently occur in association in the same subject. This event is not by chance and requires an explanation. Here, we studied the distribution of HLA-DQ αβ hetero...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.697594
更新日期:2012-09-01 00:00:00
abstract:MOTIVATION:The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to he...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.523272
更新日期:2011-06-01 00:00:00
abstract::Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2019.1575820
更新日期:2019-02-01 00:00:00
abstract::TGF-beta1 is a pleiotropic cytokine, which prevents inappropriate autoimmune responses and balances the requirements of proper immune cell levels during pathologic states that trigger the immune response. We assessed the serum levels of TGF-beta1 and determined the relationship between TGF-beta1 and clinical parameter...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902831977
更新日期:2009-05-01 00:00:00
abstract::We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly. This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/l) mice in relation to age, disease manifestations and the expression of lymphocyte homing ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909043609
更新日期:1989-01-01 00:00:00
abstract::Elevated constitutive expression of major histocompatibility (MHC) class II antigens occurs in the enterocytes of patients with IBD. It has been suggested that this aberrant expression of class II molecules may play a role in the pathogenesis of IBD. We examined two possible reasons for such a finding. 1) Heightened s...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109006750
更新日期:1991-01-01 00:00:00
abstract::A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608994714
更新日期:1996-01-01 00:00:00
abstract::Numerous human Cytochrome P450 enzymes (CYPs) associated with 'phase I' drug metabolism have been identified. Among them, CYP2D6 is thought to be the major target autoantigen to anti-liver kidney microsome (LKM)-1 autoantibody, a characteristic feature of autoimmune hepatitis (AIH) type II. In this study, we were able...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930108994106
更新日期:2000-01-01 00:00:00
abstract::The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients,...
journal_title:Autoimmunity
pub_type: 杂志文章,meta分析
doi:10.1080/08916934.2016.1261833
更新日期:2017-05-01 00:00:00
abstract::Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930290016655
更新日期:2002-03-01 00:00:00