Abstract:
:The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins including ionized Ca(2+)-binding adaptor 1, microglia response factor-1, and daintain are identical with AIF-1. The expression of AIF-1 was mostly limited to the monocyte/macrophage lineage, and augmented by cytokines such as IFN-gamma. It was assumed that AIF-1 was a novel molecule involved in inflammatory responses, allograft rejection, as well as the activation and function of macrophages. However, it has been reported that AIF-1 is also expressed in macrophages and microglial cells in autoimmune diseases such as experimental autoimmune encephalomyelitis, neuritis and uveitis models, suggesting that AIF-1 may play a pivotal role in autoimmunity. In the present manuscript, the genomic and functional characteristics of AIF-1 family proteins as well as their immune regulatory effects are reviewed.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Liu G,Ma H,Jiang L,Zhao Ydoi
10.1080/08916930601083946subject
Has Abstractpub_date
2007-03-01 00:00:00pages
95-102issue
2eissn
0891-6934issn
1607-842Xpii
773217399journal_volume
40pub_type
杂志文章,评审相关文献
AUTOIMMUNITY文献大全abstract::It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409009538
更新日期:1994-01-01 00:00:00
abstract::Evidence is growing that autoimmune reactivity results from a combination of endogenous (e.g. MHC type) and environmental factors. Our experimental study focuses on the induction of autoimmune reactivity by microbial factors. Splenic formation and serum levels of anti-erythrocyte antibodies and circulating immune comp...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309004838
更新日期:1993-01-01 00:00:00
abstract::Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2012.719953
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to characterise the functionally relevant minor lymphocyte subpopulations in whole blood of multiple sclerosis (MS) patients and their potential utility as biomarkers for treatment follow up. MATERIAL AND METHODS:Peripheral blood from 40 healthy donors (HD) and 66 MS patients [...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2016.1138271
更新日期:2016-06-01 00:00:00
abstract::Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/73-0891693021000005402
更新日期:2002-08-01 00:00:00
abstract::A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608994714
更新日期:1996-01-01 00:00:00
abstract::Anti-M2 of anti-mitochondrial antibody (AMA) is a serological marker of primary biliary cirrhosis (PBC). Anti-pyruvate dehydrogenase complex-E2 (anti-PDC-E2) is recognized as the most frequently occurring anti-M2, and a routine laboratory test for this antibody has already been established. However, it is also known t...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908994755
更新日期:1999-01-01 00:00:00
abstract::An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939509001938
更新日期:1995-01-01 00:00:00
abstract::The biological basis for autoimmunity and immunoincompetence in the BB rat has yet to be localized. In spite of normal thymic histology, thymocyte subsets and blastogenesis, thymus gland products (thymosins) have yet to be studied. In the present report, thymus gland function was studied by measuring thymosin alpha 1 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938809001924
更新日期:1988-01-01 00:00:00
abstract::Epidermolysis bullosa acquisita (EBA) is a rare and acquired autoimmune subepidermal bullous disease of skin and mucosa. EBA includes various distinct clinical manifestations resembling genetic dystrophic epidermolysis bullosa (DEB), Bullous pemphigus, Brunsting-Perry pemphigoid, or cicatricial pemphigoid. These patie...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2011.606450
更新日期:2012-02-01 00:00:00
abstract::Subcutaneous insulin treatment of young diabetes prone BB rats has been shown previously to suppress the development of autoimmune diabetes. In this study the hypothesis was tested that exogenous insulin may deviate the autoimmune process by acting on the Th1/Th2 cytokine balance in the pancreas. BB rats were implante...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939709009544
更新日期:1997-01-01 00:00:00
abstract::In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...
journal_title:Autoimmunity
pub_type:
doi:10.3109/08916934.2010.523239
更新日期:2011-06-01 00:00:00
abstract::Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental anima...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909043611
更新日期:1989-01-01 00:00:00
abstract::Non obese diabetic (NOD) mice spontaneously develop thyroiditis in addition to diabetes. Mononuclear cells begin to infiltrate the thyroid of these animals in the first month of life. The expression of major histocompatibility complex (MHC) class II (Ia) antigens by cells in the thyroid from NOD mice of various ages w...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409014653
更新日期:1994-01-01 00:00:00
abstract::CD4+ T cells play a crucial role in the development of lupus in MRL-lpr/lpr mice: incomplete deletion/silencing of self-reactive CD4+ T cells leads to T cell activation, which causes both polyclonal B cell activation and T cell infiltration of multiple organs. Furthermore, anti-CD4 antibody therapy ameliorates disease...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995346
更新日期:1996-01-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is the result of the autoimmune response against pancreatic insulin producing beta cells. This autoimmune response begins months or even years before the first presentation of signs and symptoms of hyperglycemia and at the time of clinical diagnosis near 30% of beta-cell mass still rema...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802200208
更新日期:2008-12-01 00:00:00
abstract::Human Toll-like receptors (TLRs) are crucial for the recognition of invading pathogens and for the activation of both innate and adaptive immunity. Upon stimulation, TLRs recruit various protein kinases via several adaptor molecules, such as MyD88, leading to the activation of NFkB. The identification of TLR signaling...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930410001704944
更新日期:2004-05-01 00:00:00
abstract::NZW "x" BXSB F1 mice develop SLE that is associated with an anti-phospholipid syndrome characterized by anti-cardiolipin antibodies, thrombocytopenia and small coronary artery thrombosis. This syndrome is immune mediated and, dependent, on CD4+T cells. To determine whether disease in these mice can be treated with blo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930400008524
更新日期:2004-09-01 00:00:00
abstract::Insulin-dependent diabetes mellitus (IDDM) is preceded by the presence of antibodies against islet proteins including a protein tyrosine phosphatase (PTP) designated IA-2. Recently, we cloned a novel PTP named IAR which shares 43% sequence identity with IA-2 and is recognised by antibodies from a majority of patients ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939808993841
更新日期:1998-01-01 00:00:00
abstract::The concordance rate of Graves' disease in pairs of identical twins of 30 to 60% points to the influence of environmental factors, and infections have often been incriminated in the pathogenesis. More than 15 years ago we demonstrated an increased frequency of antibodies to Yersinia enterocolitica (Y. ent.) serotype 3...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939009087588
更新日期:1990-01-01 00:00:00
abstract::Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2019.1575820
更新日期:2019-02-01 00:00:00
abstract::Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008993369
更新日期:1990-01-01 00:00:00
abstract::The nature of the immunosuppressive effect of antithyroid drugs has been a subject of controversy. It has been claimed that these agents exert a direct effect on the immune system, although we and others have suggested that the drugs affect the thyroid cells primarily with consequent reduced thyrocyte-immunocyte signa...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909019950
更新日期:1989-01-01 00:00:00
abstract::Food intake may be one of several factors which influence the risk of development of insulin dependent diabetes mellitus, but the influence of the pattern of food supply has not been studied previously. The aim of the present study was to investigate the effect of intermittent feeding and fasting upon diabetes in BB r...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908993805
更新日期:1999-01-01 00:00:00
abstract::Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209035163
更新日期:1992-01-01 00:00:00
abstract::The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrate...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002529
更新日期:2009-11-01 00:00:00
abstract::Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2014.938320
更新日期:2014-12-01 00:00:00
abstract::Decades of research have provided strong evidence for a reciprocal relationship between the immune system and hormones of the hypothalamus-pituitary-thyroid (HPT) axis. Thyroid stimulating hormone (TSH), in particular, has been shown to have a variety of immune-regulating cytokine-like activities that can influence th...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930310001603019
更新日期:2003-09-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and by ventricular dilatation. Abnormalities of the cellular and humoral immune system are present in patients with myocarditis and DCM. Various circulating cardiac autoantibodies have been d...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916930109007387
更新日期:2001-01-01 00:00:00
abstract::During apo blebs, containing nuclear components, are formed at the cells' surfaces. When these blebs separate from the dying cell an apo cell body remains. The contents of apo blebs are modified and can be released, especially in patients with systemic lupus erythematosus (SLE) since impaired clearance of apo material...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902828049
更新日期:2009-05-01 00:00:00