Abstract:
:Epidermolysis bullosa acquisita (EBA) is a rare and acquired autoimmune subepidermal bullous disease of skin and mucosa. EBA includes various distinct clinical manifestations resembling genetic dystrophic epidermolysis bullosa (DEB), Bullous pemphigus, Brunsting-Perry pemphigoid, or cicatricial pemphigoid. These patients have autoantibodies against type VII collagen (C7), an integral component of anchoring fibrils (AFs), which are responsible for attaching the dermis to the epidermis. Destruction or perturbation of the normal functioning AFs clinically results in skin fragility, blisters, erosions, scars, milia, and nail loss, all features reminiscent of genetic dystrophic epidermolysis bullosa. These anti-C7 antibodies are "pathogenic" because when injected into a mouse, the mouse develops an EBA-like blistering disease. Currently, treatment is often unsatisfactory; however, some success has been achieved with colchicine, dapsone, photopheresis, plasmapheresis, infliximab, rituximab, and IVIG.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Chen M,Kim GH,Prakash L,Woodley DTdoi
10.3109/08916934.2011.606450subject
Has Abstractpub_date
2012-02-01 00:00:00pages
91-101issue
1eissn
0891-6934issn
1607-842Xjournal_volume
45pub_type
杂志文章,评审相关文献
AUTOIMMUNITY文献大全abstract::Evidence is growing that autoimmune reactivity results from a combination of endogenous (e.g. MHC type) and environmental factors. Our experimental study focuses on the induction of autoimmune reactivity by microbial factors. Splenic formation and serum levels of anti-erythrocyte antibodies and circulating immune comp...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309004838
更新日期:1993-01-01 00:00:00
abstract::Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strept...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930500484674
更新日期:2006-02-01 00:00:00
abstract::Interleukin-1beta (IL-1beta) has been implicated to play an important role in the autoimmune beta cell lesion of insulin-dependent diabetes mellitus (IDDM) because of its inhibition of insulin secretion, direct islet cytotoxicity and alteration of islet cell antigen expression. We have previously demonstrated that IL-...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908995378
更新日期:1999-01-01 00:00:00
abstract::The present study uses the agent-based model IMMSIM to simulate immune responses to a viral infection, with a focus on the impact of preformed memory (homologous and heterologous) on the quality and the efficacy of the response. The in machina results confirm the observed thwarting of new, naïve responses exerted by c...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.523275
更新日期:2011-06-01 00:00:00
abstract::A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908998535
更新日期:1999-01-01 00:00:00
abstract::Programmed cell death 1 (PD-1) was isolated in 1992 by subtractive-hybridization technique, as a molecule whose expression is enhanced by apoptotic stimuli. Since then we have been analyzing the function of PD-1 in the regulation of immune responses. Generation of PD-1 deficient mice, pathophysiological analyses of au...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930500124072
更新日期:2005-08-01 00:00:00
abstract::The concordance rate of Graves' disease in pairs of identical twins of 30 to 60% points to the influence of environmental factors, and infections have often been incriminated in the pathogenesis. More than 15 years ago we demonstrated an increased frequency of antibodies to Yersinia enterocolitica (Y. ent.) serotype 3...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939009087588
更新日期:1990-01-01 00:00:00
abstract::The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencie...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701510673
更新日期:2007-12-01 00:00:00
abstract::Thyroid lymphocyte RNA from a Hashimoto patient with high serum levels of autoantibodies to thyroid peroxidase (TPO) was used to construct a phage display antibody library in the phagemid vector pComb3. The library (100,000cfu) encoded IgG1 heavy chains together with kappa light chains. Selection of the phages display...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409010651
更新日期:1994-01-01 00:00:00
abstract::Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701262986
更新日期:2007-05-01 00:00:00
abstract::Numerous groups have now validated high-throughput approaches to autoantibody profiling in a variety of systems. Recently, we have used autoantigen microarray technology to identify distinct autoantibody profiles in H-2 congenic MRL/lpr mice (Sekine et al., manuscript in preparation), and we are expanding this platfor...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930410001710686
更新日期:2004-06-01 00:00:00
abstract::Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. It has been proposed that IL-1 induces a race between protective and deleterious proteins i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930008995982
更新日期:2000-01-01 00:00:00
abstract::HLA-DP+ T cells in peripheral blood from 23 patients with systemic lupus erythematosus (SLE) were examined using two-colour flow cytometry analysis. A marked increase of HLA-DP+ T cells was observed in patients with SLE (20.5-98.7%; 59.8 +/- 20.8%) in comparison to normal subjects (1.3-20.6%; 11.1 +/- 7.2%), and the r...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939009002976
更新日期:1990-01-01 00:00:00
abstract::Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV). Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA....
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802668594
更新日期:2009-03-01 00:00:00
abstract::To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and meas...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2017.1385777
更新日期:2017-12-01 00:00:00
abstract::The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209112339
更新日期:1992-01-01 00:00:00
abstract::The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrate...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002529
更新日期:2009-11-01 00:00:00
abstract::To explore the natural course of beta cell function in recent onset diabetes, a subgroup (n=157) of all incident cases (n=879) 15-34 years old, 1992-1993 in Sweden, and with positivity for at least one autoantibody of islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930108995996
更新日期:2001-01-01 00:00:00
abstract::We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309079229
更新日期:1993-01-01 00:00:00
abstract::Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes utilizing a novel recombinant PR3 (rPR3) produced to accommodate manipulations of the N-terminal domain. The rPR3 molecule contains an N-terminus six ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701680104
更新日期:2007-11-01 00:00:00
abstract::Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene e...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902832652
更新日期:2009-05-01 00:00:00
abstract::Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/73-0891693021000005402
更新日期:2002-08-01 00:00:00
abstract::The possible immunosuppressive action of antithyroid drugs in vivo has been assessed using Buffalo (Buf) strain rats with thyroiditis produced by neonatal thymectomy; this model shares many features with spontaneous thyroiditis in man. Both propylthiouracil and methimazole significantly reduced the severity of thyroid...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938808997176
更新日期:1988-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002479
更新日期:2009-11-01 00:00:00
abstract::Various amounts of the bacterium, Brucella abortus (BA) were injected intravenously into autoimmune NZB/W F1 mice and non-autoimmune BDF1 mice and then the localization of BA in the thymus was traced using an immunohistochemical method at 30 min and 3 h after injection. The results showed that a greater amount of BA b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109004813
更新日期:1991-01-01 00:00:00
abstract:MOTIVATION:The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to he...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.523272
更新日期:2011-06-01 00:00:00
abstract::Murine monoclonal antibodies (mAb) produced against native human thyroid peroxidase (TPO) are powerful tools for analyzing the autoantibody (Aab) epitopes on TPO. Binding sites of thirteen mAbs cover all or most antigenic regions on TPO. We determined the competition between Aabs from 75 AITD patients and 13 mAbs in b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995338
更新日期:1996-01-01 00:00:00
abstract::Linomide is a potent immunomodulator that has been shown to inhibit autoimmunity in several animal models of autoimmune disease, including experimental autoimmune encephalomyelitis (EAE). Linomide's mechanism of action is unknown, however, it has been suggested to modulate the function of antigen presenting cells (APC...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930008994093
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVES:Autoimmune sensorineural hearing loss (ASNHL) is a relatively rare disorder which can lead to total deafness. At present, no specific laboratory test with adequate sensitivity and specificity is available to confirm the clinical suspicion of ASNHL. The aim of this study was to identify if evaluation of anti-...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930601119377
更新日期:2007-02-01 00:00:00
abstract::Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995297
更新日期:1995-01-01 00:00:00