Follow-up of avidity and titer of anti-myeloperoxidase antibodies in sera from patients with primary ANCA-associated vasculitis.

abstract：:Integrin-adressin binding is a critical step in lymphocte attachment to target tissues. The mucosal recognition systems (alpha E beta 7, alpha 4 beta 7, MADcam-1) have been implicated in the autoimmune process in rheumatoid arthritis. We developed a model for in vivo study of radio-labelled lymphocyte circulation and ...

journal_title：Autoimmunity

authors： Jorgensen C,Couret I,Canovas F,Bologna C,Brochier J,Reme T,Sany J

更新日期：1996-01-01 00:00:00

abstract：:The effects of intravenous immunoglobulin (IVIG) products were recently examined in patients with Alzheimer's disease (AD). Although encouraging results were obtained in pilot studies, later trials produced negative results. The rationale for these studies was that IVIG contains antibodies to amyloid-beta (Aβ). Howeve...

journal_title：Autoimmunity

authors： Loeffler DA,Klaver AC,Coffey MP

更新日期：2015-06-01 00:00:00

abstract：:The thymic medulla is a complex microenvironment which plays a crucial role in central tolerance induction. Using a quantitative histological analysis of non-obese diabetic (NOD) mice, we show that the medulla undergoes several structural modifications during the course of the disease in NOD mice. Indeed, the majority...

journal_title：Autoimmunity

authors： Atlan-Gepner C,Naspetti M,Valéro R,Barad M,Lepault F,Vialettes B,Naquet P

更新日期：1999-01-01 00:00:00

abstract：:Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause t...

journal_title：Autoimmunity

authors： Mauney CH,Hollis T

更新日期：2018-05-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic beta cell destruction involving auto-reactive T-cells, pro-inflammatory cytokines, reactive oxygen species (ROS) and loss of insulin. Monozygotic twin studies show a 20-60% concordance with T1D indicating there may be an environmental component...

journal_title：Autoimmunity

authors： Bekris LM,Shephard C,Peterson M,Hoehna J,Van Yserloo B,Rutledge E,Farin F,Kavanagh TJ,Lernmark A

更新日期：2005-12-01 00:00:00

abstract：:A large number of malaria immune persons from Eastern India were found to possess antibodies to the ribosomal phosphoprotein P0 (PfP0) of the human malarial parasite Plasmodium falciparum. The characterization of PfP0 has been reported recently, and it has been shown that antibodies against PfP0 inhibit P. falciparum ...

journal_title：Autoimmunity

authors： Singh S,Chatterjee S,Sohoni R,Badakere S,Sharma S

更新日期：2001-01-01 00:00:00

abstract：:Food intake may be one of several factors which influence the risk of development of insulin dependent diabetes mellitus, but the influence of the pattern of food supply has not been studied previously. The aim of the present study was to investigate the effect of intermittent feeding and fasting upon diabetes in BB r...

journal_title：Autoimmunity

authors： Pedersen CR,Hagemann I,Bock T,Buschard K

更新日期：1999-01-01 00:00:00

abstract：:The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...

journal_title：Autoimmunity

authors： Banica L,Besliu A,Pistol G,Stavaru C,Ionescu R,Forsea AM,Tanaseanu C,Dumitrache S,Otelea D,Tamsulea I,Tanaseanu S,Chitonu C,Paraschiv S,Balteanu M,Stefanescu M,Matache C

更新日期：2009-01-01 00:00:00

abstract：:Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological...

journal_title：Autoimmunity

authors： Petrovsky N,Brusic V

更新日期：2006-12-01 00:00:00

abstract：:Systemic sclerosis (SSc) is characterized by extensive fibrosis, vasculopathy and activation of the immune system. Fibrosis can be caused by profibrotic cytokines, such as transforming growth factor-beta (TGFbeta), interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective tissue growth factor. Vascul...

journal_title：Autoimmunity

authors： Sakkas LI

更新日期：2005-03-01 00:00:00

abstract：:We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly. This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/l) mice in relation to age, disease manifestations and the expression of lymphocyte homing ...

journal_title：Autoimmunity

authors： Schrieber L,Manolios N,Cohen MG,Paull SA,Guiffre AK,Hopper KE

更新日期：1989-01-01 00:00:00

abstract：:Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...

journal_title：Autoimmunity

authors： Lucke S,Klöting I,Pusch A,Heinrich HW,Hahn HJ

更新日期：2003-05-01 00:00:00

abstract：:The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...

journal_title：Autoimmunity

authors： Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

更新日期：2015-01-01 00:00:00

abstract：:In order to know whether effector cells are capable of recognizing the epidermal targets in pemphigus vulgaris (PV) and bullous pemphigoid (BP), non-adherent cells (NAC) of peripheral blood from 27 primary PV, 19 BP patients and 12 healthy volunteers were used in cytotoxic tests. Autologous, allogenic and murine epide...

journal_title：Autoimmunity

authors： Grando SA,Glukhenky BT,Drannik GN,Kostromin AP,Boiko YYa,Senyuk OF

更新日期：1989-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...

journal_title：Autoimmunity

authors： Kaplan MJ

更新日期：2009-11-01 00:00:00

abstract：:Congenital heart block (CHB), a life-threatening manifestation of neonatal lupus, offers aunique opportunity to study the effect or arm of immunity and define the pathogenicity of an autoantibody in mediating tissue injury. This review focuses on our recent in vitro model which supports a cascade from antibody insult ...

journal_title：Autoimmunity

authors： Buyon JP,Clancy RM

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:Autoantibodies to tumor-associated antigens including survivin have been detected in sera from patients with hepatocellular carcinoma (HCC). However, little is known about autoantibody responses to tumor-associated antigens in patients with chronic hepatitis, which strongly predisposes to development of HCC....

journal_title：Autoimmunity

authors： Yagihashi A,Asanuma K,Kobayashi D,Tsuji N,Torigoe T,Sato N,Watanabe N

更新日期：2005-09-01 00:00:00

abstract：:It is generally accepted that thyroid-associated ophthalmopathy (TAO) is an autoimmune disease of the eye muscle (EM) and the surrounding orbital connective tissue in which circulating antibodies play an important role. Antibodies against EM membrane proteins of 63-67kDa mol. wt. seem to be the best markers of ophthal...

journal_title：Autoimmunity

authors： Gunji K,Kubota S,Stolarski C,Wengrowicz S,Kennerdell JS,Wall JR

更新日期：1999-01-01 00:00:00

abstract：:Epitopes for > 95% stimulating thyrotropin receptor autoantibodies (TSHRAbs) causally implicated in Graves' disease (Basedow's disease or primary hyperthyroidism) have been identified on on the N-terminal portion of the TSHR extracellular domain, residues 8-165. If the stimulating TSHRAb activity is solely dependent o...

journal_title：Autoimmunity

authors： Kohn LD,Harii N

更新日期：2003-09-01 00:00:00

abstract：:Experimental myasthenia gravis (EMG) was elicited in female AO rats, 8-12 weeks of age, by injection of 100 micrograms/rat Torpedo marmorata acetylcholine receptor (AChR)-protein incorporated in CFA. Bordetella pertussis, 24 x 10(9) microorganisms, rat, was injected simultaneously as additional adjuvant. Rats were sac...

journal_title：Autoimmunity

authors： Damjanović M,Vidić-Danković B,Kosec D,Isaković K

更新日期：1993-01-01 00:00:00

abstract：:The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...

journal_title：Autoimmunity

authors： Alkhateeb A,Jarun Y,Tashtoush R

更新日期：2013-05-01 00:00:00

abstract：:It has been shown in animal toxicity models that administration of Cyclosporine, CsA, to a pregnant mouse greatly increases the risk that the offspring will develop autoimmunity. Immunization starting at birth has been shown to prevent autoimmunity in other animal models of autoimmunity and early immunization is assoc...

journal_title：Autoimmunity

authors： Classen JB

更新日期：1998-01-01 00:00:00

abstract：:Macrophages from autoimmune diabetes prone BB rats were found to produce radical oxygen intermediates (ROI) at an enhanced rate when compared to diabetes resistant BB or normal Wistar rats. The release of ROI was determined by chemiluminescence using in parallel luminol and lucigenin as detector molecules. In diabetes...

journal_title：Autoimmunity

authors： Brenner HH,Burkart V,Rothe H,Kolb H

更新日期：1993-01-01 00:00:00

abstract：:The expression of major histocompatibility complex class II molecules (Ia antigen) has been analyzed by immunoperoxidase staining in thyroids of normal C3H mice, of iodine-deficient mice with a hyperplastic goiter and of mice during goiter involution induced by administration of either a high iodide dose (HID, 10 micr...

journal_title：Autoimmunity

authors： Toussaint-Demylle D,Many MC,Theisen H,Kraal G,Denef JF

更新日期：1990-01-01 00:00:00

abstract：:Linomide is a potent immunomodulator that has been shown to inhibit autoimmunity in several animal models of autoimmune disease, including experimental autoimmune encephalomyelitis (EAE). Linomide's mechanism of action is unknown, however, it has been suggested to modulate the function of antigen presenting cells (APC...

journal_title：Autoimmunity

authors： Dahlén E,Andersson M,Dawe K,Tellander AC,Brunmark C,Björk A,Hedlund G

更新日期：2000-10-01 00:00:00

abstract：:Epidermolysis bullosa acquisita (EBA) is a rare and acquired autoimmune subepidermal bullous disease of skin and mucosa. EBA includes various distinct clinical manifestations resembling genetic dystrophic epidermolysis bullosa (DEB), Bullous pemphigus, Brunsting-Perry pemphigoid, or cicatricial pemphigoid. These patie...

journal_title：Autoimmunity

authors： Chen M,Kim GH,Prakash L,Woodley DT

更新日期：2012-02-01 00:00:00

abstract：:Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to develop when the mice are ...

journal_title：Autoimmunity

authors： Okada T,Abe M,Takiura F,Hirose S,Shirai T

更新日期：1990-01-01 00:00:00

abstract：:Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental anima...

journal_title：Autoimmunity

authors： Dancea S,Dellagi K,Renaud F,Mahouy G,Hauw JJ,Brouet JC

更新日期：1989-01-01 00:00:00

abstract：:The objective of this study was to identify new autoantibodies that could be useful for the diagnosis of rheumatoid arthritis (RA) using immunoblotting on synovial membrane proteins which represent the best source of candidate RA autoantigens. A new target protein with a molecular weight of 26 kDa was found to be reco...

journal_title：Autoimmunity

authors： Robert-Pachot M,Desbos A,Moreira A,Becchi M,Tebib J,Bonnin M,Aitsiselmi T,Bienvenu J,Fabien N

更新日期：2007-07-01 00:00:00

abstract：:In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...

journal_title：Autoimmunity

authors： Boissier MC,Texier B,Carlioz A,Fournier C

更新日期：1989-01-01 00:00:00