Abstract:
:Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with streptococcal M protein and cardiac myosin. Recent studies have unraveled the potential pathogenic mechanisms by which the immune response against the group A streptococcus attacks the rheumatic valve leading to chronic rheumatic heart disease. Both B- and T-cell responses are involved in the process, and evidence for the hypotheses of molecular mimicry and epitope spreading are reviewed.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Guilherme L,Kalil J,Cunningham Mdoi
10.1080/08916930500484674subject
Has Abstractpub_date
2006-02-01 00:00:00pages
31-9issue
1eissn
0891-6934issn
1607-842Xpii
W377202483271757journal_volume
39pub_type
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