Abstract:
:Macrophages from autoimmune diabetes prone BB rats were found to produce radical oxygen intermediates (ROI) at an enhanced rate when compared to diabetes resistant BB or normal Wistar rats. The release of ROI was determined by chemiluminescence using in parallel luminol and lucigenin as detector molecules. In diabetes prone BB rats the spontaneous release of ROI was upregulated in macrophages from different compartments, i.e. peritoneum and spleen. Also, maximal output of ROI after activation of macrophages either in vivo by injection of Corynebacterium parvum or in vitro by LPS and IFN was highest for cells from diabetes prone BB rats. This macrophage abnormality was seen in animals prior to recognizable islet inflammation and also was present at the level of macrophages grown in vitro from precursor cells of diabetes prone BB rats. Hypersecretion of oxygen radicals may contribute to Beta cell loss and diabetes development in BB rats.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Brenner HH,Burkart V,Rothe H,Kolb Hdoi
10.3109/08916939309043883subject
Has Abstractpub_date
1993-01-01 00:00:00pages
93-8issue
2eissn
0891-6934issn
1607-842Xjournal_volume
15pub_type
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