Oxygen radical production is increased in macrophages from diabetes prone BB rats.

Abstract:

:Macrophages from autoimmune diabetes prone BB rats were found to produce radical oxygen intermediates (ROI) at an enhanced rate when compared to diabetes resistant BB or normal Wistar rats. The release of ROI was determined by chemiluminescence using in parallel luminol and lucigenin as detector molecules. In diabetes prone BB rats the spontaneous release of ROI was upregulated in macrophages from different compartments, i.e. peritoneum and spleen. Also, maximal output of ROI after activation of macrophages either in vivo by injection of Corynebacterium parvum or in vitro by LPS and IFN was highest for cells from diabetes prone BB rats. This macrophage abnormality was seen in animals prior to recognizable islet inflammation and also was present at the level of macrophages grown in vitro from precursor cells of diabetes prone BB rats. Hypersecretion of oxygen radicals may contribute to Beta cell loss and diabetes development in BB rats.

journal_name

Autoimmunity

journal_title

Autoimmunity

authors

Brenner HH,Burkart V,Rothe H,Kolb H

doi

10.3109/08916939309043883

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

93-8

issue

2

eissn

0891-6934

issn

1607-842X

journal_volume

15

pub_type

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