Reduced in vitro production of interferon-gamma, interleukin-4 and interleukin-12 and increased production of interleukin-6, interleukin-10 and tumour necrosis factor-alpha in systemic lupus erythematosus. Weak correlations of cytokine production with dis

Abstract:

:Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in patients with SLE. Regression analysis revealed that production of all six cytokines tended to decrease with increasing disease activity, but negative correlation with SLEDAI was significant (p < 0.05) only for PHA-stimulated IL4, unstimulated and PHA-stimulated IL10 and SAC-stimulated IL6. Negative correlation of stimulated and unstimulated IL6 and TNF alpha production with anti-DNA antibody levels were also significant.

journal_name

Autoimmunity

journal_title

Autoimmunity

authors

Jones BM,Liu T,Wong RW

doi

10.3109/08916939908994055

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

117-24

issue

2

eissn

0891-6934

issn

1607-842X

journal_volume

31

pub_type

杂志文章
  • Immunopathology of experimental autoimmune uveoretinitis in primates.

    abstract::The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939209112339

    authors: Fujino Y,Li Q,Chung H,Hikita N,Nussenblatt RB,Gery I,Chan CC

    更新日期:1992-01-01 00:00:00

  • Detection of antimitochondrial antibodies: characterization by enzyme immunoassay and immunoblotting.

    abstract::Mitochondrial antigens were purified from rat liver and characterized by immunoblotting. Sera from 19 well defined patients with primary biliary cirrhosis (PBC) reacted with two mitochondrial polypeptides of 68 Kd and 45 Kd. Antibodies to these antigens were not detected in any of the sera of patients with cirrhosis o...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916938909014705

    authors: Zurgil N,Konikoff F,Bakimer R,Slor H,Shoenfeld Y

    更新日期:1989-01-01 00:00:00

  • Reactive animation: from piecemeal experimentation to reactive biological systems.

    abstract::Over the past decade, multi-level complex behavior and reactive nature of biological systems, has been a focus point for the biomedical community. We have developed a computational approach, termed Reactive Animation (RA) for simulating such complex biological systems. RA is an approach for describing the dynamic char...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.3109/08916934.2010.523260

    authors: Vainas O,Harel D,Cohen IR,Efroni S

    更新日期:2011-06-01 00:00:00

  • Morphological analysis of autoimmune disease in MRL-lpr,Yaa male mice with rapidly progressive systemic lupus erythematosus.

    abstract::We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939309079229

    authors: Suzuka H,Yoshifusa H,Nakamura Y,Miyawaki S,Shibata Y

    更新日期:1993-01-01 00:00:00

  • Autoreactive cytotoxic T lymphocytes in pemphigus and pemphigoid.

    abstract::In order to know whether effector cells are capable of recognizing the epidermal targets in pemphigus vulgaris (PV) and bullous pemphigoid (BP), non-adherent cells (NAC) of peripheral blood from 27 primary PV, 19 BP patients and 12 healthy volunteers were used in cytotoxic tests. Autologous, allogenic and murine epide...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916938908997095

    authors: Grando SA,Glukhenky BT,Drannik GN,Kostromin AP,Boiko YYa,Senyuk OF

    更新日期:1989-01-01 00:00:00

  • Improvement of cardiac function after immunoadsorption in patients with dilated cardiomyopathy.

    abstract::Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and by ventricular dilatation. Abnormalities of the cellular and humoral immune system are present in patients with myocarditis and DCM. Various circulating cardiac autoantibodies have been d...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.3109/08916930109007387

    authors: Felix SB,Staudt A,Friedrich GB

    更新日期:2001-01-01 00:00:00

  • Identification of a cyanogen bromide fragment of porcine type II collagen capable of modulating collagen arthritis in B10.RIII (H-2r) mice.

    abstract::Previous studies directed towards identifying epitopes on type II collagen (CII) important in collagen induced arthritis (CIA) in mice have focused primarily on responses mounted in susceptible H-2q strains. However, the nature of T and B cell responses against CII in susceptible H-2r strains remains ill-defined. In a...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939508993338

    authors: Nabozny GH,Griffiths MM,Harper DS,Luthra HS,David CS

    更新日期:1995-01-01 00:00:00

  • Role of CCR5 Delta32 bp deletion in RA and SLE.

    abstract::CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1080/08916930902827926

    authors: Martens HA,Kallenberg CG,Bijl M

    更新日期:2009-05-01 00:00:00

  • Apoptosis and NET formation in the pathogenesis of SLE.

    abstract::Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.3109/08916934.2012.719953

    authors: Bouts YM,Wolthuis DF,Dirkx MF,Pieterse E,Simons EM,van Boekel AM,Dieker JW,van der Vlag J

    更新日期:2012-12-01 00:00:00

  • Preferential adsorption of cationic anti-DNA antibodies with immobilized polyanionic compounds, dextran sulfate.

    abstract::It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939409009538

    authors: Suzuki N,Otuka I,Harada T,Mizushima Y,Sakane T

    更新日期:1994-01-01 00:00:00

  • High circulating IL-6 level in Graves' ophthalmopathy.

    abstract::IL-6 is a paracrine and autocrine cytokine, which acts in the regulation of immunological and inflammatory processes. Its production can be observed in different cell types, as well as thyrocytes. The purpose of the study was to examine the serum IL-6 levels between the patients with Graves' disease (N = 47) and witho...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939708996275

    authors: Molnár I,Balázs C

    更新日期:1997-01-01 00:00:00

  • Catastrophic relapse of Evans syndrome five years after allogeneic BMT notwithstanding full donor chimerism. Terminal hemolytic-uremic syndrome.

    abstract::A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916930600847598

    authors: Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

    更新日期:2006-09-01 00:00:00

  • Nitric oxide mediates IL-1beta stimulation of heat shock protein but not IL-1beta inhibition of glutamic acid decarboxylase.

    abstract::Interleukin-1beta (IL-1beta) has been implicated to play an important role in the autoimmune beta cell lesion of insulin-dependent diabetes mellitus (IDDM) because of its inhibition of insulin secretion, direct islet cytotoxicity and alteration of islet cell antigen expression. We have previously demonstrated that IL-...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939908995378

    authors: Hao W,Myhre AP,Palmer JP

    更新日期:1999-01-01 00:00:00

  • The frequency of occurrence of autoantibodies against beta1-adrenoceptors and its clinical relevance in patients with hepatitis virus myocarditis.

    abstract::The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=2...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916930109014693

    authors: Wang ZH,Liao YH,Fu M

    更新日期:2001-01-01 00:00:00

  • Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand.

    abstract::Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916934.2012.757307

    authors: Saito K,Mori S,Date F,Ono M

    更新日期:2013-06-01 00:00:00

  • Autoantibodies to survivin in patients with chronic hepatitis and hepatocellular carcinoma.

    abstract:OBJECTIVES:Autoantibodies to tumor-associated antigens including survivin have been detected in sera from patients with hepatocellular carcinoma (HCC). However, little is known about autoantibody responses to tumor-associated antigens in patients with chronic hepatitis, which strongly predisposes to development of HCC....

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916930500289958

    authors: Yagihashi A,Asanuma K,Kobayashi D,Tsuji N,Torigoe T,Sato N,Watanabe N

    更新日期:2005-09-01 00:00:00

  • Intermittent feeding and fasting reduces diabetes incidence in BB rats.

    abstract::Food intake may be one of several factors which influence the risk of development of insulin dependent diabetes mellitus, but the influence of the pattern of food supply has not been studied previously. The aim of the present study was to investigate the effect of intermittent feeding and fasting upon diabetes in BB r...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939908993805

    authors: Pedersen CR,Hagemann I,Bock T,Buschard K

    更新日期:1999-01-01 00:00:00

  • In vivo migration of tonsil lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: involvement of LFA-1.

    abstract::Integrin-adressin binding is a critical step in lymphocte attachment to target tissues. The mucosal recognition systems (alpha E beta 7, alpha 4 beta 7, MADcam-1) have been implicated in the autoimmune process in rheumatoid arthritis. We developed a model for in vivo study of radio-labelled lymphocyte circulation and ...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939608995363

    authors: Jorgensen C,Couret I,Canovas F,Bologna C,Brochier J,Reme T,Sany J

    更新日期:1996-01-01 00:00:00

  • Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites.

    abstract::Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore,...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916934.2016.1261837

    authors: Sarter K,Kulagin M,Schett G,Harris NL,Zaiss MM

    更新日期:2017-05-01 00:00:00

  • Pemphigus autoimmunity: hypotheses and realities.

    abstract::The goal of contemporary research in pemphigus vulgaris and pemphigus foliaceus is to achieve and maintain clinical remission without corticosteroids. Recent advances of knowledge on pemphigus autoimmunity scrutinize old dogmas, resolve controversies, and open novel perspectives for treatment. Elucidation of intimate ...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.3109/08916934.2011.606444

    authors: Grando SA

    更新日期:2012-02-01 00:00:00

  • Idiotypic characterisation of monoclonal antibodies with restricted epitope specificity for retinal S-antigen.

    abstract::This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-re...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939109006744

    authors: Suleyman S,Kasp E,Ellis B,Banga JP,Dumonde DC

    更新日期:1991-01-01 00:00:00

  • Effect of administration of apoptotic blebs on disease development in lupus mice.

    abstract:INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916934.2012.664668

    authors: Fransen JH,Berden JH,Koeter CM,Adema GJ,Van Der Vlag J,Hilbrands LB

    更新日期:2012-06-01 00:00:00

  • Immunopurification and characterization of thyroid autoantibodies with dual specificity for thyroglobulin and thyroperoxidase.

    abstract::The presence of autoantibodies (aAbs) to thyroglobulin (TG) and thyroperoxidase (TPO) in most of the patients with autoimmune thyroid disease is now well documented. Studies of these aAbs suggested that some, termed TGPO aAbs, could interact with both TG and TPO. This hypothesis was investigated using IgG fraction fro...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939209035153

    authors: Ruf J,Ferrand M,Durand-Gorde JM,Carayon P

    更新日期:1992-01-01 00:00:00

  • CRP and SAP from different species have different membrane ligand specificities.

    abstract::Human C-reactive protein (CRP) and serum amyloid component P (SAP) are well-characterised ligands for dying and dead cells, while facets of their physiological function still need to be unravelled. We partially characterised CRP and SAP from different species with similar acute-phase systems. Human, rabbit and porcine...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916934.2013.780601

    authors: Mattecka S,Bock C,Vogt B,Yapici G,Schrödl W,Janko C,Schindler R,Sheriff A

    更新日期:2013-08-01 00:00:00

  • Serum CXCL10 levels and neuromuscular manifestations in patients with autoimmune thyroid diseases.

    abstract:OBJECTIVE:Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. DESIGN:A total of ...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916934.2011.561818

    authors: Cakir M,Levendoglu F,Kiyici A,Coskun Y

    更新日期:2011-09-01 00:00:00

  • The prevalence of anti-acetylcholinesterase antibodies in autoimmune disease.

    abstract::A robust and precise enzyme linked immunosorbent assay (ELISA) with proven sensitivity and specificity has been employed to detect human antibodies (allogenic/autogenic) to human acetylcholinesterase (AChE). The sensitivity of the method has been established using mouse monoclonal antibodies (0.8 ng/ml) and uniquely, ...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916930400021360

    authors: Geen J,Howells RC,Ludgate M,Hullin DA,Hogg SI

    更新日期:2004-12-01 00:00:00

  • Introduction: knowledge is survival-the mission of the immune system and its stochastic simulations.

    abstract::In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...

    journal_title:Autoimmunity

    pub_type:

    doi:10.3109/08916934.2010.523239

    authors: Celada F

    更新日期:2011-06-01 00:00:00

  • Immunosuppressive therapies in myasthenia gravis.

    abstract::Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.3109/08916930903518107

    authors: Sanders DB,Evoli A

    更新日期:2010-08-01 00:00:00

  • Increased CD4+CXCR5+T follicular helper cells in diabetic nephropathy.

    abstract:BACKGROUND:T follicular helper (Tfh) cells are known to regulate humoral immune response. In this study we examined the correlation of different subsets of peripheral blood Tfh cells in patients with diabetic nephropathy (DN). METHODS:A total of 23 DN patients and 15 healthy controls (HC) were investigated for various...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916934.2016.1196677

    authors: Zhang N,Tai J,Qu Z,Zhang Z,Zhao S,He J,Zhang S,Jiang Y

    更新日期:2016-09-01 00:00:00

  • Differential susceptibility to experimental allergic encephalomyelitis (EAE) in genetically defined A+ and A- rabbits.

    abstract::Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939008993369

    authors: Villarroya H,Dalix AM,Paraut M,Oriol R

    更新日期:1990-01-01 00:00:00