Abstract:
:Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in patients with SLE. Regression analysis revealed that production of all six cytokines tended to decrease with increasing disease activity, but negative correlation with SLEDAI was significant (p < 0.05) only for PHA-stimulated IL4, unstimulated and PHA-stimulated IL10 and SAC-stimulated IL6. Negative correlation of stimulated and unstimulated IL6 and TNF alpha production with anti-DNA antibody levels were also significant.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Jones BM,Liu T,Wong RWdoi
10.3109/08916939908994055subject
Has Abstractpub_date
1999-10-01 00:00:00pages
117-24issue
2eissn
0891-6934issn
1607-842Xjournal_volume
31pub_type
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