Abstract:
:The T cell repertoire expressed by Tsk2 mice, a novel experimental model of systemic sclerosis, was examined to determine whether cells infiltrating the areas of involved skin exhibit a T cell receptor (TCR) bias. Reverse transcription-polymerase chain reactions (RT-PCR) were conducted using RNA extracted from lymph nodes and skin from TSk2 mice and from normal mice, with an oligonucleotide primer library specific for the variable region of the TCR (beta) chain. RT-PCR signals were observed in all lymph node cell (LNC) samples from both Tsk2 mice and control mice, with eighteen of the twenty-one Vbeta types present. In contrast, cDNA extracted from areas of involved skin from Tsk2 mice exhibited a restricted pattern, with positive Vbeta signals corresponding to eight T cell subtypes (Vbeta1, 6, 8.1, 8.2, 10, 11, 16, and 18). Band strength analysis revealed that three Vbeta subtypes dominated within this restricted pattern (Vbeta8.1, 11, and 18). Moreover, this pattern of Vbeta bias was consistent among the four skin samples from different Tsk2 mice. These data suggest that a restricted T cell population participates in the inflammatory cell infiltrate of Tsk2 skin.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Wooley PH,Sud S,Langendorfer A,Calkins C,Christner PJ,Peters J,Jimenez SAdoi
10.3109/08916939809008039subject
Has Abstractpub_date
1998-01-01 00:00:00pages
91-8issue
2eissn
0891-6934issn
1607-842Xjournal_volume
27pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract::Human C-reactive protein (CRP) and serum amyloid component P (SAP) are well-characterised ligands for dying and dead cells, while facets of their physiological function still need to be unravelled. We partially characterised CRP and SAP from different species with similar acute-phase systems. Human, rabbit and porcine...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2013.780601
更新日期:2013-08-01 00:00:00
abstract::NZW "x" BXSB F1 mice develop SLE that is associated with an anti-phospholipid syndrome characterized by anti-cardiolipin antibodies, thrombocytopenia and small coronary artery thrombosis. This syndrome is immune mediated and, dependent, on CD4+T cells. To determine whether disease in these mice can be treated with blo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930400008524
更新日期:2004-09-01 00:00:00
abstract::Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993359
更新日期:1995-01-01 00:00:00
abstract::To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thy...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008995732
更新日期:1990-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002479
更新日期:2009-11-01 00:00:00
abstract::Five separate monoclonal antibodies (MoAbs) to human thyroid peroxidase (hTPO) were raised by immunising Balb/c mice with hTPO purified from detergent solubilised thyroid microsomes by high performance liquid chromatography (HPLC). The epitope specificities of these MoAbs were determined by assessing their ability to ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209035148
更新日期:1992-01-01 00:00:00
abstract::The nature of the immunosuppressive effect of antithyroid drugs has been a subject of controversy. It has been claimed that these agents exert a direct effect on the immune system, although we and others have suggested that the drugs affect the thyroid cells primarily with consequent reduced thyrocyte-immunocyte signa...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909019950
更新日期:1989-01-01 00:00:00
abstract::Infectious agents have been implicated in the etiopathogenesis of various vasculitides via numerous and overlapping mechanisms including direct microbial invasion of endothelial cells, immune complex mediated vessel wall damage and stimulation of autoreactive B and/or T cells through molecular mimicry and superantigen...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930802613210
更新日期:2009-08-01 00:00:00
abstract::Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008993369
更新日期:1990-01-01 00:00:00
abstract::Congenital heart block is a serious condition with significant mortality due in most cases to the transplacental transfer of autoantibodies from an otherwise asymptomatic mother. Although SSA/Ro and SSB/La autoantibodies have been implicated, attention has focused recently on autoantibodies to envelope proteins of end...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908994764
更新日期:1999-01-01 00:00:00
abstract::Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental anima...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909043611
更新日期:1989-01-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) offers the unique opportunity to replace a diseased hematopoietic or immune system by healthy donor cells. Proof of principle comes from experimental animal data, from the experience with severe aplastic anemia, from observations of patients with concomitant au...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802197677
更新日期:2008-12-01 00:00:00
abstract::A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608994714
更新日期:1996-01-01 00:00:00
abstract::Over the past decade, multi-level complex behavior and reactive nature of biological systems, has been a focus point for the biomedical community. We have developed a computational approach, termed Reactive Animation (RA) for simulating such complex biological systems. RA is an approach for describing the dynamic char...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2010.523260
更新日期:2011-06-01 00:00:00
abstract::Toll-like receptors (TLRs) are evolutionary conserved molecules that recognize various microbial components and host-derived agonists from damaged cells and play a central role in innate and adaptive immunity. It has been reported that MyD88, the adaptor molecule downstream of all TLRs, except TLR3, is essential for i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903509056
更新日期:2010-06-01 00:00:00
abstract::Islet-infiltrating lymphocytes of individual male and female non-obese diabetic (NOD) mice were examined with the purpose of determining the differences that lead to a predominance of diabetes in female versus males NOD mice. When normalized for the amount of islet lymphocytes recovered, the infiltrating lymphocytes o...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903213993
更新日期:2009-01-01 00:00:00
abstract::Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. It is characterized by frequent re...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2017.1332185
更新日期:2017-08-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) induced by immunization of albino Lewis rats with a retinal soluble antigen (S-antigen) has been studied extensively by many workers. An intraorchidic injection of S-antigen 4 days prior to immunization of the animal with the antigen emulsified in adjuvant was found to preve...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209083134
更新日期:1992-01-01 00:00:00
abstract::Granulocyte macrophage-colony stimulating factor (GM-CSF) is a pleiotrophic proinflammatory cytokine that augments adaptive immunity by linking it to innate immunity. Experimental autoimmune gastritis is an animal model of human autoimmune gastritis and pernicious anaemia. We have previously shown that GM-CSF is expre...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930290005954
更新日期:2002-02-01 00:00:00
abstract::CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930902827926
更新日期:2009-05-01 00:00:00
abstract::Rheumatoid factors (RF), which are antibodies (Ab) with specificity directed against gamma (?) globulins, are the commonest auto-Ab ever described in man. Some of them are referred to as agglutinating RF, others designated non-agglutinating RF. Not only do these characterize rheumatoid arthritis (RA), but they are als...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930400022574
更新日期:2005-02-01 00:00:00
abstract::Chronic autoimmune thyroiditis (cAIT) leads to hypothyroidism due to T cell-mediated cytotoxicity in most cases. By contrast, Graves' disease (GD) with thyrotropin receptor stimulatory autoantibodies cause hyperthyroidism. Cytokines play a crucial role in modulating immune response in both disorders. The aim of study ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2014.914175
更新日期:2014-11-01 00:00:00
abstract::Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2014.938320
更新日期:2014-12-01 00:00:00
abstract::A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908998535
更新日期:1999-01-01 00:00:00
abstract::In the 1950s, the discovery of autoantibodies produced by B cells seemed to provide a compelling mechanism underlying autoimmune diseases. The discovery of T regulatory cells and other T helper cell subsets shifted the field back towards a T cell central view. The success of rituxan, a chimeric mAb targeting CD20 on B...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2013.856006
更新日期:2014-02-01 00:00:00
abstract::Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600971836
更新日期:2006-11-01 00:00:00
abstract::Although thyroid-associated ophthalmopathy (TAO) is now generally accepted as an autoimmune inflammatory disorder of the extraocular muscles and the orbital connective tissue, its aetiopathogenesis remains poorly understood. Recent data indicate that impaired interactions between T cells and extracellular matrix (ECM)...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939808993834
更新日期:1998-01-01 00:00:00
abstract::Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701356846
更新日期:2007-06-01 00:00:00
abstract:INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2020.1815194
更新日期:2020-11-01 00:00:00
abstract::HLA-DP+ T cells in peripheral blood from 23 patients with systemic lupus erythematosus (SLE) were examined using two-colour flow cytometry analysis. A marked increase of HLA-DP+ T cells was observed in patients with SLE (20.5-98.7%; 59.8 +/- 20.8%) in comparison to normal subjects (1.3-20.6%; 11.1 +/- 7.2%), and the r...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939009002976
更新日期:1990-01-01 00:00:00