Abstract:
:To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thyrotropin binding inhibitor immunoglobulin (TBII) levels gradually decreased and disappeared completely within 12 months after surgery (TBII disappearing group). Twenty-eight (56%) patients showed persistent TBII activity and their levels were not changed until 12 months after surgery (TBII persistent group). The changes of thyroid stimulating antibody (TSab) levels were very similar to those of TBII in both groups. The thyroidal lymphocytic infiltration was more prominent in the TBII disappearing group. The degree of the decrease of TBII levels after surgery correlated with the grade of thyroidal lymphocytic infiltration. There was no significant difference of TSH receptor antibody (both TBII and TSab) levels between the thyroid and peripheral venous blood. These data suggest that the persistence or disappearance of TSH receptor antibody after surgery may reflect the difference between patients in whom the thyroid is the major site of TSH receptor antibody and those in whom additional sites of TSH receptor antibody synthesis exist.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Cho BY,Oh SK,Shong YK,Kim SE,Yoo HY,Lee HK,Koh CS,Min HKdoi
10.3109/08916939008995732subject
Has Abstractpub_date
1990-01-01 00:00:00pages
143-7issue
2eissn
0891-6934issn
1607-842Xjournal_volume
8pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract:AIM:To assess the relationship of the Interleukin-10 (IL-10) -1082G/A (rs1800896), -819C/T (rs1800871) and -592C/A (rs1800872) polymorphism with inflammatory bowel disease (IBD) by means of meta-analysis. METHODS:Published data addressing the association between polymorphism of the IL-10 with Crohn's disease (CD) and ...
journal_title:Autoimmunity
pub_type: 杂志文章,meta分析
doi:10.3109/08916934.2013.843672
更新日期:2014-02-01 00:00:00
abstract::The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608994726
更新日期:1996-01-01 00:00:00
abstract::Although a variety of eye muscle antigens are recognized by autoantibodies in the serum from patients with thyroid associated ophthalmopathy (TAO) 64 kDa membrane proteins, which are also expressed in the thyroid, are most closely linked to the development of ophthalmopathy in patients with autoimmune thyroid disease....
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939308993314
更新日期:1993-01-01 00:00:00
abstract::The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2013.768617
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:Autoantibodies to tumor-associated antigens including survivin have been detected in sera from patients with hepatocellular carcinoma (HCC). However, little is known about autoantibody responses to tumor-associated antigens in patients with chronic hepatitis, which strongly predisposes to development of HCC....
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500289958
更新日期:2005-09-01 00:00:00
abstract::A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600847598
更新日期:2006-09-01 00:00:00
abstract::We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993350
更新日期:1995-01-01 00:00:00
abstract::Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). Increased prevalence of atherosclerosis may explain part of this enhanced risk, but SLE related CVD can also result from other mechanisms. Vascular events may be the result of several pathophysiologic ...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2013.856005
更新日期:2014-03-01 00:00:00
abstract::We have used the MRL/lpr murine model of spontaneous lupus to investigate three questions in infection immunity: (1) does mycobacterial infection have any effect on the mortality of the autoimmunity-prone lpr mice?; (2) does the infection modify the progression of kidney disease of lpr lupus?; and (3) does the lpr gen...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939308993323
更新日期:1993-01-01 00:00:00
abstract::In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...
journal_title:Autoimmunity
pub_type:
doi:10.3109/08916934.2010.523239
更新日期:2011-06-01 00:00:00
abstract::This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-re...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109006744
更新日期:1991-01-01 00:00:00
abstract::Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930290016655
更新日期:2002-03-01 00:00:00
abstract::Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916930903563491
更新日期:2010-08-01 00:00:00
abstract::DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701358826
更新日期:2007-06-01 00:00:00
abstract::Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and n...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2017.1347643
更新日期:2017-06-01 00:00:00
abstract::Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701262986
更新日期:2007-05-01 00:00:00
abstract::Invariant natural killer T (iNKT) cells represent an important regulatory T-cell subset that perceives signals of danger and/or cellular distress and modulate the adaptive immune response accordingly. In the presence of pathogens, iNKT cells acquire an adjuvant function that is fundamental to boost anti-microbial and ...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916931003782130
更新日期:2011-02-01 00:00:00
abstract::Immune profiling of non-obese diabetic (NOD) is a widely employed tool to assess the mechanisms of inflammatory insulitis. Our analysis of the female NOD colony revealed similar distribution of lymphoid lineages to wild type mice, and at various ages of prediabetic and diabetic mice. The profiles of mesenteric and pan...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2013.866103
更新日期:2014-03-01 00:00:00
abstract::Murine monoclonal antibodies (mAb) produced against native human thyroid peroxidase (TPO) are powerful tools for analyzing the autoantibody (Aab) epitopes on TPO. Binding sites of thirteen mAbs cover all or most antigenic regions on TPO. We determined the competition between Aabs from 75 AITD patients and 13 mAbs in b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995338
更新日期:1996-01-01 00:00:00
abstract::Six different hybridomas secreting anti-SCM mAb and one control mAb were placed into adult mice along with [14C] amino acids for biosynthetically labeling. After sacrifice, the 14C mAb ascites along with serum, heart, kidney, lung and skeletal muscle were recovered. Tissue associated specific radio-activity (SpAc) and...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939408995693
更新日期:1994-01-01 00:00:00
abstract::Type 1 diabetes (T1D) is characterized by selective autoimmune destruction of the insulin producing beta-cells in the islets of Langerhans. When the beta-cells are destroyed exogenous administration of insulin is necessary for maintenance of glucose homeostasis. Allogeneic islet transplantation has been used as a mean...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600648269
更新日期:2006-06-01 00:00:00
abstract::Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2014.938320
更新日期:2014-12-01 00:00:00
abstract::Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2018.1522305
更新日期:2018-11-01 00:00:00
abstract::The HEp2 cell cultures appeared highly sensitive in detecting the antinuclear antibodies (ANAb) in systemic sclerosis, principally anticentromere antibodies of the CREST syndrome. The immunoblotting used with either complex cellular extracts from HeLa and rabbit thymus or purified nuclear components (high mobility gro...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909019953
更新日期:1989-01-01 00:00:00
abstract::Autoantibodies against the beta-cell M(r) 64,000 protein (p64), recently identified as an isoform of glutamic acid decarboxylase (GAD), are prevalent in patients with insulin-dependent diabetes mellitus (IDDM). Dog islets were found to represent an abundant source of native p64 allowing the study of antigen-antibody i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209004823
更新日期:1992-01-01 00:00:00
abstract::Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/0891693031000094683
更新日期:2003-05-01 00:00:00
abstract::The cytokine profile and occurrence of apoptosis during experimental melanin-protein induced uveitis (EMIU) were investigated and compared with that of experimental autoimmune uveoretinitis (EAU). EMIU or EAU was induced in Lewis rats. Eyes were collected at different time points after immunization. Cytokine mRNA expr...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908993851
更新日期:1999-01-01 00:00:00
abstract::There is a need for methods to improve the diagnosis, patient staging and evaluation of therapeutic response in patients with autoimmune conditions to improve patient care. Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are two inflammatory diseases characterized by involvement of innate and adaptive i...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916931003674766
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:Autoimmune sensorineural hearing loss (ASNHL) is a relatively rare disorder which can lead to total deafness. At present, no specific laboratory test with adequate sensitivity and specificity is available to confirm the clinical suspicion of ASNHL. The aim of this study was to identify if evaluation of anti-...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930601119377
更新日期:2007-02-01 00:00:00
abstract::It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409009538
更新日期:1994-01-01 00:00:00