Surge in regulatory T cells does not prevent onset of hyperglycemia in NOD mice: immune profiles do not correlate with disease severity.

abstract：:Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological...

journal_title：Autoimmunity

authors： Petrovsky N,Brusic V

更新日期：2006-12-01 00:00:00

abstract：:The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrate...

journal_title：Autoimmunity

authors： Foteinos G,Xu Q

更新日期：2009-11-01 00:00:00

abstract：:Over the past decade, multi-level complex behavior and reactive nature of biological systems, has been a focus point for the biomedical community. We have developed a computational approach, termed Reactive Animation (RA) for simulating such complex biological systems. RA is an approach for describing the dynamic char...

journal_title：Autoimmunity

authors： Vainas O,Harel D,Cohen IR,Efroni S

更新日期：2011-06-01 00:00:00

abstract：:Anti-M2 of anti-mitochondrial antibody (AMA) is a serological marker of primary biliary cirrhosis (PBC). Anti-pyruvate dehydrogenase complex-E2 (anti-PDC-E2) is recognized as the most frequently occurring anti-M2, and a routine laboratory test for this antibody has already been established. However, it is also known t...

journal_title：Autoimmunity

authors： Miyakawa H,Abe K,Kitazawa E,Kikuchi K,Fujikawa H,Matsushita M,Kawaguchi N,Kako M

更新日期：1999-01-01 00:00:00

abstract：:Granulocyte macrophage-colony stimulating factor (GM-CSF) is a pleiotrophic proinflammatory cytokine that augments adaptive immunity by linking it to innate immunity. Experimental autoimmune gastritis is an animal model of human autoimmune gastritis and pernicious anaemia. We have previously shown that GM-CSF is expre...

journal_title：Autoimmunity

authors： Alderuccio F,Biondo M,Toh BH

更新日期：2002-02-01 00:00:00

abstract：:Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...

journal_title：Autoimmunity

authors： Bhol KC,Ahmed AR

更新日期：2002-03-01 00:00:00

abstract：:We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...

journal_title：Autoimmunity

authors： Suzuka H,Yoshifusa H,Nakamura Y,Miyawaki S,Shibata Y

更新日期：1993-01-01 00:00:00

abstract：:We have used the MRL/lpr murine model of spontaneous lupus to investigate three questions in infection immunity: (1) does mycobacterial infection have any effect on the mortality of the autoimmunity-prone lpr mice?; (2) does the infection modify the progression of kidney disease of lpr lupus?; and (3) does the lpr gen...

journal_title：Autoimmunity

authors： Castro AP,Esaguy N,Aguas AP

更新日期：1993-01-01 00:00:00

abstract：:We analysed the presence of anti-cyclic citrullinated peptide (anti-CCP) and anti-keratin (AKA) antibodies of the IgG class in sera of patients with defined juvenile idiopathic arthritis (JIA) of various subgroups with more than one year duration of the disease. Enzyme-linked immunosorbent assay (Immunoscan RA, Eurodi...

journal_title：Autoimmunity

authors： Hromadnikova I,Stechova K,Pavla V,Hridelova D,Houbova B,Voslarova S,Nekvasilova H,Vavrinec J

更新日期：2002-09-01 00:00:00

abstract：:A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...

journal_title：Autoimmunity

authors： Frey AB,Rao TD

更新日期：1999-01-01 00:00:00

abstract：:Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene e...

journal_title：Autoimmunity

authors： Haas JP,Metzler M,Frank C,Haefner R,Wassmuth R

更新日期：2009-05-01 00:00:00

abstract：:Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the...

journal_title：Autoimmunity

authors： Rego SL,Harvey S,Simpson SR,Hemphill WO,McIver ZA,Grayson JM,Perrino FW

更新日期：2018-11-01 00:00:00

abstract：:Human Toll-like receptors (TLRs) are crucial for the recognition of invading pathogens and for the activation of both innate and adaptive immunity. Upon stimulation, TLRs recruit various protein kinases via several adaptor molecules, such as MyD88, leading to the activation of NFkB. The identification of TLR signaling...

journal_title：Autoimmunity

authors： Toubi E,Shoenfeld Y

更新日期：2004-05-01 00:00:00

abstract：:In the present study, the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in kidney lymphoid cells of lupus-prone mice (MRL-lpr/lpr) is shown by Northern blot and nuclear run on transcription assay. By quantification analysis of hsp 70 gene transcription, more than ten times of the enhan...

journal_title：Autoimmunity

authors： Deguchi Y

更新日期：1991-01-01 00:00:00

abstract：:In a previous work we characterized a major epitope of thyroid peroxidase (TPO), which was recognised by 66% of 157 patients with autoimmune thyroid disease (AITD) and 9 out of 50 patients with non-thyroidal autoimmune disease (NTAID) 6 of whom had antibodies to the gastric parietal cell antigen (PCA). In the present ...

journal_title：Autoimmunity

authors： Elisei R,Mariotti S,Swillens S,Vassart G,Ludgate M

更新日期：1990-01-01 00:00:00

abstract：:Anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of autoantibody (AAb) to phospholipid (PL)-binding proteins, such as beta2-glycoprotein I (beta2GPI), and clinical manifestations including thrombosis and/or recurrent pregnancy loss. beta2GPI-reactive T cells are clearly implicat...

journal_title：Autoimmunity

authors： Tolomeo T,Rico De Souza A,Roter E,Dieudé M,Amireault P,Subang R,Levine JS,Rauch J

更新日期：2009-05-01 00:00:00

abstract：:In order to know whether effector cells are capable of recognizing the epidermal targets in pemphigus vulgaris (PV) and bullous pemphigoid (BP), non-adherent cells (NAC) of peripheral blood from 27 primary PV, 19 BP patients and 12 healthy volunteers were used in cytotoxic tests. Autologous, allogenic and murine epide...

journal_title：Autoimmunity

authors： Grando SA,Glukhenky BT,Drannik GN,Kostromin AP,Boiko YYa,Senyuk OF

更新日期：1989-01-01 00:00:00

abstract：:Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...

journal_title：Autoimmunity

authors： Keith MP,Moratz C,Egan R,Zacharia A,Greidinger EL,Hoffman RW,Tsokos GC

更新日期：2007-05-01 00:00:00

abstract：:Interleukin (IL)-1 inhibits the function of insulin-producing rat pancreatic beta-cells in vitro and in vivo, and it has been postulated that the IL-1 effect is mediated through the cytokine inducible nitric oxide (NO) synthase. IL-1 inhibits the function of cultured human thyroid cells too, and in this study human th...

journal_title：Autoimmunity

authors： Rasmussen AK,Di Marco R,Diamant M,Feldt-Rasmussen U,Bendtzen K

更新日期：1994-01-01 00:00:00

abstract：:Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...

journal_title：Autoimmunity

authors： Eliaou JF,Andary M,Favier F,Carayon P,Poncelet P,Sany J,Brochier J,Clot J

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To assess muscle strength in patients with idiopathic inflammatory myopathies (IIM) using neuromuscular scales and isokinetic testing. METHODS:Muscle function was evaluated in 27 IIM patients being followed at the Rheumatology Unit of the University of Pisa using: (i) a modified version of the grading system...

journal_title：Autoimmunity

authors： Neri R,Mosca M,Stampacchia G,Vesprini E,Tavoni A,d'Ascanio A,Bombardieri S

更新日期：2006-05-01 00:00:00

abstract：:Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and n...

journal_title：Autoimmunity

authors： Khan MA,Alam K,Hassan SM,Rizvi MMA

更新日期：2017-06-01 00:00:00

abstract：:Experimental autoimmune uveoretinitis (EAU) induced by immunization of albino Lewis rats with a retinal soluble antigen (S-antigen) has been studied extensively by many workers. An intraorchidic injection of S-antigen 4 days prior to immunization of the animal with the antigen emulsified in adjuvant was found to preve...

journal_title：Autoimmunity

authors： Peng B,Yoshitoshi T,Shichi H

更新日期：1992-01-01 00:00:00

abstract：:It has been suggested that pancreatic beta-cell destruction occurring during the process leading to insulin-dependent diabetes mellitus (IDDM) involves formation of nitric oxide (NO). We have presently studied the effect of aminoguanidine (AG), which has recently been reported to inhibit generation of NO induced by th...

journal_title：Autoimmunity

authors： Holstad M,Sandler S

更新日期：1993-01-01 00:00:00

abstract：:Various amounts of the bacterium, Brucella abortus (BA) were injected intravenously into autoimmune NZB/W F1 mice and non-autoimmune BDF1 mice and then the localization of BA in the thymus was traced using an immunohistochemical method at 30 min and 3 h after injection. The results showed that a greater amount of BA b...

journal_title：Autoimmunity

authors： Ohmori J,Miyakawa K,Matsuno K,Kotani M

更新日期：1991-01-01 00:00:00

abstract：:Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...

journal_title：Autoimmunity

authors： Le Panse R,Bismuth J,Cizeron-Clairac G,Weiss JM,Cufi P,Dartevelle P,De Rosbo NK,Berrih-Aknin S

更新日期：2010-08-01 00:00:00

abstract：:Worldwide population studies have generally agreed that rheumatoid arthritis (RA) is associated with a group of HLA-DRB1 alleles which share a common amino acid sequence at residues 70-74. This represents the first study to investigate the association of HLA-DRB1 genes with susceptibility to RA amongst Malay, Chinese ...

journal_title：Autoimmunity

authors： Kong KF,Yeap SS,Chow SK,Phipps ME

更新日期：2002-07-01 00:00:00

abstract：:We have used the reverse transcriptase polymerase chain reaction (RT-PCR) technique to assess the expression of cytokine genes in various T cell subsets of autoimmune-prone mice. Our study confirmed the previously described features in lpr mice that IFN-gamma, TNF-alpha, and TNF-beta were transcribed by various T cell...

journal_title：Autoimmunity

authors： Mori K,Kobayashi S,Inobe M,Jia WY,Tamakoshi M,Miyazaki T,Uede T

更新日期：1994-01-01 00:00:00

abstract：:Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...

journal_title：Autoimmunity

authors： Villarroya H,Dalix AM,Paraut M,Oriol R

更新日期：1990-01-01 00:00:00

abstract：:We reported a patient who gave birth to 3 children with transient neonatal hypothyroidism. She had 3 different antibodies (Ab) to the thyrotropin receptor (TSHR) in her serum, viz., TSH binding-inhibiting (TBIAb), thyroid-stimulating (TSAb) and an additional stimulating Ab (SAb). The SAb differed from TSAb in that its...

journal_title：Autoimmunity

authors： Zakarija M,De Forteza R,McKenzie JM,Ghandur-Mnaymneh L

更新日期：1994-01-01 00:00:00