Abstract:
:IL-6 is a paracrine and autocrine cytokine, which acts in the regulation of immunological and inflammatory processes. Its production can be observed in different cell types, as well as thyrocytes. The purpose of the study was to examine the serum IL-6 levels between the patients with Graves' disease (N = 47) and without (N = 29) ophthalmopathy in respect of the presence of inflammatory eye signs and thyroiditis, thyroid function and radioiodine or medical treatments. The serum IL-6 levels were greater (P < 0.025) in the patients with ophthalmopathy (440 +/- 32.4 pg/ml) than in those without eye disease (81.6 +/- 25.2 pg/ml). An elevated serum IL-6 levels could be detected in 22 out of 47 patients with ophthalmopathy with longer manifestation of thyroid disease than one year in comparison with those who had shorter (694 +/- 35.3 pg/ml vs 215.8 +/- 27.9 pg/ml, P < 0.05). The increase showed a strong association with the inflammatory signs of eye disease in the patients with Graves' hyperthyroidism compared with those without ophthalmopathy (513.3 +/- 33.7 pg/ml vs 96.9 +/- 12.1 pg/ml, P < 0.025). Euthyroid function and the presence of thyroiditis did not influence the serum IL-6 levels. Radioiodine and medical treatments did not lead to a remarkable decrease in the serum IL-6 levels. The results supported that IL-6 cytokine may be an important factor in the inflammatory events of Graves' ophthalmopathy.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Molnár I,Balázs Cdoi
10.3109/08916939708996275subject
Has Abstractpub_date
1997-01-01 00:00:00pages
91-6issue
2eissn
0891-6934issn
1607-842Xjournal_volume
25pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract::Guillain-Barre syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. However, GBS patients frequently display a psychosyndrome, indicating an accompanying involvement of the central nervous system (CNS), although the cause is not understood. Hepatic encephalopathy is possibly the best characterize...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930412331279840
更新日期:2004-09-01 00:00:00
abstract::CD4+ T cells play a crucial role in the development of lupus in MRL-lpr/lpr mice: incomplete deletion/silencing of self-reactive CD4+ T cells leads to T cell activation, which causes both polyclonal B cell activation and T cell infiltration of multiple organs. Furthermore, anti-CD4 antibody therapy ameliorates disease...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995346
更新日期:1996-01-01 00:00:00
abstract::TGF-beta1 is a pleiotropic cytokine, which prevents inappropriate autoimmune responses and balances the requirements of proper immune cell levels during pathologic states that trigger the immune response. We assessed the serum levels of TGF-beta1 and determined the relationship between TGF-beta1 and clinical parameter...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902831977
更新日期:2009-05-01 00:00:00
abstract::An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939509001938
更新日期:1995-01-01 00:00:00
abstract::The cytokine profile and occurrence of apoptosis during experimental melanin-protein induced uveitis (EMIU) were investigated and compared with that of experimental autoimmune uveoretinitis (EAU). EMIU or EAU was induced in Lewis rats. Eyes were collected at different time points after immunization. Cytokine mRNA expr...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908993851
更新日期:1999-01-01 00:00:00
abstract::Thyroid lymphocyte RNA from a Hashimoto patient exhibiting high titre serum IgG autoantibodies against thyroglobulin (Tg) has been used to construct a Fab library in phage lambda. Screening of this library with radioiodinated Tg has permitted the cloning of an anti-Tg antibody (MH52) with an affinity of 4.5 x 10(9) mo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209150320
更新日期:1992-01-01 00:00:00
abstract::The thymic medulla is a complex microenvironment which plays a crucial role in central tolerance induction. Using a quantitative histological analysis of non-obese diabetic (NOD) mice, we show that the medulla undergoes several structural modifications during the course of the disease in NOD mice. Indeed, the majority...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908994070
更新日期:1999-01-01 00:00:00
abstract::Recent findings provide evidence of the critical role of innate immunity NALP1/NLRP1 and NALP3/NLRP3/CIAS1 genes in inflammatory diseases, and also in the predisposition to autoimmune disorders. We evaluated the possible association of five single nucleotide polymorphisms (SNPs), two in NLRP1 gene and three in NLRP3 g...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903540432
更新日期:2010-12-01 00:00:00
abstract::Congenic B10.BR/SgSnJ H-2kTlaa mice were infected with a diabetogenic strain of coxsackievirus CB4 to correlate abnormalities of sugar metabolism with virus replication in islets, 64,000-M(r) (64K) islet autoantigen expression, 64K antibody development, and pancreas histopathology in early and late infection. Plaque a...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309077366
更新日期:1993-01-01 00:00:00
abstract::Toll-like receptors (TLRs) are evolutionary conserved molecules that recognize various microbial components and host-derived agonists from damaged cells and play a central role in innate and adaptive immunity. It has been reported that MyD88, the adaptor molecule downstream of all TLRs, except TLR3, is essential for i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903509056
更新日期:2010-06-01 00:00:00
abstract::NZW "x" BXSB F1 mice develop SLE that is associated with an anti-phospholipid syndrome characterized by anti-cardiolipin antibodies, thrombocytopenia and small coronary artery thrombosis. This syndrome is immune mediated and, dependent, on CD4+T cells. To determine whether disease in these mice can be treated with blo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930400008524
更新日期:2004-09-01 00:00:00
abstract::Islet-infiltrating lymphocytes of individual male and female non-obese diabetic (NOD) mice were examined with the purpose of determining the differences that lead to a predominance of diabetes in female versus males NOD mice. When normalized for the amount of islet lymphocytes recovered, the infiltrating lymphocytes o...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903213993
更新日期:2009-01-01 00:00:00
abstract::Type 1 diabetes (T1D) is characterized by selective autoimmune destruction of the insulin producing beta-cells in the islets of Langerhans. When the beta-cells are destroyed exogenous administration of insulin is necessary for maintenance of glucose homeostasis. Allogeneic islet transplantation has been used as a mean...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600648269
更新日期:2006-06-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a human herpesvirus hiding in a latent form in memory B cells in the majority of the world population. Although, primary EBV infection is asymptomatic or causes a self-limiting disease, infectious mononucleosis, the virus is associated with a wide variety of neoplasms developing in immunosu...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930802024772
更新日期:2008-05-01 00:00:00
abstract::We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993350
更新日期:1995-01-01 00:00:00
abstract::Linomide is a potent immunomodulator that has been shown to inhibit autoimmunity in several animal models of autoimmune disease, including experimental autoimmune encephalomyelitis (EAE). Linomide's mechanism of action is unknown, however, it has been suggested to modulate the function of antigen presenting cells (APC...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930008994093
更新日期:2000-10-01 00:00:00
abstract::Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene e...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902832652
更新日期:2009-05-01 00:00:00
abstract::The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.593600
更新日期:2012-03-01 00:00:00
abstract::Zinc transporter 8 (ZnT8), a product of the SLC30A8 gene, is a target-antigen in autoimmune diabetes. Associations between ZnT8 antibody (ZnT8A), phenotype and the genetic variant rs13266634 in the SLC30A8 gene have primarily been studied in patients with young-onset diabetes. We explored such associations in adult-on...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.732132
更新日期:2013-02-01 00:00:00
abstract::Worldwide population studies have generally agreed that rheumatoid arthritis (RA) is associated with a group of HLA-DRB1 alleles which share a common amino acid sequence at residues 70-74. This represents the first study to investigate the association of HLA-DRB1 genes with susceptibility to RA amongst Malay, Chinese ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930290024179
更新日期:2002-07-01 00:00:00
abstract::Multiple sclerosis (MS) is a devastating autoimmune disease that affects more than 1 million people worldwide and severely compromises motor and sensory function through demyelination and axonal loss. This review covers current therapies, lessons learned from failed clinical trials, genetic susceptibility, key cell ty...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916931003674733
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:Autoantibodies to tumor-associated antigens including survivin have been detected in sera from patients with hepatocellular carcinoma (HCC). However, little is known about autoantibody responses to tumor-associated antigens in patients with chronic hepatitis, which strongly predisposes to development of HCC....
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500289958
更新日期:2005-09-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the dysfunction of T cells, B cells, and dendritic cells and by the production of antinuclear autoantibodies. This editorial provides a synopsis of newly discovered genetic factors and signaling pathways in lupus pathogenesis that ar...
journal_title:Autoimmunity
pub_type: 社论
doi:10.3109/08916930903374741
更新日期:2010-02-01 00:00:00
abstract::T helper type 17 (Th17) cells, a newly identified effector T-cell subset, have recently been shown to play a role in numerous autoimmune diseases, including iodine-induced autoimmune thyroiditis in non-obese diabetic (NOD)-H2(h4) mice, which had previously been thought Th1-dominant. We here studied the role of Th17 in...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916931003777247
更新日期:2011-03-01 00:00:00
abstract::Numerous groups have now validated high-throughput approaches to autoantibody profiling in a variety of systems. Recently, we have used autoantigen microarray technology to identify distinct autoantibody profiles in H-2 congenic MRL/lpr mice (Sekine et al., manuscript in preparation), and we are expanding this platfor...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930410001710686
更新日期:2004-06-01 00:00:00
abstract::The T cell repertoire expressed by Tsk2 mice, a novel experimental model of systemic sclerosis, was examined to determine whether cells infiltrating the areas of involved skin exhibit a T cell receptor (TCR) bias. Reverse transcription-polymerase chain reactions (RT-PCR) were conducted using RNA extracted from lymph n...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939809008039
更新日期:1998-01-01 00:00:00
abstract::The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802282651
更新日期:2009-01-01 00:00:00
abstract::Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995297
更新日期:1995-01-01 00:00:00
abstract::Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938808997166
更新日期:1988-01-01 00:00:00
abstract::Five separate monoclonal antibodies (MoAbs) to human thyroid peroxidase (hTPO) were raised by immunising Balb/c mice with hTPO purified from detergent solubilised thyroid microsomes by high performance liquid chromatography (HPLC). The epitope specificities of these MoAbs were determined by assessing their ability to ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209035148
更新日期:1992-01-01 00:00:00