Abstract:
OBJECTIVE:To study efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. METHODS:The case records of 40 patients with lupus nephritis followed up in a single center between 1992 and 2011 (median duration = 8.37 years) were retrieved to determine efficacy and toxicity of the treatments. Patients with class III/IV/V lupus nephritis were included. RESULTS:Sustained responses were 21/40 (52.5%) at six months, 33/40 (82.5%) at 18 months and 30/40 (75.0%) at 36 months. Three deaths were observed after 18, 104 and 164 months of follow-up respectively, with one possibly associated with immunosuppression. Kidney survival was 100% at 18 months and 97.7% at 36 months. Kaplan-Meier's survival algorithm estimated a mean overall survival of 236.05 ± 11.56 months and a kidney survival of 240.77 ± 11.07 months. Kidney and overall survival were not significantly different among patients with different nephritis classes. Complications occurred in 12/40 (30.0%). Amenorrhea occurred in 20.7% of patients and was associated with higher cumulative doses of cyclophosphamide. Patients who achieved remission at 36 months or later had lower levels of proteinuria at 6 months (mean ± SD = 0.93 ± 0.97 g/24 h versus 2.60 ± 2.11 g/24 h, p = 0.002) than non-responder patients. CONCLUSIONS:The data demonstrate that in the overall Caucasian population with lupus nephritis the combination of available therapeutic tools is effective and relatively well tolerated.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Bozzolo EP,Ramirez GA,Bonavida G,Lanzani C,Scotti R,Dell'antonio G,Baldissera E,Canti V,Manfredi AA,Rovere-Querini P,Sabbadini MGdoi
10.3109/08916934.2013.817560subject
Has Abstractpub_date
2013-12-01 00:00:00pages
537-46issue
8eissn
0891-6934issn
1607-842Xjournal_volume
46pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract:OBJECTIVE:To investigate the clinical features of AIHA/ES patients with clonal Ig/TCR gene rearrangement. METHODS:Ig/TCR gene rearrangements were measured by BIOMED-2 PCR. 44 primary AIHA/ES patients were enrolled in the study. Clinical characteristics were analyzed and compared between patients with and without clona...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2020.1818231
更新日期:2020-11-01 00:00:00
abstract::Previous studies directed towards identifying epitopes on type II collagen (CII) important in collagen induced arthritis (CIA) in mice have focused primarily on responses mounted in susceptible H-2q strains. However, the nature of T and B cell responses against CII in susceptible H-2r strains remains ill-defined. In a...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993338
更新日期:1995-01-01 00:00:00
abstract::Peripheral blood B lymphocytes of multiple sclerosis (MS) patients and control persons were transformed with Epstein-Barr virus. Antibody production of transformed cells against isolated human myelin was investigated by enzyme-linked immunosorbent assay (ELISA). Cells producing reactive antibodies were cloned and prop...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909029146
更新日期:1989-01-01 00:00:00
abstract::Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice (H-2g7) and C57BL/6 mice (H-2b) by a ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939809003872
更新日期:1998-01-01 00:00:00
abstract::The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrate...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002529
更新日期:2009-11-01 00:00:00
abstract::A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908998535
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in Euro...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.755958
更新日期:2013-06-01 00:00:00
abstract::It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409009538
更新日期:1994-01-01 00:00:00
abstract::Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes utilizing a novel recombinant PR3 (rPR3) produced to accommodate manipulations of the N-terminal domain. The rPR3 molecule contains an N-terminus six ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701680104
更新日期:2007-11-01 00:00:00
abstract::Hybridoma cell lines producing natural autoantibodies (NAA), generated from A.SW mice with progressive experimental autoimmune encephalomyelitis (P-EAE), have been shown to cause demyelination and renal pathology when injected into naive mice. To investigate the relative contribution of these antibodies to disease pat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930801890280
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to characterise the functionally relevant minor lymphocyte subpopulations in whole blood of multiple sclerosis (MS) patients and their potential utility as biomarkers for treatment follow up. MATERIAL AND METHODS:Peripheral blood from 40 healthy donors (HD) and 66 MS patients [...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2016.1138271
更新日期:2016-06-01 00:00:00
abstract::Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993359
更新日期:1995-01-01 00:00:00
abstract::Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701356846
更新日期:2007-06-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the dysfunction of T cells, B cells, and dendritic cells and by the production of antinuclear autoantibodies. This editorial provides a synopsis of newly discovered genetic factors and signaling pathways in lupus pathogenesis that ar...
journal_title:Autoimmunity
pub_type: 社论
doi:10.3109/08916930903374741
更新日期:2010-02-01 00:00:00
abstract::The objective of this study was to research the functionality of anti-endothelial cell antibodies (AECA) in pulmonary arterial hypertension (PAH) by assessing the effects of IgG from AECA-positive PAH patients on the induction of adhesion molecules on human umbilical vein endothelial cells (HUVECs) and on the producti...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2013.812080
更新日期:2013-11-01 00:00:00
abstract::Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis. Using indirect immunofluorescence on ethanol-fixed neutrophils, two major fluoroscopic patterns can be recognised: a diffuse cytoplasmic staining (C-ANCA), and a perinuclear/nuclear staining (P-ANC...
journal_title:Autoimmunity
pub_type: 历史文章,杂志文章,评审
doi:10.1080/08916930400022673
更新日期:2005-02-01 00:00:00
abstract::Augmented and prolonged expression of CD40 ligand (CD40L) was recently reported in lymphoid cells from human lupus patients, suggesting that CD40/CD40L pathway was involved in the pathogenesis of systemic autoimmune diseases. This study was thus designed to study the expression of CD40 and CD40L among cell populations...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930109001958
更新日期:2001-01-01 00:00:00
abstract::Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600971836
更新日期:2006-11-01 00:00:00
abstract::NZW "x" BXSB F1 mice develop SLE that is associated with an anti-phospholipid syndrome characterized by anti-cardiolipin antibodies, thrombocytopenia and small coronary artery thrombosis. This syndrome is immune mediated and, dependent, on CD4+T cells. To determine whether disease in these mice can be treated with blo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930400008524
更新日期:2004-09-01 00:00:00
abstract::The T cell repertoire expressed by Tsk2 mice, a novel experimental model of systemic sclerosis, was examined to determine whether cells infiltrating the areas of involved skin exhibit a T cell receptor (TCR) bias. Reverse transcription-polymerase chain reactions (RT-PCR) were conducted using RNA extracted from lymph n...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939809008039
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2018.1442828
更新日期:2018-03-01 00:00:00
abstract::Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. It is characterized by frequent re...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2017.1332185
更新日期:2017-08-01 00:00:00
abstract::The biological basis for autoimmunity and immunoincompetence in the BB rat has yet to be localized. In spite of normal thymic histology, thymocyte subsets and blastogenesis, thymus gland products (thymosins) have yet to be studied. In the present report, thymus gland function was studied by measuring thymosin alpha 1 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938809001924
更新日期:1988-01-01 00:00:00
abstract::An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939509001938
更新日期:1995-01-01 00:00:00
abstract::Insulin-dependent diabetes mellitus (IDDM) is preceded by the presence of antibodies against islet proteins including a protein tyrosine phosphatase (PTP) designated IA-2. Recently, we cloned a novel PTP named IAR which shares 43% sequence identity with IA-2 and is recognised by antibodies from a majority of patients ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939808993841
更新日期:1998-01-01 00:00:00
abstract::Chronic autoimmune thyroiditis (cAIT) leads to hypothyroidism due to T cell-mediated cytotoxicity in most cases. By contrast, Graves' disease (GD) with thyrotropin receptor stimulatory autoantibodies cause hyperthyroidism. Cytokines play a crucial role in modulating immune response in both disorders. The aim of study ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2014.914175
更新日期:2014-11-01 00:00:00
abstract::Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and n...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2017.1347643
更新日期:2017-06-01 00:00:00
abstract::T lymphocytes present in thyroid infiltrates of 6 patients with Hashimoto's thyroiditis (HT) and of 4 patients with Graves' disease (GD) were analyzed at clonal level and their profiles of mitogen-induced lymphokine secretion were characterized. Production of interleukin-2 (IL-2), interleukin-4 (IL-4), interferon-gamm...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909014703
更新日期:1989-01-01 00:00:00
abstract::Myocarditis, often initiated by viral infection, may progress to autoimmune inflammatory heart disease, dilated cardiomyopathy and heart failure. Although cardiac myosin is a dominant autoantigen in animal models of myocarditis and is released from the heart during viral myocarditis, the characterization, role and sig...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802031579
更新日期:2008-09-01 00:00:00
abstract:INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2020.1815194
更新日期:2020-11-01 00:00:00