Abstract:
:The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some autoimmune diseases are associated with certain class II alleles. This article reviews the basic structural features of class II molecules, and the genes encoding them as well as mechanisms governing the development of their extraordinary polymorphism.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Rask L,Jonsson AK,Svensson AC,Gustafsson K,Andersson Ldoi
10.3109/08916939108997111subject
Has Abstractpub_date
1991-01-01 00:00:00pages
237-44issue
3eissn
0891-6934issn
1607-842Xjournal_volume
8pub_type
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