Abstract:
:Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to develop when the mice are about 5-6 months old and the titer exceeds that of IgM antibodies from age 7 months on. We asked whether or not the B cell population responsible for IgM and IgG antibody production belongs to the same lineage. The surface phenotypes of B cell populations responsible for the spontaneous production of either IgM or IgG anti-DNA antibodies were examined using panning and sorting methods with several monoclonal antibodies to B cells, including CD5 (Ly-1) and Lp-3; the latter defines a unique B cell differentiation antigen. We obtained evidence that surface phenotypes of B cells secreting IgM anti-DNA antibodies belong to CD5+ Lp-3- and those of B cells secreting IgG anti-DNA antibodies which occur only in old B/W F1 mice belong to CD5- Lp-3+ subpopulations. The majority of peritoneal B cells were CD5+ Lp-3+ throughout the life span of the mice and anti-DNA antibody production was never evidenced. These findings were discussed in relation to age-associated changes of B cell populations in the spleen of this strain of mice.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Okada T,Abe M,Takiura F,Hirose S,Shirai Tdoi
10.3109/08916939008993383subject
Has Abstractpub_date
1990-01-01 00:00:00pages
109-20issue
2-3eissn
0891-6934issn
1607-842Xjournal_volume
7pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract::The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.593600
更新日期:2012-03-01 00:00:00
abstract::On different tissue sections, binding of gliadin to reticular matrix components was observed which was Ca2+-dependent, inhibited by Cu2+ and Zn2+ ions, by putrescine, and by preincubation with antibodies against tissue transglutaminase (tTG) suggesting that binding of gliadin is mediated by tTG. tTG was able to bind t...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939808995366
更新日期:1998-01-01 00:00:00
abstract::Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strept...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930500484674
更新日期:2006-02-01 00:00:00
abstract::The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939108997111
更新日期:1991-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and contr...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2016.1196678
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16.4%. The diagnosis of CD is based on histopathological examination and se...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2018.1427226
更新日期:2018-03-01 00:00:00
abstract::Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701356846
更新日期:2007-06-01 00:00:00
abstract:MOTIVATION:The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to he...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.523272
更新日期:2011-06-01 00:00:00
abstract::The goal of contemporary research in pemphigus vulgaris and pemphigus foliaceus is to achieve and maintain clinical remission without corticosteroids. Recent advances of knowledge on pemphigus autoimmunity scrutinize old dogmas, resolve controversies, and open novel perspectives for treatment. Elucidation of intimate ...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2011.606444
更新日期:2012-02-01 00:00:00
abstract::Autoantibodies against the beta-cell M(r) 64,000 protein (p64), recently identified as an isoform of glutamic acid decarboxylase (GAD), are prevalent in patients with insulin-dependent diabetes mellitus (IDDM). Dog islets were found to represent an abundant source of native p64 allowing the study of antigen-antibody i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209004823
更新日期:1992-01-01 00:00:00
abstract::Peripheral blood B lymphocytes of multiple sclerosis (MS) patients and control persons were transformed with Epstein-Barr virus. Antibody production of transformed cells against isolated human myelin was investigated by enzyme-linked immunosorbent assay (ELISA). Cells producing reactive antibodies were cloned and prop...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909029146
更新日期:1989-01-01 00:00:00
abstract::Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916930903518107
更新日期:2010-08-01 00:00:00
abstract::IL-6 is a paracrine and autocrine cytokine, which acts in the regulation of immunological and inflammatory processes. Its production can be observed in different cell types, as well as thyrocytes. The purpose of the study was to examine the serum IL-6 levels between the patients with Graves' disease (N = 47) and witho...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939708996275
更新日期:1997-01-01 00:00:00
abstract::Autoantibodies directed against nuclear antigens often arise in autoimmune disease associated with the failure to clear apoptotic cells in a swift and timely manner. Nucleic acids present in apoptotic cells and in membranous microparticles derived thereof exert adjuvant activity in the immune response to apoptosis. Th...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2012.750298
更新日期:2013-08-01 00:00:00
abstract::Mitochondrial antigens were purified from rat liver and characterized by immunoblotting. Sera from 19 well defined patients with primary biliary cirrhosis (PBC) reacted with two mitochondrial polypeptides of 68 Kd and 45 Kd. Antibodies to these antigens were not detected in any of the sera of patients with cirrhosis o...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909014705
更新日期:1989-01-01 00:00:00
abstract::To explore the natural course of beta cell function in recent onset diabetes, a subgroup (n=157) of all incident cases (n=879) 15-34 years old, 1992-1993 in Sweden, and with positivity for at least one autoantibody of islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930108995996
更新日期:2001-01-01 00:00:00
abstract::Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause t...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916934.2018.1454912
更新日期:2018-05-01 00:00:00
abstract::We report in this paper on obvious fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). B6 CD8+ splenocytes were transferred into (bm 12 x bm 1)F1 mice to induce GVHR. Recipient mice had been thymectomized and administrated with anti-CD8 monoclonal antibody (mAb) to deplete CD8...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995313
更新日期:1995-01-01 00:00:00
abstract::Granulocyte macrophage-colony stimulating factor (GM-CSF) is a pleiotrophic proinflammatory cytokine that augments adaptive immunity by linking it to innate immunity. Experimental autoimmune gastritis is an animal model of human autoimmune gastritis and pernicious anaemia. We have previously shown that GM-CSF is expre...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930290005954
更新日期:2002-02-01 00:00:00
abstract::Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209035163
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to characterise the functionally relevant minor lymphocyte subpopulations in whole blood of multiple sclerosis (MS) patients and their potential utility as biomarkers for treatment follow up. MATERIAL AND METHODS:Peripheral blood from 40 healthy donors (HD) and 66 MS patients [...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2016.1138271
更新日期:2016-06-01 00:00:00
abstract::Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908994055
更新日期:1999-10-01 00:00:00
abstract::Islet-infiltrating lymphocytes of individual male and female non-obese diabetic (NOD) mice were examined with the purpose of determining the differences that lead to a predominance of diabetes in female versus males NOD mice. When normalized for the amount of islet lymphocytes recovered, the infiltrating lymphocytes o...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930903213993
更新日期:2009-01-01 00:00:00
abstract::To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thy...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008995732
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2020.1815194
更新日期:2020-11-01 00:00:00
abstract::A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600847598
更新日期:2006-09-01 00:00:00
abstract::Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008993369
更新日期:1990-01-01 00:00:00
abstract::Immune profiling of non-obese diabetic (NOD) is a widely employed tool to assess the mechanisms of inflammatory insulitis. Our analysis of the female NOD colony revealed similar distribution of lymphoid lineages to wild type mice, and at various ages of prediabetic and diabetic mice. The profiles of mesenteric and pan...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2013.866103
更新日期:2014-03-01 00:00:00
abstract::In a previous work we characterized a major epitope of thyroid peroxidase (TPO), which was recognised by 66% of 157 patients with autoimmune thyroid disease (AITD) and 9 out of 50 patients with non-thyroidal autoimmune disease (NTAID) 6 of whom had antibodies to the gastric parietal cell antigen (PCA). In the present ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008998434
更新日期:1990-01-01 00:00:00
abstract::Over the past decade, multi-level complex behavior and reactive nature of biological systems, has been a focus point for the biomedical community. We have developed a computational approach, termed Reactive Animation (RA) for simulating such complex biological systems. RA is an approach for describing the dynamic char...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2010.523260
更新日期:2011-06-01 00:00:00