Celiac antibodies in children with type 1 diabetes - A diagnostic validation study.

abstract：:Although thyroid-associated ophthalmopathy (TAO) is now generally accepted as an autoimmune inflammatory disorder of the extraocular muscles and the orbital connective tissue, its aetiopathogenesis remains poorly understood. Recent data indicate that impaired interactions between T cells and extracellular matrix (ECM)...

journal_title：Autoimmunity

authors： Bednarczuk T,Kiljanski J,Mrowiec T,Slon M,Ing E,Stolarski C,Kennerdell JS,Gorski A,Nauman J,Wall JR

更新日期：1998-01-01 00:00:00

abstract：AIM:To assess the relationship of the Interleukin-10 (IL-10) -1082G/A (rs1800896), -819C/T (rs1800871) and -592C/A (rs1800872) polymorphism with inflammatory bowel disease (IBD) by means of meta-analysis. METHODS:Published data addressing the association between polymorphism of the IL-10 with Crohn's disease (CD) and ...

journal_title：Autoimmunity

authors： Zou L,Wang L,Gong X,Zhao H,Jiang A,Zheng S

更新日期：2014-02-01 00:00:00

abstract：:Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable ath...

journal_title：Autoimmunity

authors： Kyaw T,Tipping P,Bobik A,Toh BH

更新日期：2017-02-01 00:00:00

abstract：:A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...

journal_title：Autoimmunity

authors： Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

更新日期：2006-09-01 00:00:00

abstract：:Diabetes mellitus is a disorder characterized by hyperglycemia in both the fasting and post-prandial states. The two most common forms of diabetes mellitus, type 1 and type 2 (previously called juvenile-onset and adult-onset, respectively), comprise the vast majority of cases. Type 1 diabetes (T1DM) has been shown to ...

journal_title：Autoimmunity

authors： Taplin CE,Barker JM

更新日期：2008-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...

journal_title：Autoimmunity

authors： Kaplan MJ

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:To assess muscle strength in patients with idiopathic inflammatory myopathies (IIM) using neuromuscular scales and isokinetic testing. METHODS:Muscle function was evaluated in 27 IIM patients being followed at the Rheumatology Unit of the University of Pisa using: (i) a modified version of the grading system...

journal_title：Autoimmunity

authors： Neri R,Mosca M,Stampacchia G,Vesprini E,Tavoni A,d'Ascanio A,Bombardieri S

更新日期：2006-05-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice (H-2g7) and C57BL/6 mice (H-2b) by a ...

journal_title：Autoimmunity

authors： Slavin A,Ewing C,Liu J,Ichikawa M,Slavin J,Bernard CC

更新日期：1998-01-01 00:00:00

abstract：:Although a variety of eye muscle antigens are recognized by autoantibodies in the serum from patients with thyroid associated ophthalmopathy (TAO) 64 kDa membrane proteins, which are also expressed in the thyroid, are most closely linked to the development of ophthalmopathy in patients with autoimmune thyroid disease....

journal_title：Autoimmunity

authors： Boucher A,Bernard N,Zhang ZG,Rodien P,Salvi M,Wall JR

更新日期：1993-01-01 00:00:00

abstract：:Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy...

journal_title：Autoimmunity

authors： Atkinson MA,Winter WE,Skordis N,Beppu H,Riley WM,Maclaren NK

更新日期：1988-01-01 00:00:00

abstract：:An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...

journal_title：Autoimmunity

authors： Jaspan JB,Luo H,Ahmed B,Tenenbaum S,Voss T,Sander DM,Bollinger K,Baquet T,Garry RF

更新日期：1995-01-01 00:00:00

abstract：:Elevated constitutive expression of major histocompatibility (MHC) class II antigens occurs in the enterocytes of patients with IBD. It has been suggested that this aberrant expression of class II molecules may play a role in the pathogenesis of IBD. We examined two possible reasons for such a finding. 1) Heightened s...

journal_title：Autoimmunity

authors： Salomon P,Pizzimenti A,Panja A,Reisman A,Mayer L

更新日期：1991-01-01 00:00:00

abstract：:Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...

journal_title：Autoimmunity

authors： Sanders DB,Evoli A

更新日期：2010-08-01 00:00:00

abstract：:NZW "x" BXSB F1 mice develop SLE that is associated with an anti-phospholipid syndrome characterized by anti-cardiolipin antibodies, thrombocytopenia and small coronary artery thrombosis. This syndrome is immune mediated and, dependent, on CD4+T cells. To determine whether disease in these mice can be treated with blo...

journal_title：Autoimmunity

authors： Akkerman A,Huang W,Wang X,Ramanujam M,Schiffer L,Madaio M,Factor SM,Davidson A

更新日期：2004-09-01 00:00:00

abstract：:The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for...

journal_title：Autoimmunity

authors： Song WC

更新日期：2006-08-01 00:00:00

abstract：:In this study we investigated one of the possible mechanisms of p56lck down-regulation in peripheral blood lymphocytes (PBLs) from Systemic Lupus Erythematosus (SLE) patients and we correlated p56lck dysregulation with accelerated apoptosis in SLE PBLs. PBLs from SLE patients and healthy donors were isolated. p56lck p...

journal_title：Autoimmunity

authors： Matache C,Onu A,Stefanescu M,Tanaseanu S,Dragomir C,Dolganiuc A,Szegli G

更新日期：2001-01-01 00:00:00

abstract：:The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrate...

journal_title：Autoimmunity

authors： Foteinos G,Xu Q

更新日期：2009-11-01 00:00:00

abstract：:Augmented and prolonged expression of CD40 ligand (CD40L) was recently reported in lymphoid cells from human lupus patients, suggesting that CD40/CD40L pathway was involved in the pathogenesis of systemic autoimmune diseases. This study was thus designed to study the expression of CD40 and CD40L among cell populations...

journal_title：Autoimmunity

authors： Liu MF,Chao SC,Wang CR,Lei HY

更新日期：2001-01-01 00:00:00

abstract：:Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...

journal_title：Autoimmunity

authors： Jones BM,Liu T,Wong RW

更新日期：1999-10-01 00:00:00

abstract：:Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...

journal_title：Autoimmunity

authors： Bouts YM,Wolthuis DF,Dirkx MF,Pieterse E,Simons EM,van Boekel AM,Dieker JW,van der Vlag J

更新日期：2012-12-01 00:00:00

abstract：:The goal of contemporary research in pemphigus vulgaris and pemphigus foliaceus is to achieve and maintain clinical remission without corticosteroids. Recent advances of knowledge on pemphigus autoimmunity scrutinize old dogmas, resolve controversies, and open novel perspectives for treatment. Elucidation of intimate ...

journal_title：Autoimmunity

authors： Grando SA

更新日期：2012-02-01 00:00:00

abstract：:The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencie...

journal_title：Autoimmunity

authors： Truedsson L,Bengtsson AA,Sturfelt G

更新日期：2007-12-01 00:00:00

abstract：:The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...

journal_title：Autoimmunity

authors： Banica L,Besliu A,Pistol G,Stavaru C,Ionescu R,Forsea AM,Tanaseanu C,Dumitrache S,Otelea D,Tamsulea I,Tanaseanu S,Chitonu C,Paraschiv S,Balteanu M,Stefanescu M,Matache C

更新日期：2009-01-01 00:00:00

abstract：:Islet-infiltrating lymphocytes of individual male and female non-obese diabetic (NOD) mice were examined with the purpose of determining the differences that lead to a predominance of diabetes in female versus males NOD mice. When normalized for the amount of islet lymphocytes recovered, the infiltrating lymphocytes o...

journal_title：Autoimmunity

authors： Young EF,Hess PR,Arnold LW,Tisch R,Frelinger JA

更新日期：2009-01-01 00:00:00

abstract：:Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...

journal_title：Autoimmunity

authors： Mzimela NC,Ngubane PS,Khathi A

更新日期：2019-02-01 00:00:00

abstract：:Integrin-adressin binding is a critical step in lymphocte attachment to target tissues. The mucosal recognition systems (alpha E beta 7, alpha 4 beta 7, MADcam-1) have been implicated in the autoimmune process in rheumatoid arthritis. We developed a model for in vivo study of radio-labelled lymphocyte circulation and ...

journal_title：Autoimmunity

authors： Jorgensen C,Couret I,Canovas F,Bologna C,Brochier J,Reme T,Sany J

更新日期：1996-01-01 00:00:00

abstract：:Blockade of the complement cascade at the C5a/C5a receptor (C5aR)-axis is believed to be an attractive treatment avenue in rheumatoid arthritis (RA). However, the effects of such interventions during the early phases of arthritis remain to be clarified. In this study we use the murine delayed-type hypersensitivity art...

journal_title：Autoimmunity

authors： Atkinson SM,Nansen A,Usher PA,Sondergaard BC,Mackay CR,Friedrichsen B,Chang CC,Tang R,Skov S,Haase C,Hornum L

更新日期：2015-01-01 00:00:00

abstract：:Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...

journal_title：Autoimmunity

authors： Saito K,Mori S,Date F,Ono M

更新日期：2013-06-01 00:00:00

abstract：:Chronic autoimmune thyroiditis (cAIT) leads to hypothyroidism due to T cell-mediated cytotoxicity in most cases. By contrast, Graves' disease (GD) with thyrotropin receptor stimulatory autoantibodies cause hyperthyroidism. Cytokines play a crucial role in modulating immune response in both disorders. The aim of study ...

journal_title：Autoimmunity

authors： Mikos H,Mikos M,Rabska-Pietrzak B,Niedziela M

更新日期：2014-11-01 00:00:00

abstract：:Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. It has been proposed that IL-1 induces a race between protective and deleterious proteins i...

journal_title：Autoimmunity

authors： Christensen UB,Larsen PM,Fey SJ,Andersen HU,Nawrocki A,Sparre T,Mandrup-Poulsen T,Nerup J

更新日期：2000-01-01 00:00:00