Functional implications of IgG anti-endothelial cell antibodies in pulmonary arterial hypertension.

abstract：:Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...

journal_title：Autoimmunity

authors： Sjöber K,Eriksson S,Tenngart B,Roth EB,Leffler H,Stenberg P

更新日期：2002-08-01 00:00:00

abstract：:In this study we investigated one of the possible mechanisms of p56lck down-regulation in peripheral blood lymphocytes (PBLs) from Systemic Lupus Erythematosus (SLE) patients and we correlated p56lck dysregulation with accelerated apoptosis in SLE PBLs. PBLs from SLE patients and healthy donors were isolated. p56lck p...

journal_title：Autoimmunity

authors： Matache C,Onu A,Stefanescu M,Tanaseanu S,Dragomir C,Dolganiuc A,Szegli G

更新日期：2001-01-01 00:00:00

abstract：:Hybridoma cell lines producing natural autoantibodies (NAA), generated from A.SW mice with progressive experimental autoimmune encephalomyelitis (P-EAE), have been shown to cause demyelination and renal pathology when injected into naive mice. To investigate the relative contribution of these antibodies to disease pat...

journal_title：Autoimmunity

authors： Peterson LK,Tsunoda I,Fujinami RS

更新日期：2008-08-01 00:00:00

abstract：:Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strept...

journal_title：Autoimmunity

authors： Guilherme L,Kalil J,Cunningham M

更新日期：2006-02-01 00:00:00

abstract：:Immune profiling of non-obese diabetic (NOD) is a widely employed tool to assess the mechanisms of inflammatory insulitis. Our analysis of the female NOD colony revealed similar distribution of lymphoid lineages to wild type mice, and at various ages of prediabetic and diabetic mice. The profiles of mesenteric and pan...

journal_title：Autoimmunity

authors： Kaminitz A,Mizrahi K,Askenasy N

更新日期：2014-03-01 00:00:00

abstract：:Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune...

journal_title：Autoimmunity

authors： Gatselis NK,Vakrakou AG,Zachou K,Androutsakos T,Azariadis K,Hatzis G,Manoussakis MN,Dalekos GN

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. DESIGN:A total of ...

journal_title：Autoimmunity

authors： Cakir M,Levendoglu F,Kiyici A,Coskun Y

更新日期：2011-09-01 00:00:00

abstract：:Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...

journal_title：Autoimmunity

authors： Lucke S,Klöting I,Pusch A,Heinrich HW,Hahn HJ

更新日期：2003-05-01 00:00:00

abstract：:The effects of intravenous immunoglobulin (IVIG) products were recently examined in patients with Alzheimer's disease (AD). Although encouraging results were obtained in pilot studies, later trials produced negative results. The rationale for these studies was that IVIG contains antibodies to amyloid-beta (Aβ). Howeve...

journal_title：Autoimmunity

authors： Loeffler DA,Klaver AC,Coffey MP

更新日期：2015-06-01 00:00:00

abstract：:The cytokine profile and occurrence of apoptosis during experimental melanin-protein induced uveitis (EMIU) were investigated and compared with that of experimental autoimmune uveoretinitis (EAU). EMIU or EAU was induced in Lewis rats. Eyes were collected at different time points after immunization. Cytokine mRNA expr...

journal_title：Autoimmunity

authors： Li Q,Sun B,Matteson DM,O'Brien TP,Chan CC

更新日期：1999-01-01 00:00:00

abstract：:The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...

journal_title：Autoimmunity

authors： Rask L,Jonsson AK,Svensson AC,Gustafsson K,Andersson L

更新日期：1991-01-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM), celiac disease (CD) and autoimmune thyroid disease (ATD) are autoimmune conditions relatively common in paediatric age and frequently occur in association in the same subject. This event is not by chance and requires an explanation. Here, we studied the distribution of HLA-DQ αβ hetero...

journal_title：Autoimmunity

authors： Larizza D,Calcaterra V,Klersy C,Badulli C,Caramagna C,Ricci A,Brambilla P,Salvaneschi L,Martinetti M

更新日期：2012-09-01 00:00:00

abstract：:Macrophages from autoimmune diabetes prone BB rats were found to produce radical oxygen intermediates (ROI) at an enhanced rate when compared to diabetes resistant BB or normal Wistar rats. The release of ROI was determined by chemiluminescence using in parallel luminol and lucigenin as detector molecules. In diabetes...

journal_title：Autoimmunity

authors： Brenner HH,Burkart V,Rothe H,Kolb H

更新日期：1993-01-01 00:00:00

abstract：:DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...

journal_title：Autoimmunity

authors： Pisetsky DS,Fairhurst AM

更新日期：2007-06-01 00:00:00

abstract：:Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...

journal_title：Autoimmunity

authors： Saito K,Mori S,Date F,Ono M

更新日期：2013-06-01 00:00:00

abstract：:NZB (H-2d) mice are well known for the production of IgM autoantibodies to ssDNA. However, an F1 cross between NZB and either NZW or SWR mice is required to produce IgG nephritogenic antibodies to dsDNA and glomerulonephritis. The contribution of parental class II loci in the hybrid mice is clearly important to the de...

journal_title：Autoimmunity

authors： Cawley D,Chiang BL,Ansari A,Gershwin ME

更新日期：1991-01-01 00:00:00

abstract：:We have used the MRL/lpr murine model of spontaneous lupus to investigate three questions in infection immunity: (1) does mycobacterial infection have any effect on the mortality of the autoimmunity-prone lpr mice?; (2) does the infection modify the progression of kidney disease of lpr lupus?; and (3) does the lpr gen...

journal_title：Autoimmunity

authors： Castro AP,Esaguy N,Aguas AP

更新日期：1993-01-01 00:00:00

abstract：:Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...

journal_title：Autoimmunity

authors： Le Panse R,Bismuth J,Cizeron-Clairac G,Weiss JM,Cufi P,Dartevelle P,De Rosbo NK,Berrih-Aknin S

更新日期：2010-08-01 00:00:00

abstract：:Carbonic anhydrase II (CAII) is expressed on alveolar epithelium and participates to CO2 elimination, fluid secretion and post-capillary pH regulation. CAII is overexpressed in animal models of lung fibrosis in sites of epithelial injury. Autoantibodies directed against CAII (anti-CAII) have been described in sera fro...

journal_title：Autoimmunity

authors： Alessandri C,Bombardieri M,Scrivo R,Viganego F,Conti F,de Luca N,Riccieri V,Valesini G

更新日期：2003-03-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta) has been implicated to play an important role in the autoimmune beta cell lesion of insulin-dependent diabetes mellitus (IDDM) because of its inhibition of insulin secretion, direct islet cytotoxicity and alteration of islet cell antigen expression. We have previously demonstrated that IL-...

journal_title：Autoimmunity

authors： Hao W,Myhre AP,Palmer JP

更新日期：1999-01-01 00:00:00

abstract：:The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomi...

journal_title：Autoimmunity

authors： Kiss E,Csipö I,Cohen JH,Reveil B,Kávai M,Szegedi G

更新日期：1996-01-01 00:00:00

abstract：:Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...

journal_title：Autoimmunity

authors： Bhol KC,Ahmed AR

更新日期：2002-03-01 00:00:00

abstract：:The presence of autoantibodies (aAbs) to thyroglobulin (TG) and thyroperoxidase (TPO) in most of the patients with autoimmune thyroid disease is now well documented. Studies of these aAbs suggested that some, termed TGPO aAbs, could interact with both TG and TPO. This hypothesis was investigated using IgG fraction fro...

journal_title：Autoimmunity

authors： Ruf J,Ferrand M,Durand-Gorde JM,Carayon P

更新日期：1992-01-01 00:00:00

abstract：:Programmed cell death 1 (PD-1) was isolated in 1992 by subtractive-hybridization technique, as a molecule whose expression is enhanced by apoptotic stimuli. Since then we have been analyzing the function of PD-1 in the regulation of immune responses. Generation of PD-1 deficient mice, pathophysiological analyses of au...

journal_title：Autoimmunity

authors： Okazaki T,Wang J

更新日期：2005-08-01 00:00:00

abstract：:Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable ath...

journal_title：Autoimmunity

authors： Kyaw T,Tipping P,Bobik A,Toh BH

更新日期：2017-02-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and by ventricular dilatation. Abnormalities of the cellular and humoral immune system are present in patients with myocarditis and DCM. Various circulating cardiac autoantibodies have been d...

journal_title：Autoimmunity

authors： Felix SB,Staudt A,Friedrich GB

更新日期：2001-01-01 00:00:00

abstract：:It has been suggested that pancreatic beta-cell destruction occurring during the process leading to insulin-dependent diabetes mellitus (IDDM) involves formation of nitric oxide (NO). We have presently studied the effect of aminoguanidine (AG), which has recently been reported to inhibit generation of NO induced by th...

journal_title：Autoimmunity

authors： Holstad M,Sandler S

更新日期：1993-01-01 00:00:00

abstract：:Recent findings provide evidence of the critical role of innate immunity NALP1/NLRP1 and NALP3/NLRP3/CIAS1 genes in inflammatory diseases, and also in the predisposition to autoimmune disorders. We evaluated the possible association of five single nucleotide polymorphisms (SNPs), two in NLRP1 gene and three in NLRP3 g...

journal_title：Autoimmunity

authors： Pontillo A,Brandao L,Guimaraes R,Segat L,Araujo J,Crovella S

更新日期：2010-12-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is characterised by immune-mediated damage to the intra-hepatic biliary epithelial cells (BEC). Immuno-modulatory/suppressive therapy represents, therefore, alogical approach to treatment in this disease. Conventional immuno-suppressive and immuno-modulatory agents suffer from the bread...

journal_title：Autoimmunity

authors： Jones DE,Palmer JM,Robe A,Kirby JA

更新日期：2002-12-01 00:00:00

abstract：:Agalactosyl IgG (Gal(0) is a glycoform lacking terminal galactose from the oligosaccharides situated on the Fc. The percentage of circulating IgG that is Gal(0) is increased in a a number of autoimmune diseases, and in certain chronic infections associated with autoantibody production. However it is not known whether ...

journal_title：Autoimmunity

authors： Pilkington C,Yeung E,Isenberg D,Lefvert AK,Rook GA

更新日期：1995-01-01 00:00:00