Functional implications of IgG anti-endothelial cell antibodies in pulmonary arterial hypertension.

abstract：:In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...

journal_title：Autoimmunity

authors： Boissier MC,Texier B,Carlioz A,Fournier C

更新日期：1989-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine an...

journal_title：Autoimmunity

authors： Sotto A,Bérard M,Bessis D,Porneuf M,Jourdan J,Boffa MC

更新日期：1995-01-01 00:00:00

abstract：:Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...

journal_title：Autoimmunity

authors： Jones BM,Liu T,Wong RW

更新日期：1999-10-01 00:00:00

abstract：:Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...

journal_title：Autoimmunity

authors： Sjöber K,Eriksson S,Tenngart B,Roth EB,Leffler H,Stenberg P

更新日期：2002-08-01 00:00:00

abstract：:Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...

journal_title：Autoimmunity

authors： Villarroya H,Dalix AM,Paraut M,Oriol R

更新日期：1990-01-01 00:00:00

abstract：:Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene e...

journal_title：Autoimmunity

authors： Haas JP,Metzler M,Frank C,Haefner R,Wassmuth R

更新日期：2009-05-01 00:00:00

abstract：:CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...

journal_title：Autoimmunity

authors： Martens HA,Kallenberg CG,Bijl M

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Autoimmune polyendocrine syndrome type 1 (APS 1) is caused by mutations in the AIRE gene that induce intrathymic T-cell tolerance breakdown, which results in tissue-specific autoimmune diseases. DESIGN:To evaluate the effect of a well-defined T-cell repertoire impairment on humoral self-reactive fingerprints...

journal_title：Autoimmunity

authors： Dubucquoi S,Proust-Lemoine E,Kemp EH,Ryndak A,Lefèvre-Dutoit V,Bellart M,Saugier-Véber P,Duban-Deweer S,Wémeau JL,Prin L,Lefranc D

更新日期：2015-01-01 00:00:00

abstract：:Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the...

journal_title：Autoimmunity

authors： Rego SL,Harvey S,Simpson SR,Hemphill WO,McIver ZA,Grayson JM,Perrino FW

更新日期：2018-11-01 00:00:00

abstract：:Systemic sclerosis (SSc) is characterized by extensive fibrosis, vasculopathy and activation of the immune system. Fibrosis can be caused by profibrotic cytokines, such as transforming growth factor-beta (TGFbeta), interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective tissue growth factor. Vascul...

journal_title：Autoimmunity

authors： Sakkas LI

更新日期：2005-03-01 00:00:00

abstract：:Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...

journal_title：Autoimmunity

authors： Girkontaite I,Urbonaviciute V,Maseda D,Neubert K,Herrmann M,Voll RE

更新日期：2007-06-01 00:00:00

abstract：:A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...

journal_title：Autoimmunity

authors： Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

更新日期：2006-09-01 00:00:00

abstract：:Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental anima...

journal_title：Autoimmunity

authors： Dancea S,Dellagi K,Renaud F,Mahouy G,Hauw JJ,Brouet JC

更新日期：1989-01-01 00:00:00

abstract：:Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...

journal_title：Autoimmunity

authors： Igarashi T,Itoh Y,Fukunaga Y,Yamamoto M

更新日期：1995-01-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic beta cell destruction involving auto-reactive T-cells, pro-inflammatory cytokines, reactive oxygen species (ROS) and loss of insulin. Monozygotic twin studies show a 20-60% concordance with T1D indicating there may be an environmental component...

journal_title：Autoimmunity

authors： Bekris LM,Shephard C,Peterson M,Hoehna J,Van Yserloo B,Rutledge E,Farin F,Kavanagh TJ,Lernmark A

更新日期：2005-12-01 00:00:00

abstract：:The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...

journal_title：Autoimmunity

authors： Alkhateeb A,Jarun Y,Tashtoush R

更新日期：2013-05-01 00:00:00

abstract：:Glucocorticoids (GCs) strongly impact on different T cell subsets inducing generally immunosuppressive effects, whereas much less is known about the effect of GC on natural killer (NK) cells. The aims of this study were to investigate the effects of GC on T cell functions, including T cell-mediated anti-tumor immune r...

journal_title：Autoimmunity

authors： Yakimchuk K,Chen L,Hasni MS,Okret S,Jondal M

更新日期：2015-03-01 00:00:00

abstract：:CD4+ T cells play a crucial role in the development of lupus in MRL-lpr/lpr mice: incomplete deletion/silencing of self-reactive CD4+ T cells leads to T cell activation, which causes both polyclonal B cell activation and T cell infiltration of multiple organs. Furthermore, anti-CD4 antibody therapy ameliorates disease...

journal_title：Autoimmunity

authors： Duan JM,Fagard R,Madaio MP

更新日期：1996-01-01 00:00:00

abstract：:Guillain-Barre syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. However, GBS patients frequently display a psychosyndrome, indicating an accompanying involvement of the central nervous system (CNS), although the cause is not understood. Hepatic encephalopathy is possibly the best characterize...

journal_title：Autoimmunity

authors： Görtzen A,Schlüter S,Veh RW

更新日期：2004-09-01 00:00:00

abstract：:Murine monoclonal antibodies (mAb) produced against native human thyroid peroxidase (TPO) are powerful tools for analyzing the autoantibody (Aab) epitopes on TPO. Binding sites of thirteen mAbs cover all or most antigenic regions on TPO. We determined the competition between Aabs from 75 AITD patients and 13 mAbs in b...

journal_title：Autoimmunity

authors： Czarnocka B,Pastuszko D,Carayon P,Ruf J,Gardas A

更新日期：1996-01-01 00:00:00

abstract：:Embryonic tissue expresses a very low level of MHC molecules, and these few appear only late in ontogeny. Possibly related are deficiencies in the expression of TAP molecules and also the fetus' need to avoid maternal immunologic rejection. However, the fetus may overcome the lack of Ag-presenting molecules when threa...

journal_title：Autoimmunity

authors： Lee MS,Sarvetnick N

更新日期：1997-01-01 00:00:00

abstract：:Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...

journal_title：Autoimmunity

authors： Eliaou JF,Andary M,Favier F,Carayon P,Poncelet P,Sany J,Brochier J,Clot J

更新日期：1988-01-01 00:00:00

abstract：:The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins including ionized Ca(2+)-binding adaptor 1, microglia response factor-1, and daintain are identical with AIF-1. The expre...

journal_title：Autoimmunity

authors： Liu G,Ma H,Jiang L,Zhao Y

更新日期：2007-03-01 00:00:00

abstract：:Five separate monoclonal antibodies (MoAbs) to human thyroid peroxidase (hTPO) were raised by immunising Balb/c mice with hTPO purified from detergent solubilised thyroid microsomes by high performance liquid chromatography (HPLC). The epitope specificities of these MoAbs were determined by assessing their ability to ...

journal_title：Autoimmunity

authors： Ewins DL,Barnett PS,Tomlinson RW,McGregor AM,Banga JP

更新日期：1992-01-01 00:00:00

abstract：:Rheumatoid factors (RF), which are antibodies (Ab) with specificity directed against gamma (?) globulins, are the commonest auto-Ab ever described in man. Some of them are referred to as agglutinating RF, others designated non-agglutinating RF. Not only do these characterize rheumatoid arthritis (RA), but they are als...

journal_title：Autoimmunity

authors： Renaudineau Y,Jamin C,Saraux A,Youinou P

更新日期：2005-02-01 00:00:00

abstract：:The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients,...

journal_title：Autoimmunity

authors： Dar SA,Haque S,Mandal RK,Singh T,Wahid M,Jawed A,Panda AK,Akhter N,Lohani M,Areeshi MY,Rai G,Datt S,Bhattacharya SN,Ramachandran VG,Das S

更新日期：2017-05-01 00:00:00

abstract：:Although a variety of eye muscle antigens are recognized by autoantibodies in the serum from patients with thyroid associated ophthalmopathy (TAO) 64 kDa membrane proteins, which are also expressed in the thyroid, are most closely linked to the development of ophthalmopathy in patients with autoimmune thyroid disease....

journal_title：Autoimmunity

authors： Boucher A,Bernard N,Zhang ZG,Rodien P,Salvi M,Wall JR

更新日期：1993-01-01 00:00:00

abstract：:We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly. This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/l) mice in relation to age, disease manifestations and the expression of lymphocyte homing ...

journal_title：Autoimmunity

authors： Schrieber L,Manolios N,Cohen MG,Paull SA,Guiffre AK,Hopper KE

更新日期：1989-01-01 00:00:00

abstract：:Interleukin (IL)-1 inhibits the function of insulin-producing rat pancreatic beta-cells in vitro and in vivo, and it has been postulated that the IL-1 effect is mediated through the cytokine inducible nitric oxide (NO) synthase. IL-1 inhibits the function of cultured human thyroid cells too, and in this study human th...

journal_title：Autoimmunity

authors： Rasmussen AK,Di Marco R,Diamant M,Feldt-Rasmussen U,Bendtzen K

更新日期：1994-01-01 00:00:00

abstract：:Linomide (quinoline-3-carboxamide), a well tolerated, orally administered compound was recently shown to be effective in the prevention and treatment of several autoimmune diseases in experimental animal models. We have investigated its effect on specific humoral immune responses directed to T-cell-dependent soluble o...

journal_title：Autoimmunity

authors： Morecki S,Nabet C,Falk P,Fridkis-Hareli M,Pecht I,Mond JJ,Slavin S

更新日期：1997-01-01 00:00:00