Abstract:
:Hybridoma cell lines producing natural autoantibodies (NAA), generated from A.SW mice with progressive experimental autoimmune encephalomyelitis (P-EAE), have been shown to cause demyelination and renal pathology when injected into naive mice. To investigate the relative contribution of these antibodies to disease pathogenesis, B-1 cells, the major producers of NAA, were depleted by hypotonic shock. Depletion of B-1 cells during the effector phase of EAE significantly decreased the severity of demyelination and overall pathology in the brain. There was also a decreased incidence of P-EAE and a decrease in clinical score. Depletion during the induction phase of the disease resulted in an increase in the incidence of P-EAE and in the clinical score. Overall, B-1 cells were found to modulate EAE pathogenesis.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Peterson LK,Tsunoda I,Fujinami RSdoi
10.1080/08916930801890280subject
Has Abstractpub_date
2008-08-01 00:00:00pages
353-62issue
5eissn
0891-6934issn
1607-842Xpii
793974989journal_volume
41pub_type
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