Association of ANCA-associated vasculitis-rheumatoid arthritis overlap syndrome in four patients: rituximab may be the right choice?

abstract：:Subcutaneous insulin treatment of young diabetes prone BB rats has been shown previously to suppress the development of autoimmune diabetes. In this study the hypothesis was tested that exogenous insulin may deviate the autoimmune process by acting on the Th1/Th2 cytokine balance in the pancreas. BB rats were implante...

journal_title：Autoimmunity

authors： Kolb H,Wörz-Pagenstert U,Kleemann R,Rothe H,Rowsell P,Rastegar S,Scott FW

更新日期：1997-01-01 00:00:00

abstract：:The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...

journal_title：Autoimmunity

authors： Rask L,Jonsson AK,Svensson AC,Gustafsson K,Andersson L

更新日期：1991-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are evolutionary conserved molecules that recognize various microbial components and host-derived agonists from damaged cells and play a central role in innate and adaptive immunity. It has been reported that MyD88, the adaptor molecule downstream of all TLRs, except TLR3, is essential for i...

journal_title：Autoimmunity

authors： Pagni PP,Traub S,Demaria O,Chasson L,Alexopoulou L

更新日期：2010-06-01 00:00:00

abstract：:Five separate monoclonal antibodies (MoAbs) to human thyroid peroxidase (hTPO) were raised by immunising Balb/c mice with hTPO purified from detergent solubilised thyroid microsomes by high performance liquid chromatography (HPLC). The epitope specificities of these MoAbs were determined by assessing their ability to ...

journal_title：Autoimmunity

authors： Ewins DL,Barnett PS,Tomlinson RW,McGregor AM,Banga JP

更新日期：1992-01-01 00:00:00

abstract：:Interleukin (IL)-15 and CD30 may be associated with the ongoing intestinal immunologic activation in celiac disease (CD). We studied duodenal biopsies and blood samples of patients with active CD (Cel) and controls in order to determine the regulatory role proposed for CD30(+) T cells in this Th1-driven disease and th...

journal_title：Autoimmunity

authors： Periolo N,Guillén L,Bernardo D,Niveloni SI,Hwang HJ,Garrote JA,Bai JC,Arranz E,Cherñavsky AC

更新日期：2010-06-01 00:00:00

abstract：:On different tissue sections, binding of gliadin to reticular matrix components was observed which was Ca2+-dependent, inhibited by Cu2+ and Zn2+ ions, by putrescine, and by preincubation with antibodies against tissue transglutaminase (tTG) suggesting that binding of gliadin is mediated by tTG. tTG was able to bind t...

journal_title：Autoimmunity

authors： Uhlig H,Osman AA,Tanev ID,Viehweg J,Mothes T

更新日期：1998-01-01 00:00:00

abstract：:This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-re...

journal_title：Autoimmunity

authors： Suleyman S,Kasp E,Ellis B,Banga JP,Dumonde DC

更新日期：1991-01-01 00:00:00

abstract：:Autoantigen-reactive T lymphocytes have been implicated in the pathogenesis organ-specific autoimmune disease. Thyroglobulin (Tg) is one of the primary autoantigens associated with autoimmune lymphocytic thyroiditis (LT). These experiments investigated the pathogenicity of a lymphocyte line derived from spontaneously-...

journal_title：Autoimmunity

authors： Allen EM,Thupari JN

更新日期：1996-01-01 00:00:00

abstract：:We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly. This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/l) mice in relation to age, disease manifestations and the expression of lymphocyte homing ...

journal_title：Autoimmunity

authors： Schrieber L,Manolios N,Cohen MG,Paull SA,Guiffre AK,Hopper KE

更新日期：1989-01-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...

journal_title：Autoimmunity

authors： Fransen JH,Berden JH,Koeter CM,Adema GJ,Van Der Vlag J,Hilbrands LB

更新日期：2012-06-01 00:00:00

abstract：:DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...

journal_title：Autoimmunity

authors： Pisetsky DS,Fairhurst AM

更新日期：2007-06-01 00:00:00

abstract：:Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis. Using indirect immunofluorescence on ethanol-fixed neutrophils, two major fluoroscopic patterns can be recognised: a diffuse cytoplasmic staining (C-ANCA), and a perinuclear/nuclear staining (P-ANC...

journal_title：Autoimmunity

authors： Radice A,Sinico RA

更新日期：2005-02-01 00:00:00

abstract：:Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore,...

journal_title：Autoimmunity

authors： Sarter K,Kulagin M,Schett G,Harris NL,Zaiss MM

更新日期：2017-05-01 00:00:00

abstract：:Anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of autoantibody (AAb) to phospholipid (PL)-binding proteins, such as beta2-glycoprotein I (beta2GPI), and clinical manifestations including thrombosis and/or recurrent pregnancy loss. beta2GPI-reactive T cells are clearly implicat...

journal_title：Autoimmunity

authors： Tolomeo T,Rico De Souza A,Roter E,Dieudé M,Amireault P,Subang R,Levine JS,Rauch J

更新日期：2009-05-01 00:00:00

abstract：:Glucocorticoids (GCs) strongly impact on different T cell subsets inducing generally immunosuppressive effects, whereas much less is known about the effect of GC on natural killer (NK) cells. The aims of this study were to investigate the effects of GC on T cell functions, including T cell-mediated anti-tumor immune r...

journal_title：Autoimmunity

authors： Yakimchuk K,Chen L,Hasni MS,Okret S,Jondal M

更新日期：2015-03-01 00:00:00

abstract：:Immune profiling of non-obese diabetic (NOD) is a widely employed tool to assess the mechanisms of inflammatory insulitis. Our analysis of the female NOD colony revealed similar distribution of lymphoid lineages to wild type mice, and at various ages of prediabetic and diabetic mice. The profiles of mesenteric and pan...

journal_title：Autoimmunity

authors： Kaminitz A,Mizrahi K,Askenasy N

更新日期：2014-03-01 00:00:00

abstract：:Embryonic tissue expresses a very low level of MHC molecules, and these few appear only late in ontogeny. Possibly related are deficiencies in the expression of TAP molecules and also the fetus' need to avoid maternal immunologic rejection. However, the fetus may overcome the lack of Ag-presenting molecules when threa...

journal_title：Autoimmunity

authors： Lee MS,Sarvetnick N

更新日期：1997-01-01 00:00:00

abstract：:Worldwide population studies have generally agreed that rheumatoid arthritis (RA) is associated with a group of HLA-DRB1 alleles which share a common amino acid sequence at residues 70-74. This represents the first study to investigate the association of HLA-DRB1 genes with susceptibility to RA amongst Malay, Chinese ...

journal_title：Autoimmunity

authors： Kong KF,Yeap SS,Chow SK,Phipps ME

更新日期：2002-07-01 00:00:00

abstract：:Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune...

journal_title：Autoimmunity

authors： Gatselis NK,Vakrakou AG,Zachou K,Androutsakos T,Azariadis K,Hatzis G,Manoussakis MN,Dalekos GN

更新日期：2017-03-01 00:00:00

abstract：:Hybridoma cell lines producing natural autoantibodies (NAA), generated from A.SW mice with progressive experimental autoimmune encephalomyelitis (P-EAE), have been shown to cause demyelination and renal pathology when injected into naive mice. To investigate the relative contribution of these antibodies to disease pat...

journal_title：Autoimmunity

authors： Peterson LK,Tsunoda I,Fujinami RS

更新日期：2008-08-01 00:00:00

abstract：:A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...

journal_title：Autoimmunity

authors： Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

更新日期：2006-09-01 00:00:00

abstract：:Evidence is growing that autoimmune reactivity results from a combination of endogenous (e.g. MHC type) and environmental factors. Our experimental study focuses on the induction of autoimmune reactivity by microbial factors. Splenic formation and serum levels of anti-erythrocyte antibodies and circulating immune comp...

journal_title：Autoimmunity

authors： Hol C,Bloembergen P,van Dijk H

更新日期：1993-01-01 00:00:00

abstract：:The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...

journal_title：Autoimmunity

authors： Canti V,Castiglioni MT,Rosa S,Franchini S,Sabbadini MG,Manfredi AA,Rovere-Querini P

更新日期：2012-03-01 00:00:00

abstract：INTRODUCTION:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice ...

journal_title：Autoimmunity

authors： Dos Santos M,Poletti PT,Favero G,Stacchiotti A,Bonomini F,Montanari CC,Bona SR,Marroni NP,Rezzani R,Veronese FV

更新日期：2018-03-01 00:00:00

abstract：:The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencie...

journal_title：Autoimmunity

authors： Truedsson L,Bengtsson AA,Sturfelt G

更新日期：2007-12-01 00:00:00

abstract：:A large number of malaria immune persons from Eastern India were found to possess antibodies to the ribosomal phosphoprotein P0 (PfP0) of the human malarial parasite Plasmodium falciparum. The characterization of PfP0 has been reported recently, and it has been shown that antibodies against PfP0 inhibit P. falciparum ...

journal_title：Autoimmunity

authors： Singh S,Chatterjee S,Sohoni R,Badakere S,Sharma S

更新日期：2001-01-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells represent an important regulatory T-cell subset that perceives signals of danger and/or cellular distress and modulate the adaptive immune response accordingly. In the presence of pathogens, iNKT cells acquire an adjuvant function that is fundamental to boost anti-microbial and ...

journal_title：Autoimmunity

authors： Caielli S,Sorini C,Falcone M

更新日期：2011-02-01 00:00:00

abstract：:CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...

journal_title：Autoimmunity

authors： Martens HA,Kallenberg CG,Bijl M

更新日期：2009-05-01 00:00:00

abstract：:In the 1950s, the discovery of autoantibodies produced by B cells seemed to provide a compelling mechanism underlying autoimmune diseases. The discovery of T regulatory cells and other T helper cell subsets shifted the field back towards a T cell central view. The success of rituxan, a chimeric mAb targeting CD20 on B...

journal_title：Autoimmunity

authors： Luu VP,Vazquez MI,Zlotnik A

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...

journal_title：Autoimmunity

authors： Bossowski A,Stożek K,Rydzewska M,Niklińska W,Gąsowska M,Polnik D,Szalecki M,Mikłosz A,Chabowski A,Reszeć J

更新日期：2020-11-01 00:00:00