听力与言语-语言病理学

行为科学

医学伦理学

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  • Implications of Nonphysiological Ovarian Primordial Follicle Activation for Fertility Preservation.

    abstract::In recent years, ovarian tissue cryopreservation has rapidly developed as a successful method for preserving the fertility of girls and young women with cancer or benign conditions requiring gonadotoxic therapy, and is now becoming widely recognized as an effective alternative to oocyte and embryo freezing when not fe...

    journal_title:Endocrine reviews

    pub_type: 杂志文章

    doi:10.1210/endrev/bnaa020

    authors: Grosbois J,Devos M,Demeestere I

    更新日期:2020-12-01 00:00:00

  • Novel Insights into Pituitary Tumorigenesis: Genetic and Epigenetic Mechanisms.

    abstract::Substantial advances have been made recently in the pathobiology of pituitary tumors. Similar to many other endocrine tumors, over the last few years we have recognized the role of germline and somatic mutations in a number of syndromic or nonsyndromic conditions with pituitary tumor predisposition. These include the ...

    journal_title:Endocrine reviews

    pub_type: 杂志文章

    doi:10.1210/endrev/bnaa006

    authors: Srirangam Nadhamuni V,Korbonits M

    更新日期:2020-12-01 00:00:00

  • Realizing a Closed-Loop (Artificial Pancreas) System for the Treatment of Type 1 Diabetes.

    abstract::Recent, rapid changes in the treatment of type 1 diabetes have allowed for commercialization of an "artificial pancreas" that is better described as a closed-loop controller of insulin delivery. This review presents the current state of closed-loop control systems and expected future developments with a discussion of ...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2018-00174

    authors: Lal RA,Ekhlaspour L,Hood K,Buckingham B

    更新日期:2019-12-01 00:00:00

  • Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries.

    abstract::This review presents a comprehensive discussion of the clinical condition of delayed puberty, a common presentation to the pediatric endocrinologist, which may present both diagnostic and prognostic challenges. Our understanding of the genetic control of pubertal timing has advanced thanks to active investigation in t...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2018-00248

    authors: Howard SR,Dunkel L

    更新日期:2019-10-01 00:00:00

  • Endometriosis.

    abstract::Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pe...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2018-00242

    authors: Bulun SE,Yilmaz BD,Sison C,Miyazaki K,Bernardi L,Liu S,Kohlmeier A,Yin P,Milad M,Wei J

    更新日期:2019-08-01 00:00:00

  • Potential Clinical Error Arising From Use of HbA1c in Diabetes: Effects of the Glycation Gap.

    abstract::The glycation gap (GGap) and the similar hemoglobin glycation index (HGI) define consistent differences between glycated hemoglobin and actual glycemia derived from fructosamine or mean blood glucose, respectively. Such a disparity may be found in a substantial proportion of people with diabetes, being >1 U of glycate...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2018-00284

    authors: Nayak AU,Singh BM,Dunmore SJ

    更新日期:2019-08-01 00:00:00

  • Growth Hormone's Links to Cancer.

    abstract::Several components of the GH axis are involved in tumor progression, and GH-induced intracellular signaling has been strongly associated with breast cancer susceptibility in genome-wide association studies. In the general population, high IGF-I levels and low IGF-binding protein-3 levels within the normal range are as...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2018-00166

    authors: Boguszewski CL,Boguszewski MCDS

    更新日期:2019-04-01 00:00:00

  • Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.

    abstract::Immune checkpoints are small molecules expressed by immune cells that play critical roles in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD-1) with inhibitory antibodies has demonstrated effective and durable antitumor ac...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2018-00006

    authors: Chang LS,Barroso-Sousa R,Tolaney SM,Hodi FS,Kaiser UB,Min L

    更新日期:2019-02-01 00:00:00

  • Insulin-like Growth Factor-I Receptor and Thyroid-Associated Ophthalmopathy.

    abstract::Thyroid-associated ophthalmopathy (TAO) is a complex disease process presumed to emerge from autoimmunity occurring in the thyroid gland, most frequently in Graves disease (GD). It is disfiguring and potentially blinding, culminating in orbital tissue remodeling and disruption of function of structures adjacent to the...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2018-00066

    authors: Smith TJ,Janssen JAMJL

    更新日期:2019-02-01 00:00:00

  • Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms.

    abstract::There has been an alarming increase in the prevalence of obesity in people with type 1 diabetes in recent years. Although obesity has long been recognized as a major risk factor for the development of type 2 diabetes and a catalyst for complications, much less is known about the role of obesity in the initiation and p...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2017-00191

    authors: Corbin KD,Driscoll KA,Pratley RE,Smith SR,Maahs DM,Mayer-Davis EJ,Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON).

    更新日期:2018-10-01 00:00:00

  • X-Linked Hypophosphatemia and FGF23-Related Hypophosphatemic Diseases: Prospect for New Treatment.

    abstract::Phosphate plays essential roles in many biological processes, and the serum phosphate level is tightly controlled. Chronic hypophosphatemia causes impaired mineralization of the bone matrix and results in rickets and osteomalacia. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate m...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2017-00220

    authors: Kinoshita Y,Fukumoto S

    更新日期:2018-06-01 00:00:00

  • 11β-HSD1 in Human Fetal Membranes as a Potential Therapeutic Target for Preterm Birth.

    abstract::Human parturition is a complex process involving interactions between the myometrium and signals derived from the placenta, fetal membranes, and fetus. Signals originating from fetal membranes are crucial components that trigger parturition, which is clearly illustrated by the labor-initiating consequence of membrane ...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2017-00188

    authors: Wang W,Chen ZJ,Myatt L,Sun K

    更新日期:2018-06-01 00:00:00

  • Ovarian Follicular Theca Cell Recruitment, Differentiation, and Impact on Fertility: 2017 Update.

    abstract::The major goal of this review is to summarize recent exciting findings that have been published within the past 10 years that, to our knowledge, have not been presented in detail in previous reviews and that may impact altered follicular development in polycystic ovarian syndrome (PCOS) and premature ovarian failure i...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2017-00164

    authors: Richards JS,Ren YA,Candelaria N,Adams JE,Rajkovic A

    更新日期:2018-02-01 00:00:00

  • Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms.

    abstract::Access to effective affordable contraception is critical for individual and public health. A wide range of hormonal contraceptives (HCs), which differ in composition, concentration of the progestin component, frequency of dosage, and method of administration, is currently available globally. However, the options are r...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2017-00103

    authors: Hapgood JP,Kaushic C,Hel Z

    更新日期:2018-02-01 00:00:00

  • The Hippo Signaling Pathway in Pancreatic β-Cells: Functions and Regulations.

    abstract::Hippo signaling is an evolutionarily conserved pathway that critically regulates development and homeostasis of various tissues in response to a wide range of extracellular and intracellular signals. As an emerging important player in many diseases, the Hippo pathway is also involved in the pathophysiology of diabetes...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2017-00167

    authors: Ardestani A,Maedler K

    更新日期:2018-02-01 00:00:00

  • The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited.

    abstract::Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989-1995. Subsequent studies have supported and amplified this hypothesis. When defined as otherwise unexplained hyperandrogenic oligoanovulation, two-thirds of PCOS...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2015-1104

    authors: Rosenfield RL,Ehrmann DA

    更新日期:2016-10-01 00:00:00

  • Role of complement and complement regulatory proteins in the complications of diabetes.

    abstract::It is well established that the organ damage that complicates human diabetes is caused by prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels of glucose cause tissue damage in humans are still not fully understood. The prevalent hypothesis explaining the mechanisms that may underlie...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2014-1099

    authors: Ghosh P,Sahoo R,Vaidya A,Chorev M,Halperin JA

    更新日期:2015-06-01 00:00:00

  • From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease.

    abstract::Long noncoding RNAs (lncRNAs) are a relatively poorly understood class of RNAs with little or no coding capacity transcribed from a set of incompletely annotated genes. They have received considerable attention in the past few years and are emerging as potentially important players in biological regulation. Here we di...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2014-1034

    authors: Sun M,Kraus WL

    更新日期:2015-02-01 00:00:00

  • Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions.

    abstract::TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary-thyroid axis. Hypophysiotropic TRH neurons involved in this neuroendocrine process are located in the hypothalamic paraventricular nucleus an...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2013-1087

    authors: Fekete C,Lechan RM

    更新日期:2014-04-01 00:00:00

  • The rachitic tooth.

    abstract::Teeth are mineralized organs composed of three unique hard tissues, enamel, dentin, and cementum, and supported by the surrounding alveolar bone. Although odontogenesis differs from osteogenesis in several respects, tooth mineralization is susceptible to similar developmental failures as bone. Here we discuss conditio...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2013-1009

    authors: Foster BL,Nociti FH Jr,Somerman MJ

    更新日期:2014-02-01 00:00:00

  • The role of adiponectin in cancer: a review of current evidence.

    abstract::Excess body weight is associated not only with an increased risk of type 2 diabetes and cardiovascular disease (CVD) but also with various types of malignancies. Adiponectin, the most abundant protein secreted by adipose tissue, exhibits insulin-sensitizing, antiinflammatory, antiatherogenic, proapoptotic, and antipro...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2011-1015

    authors: Dalamaga M,Diakopoulos KN,Mantzoros CS

    更新日期:2012-08-01 00:00:00

  • The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases.

    abstract::Insulin signaling plays a physiological role in traditional insulin target tissues controlling glucose homeostasis as well as in pancreatic β-cells and in the endothelium. Insulin signaling abnormalities may, therefore, be pathogenic for insulin resistance, impaired insulin secretion, endothelial dysfunction, and even...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2011-1042

    authors: Prudente S,Sesti G,Pandolfi A,Andreozzi F,Consoli A,Trischitta V

    更新日期:2012-08-01 00:00:00

  • Paracrine and endocrine effects of adipose tissue on cancer development and progression.

    abstract::The past few years have provided substantial evidence for the vital role of the local tumor microenvironment for various aspects of tumor progression. With obesity and its pathophysiological sequelae still on the rise, the adipocyte is increasingly moving center stage in the context of tumor stroma-related studies. To...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2010-0030

    authors: Park J,Euhus DM,Scherer PE

    更新日期:2011-08-01 00:00:00

  • Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.

    abstract::Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been us...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2010-0009

    authors: List EO,Sackmann-Sala L,Berryman DE,Funk K,Kelder B,Gosney ES,Okada S,Ding J,Cruz-Topete D,Kopchick JJ

    更新日期:2011-06-01 00:00:00

  • Coup d'Etat: an orphan takes control.

    abstract::Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) belong to the steroid/thyroid hormone receptor superfamily. Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because li...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2010-0021

    authors: Lin FJ,Qin J,Tang K,Tsai SY,Tsai MJ

    更新日期:2011-06-01 00:00:00

  • The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.

    abstract::Steroidogenesis entails processes by which cholesterol is converted to biologically active steroid hormones. Whereas most endocrine texts discuss adrenal, ovarian, testicular, placental, and other steroidogenic processes in a gland-specific fashion, steroidogenesis is better understood as a single process that is repe...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2010-0013

    authors: Miller WL,Auchus RJ

    更新日期:2011-02-01 00:00:00

  • Role of platelet-derived growth factors in the testis.

    abstract::Normal development and function of the testis are controlled by endocrine and paracrine signaling pathways. Platelet-derived growth factors (PDGFs) are growth factors that mediate epithelial-mesenchymal interactions in various tissues during normal and abnormal processes such as embryo development, wound healing, tiss...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2010-0004

    authors: Basciani S,Mariani S,Spera G,Gnessi L

    更新日期:2010-12-01 00:00:00

  • The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges.

    abstract::Ovarian steroids normally exert homeostatic negative feedback on GnRH release. During sustained exposure to elevated estradiol in the late follicular phase of the reproductive cycle, however, the feedback action of estradiol switches to positive, inducing a surge of GnRH release from the brain, which signals the pitui...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2009-0023

    authors: Christian CA,Moenter SM

    更新日期:2010-08-01 00:00:00

  • Small G proteins in islet beta-cell function.

    abstract::Glucose-stimulated insulin secretion from the islet beta-cell involves a sequence of metabolic events and an interplay between a wide range of signaling pathways leading to the generation of second messengers (e.g., cyclic nucleotides, adenine and guanine nucleotides, soluble lipid messengers) and mobilization of calc...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2009-0022

    authors: Kowluru A

    更新日期:2010-02-01 00:00:00

  • Molecular mechanisms underlying the activation of mammalian primordial follicles.

    abstract::In humans and other mammalian species, the pool of resting primordial follicles serves as the source of developing follicles and fertilizable ova for the entire length of female reproductive life. One question that has intrigued biologists is: what are the mechanisms controlling the activation of dormant primordial fo...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2008-0048

    authors: Adhikari D,Liu K

    更新日期:2009-08-01 00:00:00

  • Iodine deficiency.

    abstract::Iodine deficiency has multiple adverse effects in humans, termed iodine deficiency disorders, due to inadequate thyroid hormone production. Globally, it is estimated that 2 billion individuals have an insufficient iodine intake, and South Asia and sub-Saharan Africa are particularly affected. However, about 50% of Eur...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2009-0011

    authors: Zimmermann MB

    更新日期:2009-06-01 00:00:00

  • Vitamin D and human health: lessons from vitamin D receptor null mice.

    abstract::The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D], can now be better evaluated by critical analysis of mice with engineered deletion of the vitamin D receptor (VD...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2008-0004

    authors: Bouillon R,Carmeliet G,Verlinden L,van Etten E,Verstuyf A,Luderer HF,Lieben L,Mathieu C,Demay M

    更新日期:2008-10-01 00:00:00

  • Clinical, agricultural, and evolutionary biology of myostatin: a comparative review.

    abstract::The discovery of myostatin and our introduction to the "Mighty Mouse" over a decade ago spurred both basic and applied research and impacted popular culture as well. The myostatin-null genotype produces "double muscling" in mice and livestock and was recently described in a child. The field's rapid growth is by no mea...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2008-0003

    authors: Rodgers BD,Garikipati DK

    更新日期:2008-08-01 00:00:00

  • Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.

    abstract::Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and cardiovascular disease. Sphingolipids such as ceramide and glucosylceramides, while being a relatively minor component of the lipid milieu in most tissues, may be among the most pathogenic lipids in the onset of the sequelae assoc...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2007-0025

    authors: Holland WL,Summers SA

    更新日期:2008-06-01 00:00:00

  • Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.

    abstract::Osteoclasts and osteoblasts dictate skeletal mass, structure, and strength via their respective roles in resorbing and forming bone. Bone remodeling is a spatially coordinated lifelong process whereby old bone is removed by osteoclasts and replaced by bone-forming osteoblasts. The refilling of resorption cavities is i...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2007-0014

    authors: Kearns AE,Khosla S,Kostenuik PJ

    更新日期:2008-04-01 00:00:00

  • The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.

    abstract::Insulin resistance is a major feature of most patients with type 2 diabetes mellitus (T2D). A number of laboratories have observed that PC-1 (membrane [corrected] glycoprotein plasma cell antigen 1; also termed [corrected] ectonucleotide pyrophosphatase phosphodiesterase 1 or ENPP1) [corrected] is either overexpressed...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2007-0004

    authors: Goldfine ID,Maddux BA,Youngren JF,Reaven G,Accili D,Trischitta V,Vigneri R,Frittitta L

    更新日期:2008-02-01 00:00:00

  • Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women.

    abstract::Breast cancer, the second most common cause of cancer-related deaths in American women, varies substantially in incidence and mortality according to race and ethnicity in the United States. Although the overall incidence of breast cancer among African-American (AA) women is lower than in white American women, this can...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2006-0019

    authors: Rose DP,Haffner SM,Baillargeon J

    更新日期:2007-12-01 00:00:00

  • Extranuclear steroid receptors: nature and actions.

    abstract::Rapid effects of steroid hormones result from the actions of specific receptors localized most often to the plasma membrane. Fast-acting membrane-initiated steroid signaling (MISS) leads to the modification of existing proteins and cell behaviors. Rapid steroid-triggered signaling through calcium, amine release, and k...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2007-0022

    authors: Hammes SR,Levin ER

    更新日期:2007-12-01 00:00:00

  • Adipose tissue-derived factors: impact on health and disease.

    abstract::The endocrine functions of the adipose organ are widely studied at this stage. The adipose organ, and in particular adipocytes, communicate with almost all other organs. Although some adipose tissue pads assume the functions as distinct "miniorgans," adipocytes can also be present in smaller numbers interspersed with ...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2006-0033

    authors: Trujillo ME,Scherer PE

    更新日期:2006-12-01 00:00:00

  • Gut peptides in the regulation of food intake and energy homeostasis.

    abstract::Gut hormones signal to the central nervous system to influence energy homeostasis. Evidence supports the existence of a system in the gut that senses the presence of food in the gastrointestinal tract and signals to the brain via neural and endocrine mechanisms to regulate short-term appetite and satiety. Recent evide...

    journal_title:Endocrine reviews

    pub_type: 杂志文章,评审

    doi:10.1210/er.2006-0028

    authors: Murphy KG,Dhillo WS,Bloom SR

    更新日期:2006-12-01 00:00:00

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