abstract：:On the basis of the evidence that extracellular Zn2+ influx induced with AMPA causes Parkinson's syndrome in rats that apomorphine-induced movement disorder emerges, here we used a low dose of AMPA, which does not increase intracellular Zn2+ level in the substantia nigra pars compacta (SNpc) of young adult rats, and t...

journal_title：Neurotoxicology

authors： Nakajima S,Saeki N,Tamano H,Nishio R,Katahira M,Takeuchi A,Takeda A

更新日期：2021-01-02 00:00:00

abstract：:1-Methyl-4-phenylpyridinium ion (MPP+)-induced neurotoxicity produces cellular damage resembling that encountered in Parkinson's disease. The mechanisms of cellular death after MPP+ include the participation of oxidative stress in the loss of dopaminergic neurons. Among the mechanisms of defense against oxidative stre...

journal_title：Neurotoxicology

authors： Islas-Cortez M,Rios C,Rubio-Osornio M,Zamudio S,Orozco-Suarez S,Mendez-Armenta M,Nava-Ruiz C,Diaz-Ruiz A

更新日期：2021-01-01 00:00:00

abstract：:Cognitive dysfunction has been reported in patients with carbon monoxide (CO) poisoning. However, the underpinning mechanism remained unclear. This study examined dopamine transporter (DAT) and metabolite ratios concurrently and their relationships with cognitive dysfunction in CO poisoning. Eighteen suicide attempter...

journal_title：Neurotoxicology

authors： Yang KC,Yang BH,Lirng JF,Liu MN,Hu LY,Liou YJ,Chan LA,Chou YH

更新日期：2021-01-01 00:00:00

abstract：:Bisphenol A (BPA) is a ubiquitous environmental chemical that has been linked to behavioral differences in children and shown to impact critical neurodevelopmental processes in animal models. Though data is emerging, we still have an incomplete picture of how BPA disrupts neurodevelopment; in particular, how its impac...

journal_title：Neurotoxicology

authors： Nguyen U,Tinsley B,Sen Y,Stein J,Palacios Y,Ceballos A,Welch C,Nzenkue K,Penn A,Murphy L,Leodones K,Casiquin J,Ivory I,Ghenta K,Danziger K,Widman E,Newman J,Triplehorn M,Hindi Z,Mulligan K

更新日期：2021-01-01 00:00:00

abstract：:Continuous globalization and industrialization have ensured metals are an increasing aspect of daily life. Their usefulness in manufacturing has made them vital to national commerce, security and global economy. However, excess exposure to metals, particularly as a result of environmental contamination or occupational...

journal_title：Neurotoxicology

authors： Ijomone OM,Ijomone OK,Iroegbu JD,Ifenatuoha CW,Olung NF,Aschner M

更新日期：2020-12-01 00:00:00

abstract：:Indiscriminate overuse or occupational exposure to agricultural chemicals can lead to neurotoxicity. Many pesticides act to impair mitochondrial function which can lead to exacerbation of neurodegeneration. Triazole fungicides are applied to grain, fruit, and vegetable crops to combat mold and fungi and their use is i...

journal_title：Neurotoxicology

authors： Sanchez CL,Souders CL 2nd,Pena-Delgado CJ,Nguyen KT,Kroyter N,Ahmadie NE,Aristizabal-Henao JJ,Bowden JA,Martyniuk CJ

更新日期：2020-09-01 00:00:00

abstract：:Zinc is the second abundant trace element in the human central nervous system (CNS). Zinc homeostasis is impaired in the elderly population and Alzheimer's disease (AD) patients. Due to the failures of β-amyloid (Aβ)- and microtubule-associated protein tau (MAP-tau, tau)-targeting drugs, many researchers consider AD a...

journal_title：Neurotoxicology

authors： Xie Z,Wu H,Zhao J

更新日期：2020-09-01 00:00:00

abstract：:Ionizing radiation (IR) is increasingly used for diagnostics and therapy of severe brain diseases. However, IR also has adverse effects on the healthy brain tissue, particularly on the neuronal network. This is true for adults but even more pronounced in the developing brain of unborn and pediatric patients. Epidemiol...

journal_title：Neurotoxicology

authors： Mayer M,Arrizabalaga O,Ciba M,Schroeder IS,Ritter S,Thielemann C

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Methanol is a widely used industrial short-chain aliphatic alcohol with known neurotoxic properties. Mass poisoning outbreaks due to the consumption of methanol-adulterated alcoholic drinks present a challenge to healthcare providers due to the high mortality and serious central nervous system (CNS) damage i...

journal_title：Neurotoxicology

authors： Kotikova K,Klepis P,Ridzon P,Hlusicka J,Navratil T,Rulisek J,Zak I,Zakharov S

更新日期：2020-07-01 00:00:00

abstract：:Epilepsy is a complex and multifactorial neurodegenerative disease described by recurrent seizures. Oxidative stress and dysregulation of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) are critical factors for the development of epilepsy. Daidzin is well-known for its effective ...

journal_title：Neurotoxicology

authors： Kazmi Z,Zeeshan S,Khan A,Malik S,Shehzad A,Seo EK,Khan S

更新日期：2020-07-01 00:00:00

abstract：:Prenatal ethanol exposure affects brain development and causes neural impairment, leading to both cognitive and behavioral consequences in the offspring. Therefore, the aim of this study was to investigate the impact of prenatal exposure to small amounts of alcohol on social play behavior in adolescent male offspring....

journal_title：Neurotoxicology

authors： de Ávila MAP,Gonçalves RM,Nascimento ECC,Cabral LDM,Vilela FC,Giusti-Paiva A

更新日期：2020-07-01 00:00:00

abstract：:The increasing use of illegal drugs by pregnant women causes a public health concern because it is associated with health risks for mothers and their developing children. One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or ecstasy due to its high consumption in relevant age and sex groups and its adverse ...

journal_title：Neurotoxicology

authors： Barenys M,Reverte I,Masjosthusmann S,Gómez-Catalán J,Fritsche E

更新日期：2020-05-01 00:00:00

abstract：:The potential health risks of cannabis are of growing concern, including effects on reproduction and development. Extensive research has investigated risks associated with maternal exposure to THC during gestation and its impacts on the development of offspring, but little research has been done regarding paternal THC...

journal_title：Neurotoxicology

authors： Holloway ZR,Hawkey AB,Pippin E,White H,Wells C,Kenou B,Rezvani AH,Murphy SK,Levin ED

更新日期：2020-05-01 00:00:00

abstract：:Gulf War Illness (GWI) manifests a multitude of symptoms, including neurological and immunological, and approximately a third of the 1990-1991 Gulf War (GW) veterans suffer from it. This study sought to characterize the acute neurochemical (monoamine) and neuroinflammatory profiles of two established GWI animal models...

journal_title：Neurotoxicology

authors： Carpenter JM,Gordon HE,Ludwig HD,Wagner JJ,Harn DA,Norberg T,Filipov NM

更新日期：2020-03-01 00:00:00

abstract：AIMS:The aim of the present study was to evaluate the toxicity of magnetic iron oxide nanoparticles (MIONs) which were synthesized using carob leaf extract on various brain areas of Wistar rats. MAIN METHODS:Carob leaf synthesized-MIONs were characterized using different techniques: Dynamic Light Scattering (DLS), Tra...

journal_title：Neurotoxicology

authors： Fahmy HM,Aly EM,Mohamed FF,Noor NA,Elsayed AA

更新日期：2020-03-01 00:00:00

abstract：:The organophosphorus insecticide chlorpyrifos (CPF) is suspected to cause developmental neurotoxicity in children leading to long term effects. Developmental exposure of rat pups to CPF at low levels disrupts degradation of the brain endocannabinoids through the inhibition of fatty acid amide hydrolase (FAAH) and decr...

journal_title：Neurotoxicology

authors： Carr RL,Alugubelly N,de Leon K,Loyant L,Mohammed AN,Patterson ME,Ross MK,Rowbotham NE

更新日期：2020-03-01 00:00:00

abstract：:Malaria is an infectious disease that is caused by different species of Plasmodium. Several antimalarial drugs are used to counter the spread and infectivity of Plasmodium species. However, humans are also vulnerable to many of the antimalarial drugs, including the quinoline-based drugs. In particular, the antimalaria...

journal_title：Neurotoxicology

authors： Kumar A,Ghosh DK,Ranjan A

更新日期：2020-03-01 00:00:00

abstract：:Given the well-known antioxidant and neuroprotective properties of quercetin, the aim of this work was to evaluate the effects of quercetin stabilized by microencapsulation at two doses (10 mg kg-1 and 100 mg kg-1) on the oxidative/antioxidant status, number and morphological features of ICC, nitrergic neurons and M2-...

journal_title：Neurotoxicology

authors： Vieira-Frez FC,Sehaber-Sierakowski CC,Perles JVCM,Bossolani GDP,Verri WA Jr,Nascimento RCD,Guarnier FA,Bordini HP,Blegniski FP,Martins HA,de Souza SRG,Lima FGDM,Lima MM,Silva BT,Iwanaga CC,Zanoni JN

更新日期：2020-03-01 00:00:00

abstract：:New European legislation known as REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) was introduced in 2007 to increase the speed at which the health and/or environmental risks of industrial chemicals were being assessed and managed (REACH (EC) No 1907/2006). REACH consolidated earlier chemic...

journal_title：Neurotoxicology

authors： Armstrong V,Karyakina NA,Nordheim E,Arnold I,Krewski D

更新日期：2020-02-10 00:00:00

abstract：:There is a need for in vitro tests for the evaluation of chemicals and pharmaceuticals that may cause developmental neurotoxicity (DNT) in humans. The neural embryonic stem cell test (ESTn) is such an in vitro test that mimics early neural differentiation. The aim of this study was to define the biological domain of E...

journal_title：Neurotoxicology

authors： de Leeuw VC,Hessel EVS,Pennings JLA,Hodemaekers HM,Wackers PFK,van Oostrom CTM,Piersma AH

更新日期：2020-01-01 00:00:00

abstract：:Developmentally-lead (Pb)-exposed rats showed an enhanced vulnerability to the stimulating and motivational effects of ethanol (EtOH). This is accompanied by differential activity of the brain EtOH-metabolizing enzymes catalase (CAT) and mitochondrial aldehyde dehydrogenase (ALDH2). Based on the theory that brain acet...

journal_title：Neurotoxicology

authors： Mattalloni MS,Deza-Ponzio R,Albrecht PA,Fernandez-Hubeid LE,Cancela LM,Virgolini MB

更新日期：2019-12-01 00:00:00

abstract：:Chronic use of methamphetamine (MA), a neurotoxic psychostimulant, leads to long-lasting cognitive dysfunctions in humans and animal models. Thyroid hormones (THs) have several physiological actions and are crucial for normal behavioral, intellectual and neurological development. Considering the importance of THs in t...

journal_title：Neurotoxicology

authors： Seyedhosseini Tamijani SM,Beirami E,Ahmadiani A,Dargahi L

更新日期：2019-09-01 00:00:00

abstract：:Volatile organic solvents are frequently present in industrial atmospheres. Their lipophilic properties mean they quickly reach the brain following inhalation. Acute exposure to some solvents perturbs the middle ear reflex, which could jeopardize cochlear protection against loud noises. As the physiological mechanisms...

journal_title：Neurotoxicology

authors： Wathier L,Venet T,Bonfanti E,Nunge H,Cosnier F,Parietti-Winkler C,Campo P,Pouyatos B

更新日期：2019-09-01 00:00:00

abstract：:Chlorpyrifos (CPF) is an organophosphorus pesticide that can damage the central nervous system in children upon exposure. Taxifolin (Tax) exerts protective effects against neurotoxins; however, the mechanism has not yet been illustrated. The current study used BV2 cells to investigate the protective mechanism underlyi...

journal_title：Neurotoxicology

authors： Zhang C,Zhan J,Zhao M,Dai H,Deng Y,Zhou W,Zhao L

更新日期：2019-09-01 00:00:00

abstract：:There are no Food and Drug Administration approved pharmacotherapies for methamphetamine (METH) overdose, thus identifying novel drug targets to prevent this devastating adverse event is a public-health imperative. Previous research suggests that serotonin and sigma receptors may contribute to the adverse effects of M...

journal_title：Neurotoxicology

authors： Ray A,Canal CE,Ehlen JC,Rice KC,Murnane KS

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Bisphenol A (BPA) has been associated with impairments in children's behavior, but few studies have investigated its relationship with cognitive function. OBJECTIVE:To investigate the association of urinary BPA concentrations with cognitive domains and intelligence quotient (IQ) in Spanish boys. METHODS:BP...

journal_title：Neurotoxicology

authors： Rodríguez-Carrillo A,Mustieles V,Pérez-Lobato R,Molina-Molina JM,Reina-Pérez I,Vela-Soria F,Rubio S,Olea N,Fernández MF

更新日期：2019-09-01 00:00:00

abstract：:Knowledge on the impact of the exposure to indoor ultrafine particles (UFPs) on the human brain is restricted. Twelve non-atopic, non-smoking, and healthy adults (10 female and 7 male, in average 22 years old) were monitored for brain physiological responses via electroencephalographs (EEGs) during cooking. Frying gro...

journal_title：Neurotoxicology

authors： Naseri M,Jouzizadeh M,Tabesh M,Malekipirbazari M,Gabdrashova R,Nurzhan S,Farrokhi H,Khanbabaie R,Mehri-Dehnavi H,Bekezhankyzy Z,Gimnkhan A,Dareini M,Kurmangaliyeva A,Islam N,Crape B,Buonanno G,Cassee F,Amouei Torkmahall

更新日期：2019-09-01 00:00:00

abstract：:In order to develop a better understanding of the role environmental toxicants may play in the onset and progression of neurodegenerative diseases, it has become increasingly important to optimize sensitive methods for quickly screening toxicants to determine their ability to disrupt neuronal function. The nematode Ca...

journal_title：Neurotoxicology

authors： Smith LL,Ryde IT,Hartman JH,Romersi RF,Markovich Z,Meyer JN

更新日期：2019-09-01 00:00:00

abstract：:Metals are involved in different pathophysiological mechanisms associated with neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS). The aim of this study was to review the effects of the essential metals zinc (Zn), copper (Cu), manganese (Mn) and ...

journal_title：Neurotoxicology

authors： Mezzaroba L,Alfieri DF,Colado Simão AN,Vissoci Reiche EM

更新日期：2019-09-01 00:00:00

abstract：:As obvious from the basic prerequisite of any particle in nanoscale, Zinc oxide nanoparticles (ZnO NPs) possess numerous tunable properties distinct from their bulk formulations. Emerging innovations in various sectors of nanotechnology are exploiting ZnO NPs largely. This inturn picks up the occasions of human exposu...

journal_title：Neurotoxicology

authors： Sudhakaran S,Athira SS,Mohanan PV

更新日期：2019-07-01 00:00:00

abstract：:Peripheral neuropathy, a chronic complication of diabetes mellitus (DM), is often accompanied by the onset of severe pain symptoms that affect quality of life. However, the underlying mechanisms remain elusive. In the present study, we used Sprague-Dawley rats to establish a rodent model of the human type 1 DM by a si...

journal_title：Neurotoxicology

authors： Liu CH,Lan CT,Chen LY,Liao WC,Ko MH,Tseng TJ

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Among the adverse health effects of exposure to pesticides, an association with diabetes has been reported. However, there is a lack of epidemiologic studies on the health effects of exposure to pesticides, particularly investigating the association between occupational pesticide exposure and diabetes preval...

journal_title：Neurotoxicology

authors： Park S,Kim SK,Kim JY,Lee K,Choi JR,Chang SJ,Chung CH,Park KS,Oh SS,Koh SB

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Occupational exposure to extremely low frequency magnetic fields (ELF-MF) occurs in many occupations such as welders, electric utility workers, train drivers and sewing machine operators. There is some evidence suggesting ELF-MF exposure to be a risk factor for Alzheimer's disease (AD). The current study a...

journal_title：Neurotoxicology

authors： Jalilian H,Teshnizi SH,Röösli M,Neghab M

更新日期：2018-12-01 00:00:00

abstract：:Ethanol is one of the most widely consumed drugs in the world, and the effects of ethanol during early development include morphological and cognitive problems. The regulation of adenosine levels is essential for the proper function of major neurotransmitter systems in the brain, particularly glutamate and dopamine; t...

journal_title：Neurotoxicology

authors： Haab Lutte A,Huppes Majolo J,Reali Nazario L,Da Silva RS

更新日期：2018-12-01 00:00:00

abstract：:Dexmedetomidine, a selective α2 adrenergic agonist, has been shown to have neuroprotective and anti-apoptotic effects. To further investigate the underlying mechanisms, we used a rat model of spinal neurotoxicity induced by intrathecal administration of lidocaine. Four days after intrathecal catheter implantation, rat...

journal_title：Neurotoxicology

authors： Xu H,Zhao B,She Y,Song X

更新日期：2018-12-01 00:00:00

abstract：:Oxaliplatin is a platinum-based drug used in the treatment of gastric cancers. Oxaliplatin treatment induces sensory neuropathy characterized by cold hypersensibility in the acute phase and sensory impairment when the neuropathy becomes chronic. In order to determine the effect of oxaliplatin on sensory neurons, we us...

journal_title：Neurotoxicology

authors： López-González MJ,Soula A,Landry M,Favereaux A

更新日期：2018-09-01 00:00:00

abstract：:Mercury is a heavy metal responsible for human intoxication worldwide and especially in the Amazon, where both natural and anthropogenic sources are responsible for exposure in riverine populations. Methylmercury is the most toxic specie of mercury with recognized neurotoxicity due to its affinity for the central nerv...

journal_title：Neurotoxicology

authors： de Paula Fonseca Arrifano G,Del Carmen Rodriguez Martin-Doimeadios R,Jiménez-Moreno M,Augusto-Oliveira M,Rogério Souza-Monteiro J,Paraense R,Rodrigues Machado C,Farina M,Macchi B,do Nascimento JLM,Crespo-Lopez ME

更新日期：2018-09-01 00:00:00

abstract：:During early pregnancy, iodine deficiency (ID) is linked to adverse effects on child motor and psychomotor function. Maternal marginal ID has become a common public health problem. It is unclear whether marginal ID influences the development of the cerebellum or its underlying mechanisms. Thus, the purpose of this stu...

journal_title：Neurotoxicology

authors： Yu Y,Wang Y,Wang Y,Dong J,Min H,Chen J

更新日期：2018-09-01 00:00:00

abstract：:Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of th...

journal_title：Neurotoxicology

authors： Mónaco NM,Bartos M,Dominguez S,Gallegos C,Bras C,Esandi MDC,Bouzat C,Giannuzzi L,Minetti A,Gumilar F

更新日期：2018-07-01 00:00:00

abstract：:The development of new antiepileptic drugs is a high-risk/high-cost research field, which is made even riskier if the behavioral epileptic seizure profile is the unique approach on which the development is based. In order to increase the effectiveness of the screening conducted in the zebrafish model of status epilept...

journal_title：Neurotoxicology

authors： Mussulini BHM,Vizuete AFK,Braga M,Moro L,Baggio S,Santos E,Lazzarotto G,Zenki KC,Pettenuzzo L,Rocha JBTD,de Oliveira DL,Calcagnotto ME,Zuanazzi JAS,Burgos JS,Rico EP

更新日期：2018-07-01 00:00:00