Epigenetic influence of environmentally neurotoxic metals.

Abstract:

:Continuous globalization and industrialization have ensured metals are an increasing aspect of daily life. Their usefulness in manufacturing has made them vital to national commerce, security and global economy. However, excess exposure to metals, particularly as a result of environmental contamination or occupational exposures, has been detrimental to overall health. Excess exposure to several metals is considered environmental risk in the aetiology of several neurological and neurodegenerative diseases. Metal-induced neurotoxicity has been a major health concern globally with intensive research to unravel the mechanisms associated with it. Recently, greater focus has been directed at epigenetics to better characterize the underlying mechanisms of metal-induced neurotoxicity. Epigenetic changes are those modifications on the DNA that can turn genes on or off without altering the DNA sequence. This review discusses how epigenetic changes such as DNA methylation, post translational histone modification and noncoding RNA-mediated gene silencing mediate the neurotoxic effects of several metals, focusing on manganese, arsenic, nickel, cadmium, lead, and mercury.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

Ijomone OM,Ijomone OK,Iroegbu JD,Ifenatuoha CW,Olung NF,Aschner M

doi

10.1016/j.neuro.2020.08.005

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

51-65

eissn

0161-813X

issn

1872-9711

pii

S0161-813X(20)30123-6

journal_volume

81

pub_type

杂志文章,评审
  • Neurophysiologic effects of chemical agent hydrolysis products on cortical neurons in vitro.

    abstract::The neurophysiologic effects of chemical agent hydrolysis products were examined on cultured cortical neurons using multielectrode array (MEA) recording and the whole-cell patch clamp technique. Measurement of neuronal network extracellular potentials showed that the primary hydrolysis product of soman, pinacolyl meth...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/s0161-813x(01)00028-6

    authors: Pancrazio JJ,Keefer EW,Ma W,Stenger DA,Gross GW

    更新日期:2001-06-01 00:00:00

  • Evaluation of N-butylbenzenesulfonamide (NBBS) neurotoxicity in Sprague-Dawley male rats following 27-day oral exposure.

    abstract::N-Butylbenzenesulfonamide (NBBS) is widely used as a plasticizer in polyacetals, polyamides, and polycarbonates and has been found in ground water and effluent from wastewater treatment sites. The compound is lipophilic and distributes rapidly to the brain but also clears rapidly and shows little evidence of accumulat...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2012.07.002

    authors: Rider CV,Janardhan KS,Rao D,Morrison JP,McPherson CA,Harry GJ

    更新日期:2012-12-01 00:00:00

  • Role of ERK activation in cisplatin-induced apoptosis in A172 human glioma cells.

    abstract::Cisplatin activates multiple signal transduction pathways associated with cell survival and apoptosis in various cell types. The present study was undertaken to determine the role of extracellular signal-regulated protein kinase (ERK), a member of the mitogen-activated protein kinase family, in cisplatin-induced apopt...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2004.06.002

    authors: Choi BK,Choi CH,Oh HL,Kim YK

    更新日期:2004-12-01 00:00:00

  • Multiple dose exposure effects on the tissue distribution of lead in the preweanling rat.

    abstract::The time dependent tissue/organ distribution of Pb resulting from repeated intragastric exposure of the preweanling rat to Pb acetate was investigated. On the day of parturition, 12 dams were assigned randomly either to control (nonhandled) or Pb-treated groups and their litters were culled to 8 pups. On days 6, 9, 12...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Massaro EJ,Miller GD,Massaro TF

    更新日期:1984-10-01 00:00:00

  • L- and D- methionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro and in vivo retention of antineoplastic activity.

    abstract::Treatment of metastatic tumors with ionic platinum compounds is hampered by the potent nephrotoxic, ototoxic and neurotoxic properties of these drugs. Recent studies have shown that sulfur-containing antioxidants relieve the dose limiting side effects of cis-diamminedichloroplatinum (CDDP), the most commonly used ioni...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Reser D,Rho M,Dewan D,Herbst L,Li G,Stupak H,Zur K,Romaine J,Frenz D,Goldbloom L,Kopke R,Arezzo J,Van De Water T

    更新日期:1999-10-01 00:00:00

  • Electrophysiological investigation of IDPN neuropathy--initial studies.

    abstract::beta,beta'-iminodipropionitrile (IDPN) causes giant axon swellings in proximal internodes of spinal motor axons and in stem processes of dorsal root ganglia neurons. The electrophysiological consequences of the swellings were investigated in cats given IDPN (50 mg/kg i.p.) weekly for 0 (control), 1 (7 days), 2 (14 day...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Lowndes HE,Delio DA,Gold BG

    更新日期:1985-01-01 00:00:00

  • Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development.

    abstract::Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG). This occurs at 1.0mg/kg...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.11.016

    authors: Carr RL,Armstrong NH,Buchanan AT,Eells JB,Mohammed AN,Ross MK,Nail CA

    更新日期:2017-03-01 00:00:00

  • Dopamine sensitive adenylate cyclase inactivation by organolead compounds.

    abstract::Several organolead compounds have been shown to inhibit both the basal and dopamine-sensitive forms of adenylate cyclase obtained from rat caudate nucleus. The mode of action of the trisubstituted lead compounds is shown to depend upon the form of adenylate cyclase studied. The dopamine-sensitive form of adenylate cyc...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/0191-8869(82)90087-3

    authors: Wilson WE

    更新日期:1982-07-01 00:00:00

  • Further investigation of the effect of chronic ethanol on the electric membrane properties of adult DRG neurons in cell culture.

    abstract::Neural cell cultures were used to investigate the effects of acute and chronic ethanol exposure on electric membrane properties (EMP) of adult mouse dorsal root ganglion (DRG) neurons. These results in combination with results from additional experiments involving chronic exposure to hyposomotic medium provided furthe...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Scott B,Lew J

    更新日期:1986-04-01 00:00:00

  • Consequences of acute Nav1.1 exposure to deltamethrin.

    abstract:BACKGROUND:Pyrethroid insecticides are the most popular class of insecticides in the world, despite their near-ubiquity, their effects of delaying the onset of inactivation of voltage-gated sodium (Nav) channels have not been well-evaluated in all the mammalian Nav isoforms. OBJECTIVE:Here we compare the well-studied ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2016.12.005

    authors: James TF,Nenov MN,Tapia CM,Lecchi M,Koshy S,Green TA,Laezza F

    更新日期:2017-05-01 00:00:00

  • Ethanol and acetaldehyde differentially alter extracellular dopamine and serotonin in Aldh2-knockout mouse dorsal striatum: A reverse microdialysis study.

    abstract::Dopamine (DA) and serotonin (5-HT) seem to be involved in several of the effects of ethanol (EtOH). Acetaldehyde (AcH), especially in the brain, induces effects that mimic those of EtOH. The purpose of this study was to investigate the effects of local perfusion of EtOH and AcH on extracellular DA and 5-HT in the dors...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.12.011

    authors: Jamal M,Ameno K,Miki T,Tanaka N,Ito A,Ono J,Takakura A,Kumihashi M,Kinoshita H

    更新日期:2016-01-01 00:00:00

  • Brain and blood levels of bismuth after oral or parenteral administration of tripotassium-dicitrato bismuthate to rats.

    abstract::Bismuth levels in blood and brain of rats have been measured following acute or subchronic administration of tri-potassium-dicitrato bismuthate (TDB) by intraperitoneal injection or by gavage. After parenteral administration, the presence of bismuth in blood was associated with appreciable bismuth concentrations in br...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Abbracchio MP,Balduini W,Cavallaro A,Adamoli P,Fittipaldi M,Muzio F,Malandrino S,Cattabeni F

    更新日期:1985-10-01 00:00:00

  • Occupational aluminum exposure: evidence in support of its neurobehavioral impact.

    abstract::Aluminum is a metal with known neurotoxic properties which are linked to encephalopathy and neurodegenerative diseases. The objectives of the current meta-analysis study were: (1) to summarize neurobehavioral data obtained by epidemiological studies in occupational settings and (2) to analyze confounding within these ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.neuro.2007.07.001

    authors: Meyer-Baron M,Schäper M,Knapp G,van Thriel C

    更新日期:2007-11-01 00:00:00

  • Neurobehavioral and neurophysiological observations in six year old children with low lead levels in East and West Germany.

    abstract::Within a larger comparative environmental health screening program in East and West Germany neurobehavioral and neurophysiological measures were taken in 367 six year old children in Leipzig (N = 179), Gardelegen (N = 68), and Duisburg (N = 120). Lead concentrations from venous blood samples (PbB) and from deciduous t...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Winneke G,Altmann L,Krämer U,Turfeld M,Behler R,Gutsmuths FJ,Mangold M

    更新日期:1994-10-01 00:00:00

  • Caffeic acid phenethyl ester (CAPE) protects PC12 cells from MPP+ toxicity by inducing the expression of neuron-typical proteins.

    abstract::Neurite loss is an early event in neurodegenerative diseases; therefore, the regeneration of the network of neurites constitutes an interesting strategy of treatment for such disorders. Neurotrophic factors play a critical role in neuronal regeneration, but their clinical use is limited by their inability to cross the...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2014.09.007

    authors: dos Santos NA,Martins NM,Silva Rde B,Ferreira RS,Sisti FM,dos Santos AC

    更新日期:2014-12-01 00:00:00

  • Protective effect of betulin on cognitive decline in streptozotocin (STZ)-induced diabetic rats.

    abstract::Betulin is extracted from birch tree bark and exerts diverse pharmacological activities. The present study was designed to investigate the protective effect of betulin (BE) on cognitive decline in streptozotocin (STZ)-induced diabetic rats. The diabetic model was built by streptozotocin (STZ) (30mg/kg, ip). After 4 we...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2016.09.009

    authors: Ma C,Long H

    更新日期:2016-12-01 00:00:00

  • Absence of a protective effect of corticosterone on 0-0-diisopropyl phosphorofluoridate (DFP) induced delayed neurotoxicity in chickens.

    abstract::Chickens given 15 to 45 ppm dietary corticosterone 1 day prior to and 5 days following subcutaneous administration of 1 mg/kg 0,0-diisopropyl phosphorofluoridate (DFP) were not protected from either clinical delayed neuropathy, depression of neurotoxic esterase activity or advanced degenerative peripheral nerve myelin...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Ehrich M,Jortner BS,Gross WB

    更新日期:1985-04-01 00:00:00

  • Behavioral manifestations of prolonged lead exposure initiated at different stages of the life cycle: II. Delayed spatial alternation.

    abstract::Since both Pb exposure and aging have been associated with alterations in memory functions, this study compared the effects of Pb exposure initiated at early, middle and later stages of the life cycle on delayed spatial alternation performance. Young (21 day old), adult (8 mon old) and old (16 mon old) rats were expos...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Cory-Slechta DA,Pokora MJ,Widzowski DV

    更新日期:1991-01-01 00:00:00

  • Low intensity microwave radiation induced oxidative stress, inflammatory response and DNA damage in rat brain.

    abstract::Over the past decade people have been constantly exposed to microwave radiation mainly from wireless communication devices used in day to day life. Therefore, the concerns over potential adverse effects of microwave radiation on human health are increasing. Until now no study has been proposed to investigate the under...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.10.009

    authors: Megha K,Deshmukh PS,Banerjee BD,Tripathi AK,Ahmed R,Abegaonkar MP

    更新日期:2015-12-01 00:00:00

  • Early exposure to ethanol is able to affect the memory of adult zebrafish: Possible role of adenosine.

    abstract::Ethanol is one of the most widely consumed drugs in the world, and the effects of ethanol during early development include morphological and cognitive problems. The regulation of adenosine levels is essential for the proper function of major neurotransmitter systems in the brain, particularly glutamate and dopamine; t...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2018.08.012

    authors: Haab Lutte A,Huppes Majolo J,Reali Nazario L,Da Silva RS

    更新日期:2018-12-01 00:00:00

  • Neurofilament protein crosslinking in gamma-diketone neuropathy: in vitro and in vivo studies using the seaworm myxicola infundibulum.

    abstract::Neurofilament (NF) protein crosslinking has been proposed as the ultimate pathogenetic mechanism underlying the neuropathies caused by the gamma-diketones 2,5-hexanedione (HD) and 3,4-dimethyl-2,5-hexanedione (DMHD). Mammalian models have been used to investigate this hypothesis, but alternative experimental models ar...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: St Clair MB,Anthony DC,Wikstrand CJ,Graham DG

    更新日期:1989-01-01 00:00:00

  • Effects of aluminum lactate on murine neuroblastoma cells.

    abstract::Aluminum is the most abundant metal and the third most common element in the earth's crust. It's toxicity has emerged as one of the most serious complications in the treatment of chronic renal failure. Aluminum lactate [Al(lac)3], at concentrations less than those affecting cell viability (< 5 mM) decreased the capabi...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Zatta PF,Zambenedetti P,Masiero S

    更新日期:1994-01-01 00:00:00

  • Synergism between insecticides permethrin and propoxur occurs through activation of presynaptic muscarinic negative feedback of acetylcholine release in the insect central nervous system.

    abstract::Although synergism between pesticides has been widely documented, the physiological mechanisms by which an insecticide synergizes another remains unclear. Toxicological and electrophysiological studies were carried out on two susceptible pest species (the mosquito Culex quinquefasciatus and the cockroach Periplaneta a...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2006.01.011

    authors: Corbel V,Stankiewicz M,Bonnet J,Grolleau F,Hougard JM,Lapied B

    更新日期:2006-07-01 00:00:00

  • Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain.

    abstract::Four elements that have been implicated in free-radical-induced oxidative stress in Alzheimer's disease (AD) were measured by instrumental neutron activation analysis (INAA) in seven brain regions from 58 AD patients and 21 control subjects. A statistically significant elevation of iron and zinc was observed in multip...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Cornett CR,Markesbery WR,Ehmann WD

    更新日期:1998-06-01 00:00:00

  • Damage induced by systemic kainic acid in rats is dependent upon seizure activity--a behavioral and morphological study.

    abstract::Kainic acid (KA) was injected intraperitoneally into rats at a dose (9 mg/kg) which produced status epilepticus in approximately 50% of the animals. Rats were categorized into groups that displayed status epilepticus, partial seizures or no effect in the 4 hr following kainic acid injection. Behavioral and morphologic...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: O'Shaughnessy D,Gerber GJ

    更新日期:1986-10-01 00:00:00

  • Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway.

    abstract::The increasing use of illegal drugs by pregnant women causes a public health concern because it is associated with health risks for mothers and their developing children. One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or ecstasy due to its high consumption in relevant age and sex groups and its adverse ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2019.12.007

    authors: Barenys M,Reverte I,Masjosthusmann S,Gómez-Catalán J,Fritsche E

    更新日期:2020-05-01 00:00:00

  • Exposure to an organochlorine pesticide (chlordecone) and development of 18-month-old infants.

    abstract::Chlordecone is a persistent organochlorine pesticide that was used in the French West Indies until the early 1990s for banana weevil borer control. Human exposure to this chemical in this area still occurs nowadays due to consumption of contaminated food. Although adverse effects on neurodevelopment, including tremors...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2013.01.007

    authors: Boucher O,Simard MN,Muckle G,Rouget F,Kadhel P,Bataille H,Chajès V,Dallaire R,Monfort C,Thomé JP,Multigner L,Cordier S

    更新日期:2013-03-01 00:00:00

  • Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology.

    abstract::Okadaic acid (OKA) is one of the main polyether toxins produced by marine microalgae which causes diarrhetic shellfish poisoning. It is a selective and potent inhibitor of serine/threonine phosphatases 1 and 2A induces hyperphosphorylation of tau in vitro and in vivo. The reduced activity of phosphatases like, protein...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2013.05.002

    authors: Kamat PK,Rai S,Nath C

    更新日期:2013-07-01 00:00:00

  • Inhibition of catalase activity with 3-amino-triazole enhances the cytotoxicity of the Alzheimer's amyloid-beta peptide.

    abstract::Amyloid-beta, (Abeta) is a cytotoxic peptide implicated in the pathology of Alzheimers disease. The antioxidant enzyme catalase has been suggested to protect against Abeta cytotoxicity in both neuronal and non-neuronal cell types. Inhibition of endogenous catalase using 3-amino-1,2,4-triazole (3AT) in neuronal (NT-2) ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/s0161-813x(01)00064-x

    authors: Milton NG

    更新日期:2001-12-01 00:00:00

  • Diffusion-weighted magnetic resonance imaging in a case of methanol intoxication.

    abstract:BACKGROUND:Methanol intoxication is an uncommon clinical problem leading to profound metabolic acidosis with serious neurological deterioration. We describe methanol induced brain lesions on diffusion-weighted MR images and discuss the pathophysiology of these lesions in light of diffusion changes. CASE REPORT:Brain i...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Deniz S,Oppenheim C,Lehéricy S,Sharshar T,Lalam TF,Dormont D,Marsault C

    更新日期:2000-06-01 00:00:00