Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling.

abstract：:We have evidence that methamphetamine (METH)-induced neuronal death is morphologically necrotic, not apoptotic, as is currently believed, and that electrographic seizures may be responsible. We administered 40mg/kg i.p. to 12 male C57BL/6 mice and monitored EEGs continuously and rectal temperatures every 15min, keepin...

journal_title：Neurotoxicology

authors： Fujikawa DG,Pais ES,Aviles ER Jr,Hsieh KC,Bashir MT

更新日期：2016-01-01 00:00:00

abstract：:Knowledge on the impact of the exposure to indoor ultrafine particles (UFPs) on the human brain is restricted. Twelve non-atopic, non-smoking, and healthy adults (10 female and 7 male, in average 22 years old) were monitored for brain physiological responses via electroencephalographs (EEGs) during cooking. Frying gro...

journal_title：Neurotoxicology

authors： Naseri M,Jouzizadeh M,Tabesh M,Malekipirbazari M,Gabdrashova R,Nurzhan S,Farrokhi H,Khanbabaie R,Mehri-Dehnavi H,Bekezhankyzy Z,Gimnkhan A,Dareini M,Kurmangaliyeva A,Islam N,Crape B,Buonanno G,Cassee F,Amouei Torkmahall

更新日期：2019-09-01 00:00:00

abstract：:The use of pesticides for crop production has grown rapidly in Thailand during the last decade, resulting in significantly greater potential for exposure among children living on farms. Although some previous studies assessed exposures to pesticides in this population, no studies have been conducted to evaluate corres...

journal_title：Neurotoxicology

authors： Fiedler N,Rohitrattana J,Siriwong W,Suttiwan P,Ohman Strickland P,Ryan PB,Rohlman DS,Panuwet P,Barr DB,Robson MG

更新日期：2015-05-01 00:00:00

abstract：:Administration of 0.3% aluminum in drinking water elevated serum aluminum concentrations 8-fold in rats. Further, chronic treatment with aluminum for 2-3 mon, in both developing and adult rats, significantly decreased the levels of MAP-2 in brain, as determined by quantitative immunoblot analysis. Aluminum treatment a...

journal_title：Neurotoxicology

authors： Johnson GV,Watson AL Jr,Lartius R,Uemura E,Jope RS

更新日期：1992-07-01 00:00:00

abstract：:The time dependent tissue/organ distribution of Pb resulting from repeated intragastric exposure of the preweanling rat to Pb acetate was investigated. On the day of parturition, 12 dams were assigned randomly either to control (nonhandled) or Pb-treated groups and their litters were culled to 8 pups. On days 6, 9, 12...

journal_title：Neurotoxicology

authors： Massaro EJ,Miller GD,Massaro TF

更新日期：1984-10-01 00:00:00

abstract：:Aluminum is a metal with known neurotoxic properties which are linked to encephalopathy and neurodegenerative diseases. The objectives of the current meta-analysis study were: (1) to summarize neurobehavioral data obtained by epidemiological studies in occupational settings and (2) to analyze confounding within these ...

journal_title：Neurotoxicology

authors： Meyer-Baron M,Schäper M,Knapp G,van Thriel C

更新日期：2007-11-01 00:00:00

abstract：:Mercury (Hg) has many harmful vascular effects by increasing oxidative stress, inflammation and vascular/endothelial dysfunction, all of which may contribute to cerebrovascular diseases development. We aimed to explore the effects of chronic low-mercury concentration on vascular function in cerebral arteries and the m...

journal_title：Neurotoxicology

authors： Wiggers GA,Furieri LB,Briones AM,Avendaño MS,Peçanha FM,Vassallo DV,Salaices M,Alonso MJ

更新日期：2016-03-01 00:00:00

abstract：:Several organolead compounds have been shown to inhibit both the basal and dopamine-sensitive forms of adenylate cyclase obtained from rat caudate nucleus. The mode of action of the trisubstituted lead compounds is shown to depend upon the form of adenylate cyclase studied. The dopamine-sensitive form of adenylate cyc...

journal_title：Neurotoxicology

authors： Wilson WE

更新日期：1982-07-01 00:00:00

abstract：INTRODUCTION:Occupational exposure to extremely low frequency magnetic fields (ELF-MF) occurs in many occupations such as welders, electric utility workers, train drivers and sewing machine operators. There is some evidence suggesting ELF-MF exposure to be a risk factor for Alzheimer's disease (AD). The current study a...

journal_title：Neurotoxicology

authors： Jalilian H,Teshnizi SH,Röösli M,Neghab M

更新日期：2018-12-01 00:00:00

abstract：:Physiological methods that can be similarly recorded in humans and animals have a major role in sensory toxicology, as they provide a bridge between human sensory perception data and the molecular and cellular data obtained in animal studies. Vestibular toxicity research lags well behind other sensory systems in many ...

journal_title：Neurotoxicology

authors： Llorens J,Callejo A,Greguske EA,Maroto AF,Cutillas B,Martins-Lopes V

更新日期：2018-05-01 00:00:00

abstract：:Selenium (Se) is a well-known anti-oxidant with a critical role in the proper functioning of nervous and muscle functions. Se deficiency has been associated with both cognitive and neuromotor impairment, while sensory and motor deficits have been attributed to excess Se. In the Lower Tapajós Region of the Brazilian Am...

journal_title：Neurotoxicology

authors： Lemire M,Fillion M,Frenette B,Passos CJ,Guimarães JR,Barbosa F Jr,Mergler D

更新日期：2011-12-01 00:00:00

abstract：:In a pilot study, serum dopamine beta-hydroxylase (DBH), platelets monoamine oxidase type B (MAO B) activities and basal plasma prolactin (PRL) were measured, among 10 workers occupationally exposed to toluene and 10 control subjects, preceding and immediately following vacation. Six exposed subjects were employed in ...

journal_title：Neurotoxicology

authors： Smargiassi A,Mutti A,Bergamaschi E,Bélanger S,Truchon G,Mergler D

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Cyclophosphamide chemotherapy is a mainstay of adjuvant breast cancer treatment. Unfortunately, this drug is associated with cognitive impairments in cancer patients that may accelerate cognitive aging. Memory is particularly affected in many patients. In order to better understand the precise cognitive impa...

journal_title：Neurotoxicology

authors： Janelsins MC,Heckler CE,Thompson BD,Gross RA,Opanashuk LA,Cory-Slechta DA

更新日期：2016-09-01 00:00:00

abstract：:This study investigated the influence of succimer chelation therapy in eliminating and/or minimizing lead-associated impairments of motor functions such as postural balance and locomotion or gait activities. In this study, postural balance and functional locomotion or gait were quantitated in 161 children in Cincinnat...

journal_title：Neurotoxicology

authors： Bhattacharya A,Shukla R,Auyang ED,Dietrich KN,Bornschein R

更新日期：2007-05-01 00:00:00

abstract：:Rats were anesthetized with urethane, implanted with stimulating and recording electrodes in the perforant path and dentate gyrus, and exposed to different doses of lindane. Analysis of evoked field potential responses indicated that lindane exposure resulted in consistent, dose-dependent changes. Two separable effect...

journal_title：Neurotoxicology

authors： Joy RM,Albertson TE

更新日期：1987-01-01 00:00:00

abstract：:Among the several converging factors leading to Parkinson's disease, epidemiological studies indicate a correlation between Parkinson's disease (PD) with living in a rural area and/or exposure to agricultural pesticides. In this present study, we examined the potential of multiple agricultural pesticides for their abi...

journal_title：Neurotoxicology

authors： Leiphon LJ,Picklo MJ Sr

更新日期：2007-01-01 00:00:00

abstract：:Late Onset Alzheimer Disease (LOAD) constitutes the majority of AD cases (∼90%). Amyloidosis and tau pathology, which are present in AD brains, appear to be sporadic in nature. We have previously shown that infantile lead (Pb) exposure is associated with a change in the expression and regulation of the amyloid precurs...

journal_title：Neurotoxicology

authors： Bihaqi SW,Zawia NH

更新日期：2013-12-01 00:00:00

abstract：:Manganese-deficient individuals have decreased manganese elimination. This observation has prompted suggestions that relative manganese deficiency may increase the risk for manganese neurotoxicity following inhalation exposure. The objective of this study was to determine whether dietary manganese intake influences th...

journal_title：Neurotoxicology

authors： Dorman DC,Struve MF,Wong BA

更新日期：2002-07-01 00:00:00

abstract：:Inorganic mercury salts administered systemically at low mg/ml doses produce neurotoxic effects without penetrating the cerebral microvascular endothelial cells which form the blood-brain barrier (BBB). This phenomenon promoted investigations testing a hypothesis relating inorganic mercury-induced brain dysfunction to...

journal_title：Neurotoxicology

authors： Albrecht J,Szumanska G,Gadamski R,Gajkowska B

更新日期：1994-01-01 00:00:00

abstract：:Methylmercury has been designated a "behavioral teratogen" because of its ability to evoke abnormalities in the absence of gross morphological damage to the developing brain. Recent work indicates that exposure to doses of methylmercury associated with neurobehavioral actions causes early alterations in brain ornithin...

journal_title：Neurotoxicology

authors： Slotkin TA,Bartolome J

更新日期：1987-04-01 00:00:00

abstract：:Organophosphate poisonings are not uncommon, and are the leading cause of death in suicide patients in Taiwan. Acute cholinergic crisis caused by the inhibition of synaptic acetylcholinesterase is the major manifestation of organophosphate poisoning and may cause death within minutes. Delayed neurotoxicities include i...

journal_title：Neurotoxicology

authors： Hsieh BH,Deng JF,Ger J,Tsai WJ

更新日期：2001-08-01 00:00:00

abstract：:Mitochondrial damage and declines in ATP levels have been recently attributed to sertraline. The effects of sertraline on different parameters were investigated in washed platelets from 18 healthy male volunteers, after 24h of drug exposure. Sertraline toxicity was observed only at the highest concentrations, 30 and 1...

journal_title：Neurotoxicology

authors： Rodrigues DO,Bristot IJ,Klamt F,Frizzo ME

更新日期：2015-12-01 00:00:00

abstract：:The present study investigates the effects of 1-bromopropane (1BP) on animal behavior to determine the extent of toxicity to the central nervous system (CNS). We measured the spontaneous locomotor activity (SLA) of rats before and after 3 weeks of exposure to 1BP for 8 h per day. In control and 10 ppm groups, the SLA ...

journal_title：Neurotoxicology

authors： Honma T,Suda M,Miyagawa M

更新日期：2003-08-01 00:00:00

abstract：:Methylmercury (MeHg) and prenatal stress (PS) are risk factors for neurotoxicity that may co-occur in human populations. Because they also share biological substrates and can produce common behavioral deficits, this study examined their joint effects on behavioral and neurochemical effects in male and female rats. Dam...

journal_title：Neurotoxicology

authors： Weston HI,Sobolewski ME,Allen JL,Weston D,Conrad K,Pelkowski S,Watson GE,Zareba G,Cory-Slechta DA

更新日期：2014-03-01 00:00:00

abstract：:Synaptic dysfunction appears to be an early pathogenic event in Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's disease. Although the molecular mechanism of this synaptotoxicity is not known, evidence suggests that these diseases are characterized by a common pathophysiological cascade involving oxi...

journal_title：Neurotoxicology

authors： Lopachin RM,Gavin T,Barber DS

更新日期：2008-09-01 00:00:00

abstract：:In a previous in vitro study, we demonstrated the protective effects of a new drug, 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride (KHG26377), against glutamate-induced excitotoxicity in cultured glial cells. In this study, we explored the possible mechanisms underlying the neuroprotective and anti-inflammat...

journal_title：Neurotoxicology

authors： Kim EA,Choi J,Han AR,Choi SY,Hahn HG,Cho SW

更新日期：2013-09-01 00:00:00

abstract：:It is still being debated whether neurogenesis in the subventricular zone (SVZ) is enhanced in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injury in the adult mouse brain. Our previous studies provided evidence that MPTP induces apoptosis of migrating neuroblasts (neural progenitor cells, A cells) ...

journal_title：Neurotoxicology

authors： He XJ,Nakayama H

更新日期：2015-09-01 00:00:00

abstract：:Nerve agents are deadly threats to military and civilian populations around the world. Nerve agents cause toxicity to peripheral and central sites through the irreversible inhibition of acetylcholinesterase, the enzyme that metabolizes acetylcholine. Excessive acetylcholine accumulation in synapses results in status e...

journal_title：Neurotoxicology

authors： Pan H,Hu XZ,Jacobowitz DM,Chen C,McDonough J,Van Shura K,Lyman M,Marini AM

更新日期：2012-10-01 00:00:00

abstract：:Previous studies have shown that L-2-chloropropionic acid (L-CPA) produces necrosis to cerebellar granule cells with some associated Purkinje cell damage in the rat. We have re-evaluated the neuropathology using the original sections and fresh sections from archived brain material from rats treated with L-CPA at diffe...

journal_title：Neurotoxicology

authors： Duffell S,Lock EA

更新日期：2004-12-01 00:00:00

abstract：:Chronic manganese (Mn) exposure can lead to neuroinflammation and neurological deficit, which resemble idiopathic Parkinson's disease (IPD). However, the precise mechanisms underlying Mn exposure-induced neurotoxicity remain incompletely understood. Microglia can become hyperactivated and plays a vital role in neuroin...

journal_title：Neurotoxicology

authors： Yin L,Dai Q,Jiang P,Zhu L,Dai H,Yao Z,Liu H,Ma X,Qu L,Jiang J

更新日期：2018-01-01 00:00:00