Abstract：
:This study investigated the influence of succimer chelation therapy in eliminating and/or minimizing lead-associated impairments of motor functions such as postural balance and locomotion or gait activities. In this study, postural balance and functional locomotion or gait were quantitated in 161 children in Cincinnati enrolled in a randomized, placebo-controlled, double blind clinical trial. In comparison to the placebo group, the succimer therapy group showed significantly decreased postural sway during dynamic task performance implying improved postural balance. The results from locomotion tests demonstrated significant improvements in functional tasks of obstacle crossing and normal walking in the succimer treated group. While some beneficial neuromotor effects of succimer therapy were observed in the present study there remains several unanswered questions such as how long these effects will persist and how succimer therapy modifies lead-associated cerebellar deficits manifesting as perturbations in vestibular and/or proprioception systems for postural balance and functional locomotion.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Bhattacharya A,Shukla R,Auyang ED,Dietrich KN,Bornschein Rdoi
10.1016/j.neuro.2007.03.007subject
Has Abstractpub_date
2007-05-01 00:00:00pages
686-95issue
3eissn
0161-813Xissn
1872-9711pii
S0161-813X(07)00056-3journal_volume
28pub_type
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