Abstract：
:In a pilot study, serum dopamine beta-hydroxylase (DBH), platelets monoamine oxidase type B (MAO B) activities and basal plasma prolactin (PRL) were measured, among 10 workers occupationally exposed to toluene and 10 control subjects, preceding and immediately following vacation. Six exposed subjects were employed in an adhesive tape making industry and 4 in a paint making industry. Their median basal levels of urinary hippuric acid were 0.44 mmole/mmole creatinine (cr) (range 0.23-1.97) and 0.18 mmole/mmole cr (range 0.15-0.19) respectively, the second to last morning of the work week, preceding vacation. The level of basal urinary hippuric acid among the control group was 0.26 mmole/mmole cr (range 0.03-0.38). The workers from the adhesive tape plant reported a significantly higher number of symptoms experienced frequently (Kruskal, Wallis, p < 0.05). On a group basis, serum DBH was lowest among the workers from the adhesive tape plant, who had the highest levels of basal urinary hippuric acid. In addition, a negative relation was observed between hippuric acid and serum DBH, preceding and following vacation (Rho = -0.46, p = 0.05; Rho = -0.51, p = 0.03). The observed changes in serum DBH activity are consistent with its decrease in human, following long-term exposure to styrene, another aromatic hydrocarbon. The findings of this pilot study, on a limited number of individuals suggest that DBH may be a sensitive peripheral bioindicator. Further studies of larger groups should be done to confirm the decrease in serum DBH activity with toluene exposure and explore whether this alteration is related to the neurotoxic impairments associated with exposure.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Smargiassi A,Mutti A,Bergamaschi E,Bélanger S,Truchon G,Mergler Dsubject
Has Abstractpub_date
1996-10-01 00:00:00pages
769-75issue
3-4eissn
0161-813Xissn
1872-9711journal_volume
17pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract：:Many nanoparticles (NPs) have toxic effects on multiple cell lines. This toxicity is assumed to be related to their accumulation within cells. However, the process of internalization of NPs has not yet been fully characterized. In this study, the cellular uptake, accumulation, and localization of titanium dioxide nano...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.08.013
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Exposure to environmental levels of lead (Pb) and manganese (Mn) has been associated with detrimental effects to neurodevelopment. However, little is known about the potential association between environmental levels of Pb and Mn on intelligence of children. The aims of the study were to investigate the asso...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.03.012
更新日期：2009-07-01 00:00:00
abstract：:A review of previous evidence suggests an association between early Pb exposure and hippocampal dysfunction. This report summarizes recent experiments conducted in both our laboratory and others' examining the effects of early Pb exposure on hippocampal morphological development, and behaviors characteristic of hippoc...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1983-04-01 00:00:00
abstract：:Nickel, a known occupational/environmental hazard, may cross the placenta and reach appreciable concentrations in various fetal organs, including the brain. The aim of this study was to investigate whether nickel interferes with the process of neuronal differentiation. Following a 4 week treatment with retinoic acid (...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.01.001
更新日期：2015-03-01 00:00:00
abstract：:A pathological hallmark of Alzheimer's disease (AD), aggregation and deposition of amyloid-β peptides, has been recognized as a potent activator of microglia-mediated neuroinflammation and neuronal dysfunction. Therefore, downregulation of microglial activation has a significant therapeutic demand. In this study, focu...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.12.004
更新日期：2013-03-01 00:00:00
abstract：:beta,beta'-iminodipropionitrile (IDPN) causes giant axon swellings in proximal internodes of spinal motor axons and in stem processes of dorsal root ganglia neurons. The electrophysiological consequences of the swellings were investigated in cats given IDPN (50 mg/kg i.p.) weekly for 0 (control), 1 (7 days), 2 (14 day...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Snake venom group IA secretory phospholipase A2 (sPLA2-IA) is known as a neurotoxin. Snake venom sPLA2s are neurotoxic in vivo and in vitro, causing synergistic neurotoxicity to cortical cultures when applied with toxic concentrations of glutamate. However, it has not yet been cleared sufficiently how sPLA2-IA exerts ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.12.009
更新日期：2013-03-01 00:00:00
abstract：:Oxaliplatin is a platinum-based drug used in the treatment of gastric cancers. Oxaliplatin treatment induces sensory neuropathy characterized by cold hypersensibility in the acute phase and sensory impairment when the neuropathy becomes chronic. In order to determine the effect of oxaliplatin on sensory neurons, we us...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.07.009
更新日期：2018-09-01 00:00:00
abstract：:Prenatal ethanol exposure affects brain development and causes neural impairment, leading to both cognitive and behavioral consequences in the offspring. Therefore, the aim of this study was to investigate the impact of prenatal exposure to small amounts of alcohol on social play behavior in adolescent male offspring....
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.05.007
更新日期：2020-07-01 00:00:00
abstract：:Many soldiers that served in the 1991 Gulf War developed widespread chronic pain. Exposure to insecticides and the nerve gas prophylactic pyridostigmine bromide (PB) was identified as risk factors by the Research Advisory Committee on Gulf War Veterans' Illnesses (GWI). We examined whether a 60 day exposure to neuroto...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.08.006
更新日期：2013-12-01 00:00:00
abstract：:In 1983, Roels et al. (1987a, b) collected blood and urine samples and conducted neurological testing of workers at a manganese oxide and salt producing plant in Belgium, and at a nearby chemical plant. Workers from the manganese plant performed significantly worse than workers from the chemical plant on tests of shor...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：:Neuroinflammation and microglia as the resident immune cells of the brain has garnered a significant amount of interest with regards to brain injury and neurotoxicology. Much of this interest and research has been focused on responses in the adult brain with little attention paid to the role of these cells during deve...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.03.013
更新日期：2012-06-01 00:00:00
abstract：:Aluminum (Al) has been determined in autopsy brain samples (20 mg, dry weight) from 10 histologically verified Alzheimer's disease (AD) patients and 10 neurologically normal controls using an improved graphite furnace atomic absorption method. The method makes use of a potassium dichromate matrix modifier to circumven...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Although toxins exert their impact on a molecular level, they may yield molar effects by affecting areas large enough to be visualized by neuroimaging techniques. Therefore, neuroimaging of the brain may be used to render the macroscopic sequelae of neurotoxins visible. Toxic agents may induce brain edema or atrophy, ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：2000-10-01 00:00:00
abstract：:Microtubule (Mt) populations show large differences in dynamic properties (i.e., turnover rates) among cell types, and even within the same cell type at different stages of the cell cycle or stages of differentiation. These differences in dynamic properties are correlated with altered sensitivity to Mt-disassembling d...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1994-04-01 00:00:00
abstract：:Developmental exposure to lead (Pb) has long been associated with reductions in intellectual function in children and behavioral impairments in animal models of learning and memory. We have used long-term potentiation (LTP) in the dentate gyrus of the Pb-exposed rats to determine the potential of a reduced capacity fo...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：:3-monochloro-1,2-propanediol (3-MCPD) is a contaminant of acid-hydrolyzed vegetable protein. Several reports have suggested that chronic exposure to 3-MCPD could produce neurotoxicity in vitro or neurobehavioral effects in experimental animals. The present study further explored the in vitro neurotoxic effects of 0.1-...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2003.08.004
更新日期：2004-03-01 00:00:00
abstract：:Pheochromocytoma (PC-12) cells synthesize, store, release and metabolize dopamine (DA) and norepinephrine (NE) in a manner analogous to that observed in the mammalian central nervous system. These cells were used to develop and validate an alternate method to animal testing to assess the effects of a complex environme...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Central respiratory chemosensitivity has been ascribed to CO2-sensitive neurons located on the ventral brainstem surface. The effects of cholinergic mechanisms on CO2-sensitive neuronal activity recorded extracellularly at the brainstem respiratory chemosensitive area at the caudal ventral medullary surface (cVMS) wer...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Synaptic dysfunction appears to be an early pathogenic event in Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's disease. Although the molecular mechanism of this synaptotoxicity is not known, evidence suggests that these diseases are characterized by a common pathophysiological cascade involving oxi...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2008.04.016
更新日期：2008-09-01 00:00:00
abstract：:A growing body of experimental and clinical literature indicates an association between Gaucher disease and parkinsonism, raising the possibility that convergent mechanisms may contribute to neurodegeneration in these disorders. The aim of this study was to determine whether there is a relationship between alpha-synuc...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.06.009
更新日期：2009-11-01 00:00:00
abstract：:Young children are especially susceptible to the toxic effects of lead. Although the effects of overt lead intoxication have been well studied, critical information on the long-term effects of low level lead exposure is lacking. The results of recent clinical studies indicate that "chronic" low level lead exposure dur...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:Administration of chemotherapy during the fetal phase of pregnancy may put late-developing organs like the central nervous system at risk. METHODS:Transplacental transfer of doxorubicin and vinblastine was measured in C57/BJ mice by high-performance liquid chromatographic detection of the drugs in maternal ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.04.009
更新日期：2009-07-01 00:00:00
abstract：:Within a larger comparative environmental health screening program in East and West Germany neurobehavioral and neurophysiological measures were taken in 367 six year old children in Leipzig (N = 179), Gardelegen (N = 68), and Duisburg (N = 120). Lead concentrations from venous blood samples (PbB) and from deciduous t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:The popular recreational drug, 3,4-methylenedioxymethamphetamine (MDMA) is often taken as intermittent binges by adolescents at dance clubs. The neurobiological mechanisms that underlie MDMA-induced psychiatric conditions are still poorly understood. In the present study, mimicking adolescent patterns of administratio...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2007.07.002
更新日期：2007-11-01 00:00:00
abstract：:The herbicide cycloate (carbamothioic acid, ethyl(cyclohexyl)-S-ethyl ester) given as a single oral dose to rats, caused selective neuronal cell death in two regions in the rat forebrain, the pyramidal neurons of layers II-III throughout the pyriform cortex and in granule cells of the caudal ventro-lateral dentate gyr...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2004.07.006
更新日期：2005-01-01 00:00:00
abstract：:The organophosphorus insecticide chlorpyrifos (CPF) is suspected to cause developmental neurotoxicity in children leading to long term effects. Developmental exposure of rat pups to CPF at low levels disrupts degradation of the brain endocannabinoids through the inhibition of fatty acid amide hydrolase (FAAH) and decr...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.01.002
更新日期：2020-03-01 00:00:00
abstract：:Intracerebral injection of methylmercury (CH3Hg) into the mouse brain resulted in significant weight loss and the appearance of characteristic neurological disturbances associated with CH3Hg intoxication. Neurological effects appeared dependent upon a minimum injected dose of 16 micrograms of CH3Hg corresponding to a ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:Environmental chemicals have a potential impact on children's health as the developing brain is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that very complex processes of cell development and maturation take place within a t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.11.006
更新日期：2010-09-01 00:00:00
abstract：:Two groups of New Zealand albino rabbits were respectively exposed to 350 and 700 ppm of trichloroethylene (TRI) 4 hrs/day, 4 days/week for 12 weeks. Weekly, visual evoked potentials (VEP) recordings were obtained under mesopic condition. Blood samples were also collected weekly to determine the concentration of TRI a...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
