Abstract:
:Developmental exposure to lead (Pb) has long been associated with reductions in intellectual function in children and behavioral impairments in animal models of learning and memory. We have used long-term potentiation (LTP) in the dentate gyrus of the Pb-exposed rats to determine the potential of a reduced capacity for synaptic plasticity to contribute to Pb-induced cognitive dysfunction. Previous work demonstrated that developmental exposure resulting in moderate blood concentrations of Pb increase the threshold for induction of long-term potentiation (LTP) in the dentate gyrus in vivo. These findings were also suggestive of reductions in LTP magnitude (Gilbert et al., 1996). The present study was designed to further examine the effects of Pb on LTP magnitude and to determine if lower blood Pb levels commonly encountered in children are also effective in impairing synaptic plasticity in this rodent model. Pregnant dams were exposed to control tap water or 0.1, 0.2, 0.5 or 1.0% Pb-acetate in the drinking water beginning just prior to parturition (gestational day 16, GD16). Male offspring were weaned at 21 days of age (PN21) to the same solution given their dams and continued on this regimen until testing. As adults, animals were anesthetized with urethane and stimulating and recording electrodes placed in the perforant path and dentate gyrus, respectively. Post-train I/O functions taken 1 hour after delivery of a series of six high frequency (400Hz) trains revealed a reduced capacity for LTP of the PS amplitude and EPSP slope in Pb-exposed animals in all but the 1.0% group, indicative of a biphasic dose-effect relationship. The 1.0% Pb exposure was clearly less effective than the lower exposure levels in reducing LTP magnitude, and did not differ significantly from control values. The mechanisms underlying the reduced efficacy of higher exposure levels of Pb to impair LTP are not clear. Blood (26-117 microg/dl) and brain (220-1812 ng/g tissue) concentrations of Pb were elevated as a function of increasing exposure (0.1%-1.0%) and cannot readily account for the lack of an effect in the 1.0% group on LTP. We have observed a similar profile in hippocampal glutamate release employing a similar range of exposure levels, i.e., reduction of glutamate release that is absent at higher concentrations of Pb in the drinking water (Lasley et al., 1998). These and previously reported data suggest that the ability of Pb to diminish presynaptic transmitter release contributes to a reduced capacity for LTP at lower exposure levels. The reversal of the effect of Pb on glutamate release that accompanies higher exposure levels may serve to compensate for the mechanism underlying the LTP impairment and form the basis for the biphasic dose-response pattern seen with chronic developmental exposure.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Gilbert ME,Mack CM,Lasley SMsubject
Has Abstractpub_date
1999-02-01 00:00:00pages
71-82issue
1eissn
0161-813Xissn
1872-9711journal_volume
20pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::Lead (Pb) continues to be a significant environmental toxin and remains an integral part of many industrial processes, hobbies, and tobacco smoke. Pb has been shown to be a potent toxin to the CNS and low levels of Pb (below the CDC established toxic blood level of 10 microg/dl) have been correlated with decreases in ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2005.07.005
更新日期:2006-01-01 00:00:00
abstract::On the basis of the evidence that extracellular Zn2+ influx induced with AMPA causes Parkinson's syndrome in rats that apomorphine-induced movement disorder emerges, here we used a low dose of AMPA, which does not increase intracellular Zn2+ level in the substantia nigra pars compacta (SNpc) of young adult rats, and t...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.12.014
更新日期:2021-01-02 00:00:00
abstract::The chemosensory effects of propionic acid (PA) in humans have not been conclusively studied and there is no established occupational exposure limit (OEL) in Germany. In addition to sensory irritation caused by PA, it was hypothesized that the annoying odor of PA might interfere with the performance results. There wer...
journal_title:Neurotoxicology
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuro.2009.08.009
更新日期:2009-11-01 00:00:00
abstract::A growing body of experimental and clinical literature indicates an association between Gaucher disease and parkinsonism, raising the possibility that convergent mechanisms may contribute to neurodegeneration in these disorders. The aim of this study was to determine whether there is a relationship between alpha-synuc...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2009.06.009
更新日期:2009-11-01 00:00:00
abstract::The increasing use of illegal drugs by pregnant women causes a public health concern because it is associated with health risks for mothers and their developing children. One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or ecstasy due to its high consumption in relevant age and sex groups and its adverse ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2019.12.007
更新日期:2020-05-01 00:00:00
abstract::Studies on the toxicokinetics and biochemical effects of acrylamide are reviewed in regard to their implications concerning the mechanism of acrylamide induced neuropathy. Specifically, investigations of the effects of acrylamide on several glycolytic enzymes including neuron-specific enolase and glyceraldehyde-3-phos...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Single subcutaneous injections of triphenyl phosphite (TPP) (62.5-500 mg/kg body weight) were made in the Japanese quail (Coturnix coturnix japonica). The extent and density of resultant central nervous system degeneration were mapped by using the Fink-Heimer silver impregnation method to selectively impregnate degene...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::Many inhibitors of monoamine oxidase, particularly those developed during the past three decades, are often referred to as being "selective" for one or other isoform of the enzyme. However true this may be, selectivity within the EC 1.4.3.4 family does not preclude the possibility of interactions of these drugs with o...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/S0161-813X(03)00104-9
更新日期:2004-01-01 00:00:00
abstract::Neurotransmitter amino acid levels were measured in select brain regions of rats and mice after chronic treatment with sublethal doses of sodium hydrosulfide (NaHS). Brainstem aspartate, glutamate, glutamine, taurine and GABA levels increased in chronically but not acutely saline-treated rats. These increases may have...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::The present study investigates the effects of 1-bromopropane (1BP) on animal behavior to determine the extent of toxicity to the central nervous system (CNS). We measured the spontaneous locomotor activity (SLA) of rats before and after 3 weeks of exposure to 1BP for 8 h per day. In control and 10 ppm groups, the SLA ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/S0161-813X(03)00049-4
更新日期:2003-08-01 00:00:00
abstract::The purpose the present study was to determine if tolerance is developed to all behavioural effects produced by a single high dose of chlorpyrifos (CPF). For this, the study was divided in two phases; in the first phase, we studied the time course of the effects produced by treatment with a high dose of CPF (250 mg/kg...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2007.01.013
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:While the impact of active maternal smoking during pregnancy on child health has been well investigated, the association between maternal passive smoking, or environmental tobacco smoke (ETS), or second-hand smoke, and behavioral development of offspring is less clear. This study examines the association bet...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.11.005
更新日期:2013-01-01 00:00:00
abstract::Previous studies have shown that L-2-chloropropionic acid (L-CPA) produces necrosis to cerebellar granule cells with some associated Purkinje cell damage in the rat. We have re-evaluated the neuropathology using the original sections and fresh sections from archived brain material from rats treated with L-CPA at diffe...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2004.01.009
更新日期:2004-12-01 00:00:00
abstract::Bisphenol A (BPA) is a widely recognized endocrine disruptor prevalent in many household items. Because experimental and epidemiological data suggest links between prenatal BPA exposure and altered affective behaviors in children, even at levels below the current US FDA No Observed Adverse Effect Level (NOAEL) of 5mg/...
journal_title:Neurotoxicology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.neuro.2017.10.005
更新日期:2018-03-01 00:00:00
abstract::Nickel, a known occupational/environmental hazard, may cross the placenta and reach appreciable concentrations in various fetal organs, including the brain. The aim of this study was to investigate whether nickel interferes with the process of neuronal differentiation. Following a 4 week treatment with retinoic acid (...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2015.01.001
更新日期:2015-03-01 00:00:00
abstract::The anatomic position of olfactory receptors renders them vulnerable to airborne pollutants. Chamber inhalation studies have shown dose-dependent olfactory adaptation and temporary olfactory threshold perception shift for particular inhaled substances. The present study was undertaken to examine olfactory perception t...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::Various aspects of locomotor activity were measured, using a crossed photobeam cage, in young rhesus monkeys (M. mulatta) whose mothers had been fed low levels of polychlorinated biphenyls (PCBs, Aroclor 1248) both before and during gestation and nursing. In Exp. 1, a group of young monkeys whose mothers had been fed ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1981-10-01 00:00:00
abstract::In addition to the long history of disease and death from natural toxicants in plants, there is a growing literature about the abundant levels and varieties of natural toxicants in our foods. These natural chemicals cause mutagenicity, carcinogenicity, teratogenicity, neurotoxicity and visceral organ toxicity in routi...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Recently, it has been proposed that a variety of environmental disruptors (EDs) disturb the neonatal development of the brain in mammals because of their lipophilic characteristics. Therefore, the synergism of these lipophilic compounds is important when evaluating the risk from EDs. In mouse cerebellar granule cells ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2004.07.008
更新日期:2005-01-01 00:00:00
abstract::The notion that maternal personality characteristics influence cognitive development in their children has been grounded in stress moderation theory. Maternal personality traits, such as self-esteem, may buffer maternal stressors or lead to improved maternal-child interactions that directly impact neurodevelopment. Th...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2007.11.006
更新日期:2008-03-01 00:00:00
abstract::Cognitive dysfunction has been reported in patients with carbon monoxide (CO) poisoning. However, the underpinning mechanism remained unclear. This study examined dopamine transporter (DAT) and metabolite ratios concurrently and their relationships with cognitive dysfunction in CO poisoning. Eighteen suicide attempter...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.11.002
更新日期:2021-01-01 00:00:00
abstract::Neurobehavioral deficits have been reported in Egyptian pesticide application teams using organophosphorus (OP) pesticides, but whether these effects are related to OP pesticide exposures has yet to be established. In preparation for a comprehensive study of the relationship between OP pesticide dose and neurobehavior...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2010.02.005
更新日期:2010-06-01 00:00:00
abstract::Pollution of hydrographic basins has affected the flora and fauna that thrive in these aquatic ecosystems, and fish, which constitute an important food resource, often contain a plethora of potentially toxic chemicals. In a major research project on early neurotoxic effects of environmental exposure to manganese among...
journal_title:Neurotoxicology
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Physiological methods that can be similarly recorded in humans and animals have a major role in sensory toxicology, as they provide a bridge between human sensory perception data and the molecular and cellular data obtained in animal studies. Vestibular toxicity research lags well behind other sensory systems in many ...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2018.02.003
更新日期:2018-05-01 00:00:00
abstract::Manganese (Mn) over-exposure in occupational settings is associated with basal ganglia toxicity and a movement disorder characterized by parkinsonism (i.e., the signs and symptoms of Parkinson disease). A simple test to help non-neurologists identify workers with clinical Mn neurotoxicity represents an unmet need. In ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.02.009
更新日期:2018-01-01 00:00:00
abstract::Methylmercury (MeHg) is an environmental neurotoxicant associated with aberrant central nervous system (CNS) functions. In this study, we examined the protective effect of a novel anti-inflammatory and cytoprotective nonapeptide, termed IIIM1, against MeHg-induced toxicity in cultured rat neonatal primary astrocytes. ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.12.004
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Methanol intoxication is an uncommon clinical problem leading to profound metabolic acidosis with serious neurological deterioration. We describe methanol induced brain lesions on diffusion-weighted MR images and discuss the pathophysiology of these lesions in light of diffusion changes. CASE REPORT:Brain i...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::The in vitro and vivo effects of lead on the NMDA-receptors in adult and juvenile mice were studied by means of receptor binding assays. Adult female NMRI-mice received 100 and 1,000 ppm lead as nitrate in their drinking water for 30 and 90 days. Perinatal exposure was achieved by treating gestating mice from the 5th ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::Oxidative stress is believed to play a key role in the degeneration of dopaminergic neurons in the substantia nigra (SN) of Parkinson's disease (PD) patients. An important biochemical feature of PD is a significant early depletion in levels of the thiol antioxidant compound glutathione (GSH) which may lead to the gene...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/s0161-813x(02)00035-9
更新日期:2002-10-01 00:00:00
abstract::Monoamine oxidase (MAO) isoenzymes play a major role in regulating the concentration of several bioactive amines, including serotonin and catecholamines. Both in the nervous system and in peripheral organs, MAOs can potentially modulate all the processes involving these bioactive amines. In the present article, we rev...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/S0161-813X(03)00095-0
更新日期:2004-01-01 00:00:00