Abstract：
:Many inhibitors of monoamine oxidase, particularly those developed during the past three decades, are often referred to as being "selective" for one or other isoform of the enzyme. However true this may be, selectivity within the EC 1.4.3.4 family does not preclude the possibility of interactions of these drugs with other proteins unrelated to monoamine oxidase. Indeed, evidence exists which either suggests or demonstrates directly that many of these inhibitors do interact with, and affect the behaviour of, other enzymes, receptor systems and uptake pumps, with potentially interesting consequences, desirable or otherwise, for the patient or the pharmacologist. An overview of many such interactions, and speculation upon some of the possible consequences, are provided in this review.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Holt A,Berry MD,Boulton AAdoi
10.1016/S0161-813X(03)00104-9subject
Has Abstractpub_date
2004-01-01 00:00:00pages
251-66issue
1-2eissn
0161-813Xissn
1872-9711pii
S0161-813X(03)00104-9journal_volume
25pub_type
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