Abstract：
:Nonylphenols (NP) are endocrine-disruptors known to be widely present in our environment. This study evaluated the effects of 4-n-NP on neurobehavioral development and memory capacity after perinatal exposure on the offspring rats. Dams were gavaged with 4-n-NP (0, 50 and 200mg/kg/day) from gestational day 5 to postnatal day (PND) 21. Dams exposed to the higher dose lost weight during gestation and had a longer gestational duration. Juvenile female pups of the 200mg 4-n-NP/kg/day group were lighter. Their thyroid somatic index (TSI) was also affected. For male pups, a decrease of TSI at weaning for the 200mg 4-n-NP/kg/day group and an increase of GSI for the 50mg 4-n-NP/kg/day group were observed. Physical maturation (incisives and eyes) were likewise affected. In open field (OF) tests, females were more active than males. In the first OF (PND 36), a treatment effect was observed only for males, particularly for the high dose group, which became as active as females. The second OF (PND 71) showed few differences between groups (treated vs control), the gender difference whatever the dose was not abolished. In the Morris Water Maze test, the study of the first 30s showed that females (200mg/kg/day) were mainly affected. Their performances were improved by 4-n-NP. These effects were particularly important for the first short-term memory test and observed to a lesser extent in the second evaluation of the long-term memory (PND 69). These data showed that perinatal 4-n-NP exposure induced behavioral and neuro-developmental impairments from 50mg/kg/day.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Couderc M,Gandar A,Kamari A,Allain Y,Zalouk-Vergnoux A,Herrenknecht C,Le Bizec B,Mouneyrac C,Poirier Ldoi
10.1016/j.neuro.2014.07.002subject
Has Abstractpub_date
2014-09-01 00:00:00pages
237-49eissn
0161-813Xissn
1872-9711pii
S0161-813X(14)00131-4journal_volume
44pub_type
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