Abstract：
:1-Bromopropane (1-BP) has been widely used as a substitute for chlorofluorocarbon that destroys the ozone layer. Although the central neurotoxicity of 1-BP has been recently reported, a molecular mechanism is not clear. In particular, the effects on cells in brain have not been fully analyzed. Here, we studied the effects of 1-BP on the activation of transcription factors involved in anti-apoptotic function or cell survival in astrocytes. Astrocytoma cell lines, U251, U373 and VM, or murine primary astrocytes were used for in vitro assay. DNA binding activities of NF-kappaB in these cells induced by interleukin (IL)-1 or LPS were inhibited by 1-BP. Consequently, the treatment of U251 cells with 1-BP resulted in suppression of NF-kappaB reporter activity. Furthermore, 1-BP blocked IkappaBalpha degradation, which is important for NF-kappaB activation. In addition, the level of Bcl-xL mRNA, which is known as an anti-apoptotic gene, were reduced in U251 treated with 1-BP or in the brain from rat exposed to 1-BP (400 ppm, 12 weeks). These results suggest that subchronic inhalation exposure to 1-BP vapor may affect the Bcl-xL expression in astrocytes.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Yoshida Y,Liu JQ,Nakano Y,Ueno S,Ohmori S,Fueta Y,Ishidao T,Kunugita N,Yamashita U,Hori Hdoi
10.1016/j.neuro.2006.05.015subject
Has Abstractpub_date
2007-03-01 00:00:00pages
381-6issue
2eissn
0161-813Xissn
1872-9711pii
S0161-813X(06)00134-3journal_volume
28pub_type
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