Abstract：
:Cuprizone is used to obtain demyelination in mice. Cuprizone-treated mice show symptoms similar to several neurodegenerative disorders such as severe status spongiosus. Although it has a simple chemical formula, its neurotoxic mechanism is still unknown. In this work, we examined both physico-chemical properties and biological effects of cuprizone. Our results indicate that cuprizone has very complicated and misunderstood solution chemistry. Moreover, we show here the inability of cuprizone to cross neither the intestinal epithelial barrier nor the neuronal cell membrane, as well its high tolerability by cultured neurons. If added to mice diet, cuprizone does not accumulate in liver or in brain. Therefore, its neurotoxic effect is explainable only in terms of its capability to chelate copper, leading to chronic copper deficiency.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Benetti F,Ventura M,Salmini B,Ceola S,Carbonera D,Mammi S,Zitolo A,D'Angelo P,Urso E,Maffia M,Salvato B,Spisni Edoi
10.1016/j.neuro.2010.05.008subject
Has Abstractpub_date
2010-09-01 00:00:00pages
509-17issue
5eissn
0161-813Xissn
1872-9711pii
S0161-813X(10)00096-3journal_volume
31pub_type
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