Abstract：
:We have studied the effects of aliphatic, alicyclic, and aromatic C6-10 solvents on the formation of reactive oxygen species (ROS) in rat cerebellar granule cell cultures. ROS formation was assessed by monitoring oxidation of 2',7'-dichlorofluorescin (DCFH) to the fluorescent compound 2',7'-dichlorofluorescein (DCF). We found that aromatic solvents with C > 7, and aliphatic and alicyclic solvents with C > or = 7 induce ROS formation in rat cerebellar granule cells in vitro. The response increased with increasing solvent concentration. The potency of the compounds within each homologous group seemed to be correlated to their octanol water partition-coefficients. The aromatic solvents were generally less efficient in inducing ROS formation than the aliphatic and the alicyclic compounds.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Dreiem A,Myhre O,Fonnum Fdoi
10.1016/S0161-813X(02)00010-4subject
Has Abstractpub_date
2002-12-01 00:00:00pages
701-9issue
6eissn
0161-813Xissn
1872-9711pii
S0161-813X(02)00010-4journal_volume
23pub_type
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