Abstract：
:Oxidative stress is believed to play a key role in the degeneration of dopaminergic neurons in the substantia nigra (SN) of Parkinson's disease (PD) patients. An important biochemical feature of PD is a significant early depletion in levels of the thiol antioxidant compound glutathione (GSH) which may lead to the generation of reactive oxygen species (ROS), mitochondrial dysfunction, and ultimately to subsequent neuronal cell death. In earlier work from our laboratory, we demonstrated that depletion of GSH in dopaminergic PC12 cells affects mitochondrial integrity and specifically impairs the activity of mitochondrial complex I. Here we report that pre-treatment of PC12 cells with R-lipoic acid acts to prevent depletion of GSH content and preserves the mitochondrial complex I activity which normally is impaired as a consequence of GSH loss.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Bharat S,Cochran BC,Hsu M,Liu J,Ames BN,Andersen JKdoi
10.1016/s0161-813x(02)00035-9subject
Has Abstractpub_date
2002-10-01 00:00:00pages
479-86issue
4-5eissn
0161-813Xissn
1872-9711pii
S0161-813X(02)00035-9journal_volume
23pub_type
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