Abstract：
:Electron microscopy has been used to characterize the products of the reactions of aluminum with DNA under three different conditions, one of which, pH 5 and Al (III)/DNA(P) ratio of 0.4, has been previously shown to produce reversible interstrand crosslinking in double-stranded DNA molecules. Under this condition, aluminum produced macromolecular aggregates of DNA upon heating, with a distinctive ultrastructure reversible to double-stranded DNA after removal of the aluminum. These structures were toroidal in configuration and exhibited mean widths of 4.9 +/- 1.8 nm and were 18.6 +/- .4 nm in diameter with a toroidal internal diameter of 7.4 +/- 4.7 nm. Previous results have shown that these structures contain Al(III) - crosslinked DNA, the present data suggests that this intermolecular crosslinking is associated with the production of compacted structures.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Karlik SJ,Chong AA,Eichhorn GL,De Boni Usubject
Has Abstractpub_date
1989-07-01 00:00:00pages
167-76issue
2eissn
0161-813Xissn
1872-9711journal_volume
10pub_type
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