Abstract：
:Manganese-deficient individuals have decreased manganese elimination. This observation has prompted suggestions that relative manganese deficiency may increase the risk for manganese neurotoxicity following inhalation exposure. The objective of this study was to determine whether dietary manganese intake influences the pharmacokinetics of inhaled manganese tetroxide (Mn3O4). Postnatal day (PND) 10 rats were placed on either a low (2 ppm), sufficient (10 ppm), or high-normal (100 ppm) manganese diet for 2 months. Beginning on PND 77 +/- 2, male littermates were exposed 6 h per day for 14 consecutive days to 0, 0.042, or 0.42 mg Mn3O4/m3. End-of-exposure tissue manganese concentrations and whole-body 54Mn elimination rates were determined. Tissue manganese concentrations were dependent on the dietary intake of manganese, thus confirming that altered hepatic manganese disposition or metabolism occurred. Male rats given 100 ppm manganese diet developed increased manganese concentrations in the femur, liver, and bile and had elevated whole-body 54Mn clearance rates when compared to animals given 2 ppm manganese diet. Male rats exposed to 0.42 mg Mn3O4/m3 had increased manganese concentrations in the olfactory bulb, lung, liver, and bile when compared to air-exposed male rats. A significant interaction between the concentration of inhaled Mn3O4 and dietary manganese level was observed only with the end-of-exposure liver manganese concentration. Our results indicate that animals maintained on either a manganese-deficient or high manganese diet do not appear to be at increased risk for elevated brain manganese concentrations following inhalation exposure to high levels of Mn3O4.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Dorman DC,Struve MF,Wong BAdoi
10.1016/s0161-813x(01)00075-4subject
Has Abstractpub_date
2002-07-01 00:00:00pages
185-95issue
2eissn
0161-813Xissn
1872-9711pii
S0161-813X(01)00075-4journal_volume
23pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract：:The endoplasmic reticulum (ER) is a principal site for protein synthesis, protein folding, calcium storage, and calcium signaling. Thapsigargin (TG), an inducer of ER stress, inhibits ER-associated Ca(2+)-ATPase and disrupts Ca(2+) homeostasis. ER stress plays an important pathogenetic role in Alzheimer's disease, Par...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.02.006
更新日期：2009-05-01 00:00:00
abstract：:Sevoflurane, a commonly used inhaled anesthetic, can induce neuronal apoptosis in the developing rodent brain and correlate with functional neurological impairment later in life. However, the mechanisms underlying these deleterious effects of sevoflurane remain unclear and no effective treatment is currently available...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.11.003
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Bisphenol A (BPA) has been associated with impairments in children's behavior, but few studies have investigated its relationship with cognitive function. OBJECTIVE:To investigate the association of urinary BPA concentrations with cognitive domains and intelligence quotient (IQ) in Spanish boys. METHODS:BP...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.06.006
更新日期：2019-09-01 00:00:00
abstract：:Currently, 26 mineral elements are considered important for humans; these include essential trace and macro elements, two that may be required, and others of concern solely for their toxic properties. Almost all elements are toxic at high intakes, and excessive consumption of dietary mineral supplements is a source of...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:Emerging evidences underline the ability of several environmental contaminants to induce an inflammatory response within the central nervous system, named neuroinflammation. This can occur as a consequence of a direct action of the neurotoxicant to the CNS and/or as a response secondary to the activation of the periph...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2014.03.004
更新日期：2014-07-01 00:00:00
abstract：:The synthesis of the NMDA receptor glycine site antagonist kynurenic acid (KYNA) from exogenously added kynurenine was measured in cultured cerebral cortical neurons, cortical astrocytes and an oligodendroglial cell line OLN-93, incubated for 2 h in the presence or absence of ammonium acetate ("ammonia") at 0.1-10 mM ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2006.01.004
更新日期：2006-07-01 00:00:00
abstract：:Chlorpyrifos (CPF) is an organophosphorus insecticide that elicits toxicity through inhibition of acetylcholinesterase (AChE). Young animals are markedly more sensitive than adults to the acute toxicity of CPF. We evaluated acetylcholine (ACh) release and its muscarinic receptor-mediated regulation (i.e. muscarinic au...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(00)00009-7
更新日期：2001-02-01 00:00:00
abstract：:Methylmercury (MeHg) is an environmental neurotoxicant associated with aberrant central nervous system (CNS) functions. In this study, we examined the protective effect of a novel anti-inflammatory and cytoprotective nonapeptide, termed IIIM1, against MeHg-induced toxicity in cultured rat neonatal primary astrocytes. ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2011.12.004
更新日期：2012-08-01 00:00:00
abstract：:In a series of experiments, prenatal administration of phenytoin to rats at non-embryotoxic and non-teratogenic doses produced offspring exhibiting large and enduring abnormalities in behavior. Plasma drug concentrations on the last day of exposure in the dams were within the human therapeutic range for anticonvulsant...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:In order to develop a better understanding of the role environmental toxicants may play in the onset and progression of neurodegenerative diseases, it has become increasingly important to optimize sensitive methods for quickly screening toxicants to determine their ability to disrupt neuronal function. The nematode Ca...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.07.002
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:Magnetic resonance spectroscopy (MRS) is a non-invasive method to quantify neurometabolite concentrations in the brain. Within the framework of the WELDOX II study, we investigated the association of exposure to manganese (Mn) and iron (Fe) with γ-aminobutyric acid (GABA) and other neurometabolites in the str...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.08.004
更新日期：2018-01-01 00:00:00
abstract：:Neurotoxicity in the mouse was produced following oral administration of chlordecone at 10, 25 and 50 mg/kg/day in corn oil vehicle. Hyperexcitability and tremors were observed on the 1st, 4th and 9th day after the administration of chlordecone at 50, 25 and 10 mg/kg/day, respectively, and mortality occurred on the 5t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Gadolinium is a rare-earth lanthanide metal ion and is used as organic gadolinium complexes in magnetic resonance imaging (MRI). Although gadolinium-based MRI agents are thought to be safe in clinical use, the in vivo release of the toxic free inorganic gadolinium (Gd3+) has been reported in some patients with kidney ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2008.10.003
更新日期：2009-01-01 00:00:00
abstract：:Dopamine (DA) and serotonin (5-HT) seem to be involved in several of the effects of ethanol (EtOH). Acetaldehyde (AcH), especially in the brain, induces effects that mimic those of EtOH. The purpose of this study was to investigate the effects of local perfusion of EtOH and AcH on extracellular DA and 5-HT in the dors...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.12.011
更新日期：2016-01-01 00:00:00
abstract：:An equal amount (per weight) of 127m tellurium (Te) was injected IP into weanling and adult rats, some intoxicated with a diet containing Te, others not. The young intoxicated rats presented a segmental demyelination of the sciatic nerve and paralysis of the hind limbs; the adult intoxicated rats did not. Quantitation...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：:The occurrence of status epilepticus (SE) is considered the main cause of brain lesions and morphological alterations, such as hippocampal neuron loss, that result in chronic epilepsy. Previous work demonstrated the convulsive and widespread neuropathological effects of soman, an organophosphorus compound that causes ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.02.010
更新日期：2012-06-01 00:00:00
abstract：:The present study was designed to examine the protective potential of hydroalcoholic extract of Vitis vinifera in ameliorating the alterations induced by aluminium (Al) on behavioural and neurochemical indices. Al was given orally (100mg/kg b.wt./day) whereas V. vinifera extract was administered through diet (400mg/kg...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.01.003
更新日期：2014-03-01 00:00:00
abstract：:Mice who were exposed to phenobarbital prenatally (B mice) had at adulthood deficits in the hippocampal eight-arm maze, spontaneous alternations, and water maze behaviors. Morphological studies revealed neuronal losses in the hippocampus. The surviving neurons had reductions from control in the number of dendritic bra...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1989-10-01 00:00:00
abstract：:Bortezomib is a proteasome inhibitor with a remarkable antitumor activity, used in the clinic as first line treatment for multiple myeloma. One hallmark of bortezomib mechanism of action in neoplastic cells is the inhibition of nuclear factor kappa B (NFκB), a transcription factor involved in cell survival and prolife...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.05.004
更新日期：2016-07-01 00:00:00
abstract：:Ionizing radiation (IR) is increasingly used for diagnostics and therapy of severe brain diseases. However, IR also has adverse effects on the healthy brain tissue, particularly on the neuronal network. This is true for adults but even more pronounced in the developing brain of unborn and pediatric patients. Epidemiol...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.04.003
更新日期：2020-07-01 00:00:00
abstract：:The effects of N-methyl carbamate pesticides on the photic after discharge (PhAD) of flash evoked potentials (FEPs) and the relationship between inhibition of brain cholinesterase (ChE) activity and the PhAD were evaluated. FEPs were recorded in Long Evans rats treated with physostigmine (s.c.) 0, 0.05, 0.1, 0.2 or 0....
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2007.09.004
更新日期：2008-01-01 00:00:00
abstract：:Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D. In the literature there are only four cases of women exposed to the drug in late pregnancy. We report the first case o...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2006.10.002
更新日期：2007-05-01 00:00:00
abstract：:Administration of 0.3% aluminum in drinking water elevated serum aluminum concentrations 8-fold in rats. Further, chronic treatment with aluminum for 2-3 mon, in both developing and adult rats, significantly decreased the levels of MAP-2 in brain, as determined by quantitative immunoblot analysis. Aluminum treatment a...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Nerve agents (NAs) are potent organophosphorus (OP) compounds with applications in chemical warfare. OP compounds act by inhibiting acetylcholinesterase (AChE). Soman (O-pinacolyl methylphosphonofluoridate) is one of the most potent NAs. It is well known that small doses of NAs can be lethal, and that even non-lethal ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.01.007
更新日期：2018-03-01 00:00:00
abstract：:Acrylonitrile (ACN) is a widely used chemical in the production of plastics, resin, nitrile, acrylic fibers, synthetic rubber, and acrylamide. ACN is considered a Group 2B possible carcinogen in humans and is known to cause gliomas in rats. These gliomas are predominantly composed of microglia and not astrocytes. Inte...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.09.013
更新日期：2017-12-01 00:00:00
abstract：:Over the past decade people have been constantly exposed to microwave radiation mainly from wireless communication devices used in day to day life. Therefore, the concerns over potential adverse effects of microwave radiation on human health are increasing. Until now no study has been proposed to investigate the under...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.10.009
更新日期：2015-12-01 00:00:00
abstract：:Prior studies demonstrate a critical role for mesolimbic dopamine systems, particularly nucleus accumbens, in the mediation of fixed interval (FI) schedule-controlled behavior and an enhancement of nucleus accumbens dopamine activity as a mechanism of chronic postweaning lead (Pb)-induced increases in Fl response rate...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(02)00059-1
更新日期：2002-09-01 00:00:00
abstract：:Despite the large body of experimental evidence demonstrating the neuroprotective properties of 17beta-estradiol (17beta-E2) both in vitro and in vivo experimental models of neuronal injury, the exact mechanisms implicated in neuroprotection have not been fully delineated. Some experimental evidence highlight a role f...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2005.01.009
更新日期：2005-10-01 00:00:00
abstract：:Intracerebral injection of methylmercury (CH3Hg) into the mouse brain resulted in significant weight loss and the appearance of characteristic neurological disturbances associated with CH3Hg intoxication. Neurological effects appeared dependent upon a minimum injected dose of 16 micrograms of CH3Hg corresponding to a ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:There are reports suggesting that some autistic children are unable to mount an adequate response following exposure to environmental toxins. This potential deficit, coupled with the similarity in clinical presentations of autism and some heavy metal toxicities, has led to the suggestion that heavy metal poisoning mig...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2006.06.003
更新日期：2006-09-01 00:00:00
