Abstract:
:The present study was designed to examine the protective potential of hydroalcoholic extract of Vitis vinifera in ameliorating the alterations induced by aluminium (Al) on behavioural and neurochemical indices. Al was given orally (100mg/kg b.wt./day) whereas V. vinifera extract was administered through diet (400mg/kg, p.o.) to rats for a total duration of 45 days. Passive avoidance and open field tests revealed significant alterations in the short-term memory and cognitive behaviour in rats treated with Al. Further, locomotor as well as muscular activities were also found to be significantly affected. Co-administration of V. vinifera extract with Al caused significant improvement in the short-term memory, cognition, anxiety, locomotion and muscular activity. Al exposure led to a significant decrease in the acetylcholinesterase activity in the brain, increase in serum glucose, TG, TC, ALP and ALT. Anti-oxidant parameters-reduced glutathione, catalase and glutathione reductase levels were also found to be significantly decreased but the levels of lipid peroxidation was significantly increased in brain following Al treatment. V. vinifera extract supplementation to Al treated animals caused a significant improvement in the activity of enzyme acetylcholinesterase which was altered by Al. Serum glucose, TG, TC, ALP and ALT were brought back to normal levels. Further, V. vinifera extract when given along with Al was also able to regulate the levels of Anti-oxidant parameters in brain and the values were found close to the normal controls. Histopathological studies revealed neurodegeneration and vacuolated cytoplasm after Al treatment. Therefore, the study strengthens the hypothesis that V. vinifera extract can be used as a neuroprotectant during Al induced neurotoxicity.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Lakshmi BV,Sudhakar M,Anisha Mdoi
10.1016/j.neuro.2014.01.003subject
Has Abstractpub_date
2014-03-01 00:00:00pages
73-9eissn
0161-813Xissn
1872-9711pii
S0161-813X(14)00016-3journal_volume
41pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::Monoamine oxidase (MAO) isoenzymes play a major role in regulating the concentration of several bioactive amines, including serotonin and catecholamines. Both in the nervous system and in peripheral organs, MAOs can potentially modulate all the processes involving these bioactive amines. In the present article, we rev...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/S0161-813X(03)00095-0
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Resin-based dental restorations may intra-orally release their components and bisphenol A. Gestational bisphenol A exposure has been associated with poorer executive functioning in children. OBJECTIVES:To examine whether exposure to resin-based composite restorations is associated with neuropsychological de...
journal_title:Neurotoxicology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuro.2012.08.001
更新日期:2012-10-01 00:00:00
abstract::Bortezomib is a proteasome inhibitor with a remarkable antitumor activity, used in the clinic as first line treatment for multiple myeloma. One hallmark of bortezomib mechanism of action in neoplastic cells is the inhibition of nuclear factor kappa B (NFκB), a transcription factor involved in cell survival and prolife...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2016.05.004
更新日期:2016-07-01 00:00:00
abstract::There is a wide variation in sensitivity to lead (Pb) exposure, which may be due to genetic susceptibility towards Pb. We investigated whether a polymorphism (rs1800435) in the δ-aminolevulinic acid dehydratase (ALAD) gene affected the toxicokinetics and toxicodynamics of Pb. Among 461 Chinese Pb-exposed storage batte...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.03.006
更新日期:2011-08-01 00:00:00
abstract::Manganese (Mn) may produce neurotoxicity in man through inhalation of Mn dust. Animals exposed to excessive Mn develop neurological abnormalities, and neuropathological lesions in the brain mainly in the globus pallidus with decreased concentrations of the neurotransmitter, dopamine (DA), in the brain. Monkeys exposed...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract::Despite the large body of experimental evidence demonstrating the neuroprotective properties of 17beta-estradiol (17beta-E2) both in vitro and in vivo experimental models of neuronal injury, the exact mechanisms implicated in neuroprotection have not been fully delineated. Some experimental evidence highlight a role f...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2005.01.009
更新日期:2005-10-01 00:00:00
abstract::Snake venom group IA secretory phospholipase A2 (sPLA2-IA) is known as a neurotoxin. Snake venom sPLA2s are neurotoxic in vivo and in vitro, causing synergistic neurotoxicity to cortical cultures when applied with toxic concentrations of glutamate. However, it has not yet been cleared sufficiently how sPLA2-IA exerts ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.12.009
更新日期:2013-03-01 00:00:00
abstract::A device using four infra-red light photocells per cage which monitor simultaneously the motility of 120 individual rodents, was developed at our institute. The measuring interval can be chosen freely, the starting time may be set freely and the test may last several weeks. The motility of the offspring (day 35-39) of...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Chlordecone (0.1 to 10 mg) or corn oil vehicle was injected into Japanese quail eggs on day 1 of incubation. Higher doses (0.5-10 mg per egg) produced tremor and ataxia at hatching and dose-related decreases in hatchability and survivability. Doses lower than 0.25 mg per egg had no effects. Gonad weights were not affe...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
abstract::In a series of experiments, prenatal administration of phenytoin to rats at non-embryotoxic and non-teratogenic doses produced offspring exhibiting large and enduring abnormalities in behavior. Plasma drug concentrations on the last day of exposure in the dams were within the human therapeutic range for anticonvulsant...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::Emerging evidences underline the ability of several environmental contaminants to induce an inflammatory response within the central nervous system, named neuroinflammation. This can occur as a consequence of a direct action of the neurotoxicant to the CNS and/or as a response secondary to the activation of the periph...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2014.03.004
更新日期:2014-07-01 00:00:00
abstract::Since both Pb exposure and aging have been associated with alterations in memory functions, this study compared the effects of Pb exposure initiated at early, middle and later stages of the life cycle on delayed spatial alternation performance. Young (21 day old), adult (8 mon old) and old (16 mon old) rats were expos...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Epilepsy or seizure disorder is one of the most common neurological diseases in humans. Although genetic mutations in ion channels and receptors and some other risk factors such as brain injury are linked to epileptogenesis, the underlying cause for the majority of epilepsy cases remains unknown. Gene-environment inte...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2011.12.014
更新日期:2012-01-01 00:00:00
abstract::Organophosphate (OP) compounds, including paraoxon (POX), are similar to nerve agents such as sarin. There is a growing concern that OP agents could be weaponized to cause mass civilian causalities. We have developed a rodent survival model of POX toxicity that is being used to evaluate chronic morbidity and to screen...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.08.008
更新日期:2014-09-01 00:00:00
abstract::Morphine is recommended by WHO as the analgesic of choice for effective treatment of moderate to severe cancer pain . Indeed spinally administered morphine at small doses injected intrathecally (i.t.) or intracerebroventricularly into animals produces a profound antinociception at both spinal and supraspinal sites. Co...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2004.12.011
更新日期:2005-10-01 00:00:00
abstract::The chelating agent, CaNa2EDTA, has proven useful for both the diagnosis and treatment of lead poisoning. The EDTA lead-mobilization test has demonstrated the presence of excessive body lead stores when blood concentrations were "normal." The EDTA lead-mobilization test is, however, impractical because it requires inj...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::The chemosensory effects of propionic acid (PA) in humans have not been conclusively studied and there is no established occupational exposure limit (OEL) in Germany. In addition to sensory irritation caused by PA, it was hypothesized that the annoying odor of PA might interfere with the performance results. There wer...
journal_title:Neurotoxicology
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuro.2009.08.009
更新日期:2009-11-01 00:00:00
abstract::Malaria is an infectious disease that is caused by different species of Plasmodium. Several antimalarial drugs are used to counter the spread and infectivity of Plasmodium species. However, humans are also vulnerable to many of the antimalarial drugs, including the quinoline-based drugs. In particular, the antimalaria...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.01.006
更新日期:2020-03-01 00:00:00
abstract::On the basis of the evidence that extracellular Zn2+ influx induced with AMPA causes Parkinson's syndrome in rats that apomorphine-induced movement disorder emerges, here we used a low dose of AMPA, which does not increase intracellular Zn2+ level in the substantia nigra pars compacta (SNpc) of young adult rats, and t...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.12.014
更新日期:2021-01-02 00:00:00
abstract::This study investigated the relationship between neurobehavioral performance and pulmonary function in young and middle adults. Data were collected from 178 subjects (88 male, 90 female) aged 20-50 years. Neurobehavioral performance was assessed by the Korean version of The Swedish Performance Evaluation System (SPES-...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.03.019
更新日期:2007-03-01 00:00:00
abstract::The ubiquitous functional roles of brain catecholamines have led to the notion that in vitro neurochemical changes in these systems may predict neurotoxicity. Conversely, others have argued that the appropriate use of neurochemical methods is for testing specific hypotheses that are developed based on observed phenome...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1987-04-01 00:00:00
abstract::Parkinson's disease (PD) is a common neurodegenerative movement disorder characterized by extensive degeneration of dopaminergic neurons in the nigrostriatal system. Neurochemical and neuropathological analyses clearly indicate that oxidative stress, mitochondrial dysfunction, neuroinflammation and impairment of the u...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2009.12.003
更新日期:2010-09-01 00:00:00
abstract::Developmentally-lead (Pb)-exposed rats showed an enhanced vulnerability to the stimulating and motivational effects of ethanol (EtOH). This is accompanied by differential activity of the brain EtOH-metabolizing enzymes catalase (CAT) and mitochondrial aldehyde dehydrogenase (ALDH2). Based on the theory that brain acet...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2019.09.011
更新日期:2019-12-01 00:00:00
abstract::Given the well-known antioxidant and neuroprotective properties of quercetin, the aim of this work was to evaluate the effects of quercetin stabilized by microencapsulation at two doses (10 mg kg-1 and 100 mg kg-1) on the oxidative/antioxidant status, number and morphological features of ICC, nitrergic neurons and M2-...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.01.011
更新日期:2020-03-01 00:00:00
abstract::We have developed an estrogen sensitive reporter gene assay and report here on its responsiveness to steroid hormones and several estrogenic contaminants, including pesticides and polychlorinated biphenyls (PCBs), GH4C1 rat pituitary cells were stably transfected with the reported gene ERE-TK-Luc which contains a luci...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Cytoskeletal alteration is a key factor in neurodegenerative processes like Alzheimer's or Parkinson's disease. Colchicine is a microtubule-disrupting agent that binds to tubuline, inhibiting microtubule assembly, and which triggers apoptosis. The present research describes the transcriptional activation of molecules ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2007.11.007
更新日期:2008-03-01 00:00:00
abstract::Central respiratory chemosensitivity has been ascribed to CO2-sensitive neurons located on the ventral brainstem surface. The effects of cholinergic mechanisms on CO2-sensitive neuronal activity recorded extracellularly at the brainstem respiratory chemosensitive area at the caudal ventral medullary surface (cVMS) wer...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::beta,beta'-iminodipropionitrile (IDPN) causes giant axon swellings in proximal internodes of spinal motor axons and in stem processes of dorsal root ganglia neurons. The electrophysiological consequences of the swellings were investigated in cats given IDPN (50 mg/kg i.p.) weekly for 0 (control), 1 (7 days), 2 (14 day...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Recent findings derived from large-scale datasets and biobanks link multiple genes to autism spectrum disorders. Consequently, novel rodent mutants with deletions, truncations and in some cases, overexpression of these candidate genes have been developed and studied both behaviorally and biologically. At the Annual Ne...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2009.07.002
更新日期:2009-09-01 00:00:00
abstract::The contribution of environmental toxicants to the etiology and risk of Parkinson's disease (PD) has been clearly established, with organochlorine insecticides routinely shown to damage the nigrostriatal dopamine pathway. Although PD is generally considered an adult onset disease, it has been postulated that exposure ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.07.008
更新日期:2014-09-01 00:00:00